Eficácia da dose reduzida de gonadorelina e diferentes prostaglandinas no protocolo ovsynch em vacas holandesas / Efficacy of decreasing dose of gonadorelin and comparison between different prostaglandins on ovsynch protocol in lactating Holstein cows

Avaliou-se a eficácia da dose de 0,10 ou de 0,25mg de gonadorelina nas taxas de ovulação e de sincronização no protocolo Ovsynch e de 150mcg de D-cloprostenol ou 0,530mg de cloprostenol sódico na regressão do corpo lúteo (CL) de sete dias e de todos os CL. Foram utilizadas 136 vacas lactantes da raça Holandesa, com média de produção de leite de 23,75,8kg/dia, com 138,4±72,0 dias em lactação. As vacas foram distribuídas aleatoriamente em quatro grupos, de acordo com a dose de gonadorelina e o tipo da prostaglandina. As taxas de ovulação e de sincronização foram de 52,9 por cento e 80,9 por cento para 0,10mg de gonadorelina e de 57,4 por cento e 80,9 por cento para 0,25mg de gonadorelina, respectivamente. A taxa de regressão do CL de sete dias foi de 97,1 por cento para o D-cloprostenol e de 97,5 por cento para o cloprostenol sódico. A taxa de prenhez não foi influenciada pelos tratamentos, mas foi influenciada pela taxa de ovulação à primeira aplicação de gonadorelina, 16,0 por cento vs. 6,6 por cento para as vacas que ovularam e não ovularam, respectivamente. Conclui-se que 0,10mg de gonadorelina foi eficiente e ambas prostaglandinas podem ser usadas em protocolos de sincronização da ovulação.

The efficacy of 150mcg D-cloprostenol or 0.530mg cloprostenol sodium on the 7- day corpus luteum (CL) regression rate, and of two doses of gonadorelin, 0.10mg vs. 0.25mg, on the ovulation and synchronization rates during the Ovsynch protocol were evaluated. Lactating Holstein cows (n=136), producing 23.75.8kg milk/d and 138.4±72.0 days in milk were randomly assigned to four groups, according to dose of gonadorelin and prostaglandin type. No effect of the products and doses tested on conception rate were observed. The ovulation and synchronization rates using 0.10mg or 0.25mg of gonadorelin were 52.9 percent and 80.9 percent vs. 57.4 percent and 80.9 percent, respectively. The CL regression rates in cows ovulating after the first GnRH using D-cloprostenol or cloprostenol sodium were 97.1 percent and 97.5 percent, respectively. The pregnancy rate was not affected by treatment, but by ovulation rate after the first injection of GnRH. The pregnancy rates were 16.0 percent and 6.6 percent for ovulated and non ovulated cows, respectively. The results suggest that 0.10mg dose of gonadorelin was efficient and both prostaglandins can be used in synchronization of ovulation protocols.

Salivary prostaglandin concentration in cases of depression

This study was performed on 75 male and female subjects, they were nearly of the same socioeconomic levels from Sharqia Governorate and their ages ranged from 19 to 63 years. They were classified into three main groups. Group 1 included 25 control subjects. They were healthy and completely free from any clinical psychiatric disturbances. Group 2 comprised 16 patients having neurotic depression. Group 3 involved 34 subjects having major depression. The results were statistically analyzed and data revealed that salivary prostaglandin E2 levels were significantly higher in major depression groups as compared to the control group and patients with neurotic depression. Also, with increasing severity of major depression which was more pronounced in severe major depression. There was significant difference between female and male depression patients. In contrast, salivary PGE2 levels showed no significant difference between neurotic depression group and control group, no significant difference between unipolar depression subgroup and bipolar depression subgroup and also no significant difference between melancholic and non melancholic depression subgroups

Antiinflamatórios de última geração / Last generation antiinflammatories drugs

Os antiinflamatórios não-esteróides surgem atualmente como os melhores coadjuvantes da terapêutica odontológica em geral. Numa abrangente revisão da literatura, os autores reuniram os chamados grupos da última geração, apresentando suas indicações, interações e destacando sua farmacocinética em particular

Estimation of prostaglandin E2 and 6-Keto-prostaglandin F1 in cases of chronic tonsillitis

This study was carried out on 50 patients suffering from chronic tonsillitis of different age groups. Prostagl and in E2 and 6-ketoprostagl and in F1 were estimated in the tissue of tonsils by radioimmunoassay methods. It was concluded that the young age groups [4 - 7 years] had higher levels of prostagl and in E2 and 6-ketoprostagl and in F1. The young age groups [4 - 7 years and 8 - 12 years] had higher levels of prostagl and in E2 more than 6-ketoprostagl and in F1, the older age group [13 - 18 years] had higher levels of 6-ketoprostagl and in F1 than prostagl and in E2. The levels of prostagl and in E2 were higher than the levels of 6-ketoprostagl and in F1 in the tissues of tonsils; while in plasma 6-ketoprostagl and in, F1 was higher than prostagl and in E2. Prostagl and in E2 was secreted from lymphocytes of tonsils

Hormonal assay in cases of primary atrophic rhinitis

This study was conducted on 40 cases of primary atrophic rhinitis in comparison with 10 normal control and 10 contact persons. A nasal biopsy had taken aiming to verify the clinical diagnosis and to localize the prostaglandin in this condition using PAP technique in comparison with normal control persons. In this study we found high plasma level of prostaglandin, A.C.T.H and cortisone. But less localization of prostaglandin in the nasal tissue in cases of primary atrophic rhinitis in comparison with normal control persons. This low localization of prostaglandin is due to the unhealthy endothelial cells of the blood vessels that normally synthetize the prostaglandin. The high plasma level of prostaglandin can be explained by the production of prostaglandin from other healthy tissues that triggered by the necrosis. This hight plasma level of prostaglandin results in high level of plasma. A.C.T.H and consequently plasma cortisone. The high level of plasma cortisone may exert inhibitory effect on many immune functions that lowers the local nasal tissue immunity leading to the chronicity of this condition

Actualidad en la fisiopatología de la endometriosis e infertilidad / Update in the pathophysiology of endometriosis and infertility

El fluido peritoneal interviene en el proceso de ovulación, transporte de gameto, fertilización y en el desarrollo precoz del embrión. Los cambios fisiopatológicos en el fluido peritoneal con incremento de macrófagos pueden interferir en la fertilidad en las pacientes con endometriosis, al igual que las protaglandinas. Las respuestas autoinmunes ante los implantes endometriales podrían crear anticuerpos, provocando la infertilidad al huésped. El conocimiento más exacto de la fisiopatología de la infertilidad producida por la endometriosis nos permitirá modalidades nuevas de tratamiento

Effect of some calcium channel blockers [verapamil and nifedipine] on the level of prostaglandins in the brain of rabbit

In the present study, 3 groups of rabbits were used. One group severe controls while the 3[nd] and 3[rd] groups were given verapamil [16 mg/kg] and infedipine [3 mg/kg] orally for 7 days respectively. Verapamil and infedipine caused significant reduction in the level of brain PGS

Effect of piracetam, a nootropic agent, on rat brain monoamines and prostaglandins.

Piracetam is the prototype of a new class of psychotropic drugs, the nootropic agents, which are claimed to selectively improve the higher telencephalic integrative activities. The effect of piracetam on rat brain monoamines and prostaglandins (PGs) was assessed so as to garner information on its mode of action. Two doses of the drug were used, a lower dose (20 mg/kg ip) and a higher dose (100 mg/kg, ip), the latter being known to exert a facilitatory effect on learning and memory. Piracetam produced a dose-related effect on rat brain serotonin (5HT) and noradrenaline (NA), with the lower dose inducing a decrease in 5HT levels and an increase in NA concentrations. The higher dose of piracetam produced the opposite effect. Dopamine (DA) levels were not significantly affected. The lower dose of the drug attenuated 5HT turnover and augmented that of NA, whereas the higher dose of piracetam produced the reverse effects, in clorgyline treated rats. The lower dose of piracetam produced a slight and statistically insignificant increase in rat brain PGE2 and PGF2 alpha. However, the higher dose of the drug produced marked increase in the levels of both the PGs. The observed biochemical effects may provide a basis for the nootropic effect of piracetam. However, they may also be due to the GA-BA-mimetic action of the drug, particularly those observed with the lower dose of piracetam.