Caso clínico: hemangioma esclerosante (neumocitoma) pulmonar / Clinical case: lung sclerosing hemangioma (pneumo cytoma)

El objetivo de este artículo es presentar un caso de raro de tumor pulmonar benigno, hemangioma esclerosante (neumocitoma), en una mujer de 24 años, asintomática, con hallazgo radiológico incidental. Se describen las características clínicas, imagenológicos y anátomo-patológicos de la entidad, con una breve revisión bibliográfica.

We present a rare case of benign lung neoplasia, sclerosing hemangioma (pneumocytoma), in a woman 24 years old, asymptomatic, with radiological incidental find. The clinical, imaging and pathological features of the entity are described, with brief bibliographic review.

Bone metastasis in pulmonary sclerosing hemangioma

No abstract available.

Sclerosing Pneumocytoma with a Wax-and-Wane Pattern of Growth: A Case Report on Computed Tomography and Magnetic Resonance Imaging Findings and a Literature Review

Sclerosing pneumocytoma (SP) of the lung is a rare benign neoplasm. Here, we describe an unusual presentation of SP with a wax-and-wane pattern of growth in a 47-year-old woman. Tumor diameter decreased over a 3-year follow-up period and then increased on serial follow-up computed tomography scans. The mass showed high signal intensity on both T1- and T2-weighted chest magnetic resonance imaging (MRI) and early enhancement with a plateau on dynamic MRI. We speculate that intratumoral bleeding and resorption processes accounted for the changes in tumor size.

Histogenesis of pulmonary sclerosing hemangioma / 中华病理学杂志

<p><b>OBJECTIVE</b>To investigate the histogenesis of pulmonary sclerosing hemangioma (PSH).</p><p><b>METHODS</b>Tissue microarray and immunohistochemical technique were used to detect the expression of pan-cytokeratin, epithelial membrane antigen(EMA), vimentin, thyroid transcription factor (TTF)-1, napsin A, synaptophysin, chromogranin A, CD56, E-cadherin, β-catenin, CD117, CD68 and transforming growth factor(TGF)-β1 in 49 cases of PSH.</p><p><b>RESULTS</b>Immunohistochemistry revealed that all cuboidal surface cells expressed pan-cytokeratin, EMA, TTF-1 and napsin A. The polygonal cells expressed EMA, TTF-1, napsin A (positive rate 16.3%, 8/49), but not pan-cytokeratin. Both types of cells were negative for synaptophysin, chromogranin A and CD56. Strong positive staining for E-cadherin and β-catenin appeared on the membrane of cuboidal cells in all PSH, with cytoplasm staining for β-catenin as well. The expression levels of these adhesion molecules decreased in the polygonal cells, with the staining localized to the cytoplasm. E-cadherin staining was not detected or was weak. β-catenin staining was not detected on the cell membrane but partially in the cytoplasm. The polygonal cells stained strongly for vimentin, while only a few cuboidal cells were positive. CD117 and CD68 positive inflammatory cells were scattered between the polygonal cells, which was consistent with the distribution of TGF-β1 positive cells.</p><p><b>CONCLUSIONS</b>PSH originates from the primitive respiratory epithelium, and polygonal stromal cells may be derived from epithelial-mesenchymal transformation of the cuboidal cells. TGF-β1 may play an important role in the formation of sclerosing hemangioma.</p>

Surgery treatment for pulmonary sclerosing hemangioma / 中华外科杂志

<p><b>OBJECTIVE</b>To investigate the clinicopathological features and surgical treatment of pulmonary sclerosing hemangioma (PSH).</p><p><b>METHODS</b>Clinic data of PSH patients admitted by surgical resection from January 1985 to December 2010 was analyzed retrospectively. One hundred and sixty-five patients were enrolled in the study. There were 27 male and 138 female patients with a mean age of (48 ± 13) years. Seventy-nine patients were asymptomatic at the time of diagnosis. Eighty-nine tumors arose in the right lung (27 in right upper lobe, 24 in right middle lobe, 34 in right lower lobe, 2 in right upper lobe with invasion of right middle lobe, 1 in right middle lobe with invasion of right lower lobe, and 1 case with multiple lobe lesions), 75 in the left (33 in left upper lobe, 42 in left lower lobe), and 1 in the bilateral. There were huge mass lesions in 2 cases, endobronchial lesions in 2 cases, and multiple lesions in 6 cases. The mean size of the lesion was (2.6 ± 0.9) cm (ranging from 0.9 to 10.0 cm). Forty-eight cases (29.1%) were misdiagnosed as malignancies preoperatively, and 41 cases (24.8%) were misdiagnosed intraoperatively.</p><p><b>RESULTS</b>Resections were performed by means of video-assisted thoracoscopy (n = 53) and thoracotomy (n = 112). Surgical resection included pulmonary wedge excision in 61 patients, lobectomy in 89 patients, right bilobectomy in 5 patients, anatomic segmentectomy in 2 patient, enucleation in 6 patients, and synchronous bilateral pulmonary wedge resection in 1 patient. Operative mortality and morbidity occurred in 0 and 2 (4.3%) patients, respectively. Mean follow-up was 34.7 months (ranging from 6 to 62 months). There was no local recurrence or death from PSH.</p><p><b>CONCLUSIONS</b>PSH is a rare benign lung tumor. It is difficult to make accurate diagnosis preoperatively, and sometimes even intraoperative frozen sections can't differentiate it from malignant tumors. Surgical resection is usually indicated for definite diagnosis and treatment. Partial resection is a sufficient treatment in view of uncommon tumor recurrence. Thoracoscopic surgery is recommended for PSH.</p>

A Case of Pulmonary Sclerosing Hemangioma with an Increased Size and Chest Discomfort on 10 Years' Follow-up

Pulmonary sclerosing hemangioma is a relatively rare neoplasm of the lung with polymorphic histologic features of 2 unifying cellular components including surface cuboidal cells and interstitial round cells. Pulmonary sclerosing hemangioma typically occurs in middle aged women with asymptomatic, peripheral, solitary, well-circumscribed lesions. Although it is pathologically benign, it reveals size growing and chest symptom. We here report a case of pulmonary sclerosing hemangioma in a 72-year-old woman. She presented chest discomfort. A chest radiography and a chest computed tomography scan showed growing size from 3.2x3.1 cm to 6.0x5.3 cm in left upper lung during 10 years' follow-up period. Surgical resection of lung revealed a distinct constellation of findings including 2 epithelial cell types, surface cells, and round cells, which form 4 architectural patterns, papillary, sclerotic, solid, and hemorrhagic. She was diagnosed as pulmonary sclerosing hemangioma and chest discomfort disappeared.

Surgery for Pulmonary Sclerosing Hemangioma: Lobectomy versus Limited Resection

BACKGROUND: Pulmonary sclerosing hemangioma is a rare thoracic tumor, and pathophysiology or clinical course of this tumor is not yet fully described. Furthermore, there is no consensus on the standard operative procedure for this tumor. MATERIAL AND METHODS: Medical records of thirty-two patients, who underwent surgical resection of pulmonary sclerosing hemangioma from 1996 to 2007, were retrospectively reviewed. RESULTS: Nineteen patients underwent lobectomy and thirteen patients underwent limited resection. Video-assisted thoracoscopic surgery was performed in 9 patients in the latter group. Lymph node dissection was done in 21 patients, and one patient was found to have lymph node metastasis of the tumor. There was no postoperative complication, no early death and no tumor-related late mortality. The mean follow-up duration was 39.3 months (2 months~129 months), and all patients were free of local recurrence and distant metastasis during this period. There was no significant difference in patient's characteristics between the two groups, except that the mean hospital stay was shorter in limited resection group than in lobectomy group (p=0.0031). CONCLUSION: Pulmonary sclerosing hemangioma usually requires surgical resection for both diagnosis and treatment. Limited resection can decrease hospital stay with a surgical outcome comparable to lobectomy, and may be preferred to lobectomy if sufficient resection margin can be achieved.

Hemangioma pulmonar esclerosante / Pulmonary sclerosing hemangioma

O hemangioma pulmonar esclerosante é um tumor pouco freqüente, que se manifesta como nódulo pulmonar solitário. Entretanto, o seu comportamento biológico ainda não está definido adequadamente. O diagnóstico e a evolução dessas lesões são dificultados pelos achados radiológicos inespecíficos e a dificuldade de interpretação das biópsias de congelação. Os autores descrevem um caso em que o tumor foi completamente retirado com a lobectomia, e o diagnóstico histopatológico definitivo foi de hemangioma esclerosante de pulmão. A ressecção em cunha é realizada na maioria dos casos; porém, quando o diagnóstico não é definido no intra-operatório, é recomendada ressecção mais extensa e linfadenectomia sistemática. Mais estudos são necessários para avaliar a extensão da doença, apesar das metástases não alterarem o excelente prognóstico.

Lung sclerosing hemangioma is an uncommon tumor that presents as a solitary asymptomatic nodule. However, the biologic behavior of this tumor has not yet been characterized adequately. Diagnostic evaluation of this lesion is a diagnostic challenge due to the nonspecific radiological findings, potential intraoperative dilemmas like difficult frozen section interpretation.We describe a case of lung sclerosing hemangioma. The tumour was completely removed by lobectomy and the definitive biopsy was informed as a lung sclerosing hemangioma. Generally, wedge resection is justified in the majority of cases, but in cases of uncertain intraoperative diagnosis, extensive resection with systematic lymphadenectomy is recommended.More studies are needed to evaluate extension of this disease, despite metastasis does not seem to change theexcellent prognosis.

Study of androgen receptor and phosphoglycerate kinase gene polymorphism in major cellular components of the so-called pulmonary sclerosing hemangioma / 中华病理学杂志

<p><b>OBJECTIVE</b>To study the clonality of polygonal cells and surface cuboidal cells in the so-called pulmonary sclerosing hemangioma (PSH).</p><p><b>METHODS</b>17 female surgically resected PSH were found. The polygonal cells and surface cuboidal cells of the 17 PSH cases were microdissected from routine hematoxylin and eosin-stained sections. Genomic DNA was extracted, pretreated through incubation with methylation-sensitive restrictive endonuclease HhaI or HpaII, and amplified by nested polymerase chain reaction for X chromosome-linked androgen receptor (AR) and phosphoglycerate kinase (PGK) genes. The length polymorphism of AR gene was demonstrated by denaturing polyacrylamide gel electrophoresis and silver staining. The PGK gene products were treated with Bst XI and resolved on agarose gel.</p><p><b>RESULTS</b>Amongst the 17 female cases of PSH, 15 samples were successfully amplified for AR and PGK genes. The rates of polymorphism were 53% (8/15) and 27% (4/15) for AR and PGK genes respectively. Polygonal cells and surface cuboidal cells of 10 cases which were suitable for clonality study, showed the same loss of alleles (clonality ratio = 0) or unbalanced methylation pattern (clonality ratio < 0.25).</p><p><b>CONCLUSIONS</b>The polygonal cells and surface cuboidal cells in PSH demonstrate patterns of monoclonal proliferation, indicating that both represent true neoplastic cells.</p>

Multiple Sclerosing Hemangiomas of the Lung: A Case Report / 대한흉부외과학회지

Since sclerosing hemangioma of the lung was first described by Liebow and Hubbell in 1956, there have been several reports on cases occurring as a solitary nodule; however, sclerosing hemangiomas occurring as multiple nodules are extremely rare. The histogenesis of this tumor remains controversial and there are several hypotheses of the etiology. Three separate nodules were found in a 57-year-old housewife, one found in the right middle lobe, one in the apicoposterior segment of the left upper lobe, and one in the superior segment of the left lower lobe. The only symptom or sign presented was a dry cough. Apicoposterior segmentectomy of the left upper lobe and wedge resection of the superior segment of the left lower lobe were performed. The postoperative course was uneventful and the patient was discharged on the postoperative 15th day.

Effects of Dietary Salt Restriction in the Development of Renal Failure in the Excision Remnant Kidney Model

So-called sclerosing hemangioma of the lung is a rare benign neoplasm which usually presents with a coin lesion detected through routine chest X-ray. We report two cases showing characteristic cytologic appearances which have been rarely reported. Both cases were young females with coin lesions in the lung. Fine needle aspiration of each case revealed unique but some different cytologic features. Case 1 showed bland-looking polygonal epithelial cells resembling bronchioloalveolar cells having pre- dominantly papillary configurations with loosely arranged solid sheets or isolated cells. Cytoplasms were plump, cyanophilic, and finely granular, with eccentric nuclei, The nuclei were usually monotonous, round-to-ovoid, and vesicular with a small but conspicuous nucleolus. In comparison to case 1, case 2 revealed largely loose pavement-like solid sheets or clusters rather than papillary patterns in the hemorrhagic background. The size of tumor cells were a little smaller than that of case 1. Bronchioloalveolar carcinoma and papillary adenocarcinoma of metastatic origin were considered to be one of the important differential diagnoses with these cytologic features. Histologically, both cases exhibited findings compatible with so-called sclerosing hemangioma of the lung.

Fine Needle Aspiration Cytology of the Sclerosing Hemangioma of the Lung: A Report of Five Cases / 대한세포병리학회지

Sclerosing hemangioma is a rare, benign neoplasm of the lung, usually presented as a solitary pulmonary nodule in an otherwise asymptomatic middle-aged woman. Cytologically it shows papillary, sheet, and cyst-like arrangements representing three main histologic patterns of papillary, solid, and angiomatous ones, respectively. Herein, we report the fine needle aspiration cytology of 5 cases of sclerosing hemangioma of the lung. The most characteristic finding is cyst-like spaces intimately related to the papillary or solid cell nests. The tumor cells are relatively monotonous, round to oval, small to medium in size. They have small amount of eosinophilic cytoplasm. The nuclei are uniform, round and have small but conspicuous nucleoli. The tumor cells in one of the presenting cases are large with abundant cytoplasm and show moderate nuclear pleomorphism. The nuclear chromatin, however, is fine and even without exception, even in the case showing nuclear pleomorphism. Major differential diagnoses based on the cytologic findings are well-differentiated papillary adenocarcinoma, bronchioloalveolar carcinoma, and carcinoid tumor.

MR Findings of Sclerosing Hemangioma of the Lung: A Case Report

This report describes a sclerosing hemangioma of the lung evaluated by MRI. The mass demonstrated hyperintense signal on T1 -weighted, proton density, and T2-weighted spin-echo images. Contrast-enhanced T1 -weighted images showed marked, homogeneous enhancement of the mass. The MR appearance is not specific for sclerosing hemangioma of the lung, as other benign tumors can appear similarly. However, the appearance of homogeneous enhancement within the mass on Gd-DTPA enhanced MR may suggest the diagnosis.

MR Findings of Sclerosing Hemangioma of the Lung: A Case Report

This report describes a sclerosing hemangioma of the lung evaluated by MRI. The mass demonstrated hyperintense signal on T1 -weighted, proton density, and T2-weighted spin-echo images. Contrast-enhanced T1 -weighted images showed marked, homogeneous enhancement of the mass. The MR appearance is not specific for sclerosing hemangioma of the lung, as other benign tumors can appear similarly. However, the appearance of homogeneous enhancement within the mass on Gd-DTPA enhanced MR may suggest the diagnosis.

CT findings of sclerosing hemangioma of the lung: Two cases report

Sclerosing hemangiomas are rare benign neoplasms in pulmonary parenchyme, We analyzed CT findings of two cases of sclerosing hemangiomas of the lung in two adult females. Chest radiograph showed well-circumscuribed, round soft tissue mass with calcification in right lower lobe of one patient and without calcification and moderate or marked contrast enhancement was clearly demonstrated with CT scan. CT findings of contratst enhancement and contour of calcification allow differentiation of sclerosing hemangioma from other venign neoplasms or postinflammotory pseudotusrs of the lung.

A clinical anaylsis on 8 cases of pulmonary sclerosing hemangioma / 결핵

No abstract available.

Sclerosing hemangioma of the lung: a case report / 대한흉부외과학회지

No abstract available.

Fine needle aspiration cytology of so-called sclerosing hemangioma of the lung: report of two cases- / 대한세포병리학회지

So-called sclerosing hemangioma of the lung is a rare benign neoplasm which usually presents with a coin lesion detected through routine chest X-ray. We report two cases showing characteristic cytologic appearances which have been rarely reported. Both cases were young females with coin lesions in the lung. Fine needle aspiration of each case revealed unique but some different cytologic features. Case 1 showed bland-looking polygonal epithelial cells resembling bronchioloalveolar cells having predominantly papillary configurations with loosely arranged solid sheets or isolated cells. Cytoplasms were plump, cyanophilic, and finely granular, with eccentric nuclei. The nuclei were usually monotonous, round-to-ovoid, and vesicular with a small but conspicuous nucleolus. In comparison to case 1, case 2 revealed largely loose pavement-like solid sheets or clusters rather than papillary patterns in the hemorrhagic background. The size of tumor cells were a little smaller than that of case 1. Bronchiotoalveolar carcinoma and papillary adenocarcinoma of metastatic origin were considered to be one of the important differential diagnoses with these cytologic features. Histologically, both cases exhibited findings compatible with so-called sclerosing hemangioma of the lung.

Sclerosing hemangioma of lung: 3 case report / 영남의대학술지

Sclerosing hemangioma of the lung is uncommon benign neoplasm of uncertain histogenesis. Their radiologic appearance is relatively distinct and well defined. Recently we experienced 3 cases of sclerosing hemangioma of the lung in 54, 52, 51 years old women. The light microscopic findings are similar to the features reported by Liebow and Hubbell (1956).