ABSTRACT
La metoclopramida reduce la presión arterial en sujetos normotensos e hipertenso durante estímulos presores moderados a severos pretratados con Labetalol, igualmente tiene efecto hipotensor en hipertensos durante urgencia hipertensiva y en anillos de aorta de rata ha mostrado un efecto antidrenérgico alfa 1. En el presente trabajo se reporta la inhibición de la agregación plaquetaria inducida por ADP en presencia de metoclopramida, hallazgo este que puede ser de importancia clínico-terapéutica en pacientes con preeclampsia en donde coexiste hipertensión arterial y actividad proagregante plaquetaria aumentada así como también niveles plasmáticos de serotonina elevados
Subject(s)
Animals , Rats , Platelet Aggregation , Antihypertensive Agents/administration & dosage , Antihypertensive Agents/therapeutic use , Hypertension/therapy , Metoclopramide/antagonists & inhibitors , Metoclopramide/therapeutic use , Rats, Sprague-Dawley/blood , VenezuelaABSTRACT
Sprague-Dawley rats are frequently used in experiments and their normal hematological, serological and anatomical parameters are not easily available. The aim of this study was to measure these parameters in adult Sprague-Dawley rats. 24 rats (12 males) whose weight ranged between 200 and 300 g raised at the Instituto de salud Pública in controlled environment conditions and fed with pellets were studied. After a 24 h fast animals were anesthetized with Droperidol and Ketamine and after obtaining a cardiac blood for glucose, calcium, amylase, total proteins, cholesterol, AST, ALT, bilirrubin, alkaline phosphatases, electrolytes and complete blood count were determined. Heart, lung, pancreas, kidney and testicle mean weight was also calculated. Male and female rats had significant differences in packed red cell volume, white blood cell count and hemoglobin