1.
Journal of Forensic Medicine
;
(6): 428-430, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-983332
ABSTRACT
OBJECTIVE@#To study the role of dopamine D3 receptor involved in the amphetamine-induced conditioned place preference (CPP) in mice.@*METHODS@#The CPP was observed in D3 receptor knock-out (D3RKO) mice and C57BL/6 wild-type control mice after administration of amphetamine. The data were analyzed with a two-way ANOVA using the SPSS 13.0 software.@*RESULTS@#D3RKO mice showed a significant amphetamine-induced CPP (P<0.001), compared with the ones administered with saline in C57BL/6 control mice.@*CONCLUSION@#The results indicate that amphetamine can produce significant CPP in dopamine D3 receptor knock-out mice, suggesting that amphetamine-induced addiction can be inhibited by dopamine D3 receptor.