Allogeneic peripheral blood stem cell transplant [PBSCT] using anti-IL2 receptor antibody daclizumab for the prevention of acute graft versus host disease in steroid refractory diamond blackfan anaemia: a case report

The case report of a 2 year old boy with steroid refractory DBA, treated with allogeneic PBSCT from an HLA matched sibling is presented. Anti-IL2 receptor antibody Daclizumab was used as a prophylaxis for graft versus host disease [GvHD]. Complete recovery without any evidence of GvHD ensued

Soluble interleukin-2 receptor in patients with vitiligo: relation to types, activity and duration of the disease

In order to study the role of soluble interleukin-2 receptor [sIL-2R] in pathogenesis of vitiligo, its serum level was measured in serum of 39 patients with vitiligo and 20 normal controls using the method of sandwich ELISA. The patients were divided according to type of disease into three groups. There was a highly significant increase in sIL-2R level in patients with vitiligo compared with that of the controls. There was no significant difference among sIL- 2R levels according to sex either in patients with vitiligo or controls. It was noticed that the level of sIL-2R was significantly increased in generalized and focal types of vitiligo than segmental type, which indicated that activation of T-lymphocytes would be an important component in pathogenesis of the two types of vitiligo

Immunological status of ENL (erythema nodosum leprosum) patients: its relationship to bacterial load and levels of circulating IL-2R

Dados recentes sugerem que o curso clinico dos estados reacionais na lepra esta estritamente relacionado a liberacao local ou sistemica de citocinas. Neste estudo, pacientes com ENL (erythema nodosum leprosum) foram agrupadas segundo a intensidade de seus sintomas clinicos. Os aspectos clinicos e imunologicos do ENL e os efeitos desses parametros na carga bacilar foram estabelecidos em conjuncao com a resposta imune in vitro desses pacientes, a antigenos microbacterianos. Em 10 de 17 pacientes testados, o indice bacteriano (IB) foi reduzido em pelo menos 1 log desde o diagnostico da lepra ate o aparecimento do primeiro episodio reacional, comparado a uma reducao esperada de 0.3 log no grupo reacional no mesmo periodo de MDT (multidrogaterapia)...

Acciones de la prolactina sobre el sistema inmunen: revisión bibliográfica / Action of prolactin on the immune system : review of the literature

En el presente trabajo se evidencia el papel de esta hormona en la proliferación linfocitaria, la inducción de receptores para la interleuquina-2 en la superficie de los linfocitos, y la producción por parte de estas células, de una mólecula prolactin-like, así como otros aspectos que acentúan los novedosos efectos de la PRL sobre el sistema inmune

Studies of human leprosy lesions in situ using suction-induced blisters: cell changes with IgM antibody to PGL-1 and interleukin-2 receptor in clinical subgroups of erythema nodosum leprosum.

To examine the immunopathogenesis of type 2 erythema nodosum leprosum (ENL) reactions in leprosy, we studied cellular and soluble immunologic components of skin lesions in 57 patients with reactions (19 acute ENL and 38 chronic ENL), 61 active patients without reactions, and 33 control patients whose leprosy had been treated and cured. Cells, IgM antibody to PGL-1 and Tac peptide levels were obtained from fluid aspirated from blisters induced by suction directly over representative skin lesions. During ENL reactions: a) the lesions in chronic ENL showed a decreased number of CD8+ (T-suppressor) cells and increased helper/suppressor ratio as compared to those in acute ENL and non-reactional leprosy; b) Tac peptide and IgM antibody to PGL-1 levels were elevated in the chronic ENL lesions; c) and systemic administration of corticosteroids appeared to cause a reduction in the intralesional CD4+ cell population and IgM antibody to PGL-1 but did not change CD8+ cell population and the levels of Tac peptide in the lesions. The elevated levels of Tac peptide were localized in the skin lesions while increased levels of IgM anti-PGL-1 seemed to be filtered from the peripheral blood. We conclude that spontaneous lymphocyte activation in situ, primarily of decreased CD8+ and relatively increased CD4+ cells, are important features of chronic, recurrent ENL reactions and may be an intermittent or cyclic phenomenon during the reaction. Understanding the mechanisms of these spontaneous changes in immunity in leprosy will enlarge our knowledge of reactions and of the underlying determinants of delayed type hypersensitivity and cell-mediated immunity in leprosy, which in turn will allow us to realize the potential for artificially manipulating these responses as proposed with vaccines or immunotherapy.