ABSTRACT
ABSTRACT BACKGROUND: Sarcopenia may affect patients with liver cirrhosis and worsen disease outcomes. OBJECTIVES: To evaluate ultrasound-measured psoas major (PM) and rectus abdominis (RA) thickness for predicting survival among patients with liver cirrhosis. DESIGN AND SETTING: Prospective cohort study in a tertiary-level hospital. METHODS: 61 patients with liver cirrhosis were prospectively included during a 15-month period and followed up for at least six months. Cirrhosis was classified using the Child-Pugh score. Sarcopenia was assessed using surrogate parameters: handgrip strength (HGS), mid-arm muscle circumference (MAMC) and SGA (subjective global assessment). We used ultrasound to measure RA and PM thickness at admission. RESULTS: There were 41 men. The patients' mean age was 58.03 ± 10.8 years. 26.22% of them were Child-Pugh A, 45.9% B and 27.86% C. The patients were followed up for 11.9 ± 5.63 months. RA thickness correlated moderately with MAMC (r = 0. 596; P < 0.0001) and HGS (r = 0.515; P < 0.0001) and decreased with increasing SGA class (A, 10.6 ± 2.8 mm; B, 8.3 ± 1.9 mm; C, 6.5 ± 1.9 mm; P < 0.0001). Survival at six months was independently predicted by using the model for end-stage liver disease-serum sodium score (odds ratio, OR 1.305; 95% OR confidence interval 1.083-1.572; P = 0.005). Survival during follow-up was independently predicted by RA thickness (hazard ratio, HR 0.701; 95% HR confidence interval 0.533-0.922; P = 0.011) and ascites (HR 1.876; 95% HR confidence interval 1.078-3.267; P = 0.026). PM thickness did not have any predictive value. CONCLUSIONS: As a surrogate marker of sarcopenia, RA thickness may predict survival among patients with liver cirrhosis.
Subject(s)
Humans , Male , Female , Middle Aged , Aged , Rectus Abdominis/diagnostic imaging , Sarcopenia/diagnostic imaging , Liver Cirrhosis/complications , Prognosis , Romania/epidemiology , Severity of Illness Index , Proportional Hazards Models , Survival Analysis , Prospective Studies , Hand Strength , Sarcopenia/complications , Liver Cirrhosis/mortalityABSTRACT
El hematoma espontáneo de pared abdominal es una patología infrecuente según la literatura. Sin embargo, en los últimos años esta tendencia ha cambiado debido al aumento del número creciente de indicaciones para anticoagulación, así como a la aparición de nuevos tratamientos anticoagulantes y al incremento en el número de pacientes que las precisan. Presentamos un paciente varón, de 80 años portador de marcapasos por fibrilación auricular bloqueada y prótesis mitral mecánica anticoagulado con acenocumarol, que presenta un cuadro de dolor abdominal agudo secundario hematoma espontáneo de la pared abdominal. Se trató de forma conservadora, mediante reversión de la anticoagulación y administración de analgesia con evolución favorable. Con este caso clínico ilustramos un tipo de patología que debemos tener presente, como parte del diagnóstico diferencial del dolor abdominal agudo en el paciente anticoagulado. La mayoría de los pacientes respondieron positivamente con tratamiento conservador(AU)
The abdominal wall spontaneous hematoma is an uncommon condition, according to the literature. In recent years, however, this tendency is changing due to the increased number of indications for anticoagulation, and the emerging of new anticoagulant treatment, and the increase in the number of patients who need it. Male patient, 80, carrier of a pacemaker for blocked atrial fibrillation and mechanical mitral prosthesis, anticoagulated with acenocoumarol, who presents acute abdominal pain secondary to spontaneous hematoma of the abdominal wall. He was treated conservatively, reversing anticoagulation and administering analgesia, with favorable evolution finally. This clinical case shows a type of pathology to keep in mind, as part of the differential diagnosis of acute abdominal pain in the anticoagulated patient, who, in most cases, respond to conservative treatment(AU)