ABSTRACT
The effect of 30 mm exposure to smoke [passive smoking on ventilatory function was studied in nine normal non smokers who have deliberately dehydrated to a moderate degree, signified by 3.5 loss of body weight/day. Flow and ventilatory function improved significantly during dehydration but it did not show significant changes when the same of dehydrated subjects were exposed to smoke by sitting 30 minutes in smoking chamber. However the degree of inhalation detected by increasing the end tidal carbon monoxide level [Mean +/- SD 1.0 Pa +/- 0.1. and 3.4 Pa +/- 0.7]. before and after 30 minutes exposure to somke respectively
Subject(s)
Humans , Male , Respiratory Function Tests/physiopathologyABSTRACT
Breathing pattern, respiratory activity and respiratory muscle function were studied in 25 patients with schistosomal cor pulmonale, with mean pulmonary artery pressure [MPAP] of 47.4 +/- 21.2 mmHg, cardiac index 3.2 +/- 0.5 L/min/m2 and pulmonary vascular resistance [PVR] 7.4 +/- 4.4 units. The pattern of breathing showed near normal tidal volume, increased respiratory frequency, minute ventilation, mean inspiratory flow and decreased inspiratory duty cycle. Respiratory center activity, as measured by the mouth occlusion pressure P 0.1, was increased and demonstrated significant positive correlation with the mean pulmonary artery pressure. Data of the present study also revealed that schistosomal cor pulmonale patients have respiratory muscle weakness as evidenced by a reduction in the maximal inspiratory and expiratory pressure, while diaphragmatic function was found to be preserved. The respiratory muscle strength [PI max and PE max] revealed strong negative correlation with MPAP and PVR. Inclusion schistosomal cor pulmonary patients exhibit disturbed breathing pattern and respiratory muscle performance. The study of these parameters should be included in evaluating ventilatory function in such patients, since it reflects changes in pulmonary hemodynamics