ABSTRACT
Retinal vasoproliferative tumor is a rare disease that has capillary hemangioma as the most frequent diferential diagnosis. The tumor is considered to be of reactive nature. It can be idiophatic or secondary to other ocular diseases such as: uveitis, retinitis pigmentosa, sickle cell disease, previous surgery and retinopathy of prematurity. Lesions with no exsudation or visual decrease can be observed. Lesions that need treatment can be managed by on or more modalities such as cryotherapy, a variety of lasers, surgical excision, radiation, and antiangiogenic intravitreal injections.
O tumor vasoproliferativo da retina é uma lesão rara, cujo principal diagnóstico diferencial é o hemangioma capilar da retina. O tumor tem natureza reacional. Pode ser idiopático ou secundário a outras doenças como: uveítes, retinose pigmentar, retinopatia da anemia falciforme, cirurgia prévia e retinopatia da prematuridade. Lesões sem exsudação ou baixa visual podem ser observadas. Quando há indicação de tratamento este pode ser feito pela crioterapia, vários tipos de lasers, excisão cirúrgica, radioterapia e injeções intravítrea de antiangiogênicos, isoladamente ou em associação.
Subject(s)
Humans , Retinal Neoplasms/diagnosis , Retinal Neoplasms/therapy , Retinal Neovascularization/diagnosis , Retinal Neovascularization/therapy , Brachytherapy , Cryotherapy , Diagnosis, DifferentialABSTRACT
PURPOSE: To identify the unique pathologic findings of retinal angiomatous proliferation (RAP) in optical coherence tomography (OCT). METHODS: Retrospectively, 29 eyes of 25 patients with age-related macular degeneration and complicated RAP were analyzed. All 29 eyes had choroidal neovascularization (CNV) in the area of pigment epithelial detachment (PED) or adjacent to it, which was visible with fluorescein angiography or indocyanine green angiography. Cross-sectional images were obtained by OCT scanning through the CNV lesions. RESULTS: Six distinctive findings of OCT included drusen (100%), inner retinal cyst (80%), outer retinal cyst (68%), fibrovascular PED (84%), serous retinal detachment (40%), and PED (68%). CONCLUSIONS: Through analysis of OCT findings, we revealed six different types of lesions distinctive of RAP which may provide helpful diagnostic information for subsequent treatment and predicting the prognosis of RAP.
Subject(s)
Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Follow-Up Studies , Macular Degeneration/complications , Reproducibility of Results , Retina/pathology , Retinal Neovascularization/diagnosis , Retrospective Studies , Severity of Illness Index , Tomography, Optical Coherence/methodsABSTRACT
O objetivo deste relato é descrever um caso de degeneração macular relacionada à idade com presença de membrana neovascular sub-retiniana (MNVSR) justafoveal, tratada inicialmente com bevacizumab (Avastin®) intravítrea e posteriormente com terapia de fotocoagulação focal (TFC) com laser. A eficácia do tratamento inicial e complementar foi avaliada pela medida da acuidade visual e por exames complementares (angiografia fluoresceínica e tomografia de coerência óptica). Após três injeções intravítreas de bevacizumab ocorreu a redução excêntrica da MNVSR, alterando sua classificação para extrafoveal, o que permitiu o tratamento subsequente com TFC.
The aim of this report is to describe a case of age-related macular degeneration with juxtafoveal subretinal neovascular membrane, initially treated with intravitreal bevacizumab (Avastin®) and afterwards with focal photocoagulation laser therapy. The efficacy of the initial and complementary treatment was evaluated through the visual acuity measurement and complementary exams (fluorescein angiography and optical coherence tomography). After three bevacizumab intravitreal injections , it has occurred the eccentric reduction of the neovascular subretinal membrane, changing its classification to extrafoveal, what allowed the subsequent treatment with focal photocoagulation laser therapy.
Subject(s)
Aged , Humans , Male , Angiogenesis Inhibitors/therapeutic use , Antibodies, Monoclonal, Humanized/therapeutic use , Light Coagulation , Retinal Neovascularization/therapy , Combined Modality Therapy/methods , Fluorescein Angiography , Retinal Neovascularization/diagnosis , Tomography, Optical Coherence , Treatment OutcomeSubject(s)
Angiogenesis Inhibitors/therapeutic use , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal, Humanized , Combined Modality Therapy , Fluorescein Angiography , Humans , Injections , Male , Middle Aged , Photochemotherapy , Retinal Diseases/diagnosis , Retinal Diseases/drug therapy , Retinal Diseases/physiopathology , Retinal Neovascularization/diagnosis , Retinal Neovascularization/drug therapy , Retinal Neovascularization/physiopathology , Retinal Vessels/pathology , Telangiectasis/diagnosis , Telangiectasis/drug therapy , Tomography, Optical Coherence , Treatment Outcome , Vascular Endothelial Growth Factor A/antagonists & inhibitors , Visual Acuity , Vitreous Body , Vascular Endothelial Growth Factor A/antagonists & inhibitors , Vitreous BodyABSTRACT
Sympathetic ophthalmia following parsplana vitrectomy is a known complication. We describe here a case of recurrent disc neovascularization in a patient of sympathetic ophthalmia. It promptly responded to steroids initially but later recurred with inflammation.
Subject(s)
Adult , Combined Modality Therapy , Female , Fluorescein Angiography , Glucocorticoids/therapeutic use , Humans , Laser Coagulation , Methotrexate/therapeutic use , Ophthalmia, Sympathetic/complications , Optic Disk/blood supply , Recurrence , Retinal Neovascularization/diagnosis , Triamcinolone Acetonide/therapeutic use , Visual AcuityABSTRACT
Fundus flavimaculatus é distrofia retiniana hereditária, progressiva e bilateral, caracterizada por lesões amareladas, mal definidas, pisciformes no epitélio pigmentar retiniano. O aparecimento de membrana neovascular subretiniana tem sido raramente relatada como complicação da doença. Neste artigo, documentamos o caso de uma paciente com fundus flavimaculatus que evoluiu com baixa de acuidade visual por membrana neovascular subretiniana.
Subject(s)
Humans , Female , Aged , Retinal Degeneration/complications , Retinal Neovascularization/etiology , Fluorescein Angiography , Retinal Neovascularization/diagnosisABSTRACT
The aim of this study is to elucidate the association of neovascularization in branch retinal vein occlusion (BRVO) combined with major arterial insufficiency (MAI), compared with BRVO alone. The authors retrospectively reviewed the charts, color photographs, and fluorescein angiograms of 304 patients (308 eyes) who had BRVO from 1990 to 2002 at Hanyang University hospital. Patients with BRVO combined with MAI and patients with BRVO alone were differentiated by angiographic appearance. Of the 308 eyes, 12 (3.9%) had neovascularization, all of which were in the 56 eyes of the MAI group for which the neovascularization rate was 21.4%. Neovascularization in BRVO was more strongly associated with the non-perfusion caused by MAI, rather than with the extent of the non-perfusion area that originated from retinal capillary obstruction. MAI is considered as a risk factor for neovascularization and hence could be a prognostic factor.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Comparative Study , Fluorescein Angiography , Retinal Artery/physiopathology , Retinal Diseases/complications , Retinal Neovascularization/diagnosis , Retinal Vein Occlusion/complications , Retrospective StudiesABSTRACT
Experiments show that collaterals that develop and maturate in branch retinal vein occlusion (BRVO) are helpful in the drainage of blood from a blocked area to an adjacent area. Laser treatment on the nonperfusion area can reduce the retinal blood inflow that can impair the formation of collateral vessels. Furthermore, if collaterals were accidentally destroyed by laser photocoagulation, leakage and neovascularization would increase. Forty-five patients with BRVO were reviewed retrospectively. Collateral vessels were noted from angiographic analysis in 27 of 45 (60%) patients. Good visual prognosis was noted in the patients with collaterals. Cases with neovascularization underwent laser treatment. In one case, laser photocoagulation was applied to the collateral vessels accidentally, after which the leakage significantly increased on fluorescein angiography. In conclusion, collateral vessels in BRVO have a favorable effect on visual prognosis. Careful laser treatment is recommended to avoid destroying collaterals in BRVO.
Subject(s)
Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Collateral Circulation , Fluorescein Angiography , Prognosis , Retinal Neovascularization/diagnosis , Retinal Vein Occlusion/diagnosis , Retrospective Studies , Visual AcuityABSTRACT
Objetivo: verificar a utilidade da indocianina verde vídeo-angiografia com oftalmoscopia de rastreamento a laser (ORL-ICG, V) na fotocoagulaçäo em pacientes com degeneraçäo macular relacionado à idade e outras causas de membranas neovasculares subretinianas (MNSR). Métodos: estudar retrospectivamente os prontuários de 90 pacientes consecutivos que foram submetidos ao exame de ORL-ICG, V, que apresentavam alguma doença retiniana relacionada ao desenvolvimento de membrana neovascular subretiniana. Resultados: os pacientes apresentavam degeneraçäo macular relacionada à idade (DMRI) (96,7 por cento), neovascularizaçäo subretiniana idiopática (1,11 por cento), síndrome da histoplasmose presumível (1,11 por cento) e estrias angióides (1,11 por cento). Nos pacientes com DMRI com a forma exsudativa houve indicaçäo de fotocoagulaçäo em 35 por cento dos casos. Conclusäo: o exame ORL-ICG, V aumenta a possibilidade de difinir melhor a neovascularizaçäo subretiniana para indicar a fotocoagulaçäo
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Angiography/statistics & numerical data , Indocyanine Green , Lasers , Retinal Neovascularization/diagnosis , Ophthalmoscopy/statistics & numerical dataABSTRACT
Los traumatismos contusos del globo ocasionan frecuentemente ruptura coroides, que se asocian a diversas complicaciones tardías del polo posterior. Se presenta un caso de ruptura y neovascularización tardía de la coroides
Subject(s)
Humans , Male , Adult , Rupture/etiology , Eye Injuries/physiopathology , Choroid/injuries , Retinal Neovascularization/diagnosis , Retinal Neovascularization/etiologyABSTRACT
Propósito: Determinar o valor da angiografia com a indocianina verde (ICV) na, 1) conversäo de casos de Membranas Neovasculares Sub-Retinianas Ocultas (MNSR-O) pela angiofluoresceinografia (AF) em membranas neovasculares sub-retinianas (MNSR) bem definidas pela indocianina verde (MNSR-D-I), 2) na detecçäo de MNSR persistentes nas primeiras seis semanas após fotocoagulaçäo e recorrentes nos meses subsequentes. Determinar a frequência de recorrência, após fotocoagulaçäo, das MNSR-D-I. Avaliar o resultado visual e anatômico após a fotocoagulaçäo, das MNSR-D-I. Avaliar comparativamente o resultado do tratamento das MNSR-D-I peri e subfoveais. Avaliar o comportamento pós-fotocoagulaçäo de 3 tipos (grupos) de MNSR-O. Comparar o resultado visual final do tratamento das MNSR-D-I, com olhos adelfos mostrando cicatrizes disciformes. Testar a importância do uso de "softwares" de melhoramento de imagens e do monitor, na interpretaçäo das angiografias...
Subject(s)
Humans , Male , Female , Middle Aged , Macular Degeneration/therapy , Fluorescein Angiography/instrumentation , Light Coagulation/rehabilitation , Indocyanine Green , Retinal Neovascularization/diagnosis , Academic Dissertation , Retinal NeovascularizationABSTRACT
Os autores apresentam um caso de paciente com neovascularizaçäo coroidiana justa-foveal e inflamaçäo focal granulomatosa. A investigaçäo laboratorial falhou em demonstrar a etiologia da patologia e a resposta ao corticóide sub-tenoniano näo foi satisfatória
Subject(s)
Humans , Female , Adult , Choroid Diseases/diagnosis , Retinal Neovascularization/diagnosis , Retinal Neovascularization/etiology , Retinal Neovascularization/therapyABSTRACT
Eales disease is a disease of unknown aetiology characterised by ophthalmic changes and often neurological involvement as in multiple sclerosis. We are reporting a case of Eales' disease in a 27 yr old male with chronic progressive non compressive motor myelopathy.
Subject(s)
Adult , Humans , Male , Muscle Spasticity/diagnosis , Neurologic Examination , Paralysis/diagnosis , Phlebitis/diagnosis , Retinal Neovascularization/diagnosis , Spinal Cord/physiopathologyABSTRACT
O surgimento de membranas neo-vasculares sub-retinianas é considerado atualmente como um processo causado pelo afastamento do epitelio pigmentar da membrana de Bruch secundário à formaçäo de drusas ou outras patologias. O reconhecimento clínico destas membranas se faz com a biomicroscopia e com a angiofluoresceinografia. O tratamento convencional é feito pela fotocoagulaçäo com laser de argonio ou kriptonio. Recentemente tem se experimentado o tratamento cirúrgico através da remoçäo mecânica destas membranas