Subject(s)
Angiogenesis Inhibitors/therapeutic use , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal, Humanized , Combined Modality Therapy , Fluorescein Angiography , Humans , Injections , Male , Middle Aged , Photochemotherapy , Retinal Diseases/diagnosis , Retinal Diseases/drug therapy , Retinal Diseases/physiopathology , Retinal Neovascularization/diagnosis , Retinal Neovascularization/drug therapy , Retinal Neovascularization/physiopathology , Retinal Vessels/pathology , Telangiectasis/diagnosis , Telangiectasis/drug therapy , Tomography, Optical Coherence , Treatment Outcome , Vascular Endothelial Growth Factor A/antagonists & inhibitors , Visual Acuity , Vitreous Body , Vascular Endothelial Growth Factor A/antagonists & inhibitors , Vitreous BodyABSTRACT
INTRODUCTION: Age-related macular degeneration (ARMD) is the leading cause of blindness in the west. Radiotherapy affects the evolution of exudative macular degeneration directly by its effect on the endothelium and inflammation modulation. We conducted a retrospective study to evaluate the improvement in visual acuity and healing of sub retinal neovascular membrane (SRNV) following fractionated radiotherapy. MATERIALS AND METHODS: 47 patients (58 eyes) of ARMD were retrospectively analyzed. One of the following radiotherapy fractionation schedules was employed in all the patients in this study. a) 15 Gy/5 fractions/1 week (five patients) b) 20 Gy/5 fractions/1 week (19 patients) c) 22.5 Gy/5 fractions/1 week (21 patients) d) 25 Gy/5 fractions/1 week (two patients). VA and funduscopy was taken at each follow-up for objective improvement and to assess the healing of SRNV. RESULTS: The median follow-up was 7.23 months. The mean improvement in the VA in the entire group was of 0.44 line. (Median 1, SD 1.04). Overall 75% of the eyes showed either steady vision or an improvement in subjective vision analysis. The deterioration free survival was significantly better in the group that had a relatively short duration of symptoms (P = 0.01). Scarring at presentation was a significant adverse factor for improvement in vision after radiotherapy (P = 0.001). CONCLUSIONS: In patients of ARMD treated with radiotherapy, the initial duration of symptoms and scarring of eyes at presentation were significant prognostic variables for improvement in VA after radiotherapy.
Subject(s)
Aged , Dose Fractionation, Radiation , Humans , Macular Degeneration/physiopathology , Male , Middle Aged , Retinal Neovascularization/physiopathology , Retrospective Studies , Treatment Outcome , Visual Acuity/physiologyABSTRACT
Neovascularization at the disc (NVD) is the most serious complication in diabetic retinopathy, and leads to vitreous hemorrhage and tractional retinal detachment. We report two cases of spontaneous regression of NVD in proliferative diabetic retinopathy. Two men (31 and 46 years old) with diabetes had NVD in both eyes. They were treated with panretinal photocoagulation on the left eye first, but their right eyes went untreated, because they did not revisit our clinic for several months. Fortunately, on revisit, their neovascularization had disappeared a few months later in both eyes, including their untreated right eyes. We could not find any specific causes for the spontaneous regression of the new vessels.
Subject(s)
Adult , Humans , Male , Middle Aged , Diabetic Retinopathy/physiopathology , Fluorescein Angiography , Optic Disk/blood supply , Remission, Spontaneous , Retinal Neovascularization/physiopathologyABSTRACT
Objetivos: Relatar três casos de membrana neovascular sub-retiniana (MNVSR) associada à toxoplasmose em crianças. Pacientes e Métodos: Três crianças de nove, seis e doze anos de idade, com queixa de baixa de visão, foram submetidas a exame oftalmológico completo, propedêutica completa para uveíte e videoangiografia digital com fluoresceína. Nos três casos foram realizados videoangiografia digital com indocianina verde e, em dois casos, tomografia de coerência óptica (OCT) da região macular. Resultados: MNVSR associada à uveíte por toxoplasmose foi observada nos três pacientes estudados. Dois pacientes foram submetidos a tratamento clínico convencional para toxoplasmose. Ao término do tratamento houve melhora acentuada da acuidade visual. O terceiro paciente foi submetido à terapia fotodinâmica (PDT), havendo piora da visão de uma linha de Snellen. Conclusão: Apesar de incomum, MNVSR pode ocorrer em crianças com toxoplasmose ocular.
Subject(s)
Humans , Male , Child , Retinal Neovascularization/physiopathology , ToxoplasmosisABSTRACT
Os autores relatam dois casos de CSC, onde constataram desenvolvimento de neovascularizaçäo subretiniana após tratamento com fotocoagulaçäo. Um dos casos é o de paciente adulto jovem com quadro de CSC típico com desenvolvimento de neovascularizaçäo após considerado como favorável ao tratamento com laser, e outro caso é de paciente com quadro de CSC com membrana neovascular oculta que foi evidenciada após fotocoagulaçäo com técnica indicada para os casos de CSC. Säo discutidos quanto a fisiopatologia, indicaçäo da fotocoagulaçäo e chamam a atençäo para a possibilidade de complicaçäo como neovascularizaçäo em fotocoagulaçäo nos casos de CSC
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Light Coagulation/adverse effects , Retinal Neovascularization/physiopathology , Pigment Epithelium of Eye/abnormalities , Retinal Neovascularization/therapyABSTRACT
Os autores apresentam alguns casos de degeneraçäo macular da idade que foram estudados através da vídeo angiografia digital com a indocianina verde (ICGV). Os resultados sugerem ser a ICGV um exame importante e adjunto à angiografia fluoresceínica para estudar a circulaçäo da coróide, particularmente na identificaçäo da CNV oculta, transformando-a em clássico, permitindo um tratamento eficaz da mesma
Subject(s)
Humans , Angiography, Digital Subtraction , Fluorescein Angiography , Indocyanine Green , Retinal Neovascularization/physiopathologyABSTRACT
Os autores descrevem a história natural de 3 pacientes míopes que apresentam episódios de hemorragia sub-retiniana macular associada a lacquer crack. Em nenhum deles se evidenciou a presença de neovascularizaçäo sub-retiniana. Chamam a atençäo para a begnidade da lesäo, bem como discutem esta alteraçäo patológica