ABSTRACT
The present study aimed to investigate antibacterial activity of cinnamon and rifampicin alone and in combination against 45 Methecillin Resistant Staphylococcus aureus isolates [MRSA]. The present study deals with determination of minimal inhibitory concentration [MICs], killing curve and synergism assay of cinnamon extracts and rifampicin for MRSA isolates. The results indicate that MICs of cinnamon aqueous extract mixed with rifampicin for all tested MRSA ranged between 0.2 micro g/ml of rifampicin plus 1.5mg/ml of cinnamon aqueous extract and 16 micro g/ml of rifampicin plus 2mg/ml of cinnamon aqueous extract, that was compared with MICs of rifampicin cinnamon methanol extract, MICs of rifampicin and cinnamon hexane extract combination, rifampicin MIC and cinnamon different extracts MICs. Time-killing curve of rifampicin in combination with cinnamon aqueous extract exhibit zero CFU/ml after 10 hrs incubation period at 37°C that was compared with time-killing curve of rifampicin in combination with cinnamon methanol extract, time-killing curve of rifampicin in combination with cinnamon hexane extract, time-killing curve of rifampicin and time-killing curve of cinnamon different extracts. From our data, we conclude that, cinnamon aqueous extract combined with rifampicin is the best combination to be used as anti-staphylococcal agent