Evaluation of antihyperglycemic potential of homeopathic medicines Insulinum, Pancreatinum and Uranium nitricum in Streptozotocin Induced diabetic rats

IntroductionDiabetes Mellitusis an emerging endocrine and metabolic disorder which has affected millions of people globally. Homeopathic system of medicine uses ultra-molecular doses for treatment of Diabetes Mellitus. Homeopathic medicines are prepared from plant, mineral, sarcodes,nosodes and animal parts. Insulinum 6 CH, Pancreatinum 6CH and Uranium nitricum 6 CHareused in homeopathy for treatment of Diabetes Mellitus. However,no preclinical studies have been investigated for the anti-diabetic effect and its safety.MethodsHomeopathic medicines Insulinum 6CH, Pancreatinum 6CHandUranium nitricum6CH(1012)dilution factor were used to examine antihyperglycemic effects in streptozotocin induced diabetic rats. After 28 daysoftreatment,bodyweight, Hematology, Biochemistry (serum glucose, urea, creatinine, SGPT, SGOT, ALP, Triglyceride and HDL-cholesterol), Oral Glucose Tolerance Test, HbA1C with histopathologyof (Liver, Kidney, Pancreas) weremeasured.ResultsAfter Streptozotocin induction, the animals have shown significant increase in the fasting blood glucose level (p<0.01) as compared to normal control animals. Treatment with homeopathic medicine Insulinum 6CH, Pancreatinum 6CHandUranium nitricum6CHpotency showed significant decrease in levels of Glucose (p<0.05), OGTT, Total protein (P<0.001), ALP (P<0.05), Cholesterol (P<0.001), SGPT (P<0.001), SGOT (p<0.01), Urea, HbA1C as compared to diabetic animal.ConclusionsIn the present study homeopathic medicine Insulinum 6CH, Pancreatinum 6CH andUranium nitricum6CHpotency exhibitantihyperglycemic effects in streptozotocin induced diabetic rats.(AU)

Nosodes, isopáticos y sarcodes. El similia etiológico,¿Homeopatía? / Nosodes, isopathic and sarcodes. The etiologic similia Homeopathy?

Los nosodes, los isopáticos y los sarcodes son medicamentos homeopáticos que si bien su descubrimiento no es reciente, si lo es el uso de los mismos, cada día encontramos a más médicos homeópatas que los usan y con un gran éxito en sus pacientes. Los tres grupos de medicamentos mencionados, son preparados en base a la farmacopea homeopática, algunos de ellos en laboratorios homeopáticos y otros preparados por el médico tratante y en caso de países desarrollados como lo es Alemania, un nosode de algún microorganismo patógeno, se tiene que pedir a una Universidad capacitada y autorizada para el cultivo de cepas de éste tipo. Y en Europa más del 60 de las consultas Homeopáticas se prescriben com algún medicamento de estos grupos.

A homeopatia e uma resposta placebo? / Is the homeopathy a placebo response?

Num experimento duplo-cego randomizado, foi testada a hipotese de que as potencias homeopaticas sao placebo. O modelo escolhido para estudo comparou, os efeitos de uma preparacao de mistura de polens de capim com placebo, em 144 pacientes com Febre do Feno ativa. A resposta era mais significativa quando os resultados eram corrigidos para a dose de polen, e quando ela estava associada a uma diminuicao de 50% da necessidade de anti-histaminicos. Nos pacientes que receberam o tratamento homeopatico foi notada, inicialmente, uma agravacao mais frequente dos sintomas, seguida de melhora. Nao houve evidencia que sustentasse a ideia de que a acao do placebo explica, completamente, as respostas clinicas para as drogas homeopaticas