Dose sentinel lymph node biopsy [SLNB] reduce the necessary of axillary lymph node dissection [ALND] in female breast cancer?

From Sept.2002 to Sept 2003, all cases of female breast masses attended at surgical clinic, Al Zahraa university Hospital Al-Azhar uni. were subjected in this study. 200 cases were subjected in this study, of them 27 cases were diagnosed as breast cancer the rest of cases were excluded [173 cases] as they were diagnosed as benign breast diseases. All cases were underwent to thorough careful history, perfect examination and different investigatory tools [ultrasonography, mammography and FNAC], open excisional biopsy was the last resort and technique for diagnosis which revealed positive for cancer in only 27 cases those later on subjected in the present study to determine the status of SLN[sorguis node] after injection of blue dye and axillary dissection with axcision of this node with staining it either with H and E or with cytokeratin [IHC stain]. all positive cases [20 cases with SLNB underwent immediately to simple mastectomy and axillary clearance, while those of negative SLNS [7 cases] reprepared for straining with cytokeratin IHC stain which revealed positive malignant cells in 3 cases of seven. The results encourage the surgeons who interested in breast surgery to use this recent technique to reduce the necessary of axillaty dissection in breast cancer, this dissection may disturbe immune status of the patient as well as associated with complications such as arm oedeina and nerve injury as well as vascullar injury to the great vessles in the axilla

Role of sentinel lymph node biopsy in the management of patients with breast cancer

The status of the axillary lymph node basin remains the most powerful predictor of survival in patients with invasive breast cancer. Lymphatic mapping concept entails that lymphatic drainage from primary tumors can be mapped to the regional lymph nodes. The first node[s] of these nodes, i.e., the SLN, can then be identified and removed. This node is supposed to be the initial site of metastatic disease, and the histologic characteristics of the SLN reflect the state of the remaining nodes in the lymphatic basin. The preliminary reports of lymphatic mapping and SLN biopsy in breast cancer have shown this technique to be an accurate axillary staging procedure. It is a less invasive procedure and therefore is associated with a lower rate of complications, such as postoperative lymphoedema, seroma formation, and neuropathy of the arm, than complete ALND. It also allows more detailed examination of the lymph node at greatest risk for metastatic disease. This can be performed by serially sectioning the SLN and applying immunohistochemical [IHC] stains to the specimens, thereby enhancing the detection of nodal metastatic disease. The present study aimed at: comparing peritumoural injection with subareolar injection of dye in identifying SLN/s. Also, identifying the presence of micrometastases in the SLN/s by serial sectioning of the SLN/s and H and E staining or cytokeratin stains. The study was performed on 94 patients with stages I and II breast cancer equally divided into two groups according to method of injection of dye each of 47 patients. SLN were successfully mapped in 84 patients. Fifty three of them harbored metastases. In 45 patients metastases was discovered by ordinary H and E technique. Micrometastases were discovered in eight more patients [5 by serial sectioning of lymph nodes and H and E examination and 3 by immunohistochemical staining. The use of SLN alone would have led to understaging in two patients. It can be concluded that SLN biopsy is an accurate and useful technique. A thorough knowledge of its different methods, its indications as well as limitations maximize the value of this techniques to the oncologic surgeon. The use of modern staining techniques helps also in detecting minimal disease and allows for appropriate treatment decisions