ABSTRACT
A 50-year-old peri-menopausal woman presented with hard palpable mass on her lower abdomen and anemia from heavy menstrual bleeding. Ultrasonography showed a 13x12 cm sized hypoechoic solid mass in pelvis and a 2.5x2 cm hypoechoic cystic mass in uterine endometrium. Abdomino-pelvic computed tomography revealed a hypodense pelvic mass without enhancement, suggesting a leiomyoma of intraligamentary type or sex cord tumor of right ovary with submucosal myoma of uterus. Laparoscopy revealed a large Sertoli-Leydig cell tumor of right ovary with a very rare entity of intra-endometrial uterine leiomyoma accompanied by adenomyosis. The final diagnosis of ovarian sex-cord tumor (Sertoli-Leydig cell), stage Ia with intra-endometrial leiomyoma with adenomyosis, was made. Considering the large size of the tumor and poorly differentiated nature, 6 cycles of chemotherapy with Taxol and Carboplatin regimen were administered. There is neither evidence of major complications nor recurrence during 20 months' follow-up.
Subject(s)
Female , Humans , Male , Middle Aged , Adenomyosis/diagnosis , Carboplatin/therapeutic use , Laparoscopy , Leiomyoma/diagnosis , Menorrhagia , Neoplasm Recurrence, Local , Paclitaxel/therapeutic use , Sertoli-Leydig Cell Tumor/diagnosis , Treatment Outcome , Uterine Neoplasms/diagnosisABSTRACT
Los tumores virilizantes, corresponden al 1% de todos los tumores funcionales del ovario. Estos tipos de tumores virilizantes se originan de las células pluri-potenciales del estroma ovárico, tienen la capacidad de secretar 17-hidroxiprogesterona, testosterona y androstenediona, desencadenando hiperandrogenismo clínico. Son catalogados como de bajo potencial maligno, con un patrón de crecimiento lento, bien diferenciados, diagnosticados en su mayoría en estadío I y II, de buen pronóstico y típicos de mujeres en edad reproductiva. El objetivo de esta comunicación es presentar dos casos clínicos con diagnóstico de tumor virilizante de ovario, tratadas con cirugía laparoscópica por mono puerto.
Virilizing tumors, corresponding to 1% of all functional ovarian tumors. Those type of virilizing tumors originate from pluripotential ovarian stromal cells and have the capacity to secrete 17-hydroxyprogesterone, testosterone and androstenedione, triggering clinical hyperandrogenism. They are classified as low malignant potential, well differentiated, with a pattern of slow growth, mostly diagnosed in stage I and II, with good prognosis and typical of women of reproductive age. The aim of this paper is to present two cases of virilizing ovarian tumor treated by mono port laparoscopic surgery.
Subject(s)
Humans , Female , Adult , Ovarian Neoplasms/surgery , Laparoscopy/methods , Sertoli-Leydig Cell Tumor/surgery , Ovarian Neoplasms/complications , Ovarian Neoplasms/diagnosis , Virilism/etiology , Sertoli-Leydig Cell Tumor/complications , Sertoli-Leydig Cell Tumor/diagnosisABSTRACT
Sertoli leydig cell tumors also known as arrhenoblastoma, are a rare member of the sex cord-stromal tumor group of ovarian and testicular cancers, comprising less than 1% of all ovarian tumors, which occur in young adults and are almost always unilateral. We hereby report a case of a 17-year-old female presenting with a short history of irregular menses and an abdominal lump, which was histologically proven to be a bilateral sertoli leydig cell tumor of the ovary, an exceptionally rare entity in itself.
Subject(s)
Adolescent , Female , Humans , Ovarian Neoplasms/diagnosis , Ovariectomy , Ovary/pathology , Sertoli-Leydig Cell Tumor/diagnosisABSTRACT
Arrhenoblastoma or Sertoli-Leydig cell tumor is a rare androgen secreting ovarian tumor of unknown pathogenesis, has been reported to co-exist with other neoplasms of the female genital tract. Mostly benign, the tumor originates from the ovarian stromal sex cords, its tissue structure being similar to the Sertoli and Leydig testicular cells. Followed in detail, around one-fifth of these ovarian tumors are found to be malignant. We describe a case of slow growing Sertoli-Leydig cell tumor presenting with androgenic alopecia and virilization, associated with cervical carcinoma in-situ
Subject(s)
Humans , Female , Adult , Ovarian Neoplasms/diagnosis , Carcinoma in Situ , 31574 , Sertoli-Leydig Cell Tumor/diagnosis , Virilism/diagnosis , Virilism/etiologyABSTRACT
Los tumores del ovario se dividen en no funcionantes y funcionantes. Dentro de este último grupo existen los que presentan actividad endocrina y producen androgenización, como son los de células de Sertoli-Leydig. Presentamos el caso de una paciente de 50 años de edad que clínicamente se presenta con signos de virilización progresiva. Se encuentra en estudio de imagen por ultrasonido y TAC un tumor en ovario derecho, por lo que se decide intervención quirúrgica que da como resultado tumor de células de Sertoli-Leydig(AU)
Ovarian tumors are divided into functioning and non-functioning. Those presenting endocrine activity and producing androgenization, such as the tumors of Sertoli cells are within the latter group. A case of a 50-year-old female patient that clinically showed signs of progressive virilization was presented. A tumor on the right ovary was found by ultrasound and CAT. After performing surgery, the existence of a Sertoli-Leydig cell tumor was confirmed(AU)
Subject(s)
Humans , Female , Middle Aged , Ovarian Neoplasms/drug therapy , Surgical Procedures, Operative/methods , Sertoli-Leydig Cell Tumor/diagnosisABSTRACT
We report a 16 year old girl presenting with secondary amenorrhea, a history of voice coarsening, hirsutism and a body mass index of 35 kg/m2. Pelvic ultrasound and CT scans showed a retro uterine dense mass. She was operated and a left ovarian tumor was excised. Pathological examination disclosed a Sertoli-Leydig tumor
Subject(s)
Humans , Female , Adolescent , Ovarian Neoplasms/diagnosis , Sertoli-Leydig Cell Tumor/diagnosis , Ovarian Neoplasms/surgery , Ovarian Neoplasms/complications , Ovarian Neoplasms/pathology , Biopsy , Amenorrhea/etiology , Hirsutism/etiology , Sertoli-Leydig Cell Tumor/surgery , Sertoli-Leydig Cell Tumor/complications , Sertoli-Leydig Cell Tumor/pathologyABSTRACT
Los Androblastomas son neoplasias muy raras típicas de la edad joven, con una incidencia entre los 20 y los 30 años. Los tumores de células de Sertoli, pertenecen al grupo de los androblastomas. Los tumores de ovario en la infancia son raros, y corresponden a menos del 1 por ciento de todos los tumores malignos. El tumor de Sertoli tiene una incidencia de 2.5 por millón de niñas al año. Nosotros presentamos el caso de la primera paciente del Hospital General del Oeste
Subject(s)
Humans , Female , Child, Preschool , Child , Sertoli-Leydig Cell Tumor/diagnosis , Sertoli-Leydig Cell Tumor/surgery , Sertoli Cell Tumor/surgery , Sertoli Cell Tumor/diagnosis , Sertoli Cell Tumor/therapyABSTRACT
El tumor de Krukenberg tubular es una variante bien caracterizada del tumor de Krukenberg. Se presenta el caso del tumor más grande hasta ahora descrito en la literatura mundial, el cual afectó a una mujer embarazada de 35 años de edad. Aunque no existen diferencias clínicas o biológicas entre las variantes clásicas y tubulares del tumor de Krukenberg, la imagen microscópica merece atención especial, ya que esta última puede imitar a los tumores de Sertoli-Leydig del ovario. Por esta razón, se hacen necesarias, por un lado, la búsqueda intencionada de células en ®anillo de sello¼ y, por el otro, efectuar tinciones especiales para moco y distinguir así con certeza uno de otro. El término tubular debe utilizarse en casos como éste, ya que, independientemente de su disposición morfológica ®tubular¼, por lo demás corresponde a la descripción original de Krukenberg
Subject(s)
Humans , Female , Pregnancy , Adult , Carcinoma, Signet Ring Cell/diagnosis , Carcinoma, Signet Ring Cell/pathology , Pregnancy Complications, Neoplastic/diagnosis , Diagnosis, Differential , Krukenberg Tumor/diagnosis , Krukenberg Tumor/pathology , Neoplasm Metastasis/diagnosis , Stomach Neoplasms/diagnosis , Stomach Neoplasms/secondary , Sertoli-Leydig Cell Tumor/diagnosisABSTRACT
A case of Sertoli cells ovarian tumor in a 55 year old patient is reported. Some comments are made on this type of tumor. The tumor reported was very differentiated and non functional. The surgical indication was made on the clinical data, and a bilateral ooforectomy was performed.
Subject(s)
Humans , Female , Middle Aged , Ovarian Neoplasms/diagnosis , Sertoli-Leydig Cell Tumor/diagnosis , Ovarian Neoplasms/pathology , Ovarian Neoplasms/surgery , Sertoli-Leydig Cell Tumor/surgery , Sertoli-Leydig Cell Tumor/pathologyABSTRACT
A case of androblastoma, functioning, intermediary type, is related. The tumor was present on a 25 year old woman who presented charactheristics of defeminization and masculinization. The hormonal count of androgen was normal. The 17-OHCS were elevated. The patient was submited to total abdominal hysterectomy, bilateral salpingo-ooferectomy and omentectomy. Some endocrine aspects of this tumor are commented