ABSTRACT
INTRODUCCIÓN: Los tumores de células de Sertoli-Leydig son neoplasias de ovario infrecuentes, lo que dificulta su diagnóstico y tratamiento. OBJETIVO: Revisar y sintetizar el manejo actual de los tumores de células de Sertoli-Leydig. MÉTODO: Se realizó una revisión de la literatura reciente sobre tumores de células de Sertoli-Leydig, a propósito de un caso en nuestro centro. RESULTADOS: Los tumores de las células de Sertoli-Leydig son infrecuentes, con mayor incidencia en edades tempranas. Ante una paciente joven con una lesión anexial unilateral y signos de virilización deberán considerarse estos tumores dentro del diagnóstico diferencial. En los estadios iniciales y en pacientes jóvenes podrá plantearse un tratamiento quirúrgico que preserve la fertilidad, y la asociación de tratamiento adyuvante dependerá de la diferenciación y del estadiaje del tumor.
INTRODUCTION: Sertoli-Leydig cell tumors are infrequent ovarian neoplasms, which difficults their diagnosis and treatment. Objective: To review and synthesize the current management of the Sertoli-Leydig cell tumor. METHOD: A review of the recent literature regarding the Sertoli-Leydig cell tumor was carried out, regarding a case in our center. RESULTS: Sertoli-Leydig cell tumors are an infrequent entity, with a higher incidence in early ages. In a young patient with a unilateral adnexal lesion and signs of virilization, these tumors should be considered within the differential diagnosis. In early stages and young patients, a surgical treatment that preserves fertility may be considered, and the association of adjuvant treatment will depend on the differentiation and staging of the tumor.
Subject(s)
Humans , Female , Adult , Ovarian Neoplasms/surgery , Ovarian Neoplasms/diagnostic imaging , Sertoli-Leydig Cell Tumor/surgery , Sertoli-Leydig Cell Tumor/diagnostic imagingABSTRACT
Los tumores virilizantes, corresponden al 1% de todos los tumores funcionales del ovario. Estos tipos de tumores virilizantes se originan de las células pluri-potenciales del estroma ovárico, tienen la capacidad de secretar 17-hidroxiprogesterona, testosterona y androstenediona, desencadenando hiperandrogenismo clínico. Son catalogados como de bajo potencial maligno, con un patrón de crecimiento lento, bien diferenciados, diagnosticados en su mayoría en estadío I y II, de buen pronóstico y típicos de mujeres en edad reproductiva. El objetivo de esta comunicación es presentar dos casos clínicos con diagnóstico de tumor virilizante de ovario, tratadas con cirugía laparoscópica por mono puerto.
Virilizing tumors, corresponding to 1% of all functional ovarian tumors. Those type of virilizing tumors originate from pluripotential ovarian stromal cells and have the capacity to secrete 17-hydroxyprogesterone, testosterone and androstenedione, triggering clinical hyperandrogenism. They are classified as low malignant potential, well differentiated, with a pattern of slow growth, mostly diagnosed in stage I and II, with good prognosis and typical of women of reproductive age. The aim of this paper is to present two cases of virilizing ovarian tumor treated by mono port laparoscopic surgery.
Subject(s)
Humans , Female , Adult , Ovarian Neoplasms/surgery , Laparoscopy/methods , Sertoli-Leydig Cell Tumor/surgery , Ovarian Neoplasms/complications , Ovarian Neoplasms/diagnosis , Virilism/etiology , Sertoli-Leydig Cell Tumor/complications , Sertoli-Leydig Cell Tumor/diagnosisABSTRACT
Se reporta el caso de una paciente de 16 años con un tumor de células de Sertoli y Leydig del ovario en etapa I tratado con cirugía exclusiva. Además, se realiza una revisión de la literatura sobre este tipo de tumor.
Subject(s)
Adolescent , Female , Ovarian Neoplasms , Sertoli-Leydig Cell Tumor/surgery , Sertoli-Leydig Cell Tumor/pathology , Sertoli-Leydig Cell Tumor/drug therapyABSTRACT
We report a 16 year old girl presenting with secondary amenorrhea, a history of voice coarsening, hirsutism and a body mass index of 35 kg/m2. Pelvic ultrasound and CT scans showed a retro uterine dense mass. She was operated and a left ovarian tumor was excised. Pathological examination disclosed a Sertoli-Leydig tumor
Subject(s)
Humans , Female , Adolescent , Ovarian Neoplasms/diagnosis , Sertoli-Leydig Cell Tumor/diagnosis , Ovarian Neoplasms/surgery , Ovarian Neoplasms/complications , Ovarian Neoplasms/pathology , Biopsy , Amenorrhea/etiology , Hirsutism/etiology , Sertoli-Leydig Cell Tumor/surgery , Sertoli-Leydig Cell Tumor/complications , Sertoli-Leydig Cell Tumor/pathologyABSTRACT
Los Androblastomas son neoplasias muy raras típicas de la edad joven, con una incidencia entre los 20 y los 30 años. Los tumores de células de Sertoli, pertenecen al grupo de los androblastomas. Los tumores de ovario en la infancia son raros, y corresponden a menos del 1 por ciento de todos los tumores malignos. El tumor de Sertoli tiene una incidencia de 2.5 por millón de niñas al año. Nosotros presentamos el caso de la primera paciente del Hospital General del Oeste
Subject(s)
Humans , Female , Child, Preschool , Child , Sertoli-Leydig Cell Tumor/diagnosis , Sertoli-Leydig Cell Tumor/surgery , Sertoli Cell Tumor/surgery , Sertoli Cell Tumor/diagnosis , Sertoli Cell Tumor/therapyABSTRACT
Os autores relatam um caso de tumor de células de Sertoli e Leydig (TCSL), estádio Ia, no ovário direito de uma paciente com 10 anos de idade. O tumor era não funcionante e as manifestações iniciais foram dor e aumento do volume abdominal. Ao exame físico palpava-se uma massa endurecida na região hipogástrica. A criança não apresentava sinais de virilização ou puberdade precoce. O tratamento foi realizado com cirurgia: salpingo-ooforectomia direita e biópsia em cunha do ovário esquerdo. Histologicamente o tumor era bem diferenciado e não apresentava elementos heterólogos. A paciente apresenta há 26 meses sobrevida livre de doença. Acreditamos que este seja o primeiro caso de TCSL de ovário em crianças com idade igual ou inferior a 10 anos, publicado na literatura médica brasileira indexada.
Subject(s)
Humans , Female , Child , Ovarian Neoplasms/pathology , Ovarian Neoplasms/surgery , Sertoli-Leydig Cell Tumor/surgery , Sertoli-Leydig Cell Tumor/pathology , Neoplasm Staging , Disease-Free SurvivalABSTRACT
Los tumores malignos del estroma gonadal representan 0.2 por ciento de todos los tumores del testículo y son casi exclusivos del adulto. Son relativamente refractarios a la radioterapia y a la quimioterapia, y la sobrevida media de la enfermedad metastásica es de dos años. Se presenta un caso clínico de tumor a células de Sértoli-Leydig en un hombre de 45 años que consultó por esterilidad y se hace una revisión de la literatura
Subject(s)
Humans , Male , Middle Aged , Testicular Neoplasms/surgery , Testicular Neoplasms/diagnosis , Sex Cord-Gonadal Stromal Tumors/surgery , Sex Cord-Gonadal Stromal Tumors/diagnosis , Sertoli-Leydig Cell Tumor/surgeryABSTRACT
A case of Sertoli cells ovarian tumor in a 55 year old patient is reported. Some comments are made on this type of tumor. The tumor reported was very differentiated and non functional. The surgical indication was made on the clinical data, and a bilateral ooforectomy was performed.
Subject(s)
Humans , Female , Middle Aged , Ovarian Neoplasms/diagnosis , Sertoli-Leydig Cell Tumor/diagnosis , Ovarian Neoplasms/pathology , Ovarian Neoplasms/surgery , Sertoli-Leydig Cell Tumor/surgery , Sertoli-Leydig Cell Tumor/pathologyABSTRACT
A case of androblastoma, functioning, intermediary type, is related. The tumor was present on a 25 year old woman who presented charactheristics of defeminization and masculinization. The hormonal count of androgen was normal. The 17-OHCS were elevated. The patient was submited to total abdominal hysterectomy, bilateral salpingo-ooferectomy and omentectomy. Some endocrine aspects of this tumor are commented