Toxic effect of Solanum Lycocarpum in the male Wistar rats and swiss mice reproductive organs

Uma suspensäo de Solanum Lycocarpum foi administrada a ratos Wistar e camundongos suiços adultos em duas doses diferentes (60 mg/15ml e 120 mg/15ml de água destilada para ratos e 30 mg/15ml e 60 mg/15ml de água destilada para camundongos) para avaliar seu efeito no peso corporal, de testículos, de epidídimo esquerdo, de glândulas sexuais acessórias, de hipófise e na concentraçäo de espermatozóides. O extrato foi administrado duas vezes ao dia durante 5 dias, com sacrifício dos animais 3 dias após o término do tratamento. Os resultados indicaram que, a princípio, Solanum Lycocarpum näo tem efeito tóxico no rato Wistar adulto mas causou perda significativa de peso corporal, de próstata ventral, vesícula seminal e hipófise de camundongo suiço adulto. A reduçäo de peso de hipófise poderia estar indicando alto nível de testosterona ou ausência de estímulo para sua secreçäo. Quanto ao baixo peso de próstata ventral e vesícula seminal, mais estudos säo necessários para explicar as causas dessa reduçäo.

Avaliaçäo do potencial tóxico de extrato aquoso de Solanum lycocarpum (St. Hil) após administraçäo em camundongos suiços / Evaluation of the toxic potential of the aqueous extract of Solanum lycocarpum (St. Hil) administered to Swiss mice

The lobeira fruit (Solanum lycocarpum, St. Hil), family Solanaceae, is a globous berry which has been reported to possess sedative, diuretic, antiepileptic and antispasmodic activity. Its powder is being used as a hypoglycemic agent in Caratinga (MG). The evaluation of the lobeira toxic potential in female rats during the organogenic period showed alteration in the development of male fetuses. Owing to its popular use and the effects reported in rats, this work analyses the effect the lobeira aqueous extract, prepared with the lobeira fruit powder, in the reproductive system and different vital organs of the adult Swiss mice...

Avaliaçäo da toxidade reprodutiva de extrato aquoso de Solanum lycocarpum (St. Hil) administrado a ratos Wistar / Evaluation of the reproductive toxicity of the aqueous extract of Solanum lycocarpum (St. Hil) administered to Wistar rats

The lobeira fruit (Solanum lycocarpum, St. Hil), family Solanaceae is a plant known for its therapeutic effects - sedative, diuretic, antiepileptic and antispasmodic. Its powder is being used as a hypoglycemic agent in Caratinga (MG). The evaluation of the lobeira toxic potential in female rats during the organogenic period showed alteration in the development of male fetuses.Owing to its popular use and the effects reported above, this work analyses the effect the lobeira aqueous extract, prepared with the lobeira fruit powder, in the reproductive system and different vital organs of the adult Wistar rats...