Insulin-like growth factor-I, insulin-link growth factor binding protein-3 and insulin in normal and high risk neonates

This study included ten preterm infants, ten infants with respiratory distress [RD], eight infants of deliveries with premature rupture of membrane [PROM] and septicemia, eight infants with intrauterine growth retardation [IUGR] and sixteen infants of diabetic mothers together with ten normal full term infants representing the control group. Blood sample was obtained within 12 hours after delivery, sera were used for determination of IGF-I, IGFBP-3 and insulin. The study revealed significantly decreased levels of IGF-I, IGFBP-3 and insulin in preterm infants, infants with RD, PROM and septicemia compared with control group. However, in infants with IUGR IFF-I showed slight increase, while IGFBP-3 exhibited slight decrease and insulin was significantly decreased compared with controls. In infants of diabetic mothers, both IGF-I and insulin levels were significantly increased compared with control infants

Effect of growth hormone administration of serum somatomedin-C levels in bilharzial and liver disorders patients

This work was designed in an attempt to clarify the effect of the growth hormone injection on the serum somatomedin-C [SM-C] levels in Egyptian children with urinary bilharziasis, advanced bilharzial hepatic fibrosis and children suffering from chronic hepatitis compared with 11 healthy age and sex matched children served as controls. SM-C levels were studied prior and after the injection of human growth hormone [hGH]. The basal and hGH-stimulated SM-C levels were significantly reduced in bilharzial patients compared with controls. Patients with hepatitis had significantly lower serum SM-C values prior or post hGH administration. Liver tests carried out for bilharzial patients showed impaired function both on admission and after treatment. It can be concluded that shortness in children with bilharzial hepatic fibrosis may results from hepatic and endocrinal and nutritional factors. Also, the results suggested that the delayed skeletal maturation in chronic hepatitis cases is probably secondary to liver dysfunction, malnutrition and associated endocrinopathies

Somatomedina, crescimento e estado nutricional / Somatomedin, growth and nutritional status

Somatomedinas no plasma, originalmente caracterizadas como dependentes do hormônio do crescimento, foram encontradas também ser dependentes dos níveis de insulina e do estado nutricional. Quatro propriedades caracterizam as açöes da somatomedina: sua concentraçäo no soro é dependente do hormônio do crescimento, possuem açöes similares a da insulina em tecidos extraesqueléticos, promovem a incorporaçäo de sulfato no proteoglicano da cartilagem e estimulam a síntese de DNA e multiplicaçäo celular em crianças com desnutriçäo protéico-calórica onde se observa também que as concentraçöes de hormônio de crescimento e cortisol estäo aumentados. Há evidências experimentais e clínicas que sugerem a capacidade da somatomedina C em estimular o crescimento da cartilagem. Esta açäo é regulada por inibidores da somatomedina em condiçöes de deficiência hormonal ou nutricional. A energia e proteína da dieta säo fatores importantes na síntese e na atividade da somatomedina C nas células da cartilagem. Os níveis de somatomedina C plasmáticas representam um parâmetro sensível na detecçäo da deficiência protéico-calórica e posterior recuperaçäo nutricional em humanos e animais de laboratório