ABSTRACT
CONTEXT: The diagnosis of primary melanoma is easily confirmed after histological analysis of the lesion, whereas it is rarely diagnosed when the patient even has distant metastases. DESIGN: Case report CASE REPORT: Malignant melanoma is responsible for about 1 percent of all deaths caused by cancer in the USA and only 3 percent of all malig-nant skin diseases. Malignant melanoma is a rare disease, although it corresponds to 65 percent of all deaths caused by skin cancer. The liver and spleen are rarely the first sites of melanoma metastases. This paper reports on the clinical picture of a patient with fatal malignant melanoma and hepatic and spleen metastases. As this was an un-usual presentation, the melanoma diagnosis could only be made after pathological analysis of the skin and hepatic lesions
Subject(s)
Humans , Male , Middle Aged , Splenic Neoplasms/secondary , Ear Neoplasms/pathology , Ear, External/pathology , Liver Neoplasms/secondary , Melanoma/secondary , Splenic Neoplasms , Splenic Neoplasms/blood , Tomography, X-Ray Computed , Liver Neoplasms , Liver Neoplasms/blood , Melanoma , Melanoma/bloodABSTRACT
Isolated splenic metastasis arising from colorectal carcinoma is very rare and there has been only 6 cases reported in the English literature. A new case is esented, and its possible pathogenesis was considered with previously reported ses. A 65-year-old male patient had received a right hemicolectomy for cending colon cancer 36 months earlier. He was followed up regularly with rial measurement of serum carcinoembryonic antigen (CEA). Rising serum CEA was scovered from 33 months postoperatively and CT revealed an isolated splenic tastasis. He therefore underwent splenectomy, which was proven to be a tastatic adenocarcinoma with similar histological feature to the original mor. As all reported cases showed elevated serum CEA at the time of tastasis, isolated splenic metastasis might be associated with CEA in regard its biological functions of immunosuppression and adhesion.
Subject(s)
Aged , Humans , Male , Adenocarcinoma/surgery , Adenocarcinoma/secondary , Adenocarcinoma/pathology , Adenocarcinoma/blood , Carcinoembryonic Antigen/blood , Colorectal Neoplasms/surgery , Colorectal Neoplasms/pathology , Colorectal Neoplasms/blood , Splenic Neoplasms/surgery , Splenic Neoplasms/secondary , Splenic Neoplasms/blood , Tomography Scanners, X-Ray ComputedABSTRACT
A 25 years old male presented with hepatomegaly splenomegaly and fever. He was diagnosed as splenic lymphoma with circulating villous lymphocytes (SLVL) on morphology, cytochemistry and immunocytochemistry performed on peripheral blood and bone marrow smears. Case is being presented because of rarity and unusual presentation at young age.