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Article in English | IMSEAR | ID: sea-20417

ABSTRACT

Sodium stibogluconate, did not bring about significant increase in the production of IL-1, when both specific leishmanial antigen, or non specific Staphylococcus epidermidis was used as stimulus in normal uninfected animals. However, Staph. epidermidis was found to be a better stimulus as it brought about a significant increase (P less than 0.001) in IL-1 production when compared with leishmania antigen. In BALB/c mice infected with L. donovani there was a significant reduction (P less than 0.001) in IL-1 levels on various post infection days irrespective whether Staph. epidermidis or leishmanial antigen was used as stimulus when compared with controls. IL-1 levels were significantly increased (P less than 0.05) when L. donovani infected animals were treated with SSG, after 14 days post infection, irrespective of the stimuli used.


Subject(s)
Animals , Antimony Sodium Gluconate/pharmacology , Female , Interleukin-1/biosynthesis , Leishmaniasis, Visceral/immunology , Male , Mice , Mice, Inbred BALB C , Staphylococcus epidermidis/immunology
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