[Evaluation of the effects of chlorhexidine 0.12% mouthwash on mouth pathogen streptococcus and normal microflora]

Mouthwashes like brush and dental floss, can cause reduction in dental plaque and gingivitis. An optimal mouthwash should have antimicrobial properties, low drug resistance, and cause no decrease in normal microflora of the mouth. The purpose of this study was the evaluation of the effects of chlorhexidine 0.12% mouthwash on pathogen streptococcus and normal microflora of the mouth. In this experimental study, based on selected inclusion criteria, 28 subjects, were selected and asked to use 0.12% chlorhexidine mouthwash for 2 weeks, according to the manufacturer instruction. Before and after rinsing with the mouthwash, subjects were requested to wash their mouth with physiologic serum. After washing, 1cc of saliva of each individual was collected in sterile tube and immediately sent to microbiology laboratory. This process was repeated 2 weeks after using mouthwash. The number of pathogen streptococcus and normal microflora colonies of the mouth before and after using chlorhexidine were recorded. For analyzing the data, T and Chi Square Test were used.: Chlorhexidine mouthwash [0.12%] significantly decreased numbers of the pathogen streptococcus and mouth normal microflora [p <0/05] This study showed that, 0.12% chlorhexidine mouthwash, can destroy not only the mouth pathogen streptococci, but also the normal microflora of the mouth. The latter should be considered as its side effect

Penicillin-resistant Aerococcus viridans Bacteremia Associated with Granulocytopenia

Aerococcus viridans, a catalase-negative gram-positive coccus rarely causing bacteremia, was isolated from blood cultures of a 52-yr-old man under the gran-ulocytopenic condition. The isolate showed the typical characteristics of A. viridans, i.e., tetrad arrangements in gram stain, positive pyrrolidonyl aminopeptidase (PYR) and negative leucine aminopeptidase (LAP) reactions, and no growth at 45 degrees C.The isolate was revealed to be highly resistant to penicillin, erythromycin, clindamycin, and ceftriaxone, although most strains of A. viridans isolated from the previously reported patients were susceptible to penicillin and other commonly used antibiotics. Even though A. viridans is rarely associated with human infections, it could be a potential causative agent of bacteremia, especially in immunocompromised patients.