Pleomorphic Adenoma in a Young Female: Case Report / Adenoma Pleomórfico en una Mujer Joven: Reporte de Caso

ABSTRACT: Pleomorphic adenoma (PA) is the most common benign salivary gland neoplasm and it is frequently diagnosed in the third and fourth decade with predilection for women. PA is the most common benign lesion of minor salivary glands in children and adolescents, being the palate one of the most frequently affected site of minor salivary glands. Herein, we present a case report of a PA of the hard palate diagnosed in a 15-year-old female and a review of the Englishliterature of the reported cases of PA in children and adolescents in the hard palate.

RESUMEN: El adenoma pleomórfico (AP) es la neoplasia benigna más común de las glándulas salivales y se diagnostica frecuentemente en la tercera y cuarta década con predilección por las mujeres. El AP es la lesión benigna más común de las glándulas salivales menores en niños y adolescentes, siendo el paladar uno de los sitios más frecuentemente afectados de las glándulas salivales menores. En este trabajo se presenta un relato de caso de un AP de paladar duro diagnosticado en una mujer de 15 años de edad y una revisión de la literatura en inglés de los casos reportados de AP en niños y adolescentes en paladar duro.

Unusual Case of Sialoangiolipoma.

Sialoangiolipoma is extremely rare in adults. We report a case with an extremely unusual and atypical presentation of sialangolipoma of submandibular gland. The diagnosis of which is done on histopathology in a case with high index of clinical suspicion of pleomorphic adenoma.

Mucoepidermoid carcinoma of the submandibular gland in a 6yr old boy

Mucoepidermoid carcinoma [MEC] of the salivary glands are rarely found in childhood we report the case of a 6-year old boy presenting with 2-month history of submandibular swelling. In oral examination, a non-tender, firm mass was detected in the submandibular region involving the left cheek and left angle of the mandible. It was firm in consistency with obvious areas of multiple nodularity along the inferior border of the mass. Clinically there were no palpable lymph nodes. Radiographs revealed a radiolucent lesion in the left body of the mandible. The tumor showed sheets and nests of predominantly epidermoid cells along with occasional large pale mucous-like cells and frosted-glass appearance infiltrating the fibro-connective tissue. The lesion was diagnosed as mucoepidermoid carcinoma, high grade type

Tumours of the submandibular salivary gland: a clinicopathologic review of cases over a 17-year period / Tumores de la glándula salival submandibular: una revisión clínico-patológica de casos por un período de 17 Años

OBJECTIVE: This study presents a clinicopathologic review of cases of submandibular salivary gland tumours at the Lagos University Teaching Hospital, Nigeria, over a period of 17 years. METHODS: The records of all patients with histological diagnosis of submandibular salivary gland tumours at the Lagos University Teaching Hospital over a period of 17 years (January 1990 to December 2006) were retrospectively reviewed. Parameters studied were; age and gender of patients, symptoms and duration ofsymptoms, and histological diagnosis. RESULTS: A total of 36patients with submandibular gland tumours were seen during the period. Maleto-female ratio was 1.8:1 (male = 23, female = 13). Mean age (± SD) at presentation was 43 (± 19) years (age range, 17-84 years). There were 19 malignant tumours and 17 benign ones. Pleomorphic adenoma (36.1%) was the most frequent tumours, followed by adenoid cystic carcinoma (11.1%), anaplastic carcinoma (11.1%) and malignant lymphoma (11.1%). Patients with histological diagnosis of malignant tumours were significantly older than those with benign tumours (p = 0.01). Most patients (80.6%) presented with painless swelling. CONCLUSION: Malignant submandibular salivary gland tumours were slightly more than the benign ones in the studied population. Painful swelling or ulceration is indicative ofa malignant submandibular gland tumour.

OBJETIVO: Este estudio presenta una revisión clinicopatológica de casos de tumores de la glándula salival submandibular en el Hospital Docente de la Universidad de Lagos, Nigeria, por un periodo de 17 años. MÉTODOS: Se revisaron retrospectivamente las historias clínicas de todos los pacientes con el diagnóstico histológico de los tumores de la glándula salival submandibular en el Hospital Docente de la Universidad de Lagos, correspondientes a un periodo de 17 años (de enero de 1990 a diciembre de 2006). Los parámetros estudiados incluyeron: la edad y el género de los pacientes, síntomas y duración de síntomas, y diagnóstico histológico. RESULTADOS: Un total de 36 pacientes con tumores de la glándula de submandibular fueron atendidos durante ese periodo. La proporción varón:hembra fue 1.8:1 (varones = 23, hembras = 13). La edad promedio (± SD) al momento de su presentación fue 43 (± 19) años (rango de edad, 17-84 años). Hubo 19 tumores malignos y 17 benignos. El adenoma pleomórfico (36.1%) fue el tipo de tumor más frecuente, seguido por el carcinoma cístico adenoideo (11.1%), el carcinoma anaplástico (11.1%) y el linfoma maligno (11.1%). Los pacientes con diagnóstico histológico de tumores malignos eran significativamente de más edad que los que tenían tumores benignos (p = 0.01). La mayoría de los pacientes (80.6%) presentaban hinchazón sin dolor. CONCLUSIÓN: Los tumores malignos de la glándula salival submandibular fueron ligeramente mayor en número que los benignos en la población estudiada. Hinchazón dolorosa o la ulceración dolorosas son indicios de un tumor maligno de la glándula submandibular.

Sialoadenite esclerosante crônica (tumor de Kuttner): relato de caso clínico / Chronic sclerosing sialadenitis (Kuttner tumour): clinical case report

A sialoadenite esclerosante (tumor de Kuttner) representa um processo inflamatório crônico incomum de glândula salivar, que acomete com maior freqüência a glândula submandibular. O objetivo deste trabalho é relatar o caso clínico de um paciente que apresentou sialoadenite esclerosante crônica associada a quadro de sialolitíase. Essa entidade patológica é pouco freqüente, clinicamente pode ser confundida com uma neoplasia e, embora seja resolvida com a exérese da lesão, causa transtornos importantes ao paciente, como dor intensa, disfonia e disfagia.

Chronic sclerosing sialadenitis (Kuttner tumour) is an unusual chronic inflammatory process of the salivary gland that affects principally the submandibular gland. The aim of this work is to report a case of chronic sclerosing sialadenits associated with sialolithiasis. Kuttner tumour is an uncommon entity that clinically may not be distinguished from neoplasia and though it can be resolved by surgical excision of the lesion, it causes important upset for the patient, as intense pain, dysphonia and dysphagia.

Oncocytic variant of mucoepidermoid carcinoma of submandibular gland: an unusual clinical and morphological entity.

In this case report we describe a rare tumor--Oncocytic variant of Mucoepidermoid carcinoma of the submandibular salivary gland with a review of the literature. Oncocytic metaplasia in salivary glands is a benign change that is associated with increasing age and also seen in a few salivary gland neoplasms', which include oncocytoma, Warthin's tumor, and the rare, oncocytic carcinoma. Oncocytic differentiation in mucoepidermoid carcinoma (MEC) is uncommon. Only twelve well-documented cases of oncocytic MEC have been reported previously all of which occurred in the parotid gland. To the best of our knowledge this is the first case of oncocytic mucoepidermoid carcinoma involving the submandibular salivary gland. The recognition of this entity is important, since most of the other primary oncocytic lesions of the salivary gland are benign.

Benign stromal fragments in metastases of squamous cell carcinoma in cytology--a report of two cases.

Benign stromal fragments or extracellular matrix can be seen in aspirates of invasive carcinomas. Although well documented on histology, this feature is rarely observed on fine needle aspirates and can create diagnostic difficulties on smears. Only three such cases have been reported so far. We report two more cases where stromal fragments were seen in association with invasive squamous cell carcinoma (SCC). Two cases of biopsy proved invasive SCC of the cheek and of the larynx presented with metastases to the submandibular salivary gland and to the cervical lymph node respectively. Aspirates of the metastatic sites showed two components: one of SCC and the other benign stroma, both in close approximation with one another. Both patients were treated with radiotherapy. Biopsy of the metastatic sites was not done. Benign stromal fragments can be encountered in aspirates of invasive carcinoma. These may be cellular or myxoid. Since such stromal fragments can also be seen in salivary tumours, adnexal tumours, fibroadenoma and phylloides tumour, their presence should be interpreted in the light of clinical findings of the patient, so that an erroneous diagnosis can be avoided.

Sialadenitis crónica esclerosante inespecífica de la glándula submandibular, tumor de Kuttner: caso clínico / Chronic sclerosing unspecific sialadenitis of submandibular gland, Kuttner tumor: report of case

Chronic sclerosing unspecific sialadenitis or KYttner tumor, is an infrequent inflammatory lesion of submandibular gland. We report a 60 years old male presenting with a slowly growing, painless, bilateral submandibular tumor of two years of evolution. Pathological examinations showed marked atrophy of glandular parenchyma with increased fibrous connective tissue and an intense lymphocytic infiltration with lymphoid follicle formation. Lymphocyte population study with kappa, lambda, CD20 and CD45RO antibodies was similar to that observed in reactive lymph nodes. There was no over expression of Bcl-2 gene protein, involved in the phenomenon of apoptosis of glandular tissue, that could explain the pathogenesis of atrophy. This protein was positive only in lymphoid cells and glandular conducts. An immune etiology, with replacement of glandular tissue by lymphoid and fibrous connective tissue is suggested

Submandibular salivary gland masses: a clinicopathological study

The aims were to study the pre-operative evaluation of submandibular gland masses, operative strategies, and the variety of pathological conditions that afflict the gland, and to emphasize the role of fine needle aspiration biopsy in selecting patients for surgery. Fifty-six cases of submandibular gland masses treated surgically over a six-year period at King Hussein Medical Center between January 1991 and December 1996 were studied. Clinical presentation, diagnostic evaluation, pathological findings and treatment approaches were reviewed. Out of these 34 [60.7 percent] were non-neoplastic lesions. An asymptomatic mass was the most common presentation. Pre-operative investigations were mainly computed tomography, ultra sonography, and fine needle aspiration cytology. The study showed that the distribution of submandibular salivary gland lesions was similar to many published series. Computed tomography was found to be more accurate than ultrasound in localization of submandibular masses. Fine needle aspiration cytology was found to be helpful in preoperative planning

Paraganglioma de glomus carotídeo: un caso clínico de presentación inusual / Paraganglioma of carotid glomus: a clinical case of unusual presentation

Se presenta un caso clínico de un paraganglioma benigno, no cromafínico, del glomus carotídeo, en un hombre de 51 años que debutó con dolor torácico y al que posteriormente tras una punción aspiración con aguja fija (PAAF), el estudio citológico fue informado como compatible con oncocitoma de la glándula submaxilar

Carcinoma oncocítico / Oncocitic carcinoma

Apresentaçäo de um caso de Carcinoma Oncocítrico, que se faz ainda mais raro por sua provável origem (glândula submandibullar) e a idade do paciente (28 anos), na época