Subject(s)
Chelating Agents/administration & dosage , Child , Child, Preschool , Dose-Response Relationship, Drug , Drug Administration Schedule , Follow-Up Studies , Humans , India , Lead Poisoning/diagnosis , Male , Risk Assessment , Severity of Illness Index , Succimer/therapeutic use , Treatment OutcomeSubject(s)
Humans , Male , Child, Preschool , Female , Infant, Newborn , Infant , Child , Lead Poisoning , Edetic Acid/therapeutic use , Chelating Agents , Dimercaprol , Succimer/therapeutic useABSTRACT
Hepatic lipid peroxidation, glutathione and phospholipid contents of homogenate prepared from the liver of lead-intoxicated male rats treated with 0.3 m mol/kg CaNa2EDTA and DMSA for 8 weeks, either alone or in combination, were investigated. A significant increase in hepatic malondialdehyde (MDA) and a reduction in glutathione levels was noticed. While a marginal decrease in phosphatidyl choline (PC) level was noticed, no effect on phospholipid contents was seen. Treatment with all the three chelating agents elicited decrease in PC level. DMSA alone was partially effective in restoring lead-induced altered hepatic glutathione and MDA levels. Combined treatment may have an adverse effects on hepatic tissue and does not seem to produce immediate recoveries in the lead-induced hepatic damage.