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Indian J Physiol Pharmacol ; 1995 Jan; 39(1): 83-5
Article in English | IMSEAR | ID: sea-107732

ABSTRACT

Diltiazem, a calcium channel blocker was studied to observe its effects on the acetylcholine contractile responses of isolated frog rectus abdominis muscle. This response was modified in a dual manner i.e., initial potentiation, followed by inhibition. Diltiazem may not have anticholinesterase like mechanism, as it potentiated the responses to both acetylcholine and succinylcholine. Rectus muscle preparation, incubated in calcium free frog Ringer, showed dose dependent inhibition of acetylcholine contractile responses by diltiazem. The study suggests that diltiazem inhibits calcium ion influx across receptor operated calcium channels and may also inhibit calcium ion release from intracellular structures.


Subject(s)
Acetylcholine/antagonists & inhibitors , Animals , Anura , Calcium/metabolism , Calcium Channels/drug effects , Diltiazem/pharmacology , Dose-Response Relationship, Drug , Drug Synergism , Muscle Contraction/drug effects , Rectus Abdominis/drug effects , Succinylcholine/antagonists & inhibitors
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