Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
2.
Arq. neuropsiquiatr ; 68(3): 333-338, June 2010. ilus, tab
Article in English | LILACS | ID: lil-550261

ABSTRACT

This study evaluates the diagnostic value of morphometric magnetic resonance imaging (MRI) in the differential diagnosis among Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). We studied 21 PD cases, 11 MSA-c, 8 MSA-p and 20 PSP cases. Midbrain area (Ams), pons area (Apn), middle cerebellar peduncle (MCP) and superior cerebellar peduncle (SCP) were measured using MRI. Comparisons were made between PD, MSA-p, MSA-c and PSP. Apn, MCP and SCP morphometry dimensions presented differences among groups. Ams below 105 mm² and SCP smaller than 3 mmwere the most predictive measures of PSP (sensitivity 95.0 and 80.0 percent, respectively). For the group of MSA-c patients, Apn area below 315 mm² showed good specificity and positive predictive value (93.8 percent and 72.7 percent, respectively). In conclusion, dimensions and cut off values obtained from routine MRI can differentiate between PD, PSP and MSA-c with good sensitivity, specificity and accuracy.


Morfometria pela ressonância magnética (RM) no diagnóstico diferencial entre doença de Parkinson (DP), paralisia supranuclear progressiva (PSP) e atrofia de múltiplos sistemas (AMS). Este estudo avaliou a RM no diagnóstico diferencial de 21 casos com DP, 11 AMS-c, 8 AMS-p e 20 com PSP. A área sagital do mesencéfalo (Ams), área sagital da ponte (Apn), largura do pedúnculo cerebelar médio (PCM) e pedúnculo cerebelar superior (PCS) foram medidas pela RM e realizadas comparações entre destes pacientes. A Ams <105 mm² e a largura média do PCS <3 mm foram preditivas para PSP (sensibilidade de 95,0 e 80,0 por cento, respectivamente). Nos casos de AMS-c a área pontina <315 mm² apresentou boa especificidade e valor preditivo positivo para o diagnóstico (93,8 por cento e 72,7 por cento). Em conclusão, as dimensões e valores de cortes obtidos a partir da RM podem diferenciar PD, PSP e AMS-c, com sensibilidade, especificidade e precisão.


Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Magnetic Resonance Imaging/methods , Mesencephalon/pathology , Multiple System Atrophy/diagnosis , Parkinson Disease/diagnosis , Supranuclear Palsy, Progressive/diagnosis , Cross-Sectional Studies , Diagnosis, Differential , Multiple System Atrophy/pathology , Predictive Value of Tests , Parkinson Disease/pathology , Sensitivity and Specificity , Supranuclear Palsy, Progressive/pathology
3.
Arq. neuropsiquiatr ; 63(3B): 878-880, set. 2005. ilus
Article in Portuguese | LILACS | ID: lil-445126

ABSTRACT

Progressive supranuclear palsy (PSP) is one of the most important causes of parkinsonism non responsive to therapy. Vascular parkinsonism is not uncommon. However, the cause-effect relationship between them is uncertain. We report on a 65 year old man with probable PSP who developed the clinical features of the disease after a ischaemic stroke. Magnetic resonance imaging disclosed a corticospinal tract Wallerian degeneration. There is not such an observation in the literature about this possible correlation.


Paralisia supranuclear progressiva (PSP) é uma das principais causas de parkinsonismo-plus não responsivo a terapia. A ocorrência de doença cerebrovascular associada a parkinsonismo não é infreqüente, no entanto é difícil estabelecer a relação causa-efeito entre ambas. Relatamos o caso de um paciente de 65 anos com PSP provável iniciada após infarto cerebral, em que a imagem por ressonância magnética evidenciou sinais de degeneração walleriana do trato córtico-espinhal. Não há relato na literatura pesquisada sobre esta possível correlação.


Subject(s)
Aged , Humans , Male , Wallerian Degeneration/complications , Supranuclear Palsy, Progressive/complications , Wallerian Degeneration/pathology , Brain Ischemia/complications , Brain Ischemia/pathology , Magnetic Resonance Imaging , Supranuclear Palsy, Progressive/pathology
4.
Folha méd ; 96(6): 351-6, jun. 1988.
Article in Portuguese | LILACS | ID: lil-72378

ABSTRACT

As doenças degenerativas, como a demência senil, as enfermedades de Alzheimer, Pick e Creutzfeldt-Jakob, dentre outras, despertam interesse crescente entre os clínicos, sendo porém necessária uma visäo realista das mesmas, o que só é possível à luz da patologia


Subject(s)
Central Nervous System Diseases/pathology , Charcot-Marie-Tooth Disease/pathology , Dementia/pathology , Alzheimer Disease/pathology , Parkinson Disease/pathology , Huntington Disease/pathology , Myoclonus/pathology , Pantothenate Kinase-Associated Neurodegeneration/pathology , Shy-Drager Syndrome/pathology , Supranuclear Palsy, Progressive/pathology
SELECTION OF CITATIONS
SEARCH DETAIL