ABSTRACT
Centrally stimulated sweat rate produced by graded exercise until exhaustion was compared to the local sweat rate induced by pilocarpine, often used as a sweating index for healthy individuals. Nine young male volunteers (22 ± 4 years) were studied in temperate environment in two situations: at rest and during progressive exercise with 25 W increases every 2 min until exhaustion, on a cycle ergometer. In both situations, sweating was induced on the right forearm with 5 ml 0.5 percent pilocarpine hydrochloride applied by iontophoresis (1.5 mA, 5 min), with left forearm used as control. Local sweat rate was measured for 15 min at rest. During exercise, whole-body sweat rate was calculated from the body weight variation. Local sweat rate was measured from the time when heart rate reached 150 bpm until exhaustion and was collected using absorbent filter paper. Pharmacologically induced local sweat rate at rest (0.4 ± 0.2 mg cm-2 min-1) and mean exercise-induced whole-body sweat rate (0.4 ± 0.1 mg cm-2 min-1) were the same (P > 0.05) but were about five times smaller than local exercise-induced sweat rate (control = 2.1 ± 1.4; pilocarpine = 2.7 ± 1.2 mg cm-2 min-1), indicating different sudorific mechanisms. Both exercise-induced whole-body sweat rate (P < 0.05) and local sweat rate (P < 0.05) on control forearm correlated positively with pilocarpine-induced local sweat rate at rest. Assuming that exercise-induced sweating was a result of integrated physiological mechanisms, we suggest that local and whole-body sweat rate measured during graded exercise could be a better sweating index than pilocarpine.
Subject(s)
Adult , Humans , Male , Exercise/physiology , Muscarinic Agonists/pharmacology , Pilocarpine/pharmacology , Sweating/drug effects , Analysis of Variance , Body Temperature Regulation/physiology , Iontophoresis , Sweating/physiologyABSTRACT
O autor realizou um estudo prospectivo em 600 pacientes portadores de disdrose. Após uma revisäo bibliográfica a respeito mostra os resultados obtidos em relaçäo ao sexo, raça, idade, profissäo, localizaçöes das lesöes, meses de freqüência e possíveis causas etiológicas
Subject(s)
Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , Drug Eruptions , Sweating/drug effects , Brazil , Dermatitis, Atopic/genetics , Eczema, Dyshidrotic/diagnosis , Eczema/etiology , Foot Dermatoses/epidemiology , Hand Dermatoses/epidemiology , Prospective StudiesSubject(s)
Adult , Humans , Male , Female , Antidepressive Agents, Tricyclic/pharmacology , Salivation/drug effects , Parasympathetic Nervous System/drug effects , Sweating/drug effects , Amitriptyline/pharmacology , Clinical Trials as Topic , Double-Blind Method , Imipramine/pharmacology , Maprotiline/pharmacology , Mianserin/pharmacologyABSTRACT
Modified Pilocarpine Test was carried out in 48 patients under investigation for Leprosy. 37 cases showed deficient sweating of varying degree. Many of these patients did not reveal confirmatory histopathological changes and were bacteriologically negative. In the absence of other causes of neuropathy this finding of deficient sweating by modified pilocarpine test, was significant. Same test was carried out in 8 confirmed cases of Tuberculoid leprosy. All cases showed positive results.