ABSTRACT
Abstract Neutrophilic dermatoses encompass a wide spectrum of diseases characterized by a dense infiltration mainly composed of neutrophils. Neutrophilic dermatosis of the dorsal hands is currently considered a localized variant of Sweet syndrome. Cocaine abuse has been related to a wide range of mucocutaneous manifestations, including neutrophilic dermatoses such as pyoderma gangrenosum. The authors of this study present a patient with neutrophilic dermatosis of the dorsal hands, in which cocaine abuse was identified as a probable trigger.
Subject(s)
Humans , Sweet Syndrome/diagnosis , Sweet Syndrome/chemically induced , Pyoderma Gangrenosum , Cocaine-Related Disorders/complications , Dermatitis , NeutrophilsABSTRACT
Abstract: Cutaneous drug reactions are adverse reactions to medications that may present with different clinical features, ranging from localized to generalized lesions. In this report we describe a case of an unusual drug reaction, resembling the morphology of Sweet syndrome lesions. The patient had a psychiatric illness and was using thioridazine hydrochloride for one year. He developed infiltrated and grouped erythematous lesions on the elbows and knees three days after commencing multiple drugs (promethazine, haloperidol, mirtazapine and levomepromazine). After suspension of these four drugs and after the use of glucocorticoids, the patient had significant clinical improvement.
Subject(s)
Humans , Male , Adult , Sweet Syndrome/pathology , Drug Eruptions/pathology , Psychotropic Drugs/adverse effects , Biopsy , Sweet Syndrome/chemically induced , Drug Eruptions/etiology , Diagnosis, Differential , Drug Therapy, Combination/adverse effects , Erythema/chemically induced , Erythema/pathologyABSTRACT
Quinupristin/Dalfopristin is a new combination of streptogramin antibiotics designed specifically to treat clinically significant infections due to Vancomycin-resistant Enterococcus Faecium. Sweet's syndrome is characterized by painful skin plaques, which is associated with dermal neutrophilic infiltration, fever and peripheral blood leukocytosis. Drug-induced Sweet's syndrome has a temporal relationship between drug ingestion, clinical presentation and the temporally-related resolution of lesions following drug withdrawal or on treatment with systemic corticosteroids. A 63-year-old woman received Quinupristin/Dalfopristin for acute pyelonephritis developed fever, arthralgia, vomiting, and painful erythematous skin plaques. A skin biopsy showed neutrophilic dermatosis, and there was rapid resolution of the symptoms and cutaneous lesions after discontinuation of Quinupristin/Dalfopristin, consistent with drug-induced Sweet's syndrome. To date, there has been no reported case of Sweet's syndrome associated with the use of Quinupristin/Dalfopristin.
Subject(s)
Female , Humans , Middle Aged , Anti-Bacterial Agents/administration & dosage , Skin/drug effects , Sweet Syndrome/chemically induced , Virginiamycin/administration & dosageABSTRACT
Relata-se um caso clínico de uma paciente, 50 anos, portadora de HIV/Aids, que desenvolveu lesöes cutâneas dolorosas de forma aguda, em placas eritematosas, com superfície irregular e bem delimitada, diagnosticada como síndrome de Sweet. A analíse histopatológica revelou edema de derme papilar e infiltrado inflamatório neutrofílico difuso. Poucos casos säo descritos na literatura sobre esta condiçäo em paciente com HIV/Aids.
Subject(s)
Humans , Female , Middle Aged , Dapsone/therapeutic use , Acquired Immunodeficiency Syndrome/drug therapy , Sweet Syndrome/chemically induced , Sinusitis/drug therapy , Trimethoprim, Sulfamethoxazole Drug Combination/adverse effects , Lamivudine/therapeutic use , Stavudine/therapeutic useABSTRACT
All-trans retinoic acid (ATRA) is the standard induction treatment for acute promyelocytic leukemia (APL). Quite many ATRA-related side effects, including retinoic acid syndrome, were reported. So far, it has rarely been reported that Sweet's syndrome, characterized by fever, neutrophilia, painful erythematous cutaneous plaques, dense dermal infiltrates of mature neutrophils and rapid response to steroid therapy, is associated with ATRA. In the case that Sweet's syndrome associated with ATRA is found, physicians will have to face a great challenge over the possibility of infectious conditions. We present here a case of Sweet's syndrome associated with ATRA. A 35-year-old female with APL developed fever, painful erythematous cutaneous plaques on both cheeks, right wrist and both shins during induction chemotherapy with ATRA. A skin biopsy revealed a dense dermal infiltrate, consisting of mature neutrophils without vasculitis or cutaneous immunoglobulin deposits, which is compatible with Sweet's syndrome. Oral prednisone was administered and the lesions started to improve within 48 hours