Exposición a gas CS: a propósito de un caso peculiar / Exposure to CS gas: Case study

El gas CS (o-clorobenzolideno malononitrilo) se incluye dentro del grupo de los gases lacrimógenos. La exposición a dicho gas ocurre durante su empleo como gas de defensa o antidisturbios, así como durante el entrenamiento rutinario de las fuerzas de choque especializadas. Su acción tóxica es ejercida a través de un efecto irritante sobre piel y mucosas, así como por mecanismos inmunoalérgicos. Presentamos el caso de un paciente de 24 años, perteneciente a una fuerza de choque, que consultó por lesiones cutáneas luego de una exposición a humo y dispersión de polvo de una granada de gas CS durante ejercicios de entrenamiento. Clínicamente se presentó características peculiares, referidas a sus manifestaciones cutáneas, localización y severidad de las mismas. Se analiza la etiopatogenia de las lesiones y los posibles mecanismos involucrados, diagnósticos diferenciales, así como los pilares del tratamiento frente a una exposición a gas CS...

Usos y abusos de los gases lacrimógenos y la salud: prevención y manejo / Uses and abuses of teargas and health: prevention and management

Los gases lacrimógenos (GL) son métodos de control de manifestaciones públicas por los órganos represivos, muy utilizados y efectivos globalmente. El objetivo de esta revisión es actualizar información técnica sobre los gases lacrimógenos, añadiendo aspectos más recientes legales, éticos, médicos y preventivos del uso y abuso de estos agentes químicos durante las acciones de las fuerzas policiales y represivas. Las fuentes de información secundarias seleccionadas son portales generales con el buscador Google, académicos (Google académico), PubMed y de las organizaciones gubernamentales y no gubernamentales, también se incluyen hemerotecas de artículos periodísticos sobre su uso desde 2000 hasta 2014. La exposición aguda a (GL) se expresa con manifestaciones clínicas de afección respiratoria, irritación de los ojos y de la piel, requiriendo en la mayoría de los casos medidas generales de atención fuera del hospital. Sin embargo, en casos de personas con co-morbilidades respiratorias, alérgicas, glaucoma y del corazón, acarrean mayores consecuencias que requieren atención médica y hospitalaria. Se han reportado fatalidades relacionadas al uso y abuso de los agentes químicos. Desde el punto de vista de salud pública existe controversia sobre su uso, y definitivamente causan consternación en los afectados y los abusos de su utilización en manifestaciones pacíficas. Se hace un listado de recomendaciones ante exposiciones durante manifestaciones, como prevenir intoxicaciones severas y dar los primeros auxilios...

Tear gases (TG) are methods for public control used by police forces. The objective of this review is to update technical information about tear gas, adding more recent legal, ethical, medical and preventive aspects of the use and abuse of these chemicals during the actions of the police and repressive forces. Selected secondary sources of information are Google, Academic Google, PubMed and of governmental and non-governmental organizations, also included are newspaper archives about its use from 2000 to 2014. Acute exposure to (GL) is expressed with clinical manifestations of respiratory conditions, irritation of the eyes and skin, requiring in most cases general ambulatory measures of care. However, in persons with respiratory, allergic, glaucoma and heart comorbidities, they carry greater consequences requiring hospital care. Fatalities have been reported related to the use and abuse of chemical agents. From the viewpoint of public health there is a controversy about its use, and definitely cause consternation in the affected in peaceful demonstrations. A list of recommendations is made about how to prevent severe intoxications and give first aid...

A Study for Health Hazard Evaluation of Methylene Chloride Evaporated from the Tear Gas Mixture

This study explored the health hazard of those exposed to methylene chloride by assessing its atmospheric concentration when a tear gas mixture was aerially dispersed. The concentration of methylene chloride ranged from 311.1-980.3 ppm (geometric mean, 555.8 ppm), 30 seconds after the dispersion started. However, the concentration fell rapidly to below 10 ppm after dispersion was completed. The concentration during the dispersion did not surpass the National Institute for Occupational Safety and Health 'immediately dangerous to life or health' value of 2,300 ppm, but did exceed the American Conference of Governmental Industrial Hygienists excursion limit of 250 ppm. Since methylene chloride is highly volatile (vapor pressure, 349 mmHg at 20degrees C), the postdispersion atmospheric concentration can rise instantaneously. Moreover, the o-chlorobenzylidenemalononitrile formulation of tear gas (CS gas) is an acute upper respiratory tract irritant. Therefore, tear gas mixtures should be handled with delicate care.

A study on relationship between rat brain tissues hurts of the gas explosion and the expression of protein kinase CamRNA and c-fos gene / 中华劳动卫生职业病杂志

<p><b>OBJECTIVES</b>To explore relationship between rat brain tissues hurts of gas explosion and the expression of Protein Kinase C alpha mRNA.</p><p><b>METHODS</b>Build up rat hurt model of gas explosion. In Situ Hybridization (IDH) technique was used to test Protein Kinase C alpha mRNA. Immunohistochemical Assays (IHA) was used to determine c-fos gene protein.</p><p><b>RESULTS</b>Only a little a mount expression of PKC alpha mRNA and c-fos of the control group was detected. The expression of the cerebral cortex and hippocampus of PKC alpha mRNA 24 h, 48 h and the 48 h increased obviously, and the 48 h reached the peak of expression; (t = 4.12 P < 0.01). The expression of c-fos protein of the cerebral cortex and hippocampus started to increase obviously at 0.5 h and the 4 h reached the peak, then the strength lowered gradually and the expression level came back normal level on fifth day.</p><p><b>CONCLUSION</b>The anoxia of brain tissues due to the gas explosion may promote the expression of PKCamRNA, and PKCamRNA could regulate the expression of the gene of c-fos. Both PKCamRNA and the gene of c-fos are involved in harmful processes to the nerve cells.</p>

An Electron Microscopic Study on Cytoplasmic Organelles of the Cilicated Cell in Tracheal Epithelium in o-Chlorobenzylidene malononitrile (CS)gas exposed rat / 체질인류학회지

The effects of tear gas, o -chlorobenzylidene malononitrile (CS) on the cytoplasmic organelles were studied in the ciliated cell of rat tracheal epithelium. Albino rats (Sprague -Dawley strain), weighing about 150gm, were used as experimental animals. The experimental animals were exposed to 2.0 g/m 3 of CS gas for 20 minutes per day for the succesive 3 days. The experimental animals were sacrified at 1, 3, 6, 12 hours and 1, 3 and 5 days after final exposure to CS gas. Specimens obtained from the trachea were pre -fixed in 2% glutaraldehyde -2.5% paraformaldehyde and post -fixed in the 1% osmium tetroxide for electron microscopic study. The results obtained were as follows: 1. In 1 hour CS gas exposed group, rough endoplasmic reticulum with dilated cisternae, and mitochondria with disrupted double membrane in the ciliated cells are found. 2. In 3 hours and 6 hours CS gas exposed groups, dilated, segmented and sacculated cisterane of rough endoplasmic reticulum, mitochondria with dissolved cristae and disrupted double membrane, and Golgi complex with atrophied cisternae are observed in the ciliated cell. 3. In 12 hours CS gas exposed group, some mitochondria with swollen cristae is found in the ciliated cell. 4. In 1 day CS gas exposed group, mitochondria with dissolved cristae, Golgi complex with hypertrophied cisternae, and autophagic vacuole are found. 5. In 3 day and 5 day CS gas exposed groups, numerous mitochondria, well -developed rough endoplasmic reticulum, and supranuclear Golgi complex are found in ciliated cell. The results of the present study suggest that the o -chlorobenzylidene malononitrile (CS) gas is cytotoxic to the ciliated cells in tracheal epithelium inducing some degenerative changes, which are recovered with the lapse of time.

Efeitos lesivos causados pelo uso indiscriminado do gás lacrimogênio "CN" / Injurious effects caused by indiscriminate use of the \"CN\" tear gas

O presente trabalho analisa as várias formas de açäo e os vários tipos de Bombas de Gás Lacrimogênio (BGL) utilizadas no BRASIL, em relaçäo ao ser humano. Estuda o quadro macro e microscópico de indivíduos expostos á açäo direta desta composto por longo período, em ambiente confinado e que evoluíram para óbito. Analisa e estuda, a nível de exames clínicos e laboratoriais em ambulatório, as alteraçöes que ocorreram com os sobreviventes, alguns deles sendo seguidos por até 4,5 anos. Análise também os achados microscópicos de uma das vítimas, que faleceu, por outros motivos, quatro anos após o acidente, ocorrido na Cadeia Pública de Campinas, onde seis presidiários ficaram expostos á açäo direta do "CN" por cerca de 32 horas. Dois destes, vieram a falecer pouco tempo depois e os outros quatro se intoxicaram e sofreram lesöes corporais.