ABSTRACT
Purpose: To evaluate the effect of tetracaine on intraocular pressure [IOP] in normal and hypertensive rabbit eyes
Methods: The study was conducted on 12 healthy rabbits as controls and 6 healthy rabbits in which an experimental model of ocular hypertension [OHT] was induced by administration of 70 mL/kg of tap water through an orogastric tube. One drop of tetracaine was instilled in the left eye while a drop of normal saline [placebo] was applied to the right eye of the control group. IOP was measured before and 0, 5, 10, 15, 20, 25, 30, 35 and 40 minutes after drop administration in this group. The OHT group also received one drop of tetracaine and normal saline in the left eyes and right eyes respectively, immediately after water loading; the instillation of drops was repeated after 55 minutes. IOP was measured before and 0, 5, 10, 15, 20, 25, 30, 35, 40, 55, 70, 85, 100 and 115 minutes after water loading in this group
Results: Tetracaine treated eyes in both groups [ocular hypertensive and normal controls] demonstrated significant IOP reduction at time zero [immediately after drop instillation] which was sustained up to 20 minutes, as compared to placebo treated eyes [P<0.05]. In ocular hypertensive rabbits, repeat instillation of tetracaine significantly reduced IOP at 55 minutes up to 30 minutes thereafter
Conclusion: Topical tetracaine can reduce IOP; this fact should be considered in experiments evaluating IOP reducing agents
Subject(s)
Animals, Laboratory , Tetracaine/therapeutic use , Tetracaine/pharmacology , Glaucoma/drug therapy , Rabbits , Anesthetics, LocalABSTRACT
O uso topico de solucoes contendo anestesicos e normalmente associado ao aparecimento de uma serie de fenomenos toxicos ao epitelio da cornea. Seu uso vem sendo proposto em algumas situacoes em especial apos a ceratectomia fotorretrativa...
Subject(s)
Animals , Rabbits , Corneal Diseases/therapy , Epithelium, Corneal/pathology , Tetracaine/therapeutic use , Rabbits , Prospective Studies , Anesthetics, Local/administration & dosage , Anesthetics, Local/therapeutic use , Wound HealingABSTRACT
Sessenta e seis pacientes febris, com amigdalite aguda ou crônica reacutizada foram tratados por um período de 7 dias consecutivos com nebulizaçöes tópicas de benzidamina spray ou hexamidina + tetracaína aerosol.Ambas as medicaçöes experimentadas mostraram-se altamente efetivas, de boa tolerabilidade e palatabilidade. Observou-se tendência de melhora mais rápida com a utilizaçäo da benzidamina spray. Os resultados obtidos com o uso da benzidamina spray indicam que este potente antiinflamatório tópico deve ser incluído no arsenal terapêutico destinado ao combate das amigdalites, pelo valioso alívio sintomático que é capaz de proporcionar