ABSTRACT
Effect of chlorpromazine with biological metal ions, viz. calcium, magnesium, zink and copper was studied on T. ferrooxidans cell system. Chlorpromazine, calcium and magnesium alone could produce radioprotection. Maximum radioprotection was exhibited by chlorpromazine at lower concentration while copper and zink offered radiosensitization. However, combination of chlorpromazine with all biological metal ions exhibited radiosensitization. Dose modifying factor by chlorpromazine at lower concentration (0.025 mM) was 0.754 while in combination with Ca2+, Mg2+, Cu2+ and Zn2+ was 1.08, 1.25, 1.37 and 1.389 respectively. The possible interaction between chlorpromazine and biological metal ions is discussed at cellular membrane level.
Subject(s)
Cell Membrane/drug effects , Chlorpromazine/administration & dosage , Drug Interactions , Metals/administration & dosage , Radiation-Protective Agents/administration & dosage , Radiation-Sensitizing Agents/administration & dosage , Thiobacillus/drug effectsABSTRACT
Testou-se a eficiência dos desinfetantes: cloro livre e combinado, permanganato de potássio e sulfato de cobre em baixas e altas concentraçöes por longos e curtos períodos de tempo. Verificou-se também, o efeito do pH e da aeraçäo em poços contaminados por ferrobactérias. O pH é um dos principais fatores reguladores do crescimento destes organismos. Observou-se maior crescimento em pH 6,5 e inibiçäo a partir de 7,5. Os desinfetantes se mostraram eficientes na inibiçäo do crescimento das ferrobactérias em concentraçöes a partir de 4mg/l nos expoerimentos de longos períodos de tempo e nas concentraçöes de 10mg/l a partir de 6 horas de contato