Effect of reserpine or phenobarbitone on the acute toxicity of alphaxalone and alphadolone

Reserpine potentiated the acute toxicity of Althesin to a great extent. This was due to tranquilizing effect of reserpine, by depletion of catecholamines, and by release of progesterone which had considerable anaesthetic properties. Toxicity of thiopentone was less affected by reserpine. Phenobarbitone is a potent enzyme inducer. The rate of metabolism of Althesin was increased. So phenobarbitone antagonised the toxic effects of Althesin. Thiopentone was affected by phenobarbitone in the same way like althesin