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1.
Rev. latinoam. enferm. (Online) ; 27: e3196, 2019. tab
Article in Portuguese | LILACS, BDENF | ID: biblio-1043060

ABSTRACT

Objetivo identificar os motivos da recusa de córneas. Método estudo transversal, retrospectivo, descritivo e correlacional, composto por 5.560 córneas ópticas. As informações foram extraídas do banco de dados da Central de Notificação, Captação e Doação de Órgãos (CNCDO), bem como de prontuários de doadores. A estatística descritiva foi utilizada para a análise das variáveis categóricas e testes específicos, com nível de significância de 5% para avaliar as associações entre as variáveis. Este estudo atendeu aos aspectos éticos da pesquisa científica. Resultados 60% dos doadores eram do sexo masculino e 40% morreram por problemas circulatórios. Os principais motivos de recusa informados pelas equipes de transplante são a idade do doador e a contagem de células endoteliais. Para cada ano adicionado à idade do doador, há uma redução de 1% na chance de que essa córnea seja usada para transplante, e para cada acréscimo de 100 células por mm2 aumenta as chances de que essa córnea seja usada em 9%. Conclusão a principal causa de recusa na aceitação do tecido corneano está relacionada à idade e à contagem de células endoteliais.


Objective to identify the reasons for refusal of corneas. Method this was a cross-sectional, retrospective, descriptive and correlational study composed of 5,560 optical corneas. The information was taken from the notification, organ procurement and distribution centers database as well as donor records. Descriptive statistics were used for the analysis of categorical variables and specific tests with a significance level of 5% for assessing the associations between variables. This study met the ethical aspects of scientific research. Results 60% of the donors were male and 40% died by circulatory problems. The main reason for refusal as informed by transplant teams is the donor's age and the endothelial cell count. For each year added to the donor's age, there is a 1% decrease in the chance that this cornea will be used for transplantation, and the increase of 100 cells per mm2 increases the chances that this cornea will be used by 9%. Conclusion the main cause of refusal in the acceptance of corneal tissue is related to the age and the endothelial cell count.


Objetivo identificar los motivos para el rechazo de córneas. Método estudio transversal, retrospectivo, descriptivo y correlacional, compuesto por 5.560 córneas ópticas. La información se obtuvo de la bases de datos de Centros de Notificación, Obtención de Órganos y Distribución, así como de los registros de los donantes. Se utilizaron estadísticas descriptivas para analizar las variables categóricas y pruebas específicas con un nivel de significación de 5%, para evaluar las asociaciones entre variables. Este estudio contempla los aspectos éticos de una investigación científica. Resultados el 60% de los donantes eran hombres y el 40% falleció por problemas circulatorios. La principal razón del rechazo, informada por los equipos de trasplante, es la edad del donante y el recuento de las células endoteliales. Por cada año agregado a la edad del donante, existe una disminución de 1% en la probabilidad de que la córnea pueda ser utilizada para trasplante; el aumento de 100 células por mm2 aumenta la posibilidad de que esta córnea será usada por 9%. Conclusión la principal causa de rechazo en la aceptación del tejido corneal está relacionada con la edad y el recuento de células endoteliales.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Adult , Aged , Aged, 80 and over , Young Adult , Tissue Transplantation/standards , Corneal Transplantation/standards , Cornea/anatomy & histology , Organ Preservation/standards , Quality Control , Time Factors , Tissue Donors/statistics & numerical data , Brazil , Cross-Sectional Studies , Retrospective Studies , Medical Waste Disposal , Tissue and Organ Harvesting/standards , Correlation of Data , Middle Aged
2.
Goiânia; SES-GO; 2018. 1-50 p. quad.
Monography in Portuguese | LILACS, CONASS, ColecionaSUS, SES-GO | ID: biblio-1397254

ABSTRACT

A Central de Transplantes (CET) é um orgão executivo, subordinado Secretaria de Estado da Saúde e tem como responsabilidade planejar, coordenar, acompanhar e controlar todas as atividades de transplantes, ao nível estadual, em observância à legislação vigente referente ao processo de doação, captação, distribuição e transplantes de orgãos e tecidos no Brasil. Afim de organizar as atividades da CET-GO, criou-se este manual de rotina e procedimentos operacionais da Central de Transplantes de forma a oferecer qualidade e segurança nas tarefas executadas e resultados esperados


The Transplant Center (CET) is an executive body, subordinated to the State Health Department and is responsible for planning, coordinating, monitoring and controlling all transplant activities at the state level, in compliance with current legislation regarding the donation process, capture, distribution and transplantation of organs and tissues in Brazil. In order to organize the activities of CET-GO, this manual of routine and operational procedures of the Transplant Center was created in order to offer quality and safety in the tasks performed and expected results


Subject(s)
Humans , Transplants/standards , Tissue Donors/classification , Brain Death/classification , Brain Death/diagnosis , Tissue and Organ Harvesting/methods , Tissue and Organ Harvesting/standards
3.
Rev. bras. oftalmol ; 70(6): 430-436, nov.-dez. 2011. ilus
Article in Portuguese | LILACS | ID: lil-612922

ABSTRACT

O transplante de córnea é singular, pelo fato de ser habitualmente realizado em pessoas com deficiência visual, mas com expectativa de vida, mobilidade e convivência social preservadas. Um enxerto mal-sucedido pode levar à cegueira real ou ao sofrimento permanente, motivado por dor ou desconforto ocular. Um dos fatores fundamentais do sucesso do mesmo é o uso de córneas de boa qualidade. A seleção dessas córneas assenta-se em três princípios: inocuidade, transparência e vitalidade. Cada um deles é analisado detalhadamente neste trabalho.


Corneal transplantation is singular because it is habitually performed on persons with visual deficiency but with preserved life expectancy, mobility and social life. A graft not well succeeded may cause real blindness and permanent misery due to pain and discomfort. One of the fundamental determinants of the success of corneal transplantation is the use of corneas of good quality. The selection of these corneas is based on three rules: innocuousness, transparency and vitality. Each one of these concepts is considered in detail in this work.


Subject(s)
Humans , Organ Preservation/methods , Tissue Donors , Corneal Transplantation , Tissue and Organ Harvesting/standards , Donor Selection/standards , Eye Banks/standards , Quality Control , Tissue and Organ Procurement/standards , Endothelium, Corneal/pathology , Disease Transmission, Infectious
4.
Article in English | IMSEAR | ID: sea-140057

ABSTRACT

Although bone allografts are being widely used in dentistry, many of clinicians appear to be unfamiliar with their preparation and processing as well as their use as safe and effective graft materials. The major concerns associated with these materials are antigenicity and risk of disease transmission from donor to recipient. To minimize this risk, the production of an allograft worthy of distribution and implantation requires strict attention to detail through a comprehensive process. With an increasing clinical requirement for bone grafting procedures, there is a commensurate increase in patients' demands for assurance that bank bone will not be infected with pathogens. To ensure the patients, dental surgeons should be able to cite factual information and recommendations by responsible organizations regarding safety of allografts. Knowledge of human bone allograft procurement, processing, and tracking may allow dentists to better educate patients and address concerns about this valuable treatment option. The purpose of this review is to furnish and update the current knowledge on processing, safety, and efficacy of allograft materials.


Subject(s)
Bone Transplantation/standards , Humans , Oral Surgical Procedures/methods , Plastic Surgery Procedures/methods , Safety , Tissue and Organ Harvesting/standards , Tissue and Organ Procurement/standards , Transplantation, Homologous/standards
6.
Acta cir. bras ; 24(5): 400-404, Sept.-Oct. 2009. ilus, graf
Article in English | LILACS | ID: lil-529160

ABSTRACT

PURPOSE: To assess the technique for the collection of rabbit bone marrow stem cells from different regions to be used as an experimental model in regenerative medicine. METHODS: Thirty rabbits were allocated into 2 groups: GROUP A, n=8, animals that underwent bone marrow blood (BMB) harvesting from the iliac crest; and GROUP B: including 22 rabbits that underwent BMB harvesting from the femur epiphysis. After harvesting, mononuclear cells were isolated by density gradient centrifugation (Ficoll - Histopaque). The number of mononuclear cells per ml was counted in a Neubauer chamber and cell viability was checked through Tripan Blue method. RESULTS: Harvesting from the iliac crest yielded an average of 1 ml of BMB and 3,6.10(6) cells/ml over 1 hour of surgery, whereas an average of 3ml of BMB and 11,79.10(6) cells./ml were obtained in 30 min from the femur epiphysis with a reduced animal death rate. CONCLUSION: The analysis for the obtention of a larger number of mononuclear cells/ml from rabbit bone marrow blood was more satisfactory in the femur epiphysis than in the iliac crest.


OBJETIVO: Avaliar a técnica mais promissora para a coleta de células tronco adultas de medula óssea de coelhos para a utilização do mesmo como modelo experimental na medicina regenerativa. MÉTODOS: Foram utilizados 30 coelhos divididos em 2 grupos: GRUPO A, n=8, onde realizamos a coleta de sangue de medula óssea (MO) da crista ilíaca e grupo B, n=22, onde realizamos a coleta de sangue da medula óssea da epífise do fêmur. Após as coletas, realizamos a separação das células mononucleadas através do gradiente de densidade (Ficoll-Hystopaque). Através da câmara de Neubauer realizamos a contagem das células mononucleadas por ml. Testamos a viabilidade celular através do método Tripan Blue. RESULTADOS: Na coleta de sangue de MO na crista ilíaca obtivemos a média de 1 ml durante 1 hora de procedimento cirúrgico, obtendo a quantidade de 3,6 .10(6) células/ml, enquanto que a punção na epífise do fêmur obtivemos a média de 3 ml durante 30 minutos de procedimento cirúrgico obtendo a quantidade de 11,79.10(6) cél./ml diminuindo o óbito dos animais. CONCLUSÃO: A análise para a obtenção de maior número de células mononucleadas/ml de sangue de medula óssea de coelho foi mais satisfatória na região da epífise do fêmur em comparação com a crista ilíaca.


Subject(s)
Animals , Male , Rabbits , Adult Stem Cells/cytology , Blood Specimen Collection/methods , Bone Marrow Cells/cytology , Cell Separation/methods , Hematopoietic Stem Cell Transplantation/methods , Tissue and Organ Harvesting/methods , Blood Specimen Collection/standards , Cell Differentiation , Centrifugation, Density Gradient , Disease Models, Animal , Femur/cytology , Hematopoietic Stem Cell Transplantation/standards , Ilium/cytology , Random Allocation , Regenerative Medicine/methods , Tissue and Organ Harvesting/standards
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