Effect of toxaphene toxicity on enzyme activity & residue levels in vital organs of guineapig.

Guineapigs exposed to acute and subacute levels of toxaphene revealed a marginal reduction in the body weight. There was a significant inhibition of acetylcholinesterase and ATPases in the brain, liver and kidney. The effect of subacute toxicity of toxaphene resulted in an enhancement of cytochrome P450 and induction of aniline hydroxylase in liver and kidney. Biochemical investigations on the backbone revealed that toxaphene toxicity caused an increase in the calcium content and a decrease in the collagen content significantly. Toxaphene was accumulated more in the liver than in the kidney as reflected by residue studies.