ABSTRACT
A fasciite necrotizante e uma forma rara de infeccao bacteriana comprometendo fascias musculares superficiais, tecido celular subcutaneo e pele. Clinicamente caracteriza-se por um curso fulminante com rapida progressao ao longo das fascias musculares, frequentemente poupando os musculos com alta letalidade associada ao retardo no diagnostico e tratamento. O reconhecimento precoce com amplo debridamento cirurgico e antibioticoterapia apropriada constituem o tratamento de escolha. Os autores apresentam um caso em um paciente de 36 anos e discutem os aspectos clinicos, fisiopatologicos e terapeuticos
Subject(s)
Humans , Male , Adult , Fasciitis, Necrotizing/diagnosis , Shock, Septic , Streptococcus pyogenes/isolation & purification , Clindamycin/therapeutic use , Fasciitis, Necrotizing/surgery , Toxemia/etiologySubject(s)
Animals , Cholestasis/complications , Endotoxins/blood , Humans , Renal Insufficiency/etiology , Toxemia/etiologySubject(s)
Anemia/classification , Anemia/diagnosis , Anemia/epidemiology , Anemia/etiology , Calcium/classification , Iron/administration & dosage , Iron/classification , Nutritional Sciences/education , Pregnancy/statistics & numerical data , Toxemia/classification , Toxemia/diagnosis , Toxemia/etiologySubject(s)
Humans , Female , Liver Function Tests/methods , Jaundice/complications , Toxemia/etiology , Hepatitis/etiologyABSTRACT
The effect of a reduction in maternal perfusate flow on maternal-fetal transport of urea and antipyrine has been investigated in vitro using the isolated human placental lobule. The protocol was so designed that the same lobule served as its own control for the study. On reducing the maternal perfusate flow to about half of the control value, mimicking a 'toxemia' situation, urn transport rose significantly to about twice the control level while antipyrine transport remained unchanged. The high wrea transport in the simulated toxemia model is in accord with data obtained earlier from preeclamptic pregnancies