ABSTRACT
Inductively coupled plasma-mass spectrometry (ICP-MS) is the most common technique for elements analysis at present. ICP-MS with high sensitivity and wide linear range can be applied to multi-elements analysis in blood and urine. This paper reviews the common means of sample pretreatment (direct dilution method and wet digestion method), the method for correction of mass spectral interference and non-interference, the main influence factors of analysis results, and provides an outlook of the application of ICP-MS in forensic toxicological analysis.
Subject(s)
Humans , Body Fluids/chemistry , Mass Spectrometry/methods , Metals, Heavy/urine , Microwaves , Sensitivity and Specificity , Specimen Handling/methods , Trace Elements/urineABSTRACT
Se investigaron cinco metales, aluminio, calcio, cromo, manganeso y zinc en suero, orina y cabello de enfermos de Alzheimer, comparados con tres testigos sanos de edad similar. La determinación se efectuó por Absorción Atómica en la llama o electrotérmica. No se hallaron diferencias significativas con los testigos. Esto indicaría que estos oligoelementos en especial el aluminio no guardan una relación causal directa con la enfermedad.