Factors affecting efficacy of oral trimeprazine sedation for dental procedures in children: a retrospective study

To investigate the influence of factors such as age, gender and pre-operative behavior rating on the outcome of sedation using oral trimeprazine during dental treatment of children. Records of children who received dental treatment under sedation with oral trimeprazine between 2000 and 2007 were reviewed and the following data were obtained: age and weight of patient at the time of treatment, gender, behavior classification prior to sedation, dose of medication used, efficacy of sedation and treatment accomplished. Descriptive statistics, cross-tabulations and Chi[2] analysis were done. Forty-eight sedation sessions met the inclusive criteria for children whose mean age was 4.92 [SD 1.65, range 3.0-8.0] years and mean weight was 18.23 [SD 4.82, range: 12.0-31.0] kg. Overall, 54.2% [26/48] of the sedations were rated successful, 20.8% [10/48] were partially successful and 25.0% [12/48] not successful. Younger children 3-5 years, and those with only negative pre-operative behavior rating had more successful sedation sessions than older, 6-8 years or children with definitely negative pre-operative behavior rating [X[2] =8.165, p= .017] and [X[2] = 17.258, P= .001], respectively. Variables such as patient's age and pre-operative behavior but not gender and type of treatment could predict outcome of dental sedation using trimeprazine in children

Trimeprazine as oral premedication in children.

The effect of oral trimeprazine alone or in combination with either atropine or glycopyrrolate or pethidine as oral premedication in children was studied. The effects of different drug combinations were evaluated in respect of pre-operative sedation, salivary secretion, induction characteristic, postoperative sedation and postoperative vomiting. The study concludes that trimeprazine in combination with either atropine or glycopyrrolate is mostly effective, safe and satisfactory as oral premedication in children. Trimeprazine along with pethidine can be recommended for all purpose oral medication both in pre- and post-operative period.