ABSTRACT
Human nonspecific polyclonal IgG and granulocytes, which accumulate in inflammation foci, were radiolabeled with 125I and "'In-Tropolone, respectively. Biodistribution of these two radiolabels was assessed in normal and inflammation-induced mice. 125I-IgG showed better localization to the inflammated areas. Blood levels with "'In-Tropolone leukocytes were lower at all time points. In addition, the inflammatory thigh-to-blood ratios showed an improvement, whereas the ratios of inflammatory thigh-to-other normal tissues were higher for 125I-IgG than "'In-Tropolone leukocytes. In conclusion, labeled IgG due to better localization in inflammated sites and higher target-to-background ratios is more suitable agent than labeled leukocytes for immunoscintigraphy of inflammation