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Indian J Med Sci ; 2011 Aug; 65(8) 317-320
Article in English | IMSEAR | ID: sea-145623

ABSTRACT

The world has seen the emergence of many micro-organisms in the recent past, which can curb human population with their newly built genetic make-up. The latest addition to this list of panic creating organisms is, bacteria encoding the gene for New Delhi metallo-beta-lactamase (NDM-1). NDM-1 is an enzyme that can hydrolyze and inactivate carbapenems, which are used as a last resort for the treatment of multi-resistant bacterial infections. Names of these bacteria were not found in the medical literature before December 2009, because of which it can take the credit of becoming a powerful emerging bacteria, which are difficult to treat. Besides Escherichia coli and Klebsiella pneumoniae, other bacterial strains have also expressed the gene for NDM-1, which are detected in many countries.


Subject(s)
Carbapenems/metabolism , Drug Resistance, Multiple, Bacterial/drug effects , Drug Resistance, Multiple, Bacterial/genetics , Escherichia coli/drug effects , India , Klebsiella pneumoniae/drug effects , beta-Lactams/biosynthesis , beta-Lactams/genetics , beta-Lactam Resistance/genetics , beta-Lactamases/biosynthesis , beta-Lactamases/genetics
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