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1.
Article in English | WPRIM (Western Pacific) | ID: wprim-816616

ABSTRACT

BACKGROUND: We evaluated the association of visceral-to-subcutaneous fat ratio (VSR) with nonalcoholic fatty liver disease (NAFLD) and advanced fibrosis degree based on noninvasive serum fibrosis markers in the general population with NAFLD.METHODS: This is a cross-sectional study, in 7,465 Korean adults who underwent health screening examinations. NAFLD was defined as fatty liver detected on ultrasonography, and visceral and subcutaneous abdominal fat was measured using computed tomography. We predicted fibrosis based on the fibrosis-4 (FIB-4) score and aspartate aminotransferase-to-platelet ratio index (APRI) and categorized the risk for advanced fibrosis as low, indeterminate, or high.RESULTS: The multivariable-adjusted prevalence ratios for indeterminate to high risk of advanced fibrosis based on FIB-4, determined by comparing the second, third, and fourth quartiles with the first quartile of VSR, were 3.38 (95% confidence interval [CI], 0.64 to 17.97), 9.41 (95% CI, 1.97 to 45.01), and 19.34 (95% CI, 4.06 to 92.18), respectively. The multivariable-adjusted prevalence ratios for intermediate to high degree of fibrosis according to APRI also increased across VSR quartiles (5.04 [95% CI, 2.65 to 9.59], 7.51 [95% CI, 3.91 to 14.42], and 19.55 [95% CI, 9.97 to 38.34], respectively). High VSR was more strongly associated with the prevalence of NAFLD in nonobese subjects than in obese subjects, and the associations between VSR and intermediate to high probability of advanced fibrosis in NAFLD were stronger in obese subjects than in nonobese subjects.CONCLUSION: High VSR values predicted increased NAFLD risk and advanced fibrosis risk with NAFLD, and the predictive value of VSR for indeterminate to high risk of advanced fibrosis was higher in obese subjects than in nonobese subjects.


Subject(s)
Abdominal Fat , Adult , Aspartic Acid , Cross-Sectional Studies , Fatty Liver , Fibrosis , Humans , Intra-Abdominal Fat , Liver Cirrhosis , Mass Screening , Non-alcoholic Fatty Liver Disease , Prevalence , Subcutaneous Fat, Abdominal , Ultrasonography
2.
Autops. Case Rep ; 9(4): e2019121, Oct.-Dec. 2019. ilus, tab
Article in English | LILACS (Americas) | ID: biblio-1024063

ABSTRACT

Plasminogen activator inhibitor-1 (PAI-1) is a biomarker of thrombosis. Adipose and vascular tissues are among the major sources of PAI-1 production. Previous studies indicated that fat deposits mediate increased cardiovascular risk among obese individuals. We investigated the immunohistochemical (IHC) expression of PAI-1 in adipose and vascular tissues from the omentum and the subcutaneous tissue. The pathology samples were selected from 37 random patients who underwent elective abdominal surgery between 2008-2009. PAI-1 expression was semi-quantitatively scored and compared between the groups. Significant differences were noted in the IHC expression of PAI-1 between the omental and the subcutaneous adipose tissues (1.1 ± 0.8 versus 0.8 ± 0.6, respectively (p=0.05)). Adipose tissue displayed higher IHC expression of PAI-1 compared to vascular wall tissue in both omentum and subcutaneous sections (1.1 ± 0.8 versus 0.5 ± 0.9 (p=0.004), and 0.8 ± 0.6 versus 0.4 ± 0.6 (p=0.003), respectively). In conclusion, our study compared PAI-1 expression in the omentum versus the subcutaneous tissue and adipose versus vascular tissues. IHC expression of PAI-1 level was significantly higher in the omental adipose tissue compared to the subcutaneous adipose tissue. Adipose tissue displayed significantly higher PAI-1 expression than vascular tissue. The study elucidates the biological differences of adipose and vascular tissue from subcutaneous versus omental sections.


Subject(s)
Humans , Plasminogen Activator Inhibitor 1/analysis , Immunohistochemistry , Adipose Tissue , Abdominal Fat/surgery
3.
Arch. argent. pediatr ; 117(4): 230-236, ago. 2019. graf, tab
Article in English, Spanish | LILACS (Americas), BINACIS | ID: biblio-1054926

ABSTRACT

Introducción. La obesidad está asociada a un descenso acelerado de la función ventilatoria. Las formas más frecuentes de evaluar el estado nutricional y medir la grasa abdominal y las caderas son el índice de masa corporal (IMC) y el índice cintura-cadera (ICC). Existe escasa evidencia que sugiera su relación con la capacidad residual funcional (CRF). Nuestro objetivo fue determinar la relación entre el IMC, el ICC y la CRF en niños obesos de la ciudad de Talca, Chile. Población y métodos. Se reclutaron niños de ambos sexos (6-12 años). Se evaluaron peso, talla, IMC, ICC y función pulmonar a través de pletismografía corporal. Dependiendo de la distribución de los datos, se utilizó la prueba t de Student o U de Mann-Whitney para muestras independientes y, la prueba r de Pearson o Spearman para establecer la correlación entre ICC y CRF. Resultados. Los niños se dividieron en normopeso (n= 18) y obesos (n= 18). Se reportó una disminución significativa de la CRF (p= 0,025) en niños obesos y una relación inversa entre ICC y CRF, la cual fue moderada en niños normopeso (s= -0,489; p= 0,03) y alta en obesos (r= -0,681; p= 0,001). Conclusiones. Los niños obesos mostraron una menor CRF respecto de los normopeso, que, a su vez, se relacionó con el ICC. Estos resultados indican efectos sistémicos que produce la obesidad en la función ventilatoria en niños y la necesidad de incorporar indicadores de distribución de grasa corporal a temprana edad.


Introduction. Obesity is associated with a rapid decrease in ventilatory function. The most common way of assessing nutritional status and measuring abdominal fat and hips are the body mass index (BMI) and the waist-hip ratio (WHR). There is scarce evidence suggesting their relation to functional residual capacity (FRC). Our objective was to determine the relation among BMI, WHR, and FRC in obese children in the city of Talca, Chile. Population and methods. Male and female children were recruited (6-12 years). Weight, height, BMI, WHR, and pulmonary function were assessed; the latter with body plethysmography. Depending on data distribution, Student's t test or the Mann-Whitney U test were used for independent samples, while Pearson's or Spearman's r test was used to establish the correlation between WHR and FRC. Results. Children were divided into normal weight (n = 18) and obese (n = 18). A significant reduction in FRC (p = 0.025) was reported in obese children, while a reverse association was observed between WHR and FRC, which was moderate in normal weight children (s = -0.489; p = 0.03) and high in obese children (r = -0.681; p = 0.001). Conclusions. Obese children showed a lower FRC compared to normal weight children, which, in turn, was associated with WHR. These results are indicative of the systemic effects caused by obesity on children's ventilatory function and the need to use body fat distribution indicators at an early age.


Subject(s)
Humans , Child , Adolescent , Body Mass Index , Functional Residual Capacity , Waist-Hip Ratio , Abdominal Fat
4.
Article in Korean | WPRIM (Western Pacific) | ID: wprim-787466

ABSTRACT

BACKGROUND: Visceral adiposity index (VAI) was developed to estimate visceral fat, and its association with various diseases including cardiovascular disease, insulin resistance, and fatty liver has been revealed. The Chinese VAI (CVAI) has been newly developed in China. This study aimed to compare the VAI and CVAI for coronary artery calcification by using the coronary artery calcium score (CACs)-a predictable index of asymptomatic atherosclerosis.METHODS: We conducted a cross-sectional study that included 66,011 participants (76.3% male and 23.7% female participants) visiting an university hospital for medical check-ups between January 2014 and December 2016. A receiver operating characteristic curve analysis was performed and the area under the curve (AUC) was calculated to compare the concordance of the CACs and the VAI, CVAI, waist circumference, body mass index, triglycerides, and high-density lipoprotein cholesterol.RESULTS: In all participants, the AUC for the CVAI was the largest, while that for the VAI was fourth among all the indices (AUC(CVAI)=0.653, AUC(VAI)=0.592). The AUC for the CVAI was the largest among the indices in both sexes (female AUC(CVAI)=0.77, male AUC(CVAI)=0.592), while that for the VAI was the second largest (female, AUC(CVAI) 0.771>AUC(VAI) 0.651; male, AUC(CVAI) 0.592>AUC(VAI) 0.564).CONCLUSION: In conclusion, the CVAI showed a higher degree of concordance with CACs, which is an indirect indicator of cardiovascular disease, than the VAI in Korean adults.


Subject(s)
Abdominal Fat , Adiposity , Adult , Area Under Curve , Asian Continental Ancestry Group , Atherosclerosis , Body Mass Index , Calcium , Cardiovascular Diseases , China , Cholesterol , Coronary Vessels , Cross-Sectional Studies , Fatty Liver , Female , Humans , Insulin Resistance , Intra-Abdominal Fat , Lipoproteins , Male , ROC Curve , Triglycerides , Vascular Calcification , Waist Circumference
5.
Article in English | WPRIM (Western Pacific) | ID: wprim-738867

ABSTRACT

BACKGROUND: Osteoporosis and osteopenia are characterized by reduced bone mineral density (BMD) and increased fracture risk. Although the risk of fractures is higher in underweight people than in overweight people, the accumulation of body fat (especially abdominal fat) can increase the risk of bone loss. This study aimed to evaluate the association between body fat percentage and BMD in normal-weight middle-aged Koreans. METHODS: This study included 1,992 adults (mean age, 48.7 years; 52.9% women). BMD and body fat were measured using dual-energy X-ray absorptiometry. Multiple linear regression analyses and analysis of covariance were used to assess the association between BMD and body fat. Body fat percentage was grouped by cut-off values. The cut-off values were 20.6% and 25.7% for men with a body mass index of 18.5–22.9 kg/m2, while the cut-off values were 33.4% and 36% for women. RESULTS: Body fat percentage tended to be negatively associated with BMD. Increased body fat percentage was associated with reduced BMD in normal-weight middle-aged adults. The effects of body fat percentage on BMD in normal-weight individuals were more pronounced in men than in women. CONCLUSION: There was a negative correlation between BMD and body fat percentage in middle-aged Korean men and women with normal body weight. This association was stronger in men than in women.


Subject(s)
Abdominal Fat , Absorptiometry, Photon , Adipose Tissue , Adult , Body Mass Index , Bone Density , Bone Diseases, Metabolic , Female , Humans , Ideal Body Weight , Linear Models , Male , Osteoporosis , Overweight , Thinness
6.
Intestinal Research ; : 404-412, 2019.
Article in English | WPRIM (Western Pacific) | ID: wprim-764150

ABSTRACT

BACKGROUND/AIMS: To examine whether visceral adiposity serves as a risk factor for colorectal cancer (CRC) and colorectal adenomas. METHODS: Two hundred healthy subjects, 200 patients with colorectal adenoma, and 151 patients with CRC (46 with early-stage and 105 with advanced-stage cancers) were enrolled at a tertiary referral hospital. All subjects underwent colonoscopy, and had laboratory data, and computed tomography (CT) scan available for abdominal fat measurement. An abdominal CT scan taken 1 to 4 years (mean interval, 20.6 months) before the diagnosis of CRC was also available in the 42 CRC patients. RESULTS: The mean areas of visceral adipose tissue (VAT) areas in the control, adenoma, early- and advanced-stage CRC groups were 94.6, 116.8, 110.4, and 99.7 cm², respectively (P0.05). The risk of both adenoma and CRC positively correlated with fasting plasma glucose levels (P for trend <0.05). In patients with early-stage cancer (n=17), VAT area decreased when the CT scan at diagnosis was compared with that taken before the diagnosis of CRC, but superficial adipose tissue area did not, so visceral-to-total fat ratio significantly decreased (46.6% vs. 50.7%, respectively, P=0.018) CONCLUSIONS: VAT area is related to the risk of colorectal adenoma. However, VAT decreases from the early stages of CRC. Impaired fasting glucose has a role in colorectal carcinogenesis.


Subject(s)
Abdominal Fat , Adenoma , Adipose Tissue , Adiposity , Blood Glucose , Carcinogenesis , Colonoscopy , Colorectal Neoplasms , Diagnosis , Fasting , Glucose , Healthy Volunteers , Humans , Insulin Resistance , Insulin , Intra-Abdominal Fat , Obesity , Risk Factors , Tertiary Care Centers , Tomography, X-Ray Computed
7.
Prensa méd. argent ; 104(9): 457-460, nov 2018. fig
Article in Spanish | LILACS (Americas), BINACIS | ID: biblio-1047088

ABSTRACT

Los lipomas retroperitoneales son infrecuentes y suelen representar el 2.9% de los tumores primarios de origen en retroperitoneo1 . Pueden alcanzar gran tamaño y el diagnóstico diferencial debe hacer con el liposarcoma bien diferenciado, aunque es muy difícil de realizar en el preoperatorio2 . Se presenta el caso de un paciente con lipoma retroperitoneal cuyo diagnóstico se realizó por tomografía axial computada (TAC) y que fue extirpado en su totalidad.


Retroperitoneal lipomas are infrequent and can represent a 2.9 % of the primary tumors originated in the retroperitoneum. They can reach a great size and the differential diagnosis must be performed with the well differentiated liposarcoma, even though it is very difficult to establish it during the preoperative time. We describe herein a case of a patient with a retroperitoneal lipoma. The diagnosis was established with a computed axial tomography (CAT) and it was totally surgically removed.


Subject(s)
Humans , Male , Adult , Retroperitoneal Fibrosis , Magnetic Resonance Imaging , Densitometry , Abdominal Fat/pathology , Aponeurosis
8.
Rev. chil. nutr ; 45(1): 28-36, 2018. tab
Article in Spanish | LILACS (Americas) | ID: biblio-899851

ABSTRACT

RESUMEN La grasa visceral es una importante medida predictora de riesgo cardiometabólico, sin embargo, se ha sugerido que la razón entre los componentes visceral y subcutáneo (TAV/TAS ≥ 0,4) puede ser un indicador más apropiado para evaluar la predisposición para acumular grasa visceral (GV) y las alteraciones cardio-metabólicas. Objetivo: Evaluar la predisposición para acumular GV y su asociación con alteraciones cardio-metabólicas. Métodos: Estudio transversal con 147 individuos atendidos en un ambulatorio de un hospital en el Nordeste brasileño. Se evaluaron el TAV y el TAS por tomografía computarizada y se investigaron variables demgráficas, clínicas, antropométricas y factores de riesgo cardiometabólico. Resultados: El promedio de edad fue 52,7±13,2 años y se observó una elevada razón TAV/TAS de 0,79±0,29 en hombres y 0,54±0,22 en mujeres. Se correlacionó la razón TAV/TAS con perfil glucídico y puntuacion de calcio coronariano (PCC) (p< 0,05), mientras que el TAV aislado presentó correlación directa con colesterol no-HDL, triglicéridos (TG), razón TG/HDL, glicemia, hemoglobina glicosilada y PCC (p<0,05) e inversa con HDL-c (p= 0,001). Conclusiones: Se observó una elevada predisposición para la acumulación de TAV. La razón TAV/TAS presentó correlación con alteraciones cardiometabólicas, pero la concentración de TAV aislada se correlacionó con un número superior de parámetros, siendo en esta investigación un predictor más potente que la razón TAV/TAS para indicar esas alteraciones.


ABSTRACT Visceral fat is an important predictor of cardiometabolic risk, but evidence suggests that the ratio between visceral and subcutaneous fat (≥0.4) may be a more appropriate indicator to assess individual predisposition to accumulate visceral fat (VF) and predict cardiometabolic alterations. Objective: To evaluate the predisposition to accumulate VF and its association with cardiometabolic alterations. Methods: A cross-sectional study was conducted with 147 patients seen at a hospital in Northeast Brazil. VF and subcutaneous fat (SF) were evaluated by computed tomography and anthropometric and cardiometabolic risk factors were investigated. Results: The mean age was 52.7±13.2 years. Mean VF/SF ratio was high: 0.79±0.29 for men and 0.54±0.22 for women and was correlated with the glucose profile and coronary calcium score (CCA) (p< 0.05). VF was directly correlation with non-HDL cholesterol, triglycerides (TG), TG/HDL ratio, glycemia, glycated hemoglobin and CCA (p< 0.05) and inversely with HDL-c (p= 0.001). Conclusions: A high predisposition to VF accumulation was observed in the population. VF/SF ratio correlated with cardiometabolic alterations, but the concentration of isolated VF correlated with a higher number of parameters. In this investigation, VF alone was a more powerful predictor of cardiometabolic alterations than the ratio of VF/SF.


Subject(s)
Humans , Cardiovascular Diseases , Abdominal Fat , Subcutaneous Fat , Obesity, Abdominal , Metabolic Diseases
9.
Article in English | WPRIM (Western Pacific) | ID: wprim-715258

ABSTRACT

OBJECTIVES: To investigate the effect of smoking upon cardiopulmonary function, maximal oxygen uptake, and obesity index, in middle-aged and older workers to propose guidelines on healthcare for these age groups. METHODS: This study analyzed medical data from 2,753 white-collar workers aged 50 years or older from workplaces located in Seoul, South Korea. Blood pressure (BP), resting heart rate, maximal oxygen uptake (VO2max), and body mass index (BMI) of each subject were measured. The collected data were analyzed using SPSS 21.0. RESULTS: In the smoking group BP and resting heart rate were significantly higher than in the non-smoking and smoking-cessation groups (p < 0.05). In addition, VO2max was lower in the smoking group compared to the other 2 groups. BP closely correlated with resting heart rate, abdominal fat ratio, and BMI. BMI was the highest in the group that stopped smoking and, BMI and abdominal fat ratio negatively correlated with VO2max. CONCLUSION: Smoking increases the risk of cardiopulmonary disease but obesity may be caused by stopping smoking. Therefore, healthcare guidelines on smoking cessation should also include nutritional advice.


Subject(s)
Abdominal Fat , Blood Pressure , Body Mass Index , Delivery of Health Care , Heart Rate , Humans , Korea , Obesity , Oxygen , Seoul , Smoke , Smoking Cessation , Smoking
10.
Article in English | WPRIM (Western Pacific) | ID: wprim-715241

ABSTRACT

BACKGROUND/OBJECTIVES: There are few studies that forecast the future prevalence of obesity based on the predicted prevalence model including contributing factors. The present study aimed to identify factors associated with obesity and construct forecasting models including significant contributing factors to estimate the 2020 and 2030 prevalence of obesity and abdominal obesity. SUBJECTS/METHODS: Panel data from the Korea National Health and Nutrition Examination Survey and national statistics from the Korean Statistical Information Service were used for the analysis. The study subjects were 17,685 male and 24,899 female adults aged 19 years or older. The outcome variables were the prevalence of obesity (body mass index ≥ 25 kg/m2) and abdominal obesity (waist circumference ≥ 90 cm for men and ≥ 85 cm for women). Stepwise logistic regression analysis was used to select significant variables from potential exposures. RESULTS: The survey year, age, marital status, job status, income status, smoking, alcohol consumption, sleep duration, psychological factors, dietary intake, and fertility rate were found to contribute to the prevalence of obesity and abdominal obesity. Based on the forecasting models including these variables, the 2020 and 2030 estimates for obesity prevalence were 47% and 62% for men and 32% and 37% for women, respectively. CONCLUSIONS: The present study suggested an increased prevalence of obesity and abdominal obesity in 2020 and 2030. Lifestyle factors were found to be significantly associated with the increasing trend in obesity prevalence and, therefore, they may require modification to prevent the rising trend.


Subject(s)
Abdominal Fat , Adult , Alcohol Drinking , Birth Rate , Female , Forecasting , Humans , Information Services , Korea , Life Style , Logistic Models , Male , Marital Status , Nutrition Surveys , Obesity , Obesity, Abdominal , Prevalence , Psychology , Risk Factors , Smoke , Smoking
11.
Article in English | WPRIM (Western Pacific) | ID: wprim-787110

ABSTRACT

BACKGROUND: Body fats, especially both of abdominal fat pad mass and skeletal muscle fat content, are inversely related to insulin action. Therefore, methods for decreasing visceral fat mass and muscle triglyceride content may be helpful for the prevention of insulin resistance.METHODS: Thalidomide, used for its anti-angiogenic and anti-inflammatory properties, was administered to rats for 4 weeks. A 10% solution of thalidomide in dimethyl sulfoxide was injected daily into the peritoneal cavity as much as 100 mg/kg of body weight.RESULTS: The total visceral fat pad mass in the thalidomide-treated group was 11% lower than in the control group. The size of adipocytes of the epididymal fat pad mass in the thalidomide-treated group was smaller than in the control group. The intraperitoneal thalidomide treatment increased triglyceride concentrations by 16% in the red muscle, but not in the white muscle.CONCLUSION: The results suggested that intraperitoneal thalidomide treatment inhibited abdominal fat accumulation, and that the free fatty acids in the blood were preferentially accumulated in the red muscle rather than in the white muscle.


Subject(s)
Abdominal Fat , Adipocytes , Adipose Tissue , Animals , Body Weight , Dimethyl Sulfoxide , Fatty Acids, Nonesterified , Insulin , Insulin Resistance , Intra-Abdominal Fat , Muscle, Skeletal , Peritoneal Cavity , Rats , Thalidomide , Triglycerides
12.
Article in English | WPRIM (Western Pacific) | ID: wprim-714391

ABSTRACT

PURPOSE: We investigated the correlations of serum total testosterone (TT) levels with body composition and physical fitness parameters in patients with erectile dysfunction (ED) to know the best exercise for testosterone deficiency. MATERIALS AND METHODS: Eighty-seven ED patients underwent serum TT assessment as well as body composition and basic exercise testing. The bioelectrical impedance analysis was used to assess body composition. Seven types of basic exercise tests were used to determine physical fitness. Correlations between serum TT levels and body composition/physical function parameters were evaluated using partial correlation analyses. A serum TT cut-off value was obtained for the parameters significantly correlated with serum TT levels. RESULTS: The subjects had a mean serum TT level of 342.1 ng/dL. Among the body composition parameters, body and abdominal fat percentages showed statistically significant negative correlations with serum TT levels. Among the basic exercise test parameters, only the cycle ergometer test for cardiorespiratory fitness showed a statistically significant positive correlation with serum TT levels. CONCLUSIONS: Serum TT levels in patients with ED, may be increased by reducing fat percentage and improving cardiorespiratory fitness via aerobic exercise.


Subject(s)
Abdominal Fat , Body Composition , Electric Impedance , Erectile Dysfunction , Exercise , Exercise Test , Humans , Male , Physical Fitness , Testosterone
13.
Article in English | WPRIM (Western Pacific) | ID: wprim-718829

ABSTRACT

BACKGROUND: Skeletal muscle plays a major role in glucose metabolism. We investigated the association between thigh muscle mass, insulin resistance, and incident type 2 diabetes mellitus (T2DM) risk. In addition, we examined the role of body mass index (BMI) as a potential effect modifier in this association. METHODS: This prospective study included 399 Japanese Americans without diabetes (mean age 51.6 years) who at baseline had an estimation of thigh muscle mass by computed tomography and at baseline and after 10 years of follow-up a 75-g oral glucose tolerance test and determination of homeostasis model assessment of insulin resistance (HOMA-IR). We fit regression models to examine the association between thigh muscle area and incidence of T2DM and change in HOMA-IR, both measured over 10 years. RESULTS: Thigh muscle area was inversely associated with future HOMA-IR after adjustment for age, sex, BMI, HOMA-IR, fasting plasma glucose, total abdominal fat area, and thigh subcutaneous fat area at baseline (P=0.033). The 10-year cumulative incidence of T2DM was 22.1%. A statistically significant interaction between thigh muscle area and BMI was observed, i.e., greater thigh muscle area was associated with lower risk of incident T2DM for subjects at lower levels of BMI, but this association diminished at higher BMI levels. CONCLUSION: Thigh muscle mass area was inversely associated with future insulin resistance. Greater thigh muscle area predicts a lower risk of incident T2DM for leaner Japanese Americans.


Subject(s)
Abdominal Fat , Asian Americans , Asian Continental Ancestry Group , Blood Glucose , Body Mass Index , Diabetes Mellitus , Diabetes Mellitus, Type 2 , Fasting , Follow-Up Studies , Glucose , Glucose Tolerance Test , Homeostasis , Humans , Incidence , Insulin Resistance , Insulin , Metabolism , Muscle, Skeletal , Prospective Studies , Subcutaneous Fat , Thigh
14.
Article in English | WPRIM (Western Pacific) | ID: wprim-718723

ABSTRACT

OBJECTIVES: Regenerative treatment using stem cells may serve as treatment option for empty nose syndrome (ENS), which is caused by the lack of turbinate tissue and deranged nervous system in the nasal cavity. We aimed to assess the efficacy and safety of the autologous stromal vascular fraction (SVF) in the treatment of ENS. METHODS: In this prospective observational clinical study, we enrolled 10 ENS patients who volunteered to undergo treatment of ENS through the injection of autologous SVF. Data, including demographic data, pre- and postoperative Sino-Nasal Outcome Test-25 (SNOT-25) scores, overall patient satisfaction, and postoperative complications, were prospectively collected. Nasal secretion was assessed using the polyurethane foam absorption method, and the levels of biological markers were analyzed in both ENS group and control group using enzyme-linked immunosorbent assay. The SVF extracted from abdominal fat was diluted and injected into both inferior turbinates. RESULTS: Among the 10 initial patients, one was excluded from the study. Subjective satisfaction was rated as “much improved” in two and “no change” in seven. Among the improved patients, the mean preinjection SNOT-25 score was 55.0 and the score at 6 months after injection was 19.5. However, the average SNOT-25 score of nine participants at 6 months after injection (mean±standard deviation, 62.4±35.8) did not differ significantly from the baseline SNOT-25 score (70.1±24.7, P>0.05, respectively). Among the various inflammatory markers assessed, the levels of interleukin (IL)-1β, IL-8, and calcitonin gene-related peptide were significantly higher in ENS patients. Compared with preinjection secretion level, the nasal secretions from SVF-treated patients showed decreased expressions of IL-1β and IL-8 after injection. CONCLUSION: Although SVF treatment appears to decrease the inflammatory cytokine levels in the nasal mucosa, a single SVF injection was not effective in terms of symptom improvement and patient satisfaction. Further trials are needed to identify a more practical and useful regenerative treatment modality for patients with ENS.


Subject(s)
Abdominal Fat , Absorption , Biomarkers , Calcitonin Gene-Related Peptide , Clinical Study , Cytokines , Enzyme-Linked Immunosorbent Assay , Humans , Interleukin-8 , Interleukins , Methods , Nasal Cavity , Nasal Mucosa , Nervous System , Nose , Patient Satisfaction , Polyurethanes , Postoperative Complications , Prospective Studies , Stem Cells , Turbinates
15.
Article in English | WPRIM (Western Pacific) | ID: wprim-717856

ABSTRACT

OBJECTIVE: To investigate the correlation between non-alcoholic fatty liver disease and visceral adipose tissue in non-obese Chinese adults using computed tomography (CT). MATERIALS AND METHODS: The study included 454 subjects undergoing abdominal CT scan. Degree of CT attenuation in liver and spleen, and the degree of fat infiltration in liver were evaluated according to three indices: the attenuation value of liver parenchyma (CTLP), the attenuation ratio of liver and spleen (LSratio) and the attenuation difference between liver and spleen (LSdif). Visceral fat area (VFA) and total fat area (TFA) at L2/3 and L4/5 levels were measured, and the abdominal subcutaneous fat area (SFA) was calculated. Bivariate correlation analysis was carried out to determine the correlation among these factors. RESULTS: In men, VFA, SFA and TFA at L2/3 and L4/5 levels showed significant differences in terms of the three indices to distinguish fatty liver from non-fatty liver (all, p < 0.001). In men, all the three indices showed negative correlation with TFA, SFA and VFA (all, p < 0.001). The negative correlation between the three indices and VFA at the L2/3 level was higher than at L4/5 level (r = −0.476 vs. r = −0.340 for CTLP, r = −0.502 vs. r = −0.413 for LSratio, r = −0.543 vs. r = −0.422 for LSdif, p < 0.001, respectively). The negative correlation between LSratio, LSdif and VFA at L2/3 and L4/5 levels was higher than SFA at the corresponding level. In women, all the three indices showed negative correlation with VFA and TFA at L2/3 and L4/5 levels, and the negative correlation between CTLP and VFA was higher at L2/3 level than at L4/5 level (r = −0.294 vs. r = −0.254, p < 0.001). CONCLUSION: In non-obese Chinese adults, the degree of hepatic fatty infiltration showed a strong correlation with abdominal fat on CT. VFA at L2/3 level was more closely related to fatty liver compared with VFA at L4/5 level.


Subject(s)
Abdominal Fat , Adult , Asian Continental Ancestry Group , Fatty Liver , Female , Humans , Intra-Abdominal Fat , Liver , Male , Non-alcoholic Fatty Liver Disease , Spleen , Subcutaneous Fat, Abdominal , Tomography, X-Ray Computed
16.
Article in English | WPRIM (Western Pacific) | ID: wprim-716680

ABSTRACT

PURPOSE: We aimed to investigate whether airway parameters, assessed via computed tomography (CT), are associated with abdominal fat areas and to compare the clinical characteristics of asthmatic patients with and without elevated visceral to subcutaneous fat area ratio (EV). METHODS: Asthmatic patients (aged ≥40 years) were prospectively recruited. Chest (airway) and fat areas were assessed via CT. Airway parameters, including bronchial wall thickness (WT), lumen diameter (LD), lumen area (LA), wall area (WA), total area (TA), as well as WA/TA percentage (wall area %) were measured at the apical segmental bronchus in the right upper lobe. Visceral (VFA), subcutaneous (SFA) and total (TFA) fat areas (cm2) were also measured. The correlations between abdominal fat areas and airway parameters were assessed. EV was defined as VFA/SFA ≥ 0.4. RESULTS: Fifty asthmatic patients were included (mean age 62.9 years; 52% female); 38% had severe asthma. Significant correlations were found between VFA and both LD and LA (r = −0.35, P = 0.01; r = −0.34, P = 0.02, respectively), and SFA and both WA and TA (r = 0.38, P = 0.007; r = 0.34, P = 0.02, respectively). Exacerbations, requiring corticosteroid therapy or ER visitation, were significantly more frequent in subjects without EV (83% vs. 34%, P = 0.05). CONCLUSIONS: Abdominal fat is associated with asthma, according to the location of fat accumulation. In asthmatic subjects, visceral fat seems to be attributable to the bronchial luminal narrowing, while subcutaneous fat may be related to thickening of bronchial wall.


Subject(s)
Abdominal Fat , Asthma , Bronchi , Humans , Intra-Abdominal Fat , Multidetector Computed Tomography , Phenobarbital , Prospective Studies , Subcutaneous Fat , Thorax
17.
Article in English | WPRIM (Western Pacific) | ID: wprim-715973

ABSTRACT

PURPOSE: The purpose of this study was to demonstrate the prognostic significance of changes in body composition in patients with newly diagnosed hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Patients (n=178) newly diagnosed with HCC participated in the study between 2007 and 2012. Areas of skeletal muscle and abdominal fat were directly measured using a three-dimensional workstation. Cox proportional-hazards modes were used to estimate the effect of baseline variables on overall survival. The inverse probability of treatmentweighting (IPTW) method was used to minimize confounding bias. RESULTS: Cutoff values for sarcopenia, obtained from receiver-operating characteristic curves, were defined as skeletal muscle index at the third lumbar vertebra of ≤ 45.8 cm/m2 for males and ≤ 43.0 cm/m2 for females. Sarcopenia patients were older, more likely to be female, and had lower body mass index. Univariable analysis showed that the presence of sarcopenia and visceral to subcutaneous fat area ratio (VSR) were significantly associatedwith prognosis. The multivariable analyses revealed that VSR was predictive of overall survival. However, in the multivariable Cox model adjusted by IPTW, sarcopenia, not VSR, were associated with overall survival. CONCLUSION: The presence of sarcopenia at HCC diagnosis is independently associated with survival.


Subject(s)
Abdominal Fat , Bias , Body Composition , Body Mass Index , Carcinoma, Hepatocellular , Diagnosis , Female , Humans , Intra-Abdominal Fat , Liver , Male , Methods , Muscle, Skeletal , Prognosis , Sarcopenia , Spine , Subcutaneous Fat
18.
Article in English | WPRIM (Western Pacific) | ID: wprim-715929

ABSTRACT

BACKGROUND: Cut-off values for visceral fat area (VFA) measured by computed tomography (CT) for identifying individuals at risk of metabolic syndrome (MetS) have not been clearly established in Korean adults, particularly for large populations. We aimed to identify optimal VFA and waist circumference (WC) cut-off values and compare the ability of VFA and WC to predict the presence of ≥2 metabolic risk factors. METHODS: We included 36,783 subjects aged 19–79 years undergoing abdominal fat CT during regular health checkups between January 2007 and February 2015 in Seoul. The risk factors for MetS except WC were based on the International Diabetes Federation criteria. Receiver operating characteristic curve analyses were used to determine the appropriate VFA and WC cut-off values for MetS. RESULTS: VFA was a more significant predictor of metabolic risk factors than WC and body mass index (BMI). The optimal cut-off values for VFA and WC were 134.6 cm2 and 88 cm for men and 91.1 cm2 and 81 cm for women, respectively. We estimated age-specific cut-off values for VFA, WC, and BMI. VFA cut-off values increased with age, particularly among women. CONCLUSION: This large population study proposed the cut-off values for VFA and WC for identifying subjects at risk of MetS among Korean adults. For more accurate diagnosis, different age-specific cut-off values for VFA and WC may be considered.


Subject(s)
Abdominal Fat , Adult , Body Mass Index , Diagnosis , Female , Humans , Intra-Abdominal Fat , Male , Obesity, Abdominal , Risk Factors , ROC Curve , Seoul , Waist Circumference
19.
Article in English | WPRIM (Western Pacific) | ID: wprim-715369

ABSTRACT

BACKGROUND/AIMS: The aim of this study was to assess whether increased intestinal gas or fat content in the abdominal cavity is related to abdominal bloating, using three-dimensional abdominal computed tomography scan. METHODS: Twenty-nine healthy individuals without abdominal bloating and organic disease (15 women; mean age, 49 years; range of age, 23–73 years) and 30 patients with chronic recurrent abdominal bloating-diagnosed with functional bloating (10 women; mean age, 53 years; range of age, 35–75 years) - participated in this study. The mean values of measured parameters were compared using independent sample t-test. RESULTS: The mean volume of total colon gas in bloated patients was similar to that in control subjects. The distribution of intra-abdominal gas was also similar between the two groups. However, the amount of gas in the transverse colon tended to be significantly higher in patients with bloating than in controls (p=0.06). Body mass index was similar between the two groups (23.4±3.2 kg/m2 and 22.3±3.1 kg/m2, respectively). Moreover, no significant differences with respect to circumferential area, subcutaneous fat, visceral fat area, and total fat area were found between the two groups. CONCLUSIONS: Bloating might not just be the result of gastrointestinal gas or intra-abdominal fat. Other contributing factors, such as localized abnormality in gas distribution and visceral hypersensitivity, may be involved.


Subject(s)
Abdominal Cavity , Abdominal Fat , Body Mass Index , Colon , Colon, Transverse , Female , Gastrointestinal Contents , Humans , Hypersensitivity , Intra-Abdominal Fat , Irritable Bowel Syndrome , Multidetector Computed Tomography , Subcutaneous Fat
20.
Encarnación; s.n; 2017; 2017. 36 p. graf, tab, ilus.
Thesis in Spanish | LILACS (Americas), BDNPAR | ID: biblio-915347

ABSTRACT

La intención de la elección del tema de Síndrome Metabólico surge a raíz de la epidemia mundial de obesidad en la infancia y adolescencia observada en las últimas décadas, y que ha supuesto la aparición en pediatría de alteraciones hasta ahora más propias de la edad adulta, como el Síndrome Metabólico (SM) y que generen día a día numerosas complicaciones de salud como las Enfermedades Cardiovasculares (ECV) y Diabetes tipo 2. Se tienen como objetivo determinar la frecuencia de SM en niños y adolescentes del Paraguay y sus componentes. Se ha encontrado que el sobrepeso y la obesidad abdominal son los factores principales que contribuyen a las manifestaciones del Síndrome Metabólico en niños y adolescentes del Paraguay, por ese motivo corren mayor riesgo de sufrir enfermedades cardiovasculares y diabetes tipo 2 en el futuro y de forma más precoz. Se ha visto en estudios realizados en América que los componentes más prevalentes fueron la obesidad y la dislipidemia, mientras que; alrededor del 7% con hiperglucemia y síndrome metabólico de manera general. Según estudios realizados en Paraguay, se vio que la frecuencia de sobrepeso y obesidad es muy alta al igual que la incidencia del síndrome metabólico


The purpose of the choice of the Metabolic Syndrome issue arises from the worldwide epidemic of obesity in infancy and adolescence observed in the last decades, and which has led to the appearance in pediatrics of alterations that have hitherto been more typical of adulthood, Such as Metabolic Syndrome (MS) and that generate daily complications of health such as Cardiovascular Diseases (CVD) and Type 2 Diabetes. Its objective is to determine the frequency of MS in children and adolescents in Paraguay and its components. It has been found that overweight and abdominal obesity are the main factors that contribute to the manifestations of the Metabolic Syndrome in children and adolescents of Paraguay, for that reason they are at greater risk of suffering cardiovascular diseases and type 2 diabetes in the future and in a more early. It has been seen in studies carried out in America that the most prevalent components were obesity and dyslipidemia, whereas; around 7% with hyperglycemia and metabolic syndrome in general. According to studies in Paraguay, it was found that the frequency of overweight and obesity is very high, as is the incidence of the metabolic syndrome


Subject(s)
Humans , Male , Female , Child , Adolescent , Metabolic Syndrome/epidemiology , Paraguay/epidemiology , Insulin Resistance , Cardiovascular Diseases/complications , Prevalence , Risk Factors , Glucose Intolerance/complications , Metabolic Syndrome/complications , Metabolic Syndrome/diagnosis , Metabolic Syndrome/therapy , Diabetes Complications/complications , Albuminuria/complications , Abdominal Fat , Dyslipidemias/complications , Overweight/complications , Pediatric Obesity/complications , Hypertension/complications
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