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2.
Rev. Méd. Clín. Condes ; 31(3/4): 317-329, mayo.-ago. 2020. tab
Article in Spanish | LILACS | ID: biblio-1223762

ABSTRACT

Los sujetos con infección por Virus de inmunodeficiencia humana (VIH) tienen mayor susceptibilidad de adquirir infecciones por su deterioro inmunológico. Según el deterioro inmunológico y el uso de terapia antiretroviral (TARV) en niños y adultos VIH (+), la intensidad de la respuesta inmune a las vacunas es menor que la población general. Por este motivo es preferible administrar vacunas una vez que la TARV haya permitido la inmunoreconstitución, y se recomiendan dosis de refuerzo. Por otra parte, las vacunas vivas atenuadas deben ser usadas con precaución, y están contraindicadas en inmunosupresión severa.


Patients with Human Immunodeficiency Virus (HIV) are more susceptible to acquiring infections due to their immune deterioration. The intensity of the immune response to vaccines is lower than general population, depending on immune status and the use of antiretroviral therapy (ARV). For this reason, it is preferable to administer vaccines once ART has allowed immune reconstitution, and booster doses are recommended. On the other hand, live vaccines should be used with caution, and are contraindicated in severe immunosuppression.


Subject(s)
Humans , Infant, Newborn , Child , Adult , Vaccines/administration & dosage , Communicable Disease Control/methods , Acquired Immunodeficiency Syndrome/complications , Vaccination , Vaccines/immunology , HIV Infections/complications , Acquired Immunodeficiency Syndrome/immunology , Immunosuppression , Immunization/methods , AIDS-Related Opportunistic Infections/prevention & control , Antiretroviral Therapy, Highly Active
3.
Rev. méd. Chile ; 148(6): 778-786, jun. 2020. tab, graf
Article in English | LILACS | ID: biblio-1139371

ABSTRACT

ABSTRACT Background: Cytomegalovirus (CMV) is an opportunistic infection (OI) in immunosuppressed patients. However, there are no clear cut-off values available for quantitative plasmatic CMV measures (viral load [VL]) to discriminate those with CMV illness from those infected suffering a transient viral reactivation. Aim: To estimate a CMV VL cut-off point that discriminates infected patients and those with CMV related diseases, and to clinically characterize AIDS patients with this OI. Patients and Methods: Retrospective analysis of AIDS patients admitted by any reason between years 2017 and 2019 and who had a positive plasma CMV VL at any titer. Cases were categorized with illness or infected using accepted criteria and the cut-off value was obtained by receiver operating characteristic curve (ROC) analysis. Results: Twelve patients were identified as having a CMV-associated illness and seven with CMV infection. A CMV VL of 3,800 copies/mL had a sensitivity of 91.6% and 100% specificity to discriminate both states. Of the 12 patients with CMV illness, all were in AIDS stage and only five were receiving HIV therapy. Predominant clinical presentations were gastrointestinal (50%), followed by liver involvement (25%) and CMV disease (25%). All patients were treated with ganciclovir or valganciclovir. Ten patients had a favorable response (83.3%), one patient only had a laboratory improvement (8.3%) and one died during treatment (8.3%). Drug toxicity was recorded in nine patients but in only three cases, a dose adjustment was necessary. Conclusions: The predominant clinical manifestation in our series was gastrointestinal. A CMV VL cutoff level of CMV VL of 3,800 copies / mL is useful to discriminate infected patients from those with CMV related disease.


Antecedentes: Citomegalovirus (CMV) es una infección oportunista (IO) en pacientes inmunosuprimidos. Sin embargo, se requieren puntos de corte de carga viral (CV) para discriminar a aquellos con enfermedad por CMV de aquellos infectados que sufren una reactivación viral transitoria. Objetivos: Estimar un punto de corte de la CV de CMV que discrimine a los enfermos de los infectados y, además, caracterizar clínicamente a los pacientes con sida que presentan esta IO. Pacientes y Métodos: Análisis retrospectivo de pacientes con sida hospitalizados por cualquier motivo entre los años 2017 y 2019, y que presentaron un CV de CMV plasmática positiva a cualquier título. Los casos se clasificaron como enfermos utilizando criterios aceptados y el valor de corte se obtuvo mediante análisis de una curva ROC. Resultados: Durante el período de estudio, 12 pacientes fueron identificados con enfermedad asociada al CMV y siete con infección. Una CV de 3.800 copias/ml logró una sensibilidad de 91,6% y una especificidad de 100% para discriminar ambos estados. De los 12 pacientes enfermos, todos estaban en etapa de sida y solo 5 recibían terapia contra el VIH. La presentación clínica predominante fue gastrointestinal (50%) seguida del compromiso hepático (25%) y de la enfermedad por CMV (25%). Todos los pacientes fueron tratados con ganciclovir o valganciclovir. Diez pacientes tuvieron una respuesta favorable (83,3%), uno solo tuvo mejoría de laboratorio (8,3%) y otro paciente falleció durante el tratamiento (8,3%). Nueve pacientes evolucionaron con toxicidad farmacológica, pero en solo 3 casos fue necesario ajustar las dosis. Conclusiones: La forma predominante de presentación de la enfermedad fue gastrointestinal. Un punto de corte de 3.800 copias/ml discrimina pacientes infectados de aquellos con la enfermedad.


Subject(s)
Humans , Acquired Immunodeficiency Syndrome/complications , Acquired Immunodeficiency Syndrome/drug therapy , Cytomegalovirus Infections/complications , Cytomegalovirus Infections/diagnosis , Cytomegalovirus Infections/drug therapy , Antiviral Agents/therapeutic use , Ganciclovir/therapeutic use , Retrospective Studies , Viral Load , Cytomegalovirus
4.
Ciênc. Saúde Colet ; 25(3): 837-844, mar. 2020. tab
Article in Portuguese | LILACS | ID: biblio-1089489

ABSTRACT

Resumo O WHODAS 2.0 (World Health Organization Disability Assesment Schedule) é um instrumento criado pela OMS (Organização Mundial da Saúde) para medida de funcionalidade e deficiência, fundamentado no modelo biopsicossocial e totalmente amparado no arcabouço teórico-conceitual da CIF (Classificação Internacional de Funcionalidade, Incapacidade e Saúde). O objetivo deste artigo é validar a versão brasileira do WHODAS 2.0 para o uso em pessoas com HIV/AIDS. Participaram 100 pessoas com diagnóstico de HIV/AIDS. Foram utilizados dois instrumentos de avaliação, o WHODAS 2.0 na versão de 36 itens e o WHOQoL-HIV-Bref (World Health Organization Quality of Life em pessoas com HIV, versão abreviada). As propriedades psicométricas testadas foram consistência interna e validade de critério. A consistência interna foi adequada para todos os domínios, com exceção do domínio Atividades de Vida (α = 0,69) e Autocuidado (α = 0,32). A validade de critério foi adequada, com correlações moderadas aos domínios do WHODAS 2.0 com os domínios do WHOQoL-HIV-Abreviado. Os resultados indicaram o instrumento WHODAS 2.0 como válido para avaliação da funcionalidade de pessoas com HIV/AIDS. O uso dos dados do domínio de Autocuidado deve ser cuidadosamente considerado.


Abstract The WHODAS 2.0 (World Health Organization Disability Assessment Schedule) is an instrument developed by the WHO (World Health Organization) for functioning and disability assessment based on the biopsychosocial framework, fully supported by the theoretical-conceptual framework of the ICF (International Classification of Functioning, Disability and Health). To validate the Brazilian version of the WHODAS 2.0 for individuals with HIV/AIDS. 100 individuals with diagnosis of HIV/AIDS participated in the study. Two assessment instruments were used: the 36-item version of WHODAS 2.0 and the WHOQOL-HIV-BREF (World Health Organization Quality of Life assessment in persons infected with HIV, shorter version). The psychometric properties tested were internal consistency and criterion validity. Internal consistency was adequate for all domains, with the exception of Life Activities (α = 0.69) and Self-care (α = 0.32). Criterion validity was adequate, with moderate correlations between the WHODAS 2.0 and the WHOQOL-HIV-BREF domains. The results indicated the WHODAS 2.0 instrument as a valid tool for assessing functioning of individuals with HIV/AIDS. The use of data from the Self-care domain should be carefully considered.


Subject(s)
Humans , Male , Female , Adult , Acquired Immunodeficiency Syndrome/complications , Disability Evaluation , World Health Organization , Brazil , Middle Aged
5.
Rev. Assoc. Med. Bras. (1992) ; 66(1): 81-86, Jan. 2020. tab, graf
Article in English | LILACS | ID: biblio-1091908

ABSTRACT

SUMMARY OBJECTIVE To evaluate the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with HIV/AIDS. METHODS The systematic review included articles indexed in MEDLINE (by PubMed), Web of Science, IBECS, and LILACS. Studies eligible included the year of publication, diagnose criteria of NAFLD and HIV, and were published in English, Portuguese, or Spanish from 2006 to 2018. The exclusion criteria were studies with HIV-infection patients and other liver diseases. Two reviewers were involved in the study and applied the same methodology, according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). RESULTS One hundred and sixteen papers were selected, including full articles, editorial letters, and reviews. Twenty-seven articles were excluded because they did meet the inclusion criteria. A total of 89 articles were read, and 13 were considered eligible for this review. Four case series used imaging methods to identify NAFLD, and nine included histology. The prevalence of NAFLD in HIV-patients ranged from 30%-100% and, in nonalcoholic steatohepatitis (NASH), from 20% to 89%. A positive association between dyslipidemia, insulin resistance, and body mass index was observed. There was no agreement between the studies that evaluated the relationship between antiretroviral drugs and NAFLD. CONCLUSION This systematic review showed a high prevalence of NAFLD in HIV-patients, which was associated with metabolic risk factors. The possible association between antiretroviral therapy and NAFLD needs further studies.


RESUMO OBJETIVO Avaliar a relevância da doença hepática gordurosa não alcoólica (DHGNA) em pacientes com HIV / AIDS. MÉTODOS A revisão sistemática foi realizada utilizando instrumentos de busca de material científico indexado, incluindo MEDLINE (pela PubMed), Web of Science, IBECS e LILACS. Estudos elegíveis incluíram o ano de publicação, critérios para diagnostico de DHGNA e HIV, publicados em inglês, português e espanhol, entre 2006 a 2018. Os critérios de exclusão incluíram estudos com pacientes com outras doenças do fígado. Dois revisores foram envolvidos na pesquisa dos artigos e o PRISMA (Preferred Reporting Items for Systematic Reviews and Meta - Analyses) foi utilizado nas análises. RESULTADOS Cento e dezesseis artigos foram selecionados, 27 excluídos porque não preencheram critérios de inclusão e assim, 89 foram lidos pelos investigadores. Desses, 13 artigos foram incluídos na revisão. Quatro séries de casos utilizaram métodos por imagens para identificação de DHGNA e nove estudos utilizaram biópsia hepática. A prevalência de DHGNA em pacientes com HIV variou de 30% a 100% e esteato-hepatite não alcoólica (EHNA) entre 20% e 89%. Na avaliação das principais variáveis estudadas, observou-se a associação positiva entre dislipidemia, resistência à insulina e índice de massa corporal. Não houve concordância entre os artigos que avaliaram a relação dos antiretrovirais com a DHGNA. CONCLUSÕES A presente revisão sistemática sugere elevada prevalência de DHGNA em pacientes infectados com HIV. DHGNA nesses pacientes foi associada principalmente a fatores metabólicos. A possível associação entre terapia antiretroviral e DHGNA nesses pacientes vem sendo discutida, mas são necessários mais estudos para estabelecer essa associação.


Subject(s)
Humans , Acquired Immunodeficiency Syndrome/complications , Acquired Immunodeficiency Syndrome/epidemiology , Non-alcoholic Fatty Liver Disease/etiology , Non-alcoholic Fatty Liver Disease/epidemiology , Prevalence , Risk Factors , Acquired Immunodeficiency Syndrome/drug therapy , Antirheumatic Agents/adverse effects , Antiretroviral Therapy, Highly Active/adverse effects
6.
Rev. bras. cancerol ; 66(4): e-041053, 2020.
Article in Portuguese | LILACS, Inca | ID: biblio-1123243

ABSTRACT

Introdução: O câncer acometerá cerca de 50% dos indivíduos com infecção pelo vírus da imunodeficiência adquirida (HIV), com importante carga daqueles do tipo não definidores da síndrome da imunodeficiência adquirida (aids). Objetivo: Analisar diferentes fatores de risco para câncer do tipo não definidor na população HIV positiva, por meio da seleção de estudos de coorte realizados em diferentes Regiões do mundo. Método: Trata-se de uma revisão de literatura realizada no período de março a abril de 2019, utilizando os descritores Cancer Risck, HIV e non-AIDS-defining Cancer. Resultados: Os cânceres não definidores, que representam maior incidência entre a população HIV positiva, são o de pulmão, colorretal, cervical, de vagina e útero, gástrico, linfoma de Hodgkin e de fígado. Conclusão: Os estudos demonstram risco aumentado para diversos tipos de câncer não definidores da aids, o que nos leva a um novo paradigma, voltado não somente para o controle do HIV, mas também para a detecção precoce e tratamento oportuno, a fim de minimizar as morbidades e aumentar a expectativa de vida desses indivíduos.


Introduction: Cancer will affect about 50% of HIV (human immunodeficiency virus) infected individuals with a significant burden of non-AIDS-defining cancers (acquired immunodeficiency syndrome). Objective: To analyse different risk factors for the non-defining type in the HIV positive population through selection of cohort studies conducted in several regions of the world. Method: Literature review conducted from March to April 2019 using the descriptors Cancer Risk, HIV and non-AIDS-defining Cancer. Results: Non-defining cancers representing the greatest incidence among HIV-positive population are lung, colorectal, cervical, vaginal and uterine, gastric, Hodgkin's lymphoma, and liver. Conclusion: Studies demonstrate that there are increased risks for several types of non-AIDS defining cancers, leading to a new paradigm, not only for HIV control but for early detection and timely treatment, in order to minimize the morbidities and increase life expectancy of these individuals.


Introducción: El cáncer afectará aproximadamente al 50% de las personas con infección por virus de inmunodeficiencia adquirida (VIH) con una carga significativa de cánceres que no definen el síndrome de inmunodeficiencia adquirida (sida). Objetivo: Analizar diferentes factores de riesgo para el cáncer no definitorio en la población VIH positivo en estudios de cohortes realizados en diferentes regiones del mundo. Método: Esta es una revisión de la literatura realizada de marzo a abril de 2019 utilizando los descriptores Cancer Risk, HIV non-AIDS-defining Cancer. Resultados: Los cánceres no definitorios que representan el mayor riesgo e incidencia entre la población VIH positivo son de pulmón, colorrectal, cervical, vaginal y uterino, gástrico, linfoma de Hodgkin y de hígado. Conclusión: Los estudios muestran riesgos para varios tipos de cáncer que no definen el sida, lo que nos lleva a un nuevo paradigma, que se centra no solo en el control del VIH sino también en la detección temprana y el tratamiento oportuno.


Subject(s)
Humans , Male , Female , HIV Infections/complications , Neoplasms/epidemiology , Incidence , Risk Factors , Life Expectancy , Acquired Immunodeficiency Syndrome/complications , Neoplasms/complications
7.
Rev. bras. enferm ; 72(5): 1226-1234, Sep.-Oct. 2019. tab
Article in English | LILACS, BDENF | ID: biblio-1042133

ABSTRACT

ABSTRACT Objective: To analyze the association between the empirical indicators and ICNP® nursing diagnoses in people living with AIDS, as well as to identify the predictive indicators for the establishment of these diagnoses. Method: A cross-sectional study with 120 people living with AIDS, in a hospital in Northeastern Brazil, conducted from August to September 2015, following the steps: identification and validation of Empirical Indicators; preparation and validation of the ICNP® Nursing Diagnoses; and analysis of the association between the Empirical Indicators and the Nursing Diagnoses resulting from the two previous steps. To analyze the data, we used logistic regression. Results: 74 Empirical Indicators were identified, being 31 of which were validated. 55 diagnoses were elaborated and 19 were validated, of which 16 were associated with the Empirical Indicators, identifying 31 predictors. Conclusion: The diagnoses presented significant associations with the Empirical Indicators. In addition, it was observed that the predictive factors of these diagnoses involved the human responses and complications related to the disease, which should be considered during the care provided by the nurse.


RESUMEN Objetivo: Analizar la asociación entre los indicadores empíricos y diagnósticos de enfermería de la CIPE® en personas viviendo con Sida, así como identificar los indicadores predictores para el establecimiento de esos diagnósticos. Método: Estudio transversal con 120 personas viviendo con Sida, en un hospital en el Nordeste de Brasil, realizado de agosto a septiembre de 2015, siguiendo las etapas: identificación y validación de los indicadores empíricos; elaboración y validación de los diagnósticos de enfermería de la CIPE®; y análisis de la asociación entre los indicadores empíricos y los diagnósticos de enfermería resultantes de las dos etapas anteriores. Para el análisis de los datos se utilizó la regresión logística. Resultados: Se identificaron 74 indicadores empíricos, siendo 31 validados. Se elaboraron 55 diagnósticos y 19 fueron validados, de los cuales 16 obtuvieron asociación con los indicadores empíricos, identificándose 31 predicadores. Conclusión: Los diagnósticos presentaron asociaciones significativas con los indicadores empíricos. Además, se observó que los factores predictores de estos diagnósticos involucraron las respuestas humanas y complicaciones relacionadas con la enfermedad, las cuales deben ser consideradas durante la asistencia prestada por el enfermero.


RESUMO Objetivo: Analisar a associação entre os Indicadores Empíricos e Diagnósticos de Enfermagem da CIPE® em pessoas vivendo com AIDS, bem como identificar os indicadores preditores para o estabelecimento desses diagnósticos. Método: Estudo transversal com 120 pessoas vivendo com AIDS, em um hospital no Nordeste do Brasil, realizado de agosto a setembro de 2015, seguindo as etapas: identificação e validação dos Indicadores Empíricos; elaboração e validação dos Diagnósticos de Enfermagem da CIPE®; e análise da associação entre os Indicadores Empíricos e os Diagnósticos de Enfermagem resultantes das duas etapas anteriores. Para análise dos dados, foi utilizada a regressão logística. Resultados: Identificaram-se 74 Indicadores Empíricos, sendo 31 validados. Elaboraram-se 55 diagnósticos e 19 foram validados, dos quais 16 obtiveram associação com os Indicadores Empíricos, identificando-se 31 preditores. Conclusão: Os diagnósticos apresentaram associações significativas com os Indicadores Empíricos. Além disso, observou-se que os fatores preditores desses diagnósticos envolveram as respostas humanas e complicações relacionadas à doença, as quais devem ser consideradas durante a assistência prestada pelo enfermeiro.


Subject(s)
Humans , Male , Female , Adult , Young Adult , Nursing Diagnosis/statistics & numerical data , Acquired Immunodeficiency Syndrome/nursing , Brazil , Cross-Sectional Studies , Acquired Immunodeficiency Syndrome/complications , Empirical Research , Standardized Nursing Terminology , Middle Aged
8.
Rev. chil. infectol ; 36(3): 331-339, jun. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1013791

ABSTRACT

Resumen Introducción: El tratamiento anti-retroviral (TAR) es indispensable en pacientes con infección por VIH/ SIDA; suprimir la carga viral requiere de un estricto apego a éste, por compromiso del paciente. El fracaso del TAR es primordialmente por falta de adherencia, que puede ser debida a una deficiente calidad de vida y/o a variables psicológicas. Objetivo: Determinar la calidad de vida, variables psicológicas y la adherencia al TAR, en pacientes con infección por VIH/SIDA. Material y Método: Se incluyeron 160 pacientes con diagnóstico de infección por VIH/SIDA y con TAR. Se recabaron los instrumentos MOS SF-36 y VPAD-24, una encuesta demográfica, y datos clínicos. Se hicieron asociaciones cuantitativas y cualitativas entre las variables. Resultados: La adherencia al TAR estuvo asociada con evitar comportamiento depresivo y con ausencia de adicciones. El comportamiento depresivo se encontró asociado con las adicciones. Un 87% de pacientes estaba en el rango de mejor calidad de vida. Por debajo del promedio del puntaje de salud general estuvieron masculinos, con orientación sexual HSH, solteros, en la vitalidad a los ≥ 38 años, en dolor corporal y función social a tres esquemas TAR. Conclusión: La buena adherencia al TAR estuvo asociada a evitar comportamiento depresivo y a la ausencia de adicciones y no se asoció a la calidad de vida.


Background: Antiretroviral treatment (ART) is essential in HIV/AIDS patients. Suppressing viral load requires strict adherence to ART in addition to the patient's commitment to treatment. The failure of ART is mainly due to lack of adherence, which may in turn be due to poor quality of life and/or to psychological variables. Aim: To determine the quality of life and psychological variables and adherence to ART, in patients with HIV/AIDS. Material and Method: 160 patients diagnosed with HIV/AIDS and with ART were included. The MOS SF-36 and VPAD-24 instruments, a socio-demographic survey, and clinical data were collected. Quantitative and qualitative associations were made between the variables. Results: The adherence to ART was associated with avoidance of depressive behavior and with the absence of addictions. Depressive behavior associated with addictions. 87% of patients ranked in the best quality of life. Below the average of the general health score were males, with MSM sexual orientation, single, in vitality at ≥ 38 years, in corporal pain and with social function to three ART schemes. Conclusion: Good adherence to ART was associated with avoiding depressive behavior and with non-addictions and not associated with quality of life.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Quality of Life/psychology , Acquired Immunodeficiency Syndrome/psychology , Antiretroviral Therapy, Highly Active/psychology , Medication Adherence/psychology , Sexual Behavior/psychology , Socioeconomic Factors , Cross-Sectional Studies , Surveys and Questionnaires , Acquired Immunodeficiency Syndrome/complications , Acquired Immunodeficiency Syndrome/drug therapy , Substance-Related Disorders/complications , Anti-Retroviral Agents/therapeutic use , Depression/complications , Depression/psychology , Mexico
9.
Autops. Case Rep ; 9(1): e2018063, Jan.-Mar. 2019. ilus
Article in English | LILACS | ID: biblio-986756

ABSTRACT

Progressive multifocal leukoencephalopathy (PML) is a feared entity that occurs most frequently in conditions of extreme immunodeficiency. The diagnosis is often made long after the onset of symptoms due to the physicians' unfamiliarity, and the unavailability of diagnostic tests in some medical centers. Although the incidence of PML is decreasing among HIV patients with the advent of highly active antiretroviral therapy (HAART), in Brazil this entity is the fourth highest neurological complication among these patients. The authors present the case of a middle-aged man who tested positive for HIV concomitantly with the presentation of hyposensitivity in the face and the right side of the body, accompanied by mild weakness in the left upper limb. The clinical features worsened rapidly within a couple of weeks. The diagnostic work-up pointed to the working diagnosis of PML after brain magnetic resonance imaging; however, the detection of the John Cunningham virus (JCV) in the cerebral spinal fluid was negative. HAART was started but the patient died after 7 weeks of hospitalization. The autopsy revealed extensive multifocal patchy areas of demyelination in the white matter where the microscopy depicted demyelination, oligodendrocytes alterations, bizarre atypical astrocytes, and perivascular lymphocytic infiltration. The immunohistochemistry was positive for anti-SV40, and the polymerase chain reaction of the brain paraffin-embedded tissue was positive for JCV. The authors highlight the challenges for diagnosing PML, as well as the devastating outcome of PML among HIV patients.


Subject(s)
Humans , Male , Adult , Acquired Immunodeficiency Syndrome/complications , Leukoencephalopathy, Progressive Multifocal/diagnosis , Autopsy , Leukoencephalopathy, Progressive Multifocal/pathology , Fatal Outcome , JC Virus
10.
Rev. Soc. Bras. Med. Trop ; 52: e20180405, 2019. tab
Article in English | LILACS | ID: biblio-1041592

ABSTRACT

Abstract INTRODUCTION: Low handgrip strength (HS) is associated with cardiometabolic alterations that have affected people with HIV/AIDS. METHODS: This was a cross-sectional study performed in adults receiving antiretroviral treatment. HS was evaluated using a dynamometer and divided by body weight to obtain the relative strength. The association between relative HS and overweight, increased waist circumference (WC), high body fat percentage, glycemia, and lipid ratios were assessed using logistic regression. RESULTS: Low relative HS was identified in 35% of participants and associated with increased WC (odds ratio = 9.7; 95% confidence interval = 2.8-33.0). CONCLUSIONS: The prevalence of low HS was high and associated with increased WC.


Subject(s)
Humans , Male , Female , Adult , Biomarkers/blood , Cardiovascular Diseases/etiology , Acquired Immunodeficiency Syndrome/complications , Hand Strength/physiology , Cardiovascular Diseases/physiopathology , Cardiovascular Diseases/blood , Body Mass Index , Cross-Sectional Studies , Risk Factors , Acquired Immunodeficiency Syndrome/physiopathology , Acquired Immunodeficiency Syndrome/blood , Waist Circumference
11.
Rev. cuba. reumatol ; 20(3): e650, sept.-dic. 2018.
Article in Spanish | LILACS, CUMED | ID: biblio-1093790

ABSTRACT

Introducción: La infección por VIH/SIDA constituye uno de los principales problemas de salud en el mundo con elevadas tasas de morbilidad y mortalidad demostradas. En diferentes estudios epidemiológicos ha quedado confirmado que 36,3 millones de personas vivían con el VIH hasta el año 2015 en todo el mundo. Hasta este momento 78 millones han sido infectados desde 1981, año en que comenzó la epidemia, y el 25 por ciento de los pacientes desconocen que están infectados, lo cual propicia el contagio. Objetivo: Realizar una revisión bibliográfica relacionada con la infección por el VIH/SIDA, sus complicaciones en las enfermedades reumáticas y metabólicas y su respuesta al tratamiento antirretroviral de alta eficiencia. Método: Se realizó una búsqueda bibliográfica en bases de datos nacionales e internacionales y en diferentes fuentes de información para recuperar los artículos relacionados con el tema sobre el VIH-SIDA, las complicaciones reumáticas y metabólicas y su respuesta al tratamiento antirretroviral de alta eficiencia, tema escogido para este trabajo. Resultados: Se recuperaron 78 artículos y nueve textos que trataban temas relacionados con la infección por VIH-SIDA; de ellos fueron útiles para nuestros objetivos 55 documentos que forman parte de nuestras referencias bibliográficas, los cuales agrupamos de acuerdo con los diferentes temas planteados para este estudio y se llegó a conclusiones útiles para nuestra comunidad científica. Conclusiones: Las enfermedades reumáticas y autoinmunes han sido diagnosticadas con mucha frecuencia en los pacientes infectados con el VIH-SIDA en Cuba y en el mundo antes del tratamiento antirretroviral de alta eficiencia, mediante el cual ha aumentado la expectativa de supervivencia de estos enfermos y disminuido la aparición de síntomas clínicos y afecciones, así como infecciones oportunistas, después de su inclusión en el enfoque terapéutico(AU)


Introduction: HIV/AIDS infection is one of the main health problems worldwide, with high morbidity and mortality. Different epidemiological studies have confirmed that 36.3 million people worldwide were living with HIV until 2015. So far, 78 million have been infected since 1981, the year in which the epidemic began, and 25 percent of patients do not know they are infected, which spreads infection. Objective: To carry out a literature review about HIV/AIDS infection, its complications in rheumatic metabolic manifestations, and its response to highly efficient antiretroviral treatment. Method: A literature search was carried out in the databases PudMed/MEDLINE, Cumed and Lilac, as well as in the regional information sources SciELO and ScienceDirect, using the key phrases manifestaciones reumáticas y VIH-SIDA [rheumatic manifestations and HIV-AIDS], complicaciones metabólicas y VIH-SIDA [metabolic complications and HIV-AIDS], tratamiento antirretroviral de alta eficiencia y VIH-SIDA [high-efficiency antiretroviral treatment and HIV-AIDS], in order to recover the articles about HIV-AIDS and rheumatic and metabolic complications and their response to highly efficient antiretroviral treatment. Results: 78 articles and nine texts dealing about the aforementioned topics were recovered; of them, 55 documents that are part of our bibliographical references were useful for our purposes, which were grouped according to the different topics proposed for this study. We reached useful conclusions for our scientific community. Conclusions: Rheumatic and autoimmune diseases have been diagnosed very frequently in patients infected with HIV/AIDS in Cuba and worldwide during the era prior to highly efficient antiretroviral treatment. Its incorporation into the therapeutic approach has increased the survival expectations of these patients, in addition to the substantial decrease in the appearance of clinical symptoms and conditions, especially the inflammatory arthritic conditions, seronegative spondyloarthropathies, psoriasis and opportunistic infections(AU)


Subject(s)
Humans , Autoimmune Diseases , Rheumatic Diseases/complications , Acquired Immunodeficiency Syndrome/complications , HIV/metabolism , Spondylarthropathies , Epidemiologic Studies , Antiretroviral Therapy, Highly Active/methods
12.
Rev. enferm. UERJ ; 26: e31156, jan.-dez. 2018. tab
Article in Portuguese | LILACS, BDENF | ID: biblio-970289

ABSTRACT

Objetivo: descrever o perfil de adesão à terapia antirretroviral (TARV) de pacientes com Síndrome Lipodistrófica do Vírus da Imunodeficiência Humana (SLHIV), em uma unidade especializada do Estado do Pará, Brasil. Método: estudo qualiquantitativo, envolvendo questionário e prontuários de 124 pacientes, no período de fevereiro e março de 2013, após aprovação por Comitê de Ética. Na análise, a variância (p<0,05) articulou testes estatísticos, com dados apresentados em tabelas. Resultados: as dificuldades de entender e conhecer o esquema terapêutico, o Diabetes Mellitus e as alterações da lipodistrofia foram significantes na interferência da adesão à TARV. O grupo de adesão irregular está em risco para a eficácia do tratamento. Os demais têm a possibilidade de migração de um grupo para outro a qualquer momento. Conclusão: o perfil de adesão à TARV não é definida por dados socioeconômicos. A participação em grupos de adesão deve ser estimulada como fator de reversão do padrão de abandono. Descritores: HIV; AIDS; lipodistrofia; adesão à medicação.


Objective: to profile adherence to antiretroviral therapy (ART) by patients with human immunodeficiency virus lipodystrophy syndrome (HIVLS) at a specialized unit in Pará, Brazil. Method: this quali-quantitative study, involving a questionnaire and medical records of 124 patients, was conducted from February to March 2013, after research ethics approval. In the analysis, statistical tests were related by variance (p <0.05) and data were presented in table form. Results: the difficulties of understanding and knowing the therapeutic regimen, mellitus diabetes and changes in lipodystrophy were significant in the interference of ART adherence. The irregular adherence group is at risk for treatment efficacy. The others have the possibility of migrating from one group to another at any time. Conclusion: the profile of adherence to ART is not defined by socioeconomic data. Participation in membership groups should be encouraged as a factor in reversing the pattern of abandonment.


Objetivo: describir el perfil de adhesión a la terapia antirretroviral (TARV) de pacientes con síndrome lipodistrófico del virus de la inmunodeficiencia humana (SLHIV), en una unidad especializada del Estado de Pará, Brasil. Método: estudio cualiquantitativo involucrando cuestionario e historias clínicas de 124 pacientes, en el período de febrero y marzo de 2013, después de la aprobación por el Comité de Ética. En el análisis, la varianza (p <0,05) articuló pruebas estadísticas, con datos presentados en tablas. Resultados: las dificultades en entender y conocer el esquema terapéutico, la Diabetes Mellitus y las alteraciones de la lipodistrofia fueron significantes en la interferencia de la adhesión a la TARV. El grupo de adhesión irregular está en riesgo para la eficacia del tratamiento. Los demás tienen la posibilidad de migración de un grupo a otro en cualquier momento. Conclusión: el perfil de adhesión a la TARV no está definido por datos socioeconómicos. La participación en grupos de adhesión debe ser estimulada como factor de reversión del patrón de abandono.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , HIV Infections/complications , Acquired Immunodeficiency Syndrome/complications , Antiretroviral Therapy, Highly Active , HIV-Associated Lipodystrophy Syndrome , Medication Adherence , Brazil , Epidemiology, Descriptive , Cross-Sectional Studies , Statistics, Nonparametric
13.
Autops. Case Rep ; 8(3): e2018029, July-Sept. 2018. ilus tab
Article in English | LILACS | ID: biblio-911893

ABSTRACT

Disseminated human cytomegalovirus (CMV) disease occurs mainly as a congenital infection and among immunocompromised hosts. Patients with acquired immunodeficiency syndrome (AIDS) are at increased risk for CMV infection, and the most prevalent clinical manifestation is retinitis, followed by colitis, esophagitis, pneumonitis, and encephalitis. CMV oophoritis is poorly described in the literature with some cases reported in patients with hematological or solid malignancies, bone marrow or solid organ transplantation, immunosuppressive therapy, and advanced AIDS cases. We report the case of a 61-year-old woman with a recent diagnosis of AIDS, which was associated with a wasting syndrome. The patient presented with abdominal pain, headache, cutaneous vesicular lesions on the abdomen, anemia, lymphopenia, and hyponatremia; she died suddenly on the fourth day of hospitalization. The autopsy was performed and demonstrated disseminated CMV infection with hemorrhagic encephalitis as the immediate cause of death. Additionally, pneumonitis, extensive adrenalitis, ulcerated enteritis, focal hepatitis, and necrotizing oophoritis were found.


Subject(s)
Humans , Female , Middle Aged , Acquired Immunodeficiency Syndrome/complications , Cytomegalovirus Infections/complications , Autopsy , Cytomegalovirus Infections/pathology , Encephalitis/pathology , Fatal Outcome , Oophoritis/complications
14.
Autops. Case Rep ; 8(2): e2018028, Apr.-May 2018. tab, ilus
Article in English | LILACS | ID: biblio-905529

ABSTRACT

In the advanced stage of AIDS, the diagnosis of the opportunistic infections may be challenging due to the high risk of performing invasive diagnostic methods in a patient with a critical clinical condition, as well as the correct interpretation of the results of microbiological exams. One of the challenges for the diagnosis and treatment of the opportunistic infections is that they may occur concomitantly in the same patient and they may mimic each other, leading to a high discrepancy between clinical and autopsy diagnoses. We describe the case of a 52-year-old man who was hospitalized because of weight loss, anemia, cough, and hepatosplenomegaly. During the investigation, the diagnosis of AIDS was made, and the patient developed respiratory failure and died on the fourth day of hospitalization. At autopsy, disseminated non-tuberculosis mycobacteriosis was found, affecting mainly the organs of the reticuloendothelial system. Also, severe and diffuse pneumonia caused by multiple agents (Pneumocystis jirovecii, Histoplasma capsulatum, suppurative bacterial infection, non-tuberculosis mycobacteria, and cytomegalovirus) was seen in a morphological pattern that could be called "collision pneumonia." The lesson from this case, revealed by the autopsy, is that in advanced AIDS, patients often have multiple opportunistic infections, so the principle of Ockham's razor­that a single diagnosis is most likely the best diagnosis­fails in this clinical context.


Subject(s)
Humans , Male , Middle Aged , Acquired Immunodeficiency Syndrome/complications , AIDS-Related Opportunistic Infections/complications , Lung Diseases, Fungal/complications , AIDS-Related Opportunistic Infections/pathology , Autopsy , Cytomegalovirus Infections/complications , Fatal Outcome , Histoplasmosis/complications , Mycobacterium Infections, Nontuberculous/complications , Pneumocystis Infections/complications
15.
Rev. Soc. Bras. Med. Trop ; 51(2): 203-206, Mar.-Apr. 2018. tab
Article in English | LILACS | ID: biblio-1041451

ABSTRACT

Abstract INTRODUCTION: Hypoalbuminemia may predict progression of disease and mortality in patients with human immunodeficiency virus (HIV) infection/acquired immune deficiency syndrome (AIDS). This study was conducted to investigate the risk factors associated with hypoalbuminemia in outpatients with HIV/AIDS. METHODS: A cross-sectional study was performed in 196 outpatients with HIV/AIDS. RESULTS: The prevalence of hypoalbuminemia was 11.7%. The only risk factor associated with hypoalbuminemia was current antiretroviral therapy (no exposure: odds ratio=3.46, 95% confidence interval=1.20-10.02). CONCLUSIONS: The monitoring of plasma albumin is key to determine when antiretroviral therapy should be initiated in individuals not exposed to antiretroviral medicines.


Subject(s)
Humans , Male , Female , Adult , Acquired Immunodeficiency Syndrome/complications , Hypoalbuminemia/etiology , Anti-Retroviral Agents/administration & dosage , Outpatients , Prevalence , Cross-Sectional Studies , Predictive Value of Tests , Risk Factors , Acquired Immunodeficiency Syndrome/drug therapy , Acquired Immunodeficiency Syndrome/blood , Disease Progression , Hypoalbuminemia/blood , Hypoalbuminemia/epidemiology , Anti-Retroviral Agents/adverse effects , Middle Aged
16.
Rev. latinoam. enferm. (Online) ; 26: e3066, 2018. tab
Article in English | LILACS, BDENF | ID: biblio-978588

ABSTRACT

ABSTRACT Objectives: to verify the prevalence of arterial hypertension and its risk factors among people with acquired immunodeficiency syndrome under antiretroviral therapy. Method: cross-sectional study with 208 patients. Data collection was conducted through interviews using a form containing data on sociodemographic, clinical and epidemiological aspects, hypertension risk factors, blood pressure, weight, height, body mass index and abdominal circumference. Mean, standard deviation, odds ratio and confidence interval were calculated, t-test and Chi-square test were used, considering P < 0.05 as statistically significant. Hypertension associated variables were selected for logistic regression. Results: patients were male (70.7%), self-reported as mixed-race (68.2%), had schooling between 9 and 12 years of study (46.6%), had no children (47.6%), were single (44.2%), in the sexual exposure category (72.1%) and heterosexual (60.6%). The prevalence of people with acquired immunodeficiency syndrome and arterial hypertension was 17.3%. Logistic regression confirmed the influence of age greater than 45 years, family history of hypertension, being overweight and antiretroviral therapy for more than 36 months for hypertension to occur. Conclusion: the prevalence of hypertension was 17.3%. Patients with acquired immunodeficiency syndrome and hypertension were older than 45 years, had family history of hypertension, were overweight and under antiretroviral therapy for more than 36 months.


RESUMO Objetivos: verificar a prevalência de hipertensão arterial e seus fatores de risco entre pessoas com síndrome da imunodeficiência adquirida em terapia antirretroviral. Método: estudo transversal, com amostra de 208 pacientes. Coleta de dados realizada por meio de entrevista, com formulário envolvendo dados sociodemográficos, clínicos, epidemiológicos, fatores de risco para hipertensão, verificação da pressão arterial, peso, altura, índice de massa corporal e circunferência abdominal. Foram calculadas média, desvio padrão, odds ratio e intervalo de confiança e utilizados testet e teste do qui-quadrado, considerando-se estatisticamente significante P < 0,05. Variáveis associadas à hipertensão foram selecionadas para regressão logística. Resultados: destacaram-se pacientes do sexo masculino (70,7%), cor parda (68,2%), escolaridade entre nove e 12 anos de estudo (46,6%), sem filhos (47,6%), solteiros (44,2%), categoria de exposição sexual (72,1%) e heterossexuais (60,6%). A prevalência de pessoas com síndrome da imunodeficiência adquirida e hipertensão foi de 17,3%. Regressão logística confirmou influência da idade maior que 45 anos, história familiar de hipertensão, sobrepeso e terapia antirretroviral acima de 36 meses para ocorrer hipertensão. Conclusão: a prevalência de hipertensão foi de 17,3%. Pacientes com síndrome da imunodeficiência adquirida e hipertensão tinham mais de 45 anos, história familiar de hipertensão, sobrepeso e terapia antirretroviral por mais de 36 meses.


RESUMEN Objetivos: verificar la prevalencia de hipertensión arterial y sus factores de riesgo entre personas con síndrome de inmunodeficiencia adquirida en terapia antirretroviral. Método: estudio transversal, con muestra de 208 pacientes. La recolección de datos se realizó a través de entrevistas con formulario de datos sociodemográficos, clínicos, epidemiológicos, factores de riesgo para la hipertensión arterial, verificación de la presión arterial, peso, altura, índice de masa corporal y la circunferencia abdominal. Se calcularon la media, la desviación estándar, la razón de probabilidades (odds ratio)y el intervalo de confianza, y se utilizaron la prueba t y la prueba del chi-cuadrado, considerándose estadísticamente significante P <0,05. Las variables asociadas a la hipertensión fueron seleccionadas para la regresión logística. Resultados: se destacaron pacientes del género masculino (70,7%), color parda (68,2%), escolaridad entre nueve y 12 años de estudio (46,6%), sin hijos (47,6% ), solteros (44,2%), categoría de exposición sexual (72,1%) y heterosexuales (60,6%). La prevalencia de personas con síndrome de inmunodeficiencia adquirida e hipertensión fue del 17,3%. La regresión logística confirmó que hay influencia de la edad mayor de 45 años, del historial familiar de hipertensión, del sobrepeso y de la terapia antirretroviral por más de 36 meses para ocurrir la enfermedad. Conclusión: la prevalencia de hipertensión fue del 17,3%. Los pacientes con el síndrome de inmunodeficiencia adquirida y hipertensión tenían más de 45 años, historial familiar de hipertensión, sobrepeso y terapia antirretroviral por más de 36 meses.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Acquired Immunodeficiency Syndrome/complications , Acquired Immunodeficiency Syndrome/therapy , Anti-HIV Agents/classification , Anti-HIV Agents/adverse effects , Anti-HIV Agents/therapeutic use , Blood Pressure/physiology , Brazil/epidemiology , Body Mass Index , Cross-Sectional Studies
17.
Medisan ; 21(12)dic. 2017. ilus
Article in Spanish | LILACS | ID: biblio-997338

ABSTRACT

La infección por el virus de la inmunodeficiencia humana/sida es uno de los problemas de salud pública más importante en todo el mundo. Se estima que hasta 95 por ciento de los afectados presentan manifestaciones cutáneas durante el curso de la infección, entre las cuales se encuentran las producidas por hongos. A tales efectos, se describen algunas de ellas, las cuales deben ser reconocidas por los médicos y el personal de salud a cargo del tratamiento y control de los pacientes con esta enfermedad.


Human immunodeficiency virus/AIDS infection is one of the most important public health problems worldwide. It is considered that up to 95 percent of the affected patients present cutaneous manifestations during the course of the infection, among which we can mention those caused by fungus. To such effects, some of these are described, which should be recognized by doctors and health staff in charge of the treatment and control of patients with this disease


Subject(s)
Humans , Male , Female , Skin Diseases/etiology , Acquired Immunodeficiency Syndrome/complications , HIV , Communication , Immunity, Humoral , Immunity, Cellular
18.
Rev. bras. enferm ; 70(6): 1309-1317, Nov.-Dec. 2017. tab, graf
Article in English | LILACS, BDENF | ID: biblio-898308

ABSTRACT

ABSTRACT Objective: To analyze scientific productions about the relationship between HIV and Systemic Arterial Hypertension (SAH) in people living with HIV/AIDS (PLWHA). Method: Integrative literature review in six databases, held in March 2016. "AIDS" and "hypertension" were the keywords used in Portuguese, English and Spanish languages. We found 248 articles and selected 17. The categories formulated were "prevalence of SAH in PLWHA," "risk factors for SAH in PLWHA" and "adverse events of antiretroviral therapy (ART) that contribute to HAS." Results: There is no consensus whether HIV and ART influence the SAH development, but there are several risk factors for SAH among PLWHA. It was observed that protease inhibitors medicines influence SAH the most. Conclusion: Guidelines for SAH prevention must be performed in all individuals, however, in PLWHA, they must focus on characteristic risk factors of this population.


RESUMEN Objetivo: Analizar la producción científica sobre la relación entre el VIH y la Hipertensión Arterial (HTA) en Personas que Viven con el VIH/sida (PVVS). Método: Revisión integradora de la literatura en seis bases de datos, realizada en marzo de 2016. Se utilizaron los descriptores "sida" y "hipertensión" en portugués, inglés y español. Se encontraron 248 artículos, entre los cuales se seleccionaron 17. Las categorías formuladas fueron "prevalencia de la HTA en PVVS", "factores de riesgo de HTA en PVVS" y "eventos adversos de la terapia antirretroviral (TAR) que contribuyen con la HTA". Resultados: No hay consenso si el VIH y la TAR influyen en el desarrollo de la HTA, pero hay varios factores de riesgo de HTA entre PVVS. Se constató que los fármacos inhibidores de la proteasa son los que más influencian en la HTA. Conclusión: Las directrices para la prevención de la HTA deben ser puestas en práctica en todos los individuos. Sin embargo, en PVVS, deberían centrarse en factores de riesgo propios de esta población.


RESUMO Objetivo: Analisar as produções científicas sobre a relação entre o HIV e Hipertensão Arterial Sistêmica (HAS) em Pessoas Vivendo com HIV/aids (PVHA). Método: Revisão integrativa da literatura em seis bases de dados, realizada no mês de março de 2016. Utilizaram-se os descritores "aids" e "hipertensão", nos idiomas português, inglês e espanhol. Foram encontrados 248 artigos e selecionados 17. As categorias formuladas foram "prevalência de HAS em PVHA", "fatores de risco para HAS em PVHA" e "eventos adversos da terapia antirretroviral (TARV) que contribuem para HAS". Resultados: Não há consenso se o HIV e TARV influenciam no desenvolvimento da HAS, mas existem diversos fatores de risco para HAS entre PVHA. Constata-se que os fármacos inibidores de protease são os que mais influenciam na HAS. Conclusão: As orientações para prevenção da HAS devem ser realizadas em todos os indivíduos, porém, nas PVHAs, devem focar nos fatores de risco característicos dessa população.


Subject(s)
Humans , Acquired Immunodeficiency Syndrome/complications , Hypertension/epidemiology , Brazil/epidemiology , HIV Infections/complications , HIV Infections/physiopathology , Prevalence , Acquired Immunodeficiency Syndrome/epidemiology , Hypertension/therapy
19.
Rev. medica electron ; 39(6): 1308-1318, nov.-dic. 2017.
Article in Spanish | LILACS, CUMED | ID: biblio-902241

ABSTRACT

La tuberculosis es un factor de riesgo en los pacientes con sida, ya que una vez iniciado el tratamiento antirretroviral pueden de desarrollar un síndrome de reconstitución inmune, lo que favorecería el deterioro del su estado clínico. Se presenta el caso de un paciente masculino, de 24 años de edad, diagnosticado de sida hace 4 años, y tratamiento irregular con antirretrovirales. Acudió al Hospital Universitario Clínico Quirúrgico "Comandante Faustino Pérez Hernández" con fiebre elevada, acompañado de cuadro general, manifestaciones respiratorias y dolor inguinal derecho. En el examen físico se constató un cuadro adénico generalizado, fue hospitalizado para estudio y tratamiento. Se diagnosticó un síndrome de reconstitución inmune en un paciente de sida con una tuberculosis diseminada, el cual fallece a pesar de la terapéutica impuesta. Este síndrome se caracteriza por una restauración gradual de la inmunidad patógeno-específica, donde el sistema inmune es capaz de reconocer patógenos presentes pero clínicamente ocultos. Se asocia a otros factores de riesgo y puede ser letal; de ahí que el reconocimiento oportuno de los pacientes con alto riesgo de contraerlo, así como un adecuado manejo sobre cuándo iniciar la terapia antirretroviral en cada caso específico, es quizá la única forma de prevenir su desarrollo (AU).


Tuberculosis is a risk factor in patients with AIDS, because once the retroviral treatment begins they can develop an immune reconstitution syndrome that would favor the deterioration of their clinical status. The case of a male patient, aged 24 years is presented. He was diagnosed with AIDS four years ago, and was irregularly treated with antiretroviral. The patient assisted the Clinic-surgical University Hospital "Comandante Faustino Pérez Hernández" with high fever accompanied by general characteristics, respiratory manifestations and right inguinal pain. At the physical examination, generalized adenic characteristics were found. A syndrome of immune reconstitution was diagnosed in an AIDS patient with disseminated tuberculosis; the patient died in spite of the imposed therapy. This syndrome is characterized by the gradual restoration of the pathogen-specific immunity, where the immune system is able of recognizing the pathogens that are present but clinically hidden. It is associated to other risk facts and may be lethal; therefore the timely recognition of the patients at high risk of suffering it, and also an adequate management about when to begin the anti-retroviral therapy in each specific case, is the unique way of preventing its development (AU).


Subject(s)
Humans , Male , Tuberculosis/complications , Acquired Immunodeficiency Syndrome/complications , Immune Reconstitution/immunology , Tuberculosis/diagnosis , Tuberculosis/mortality , Medical Records , Acquired Immunodeficiency Syndrome/mortality , Acquired Immunodeficiency Syndrome/rehabilitation , Antiretroviral Therapy, Highly Active/mortality , Alcoholism/complications
20.
Rev. chil. infectol ; 34(5): 507-510, oct. 2017. graf
Article in Spanish | LILACS | ID: biblio-899751

ABSTRACT

Resumen Las manifestaciones clínicas en los niños con infección por el virus de la inmunodeficiencia humana (VIH) de transmisión perinatal, pueden ser de inicio precoz o tardío. El linfoma asociado a VIH es una manifestación tardía que se asocia a estadios avanzados de inmunosupresión. Se presenta el caso de un escolar de 9 años con diagnóstico de novo de infección por VIH que debutó con un linfoma de Burkitt. En niños, la frecuencia de esta asociación es de 1-2% con pocos casos reportados en la literatura médica.


Children with perinatal human immunodeficiency virus (HIV) infection can present early or late clinical disease. HIV-associated lymphoma is a later manifestation that is associated with advanced immunosuppression (acquired immunodeficiency syndrome -AIDS). This is a case of a 9-year-old boy with recent diagnosis of HIV with Burkitt's lymphoma as first clinical manifestation. In children, the frequency of this association is very low and there are few cases reported.


Subject(s)
Humans , Male , Child , Burkitt Lymphoma/virology , Acquired Immunodeficiency Syndrome/complications , Acquired Immunodeficiency Syndrome/congenital , Lymphoma, AIDS-Related/virology , Magnetic Resonance Imaging , Tomography, X-Ray Computed , Burkitt Lymphoma/diagnosis , Burkitt Lymphoma/drug therapy , Treatment Outcome , Lymphoma, AIDS-Related/diagnosis , Lymphoma, AIDS-Related/drug therapy , Infectious Disease Transmission, Vertical , Disease Progression , Antiretroviral Therapy, Highly Active
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