Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 33
Filter
1.
Rev. cient. odontol ; 9(2): e057, abr.-jun. 2021. tab
Article in Spanish | LILACS, LIPECS | ID: biblio-1254596

ABSTRACT

Objetivo: Determinar la prevalencia de trastornos del gusto en pacientes niños y adolescentes diagnosticados con infección por coronavirus, a través de la evidencia en la literatura científica. Materiales y métodos: Una revisión sistemática de los artículos publicados entre el 19 de diciembre del 2019 y el 20 de diciembre del 2020 en las bases de datos Medline, Lilacs, BVS, Cochrane, SCOPUS y ScienceDirect. La estrategia de búsqueda de información se basó en el diagrama de flujo clásico de PRISMA. Para la evaluación del riesgo de sesgo, se usó la escala Newcastle-Ottawa. Resultados: Se encontraron 443 artículos en seis bases de datos y se incluyó un total de 7 artículos después de la evaluación, según los criterios de selección. Los artículos abordaron la variable de trastornos del gusto en tres formas: ageusia, disgeusia e hipogeusia, y se halló que esta manifestación clínica estaba presente desde los inicios de la infección. Conclusiones: Se ha encontrado una prevalencia de trastornos del gusto en niños y adolescentes diagnosticados con infección por coronavirus desde un 3,3% hasta un 26,9%. (AU)


Aim: To assess the prevalence of taste disorders in children and adolescents diagnosed with coronavirus infection according to the evidence reported in the scientific literature. Materials and Methods: A systematic review of articles published between December 19, 2019, and December 20, 2020 in the Medline, Lilacs, BVS, Cochrane, SCOPUS and ScienceDirect databases. The information search strategy was based on the classic PRISMA flow diagram. The Newcastle-Ottawa scale was used to assess the risk of bias. Results: 443 articles were found in six databases, and a total of 7 articles were included after evaluation according to the selection criteria. The articles addressed the variable of taste disorders in three ways: ageusia, dysgeusia and hypogeusia; finding that this clinical manifestation was present from the beginning of the infection. Conclusions: The prevalence of taste disorders in children and adolescents diagnosed with coronavirus infection is from 3.3% to 26.9%. (AU)


Subject(s)
Humans , Male , Female , Child , Adolescent , Taste Disorders , Coronavirus Infections , Ageusia , Dysgeusia
2.
Rev. inf. cient ; 100(2): e3411, mar.-abr. 2021.
Article in Spanish | LILACS, CUMED | ID: biblio-1251822

ABSTRACT

RESUMEN Introducción: Múltiples reportes de la literatura científica avalan, que los trastornos del olfato y el gusto son cada vez más frecuentes desde el inicio de la COVID-19, ofreciendo diversos mecanismos fisiopatológicos para explicar estas alteraciones. Objetivo: Sistematizar las evidencias científicas disponibles, relacionadas con alteraciones del olfato y gusto producidas por SARS-CoV-2. Método: Se desarrolló una revisión bibliográfica basada en el análisis documental, la sistematización y contrastación de la información científica realizada sobre el tema. Las búsquedas se realizaron en bases de datos disponibles (SciELO, Medline, Scopus, Medscape), con el buscador Google Académico. Desarrollo: La información se estructuró en aspectos morfofuncionales de los sistemas del olfato y el gusto; estructura y replicación del SARS-CoV-2; interacción del virus con el sistema renina-angiotensina-aldosterona, su afinidad por el receptor enzima convertidora; mecanismos fisiopatológicos de estas disfunciones. Conclusiones: Aunque se describen las alteraciones del olfato y el gusto en pacientes con COVID-19, no están totalmente esclarecidos los mecanismos fisiopatogénicos relacionados con estas disfunciones quimiosensoriales. No obstante, su aparición en ausencia de otras enfermedades respiratorias, debe alertar al personal de salud sobre la posibilidad de infección por SARS-CoV-2.


ABSTRACT Introduction: Multiple scientific reports certified that disorders of taste and smell are more frequent since COVID-19 onset, reporting various pathophysiological mechanisms to explain these alterations. Objective: To methodize the available scientific evidence related to smell and taste disorders caused by SARS-CoV-2. Method: A bibliographic review, based on the documentary analyses, systematization and contrasting view of scientific information on the topic, was carried out. Search was conducted on available databases (SciELO, Medline, Scopus, Medscape), using the web search engine Academic Google. Development: Information gathered was performed based on taste and smell morphofunctional aspects; structure and replication of SARS-CoV-2; virus interaction with renin-angiotensin-aldosterone system and its affinity for the converting enzyme receptor; pathophysiological mechanisms of these dysfunctions. Conclusions: Although alterations of smell and taste are described in patients with COVID-19, the pathophysiological mechanisms associated with these chemosensory dysfunctions are not totally clarified. However, the onset of these symptoms in absence of other respiratory illnesses should alert health care personnel concerning to a possible SARS-CoV-2 infection.


RESUMO Introdução: Diversos relatos da literatura científica sustentam que os distúrbios do olfato e do paladar são cada vez mais frequentes desde o início da COVID-19, oferecendo vários mecanismos fisiopatológicos para explicar essas alterações. Objetivo: Sistematizar as evidências científicas disponíveis relacionadas às alterações de olfato e paladar produzidas pelo SARS-CoV-2. Método: Foi desenvolvida uma revisão bibliográfica a partir da análise documental, da sistematização e do contraste das informações científicas realizadas sobre o assunto. As buscas foram realizadas nas bases de dados disponíveis (SciELO, Medline, Scopus, Medscape), com a ferramenta de busca Google Scholar. Desenvolvimento: A informação foi estruturada em aspectos morfofuncionais dos sistemas olfativo e gustativo; estrutura e replicação de SARS-CoV-2; interação do vírus com o sistema renina-angiotensina-aldosterona, sua afinidade pelo receptor enzima conversora; mecanismos fisiopatológicos dessas disfunções. Conclusões: Embora as alterações do olfato e do paladar sejam descritas em pacientes com COVID-19, os mecanismos fisiopatogênicos relacionados a essas disfunções quimiossensoriais não estão totalmente esclarecidos. No entanto, seu aparecimento na ausência de outras doenças respiratórias deve alertar o pessoal de saúde para a possibilidade de infecção pelo SARS-CoV-2.


Subject(s)
Ageusia/physiopathology , SARS-CoV-2 , Anosmia/physiopathology , COVID-19/etiology , COVID-19/physiopathology
4.
Rev. gaúch. enferm ; 42(spe): e20200205, 2021. tab, graf
Article in English | LILACS, BDENF | ID: biblio-1251789

ABSTRACT

ABSTRACT Objective To identify symptoms of COVID-19 in adults in the scientific literature. Method Systematic review of studies published from December 1, 2019 to April 21, 2020 from the Scopus, Web of Science and PubMed databases, in order to answer the following research question: "What are the symptoms caused by COVID-19 in adults?" using the keywords "Symptoms", "Clinical Manifestations", "Coronavirus", "COVID-19". Results Of the total 105 references, 13 references that addressed the symptoms of COVID-19 were selected. Fever and normal or dry cough were symptoms present in all studies. Conclusion The symptoms identified in adult patients were fever, normal or dry cough, headache, pharyngalgia, dyspnea, diarrhea, myalgia, vomiting, sputum or expectoration, anxiety or chest pain, fatigue, nausea, anorexia, abdominal pain, rhinorrhea, runny nose or nasal congestion, dizziness, chills, systemic pain, mental confusion, hemoptysis, asthma, taste disorder, smell disorder, belching and tachycardia.


RESUMEN Objetivo Verificar en la literatura científica las manifestaciones sintomáticas de COVID-19 en adultos. Método Una revisión sistemática realizada en las bases de datos Scopus, Web of Science y PubMed con estudios publicados del 1 de diciembre de 2019 al 21 de abril de 2020, con el fin de responder a la pregunta orientadora: "¿Cuáles son las manifestaciones sintomáticas causada por COVID-19 en adultos?" utilizando las palabras clave: "Síntomas", "Manifestaciones clínicas", "Coronavirus", "COVID-19". Resultados Del total de 105 referencias, se seleccionaron 13 que abordaron las manifestaciones sintomáticas de COVID-19, con fiebre y tos normal o seca presente en todos los estudios. Conclusión Las manifestaciones sintomáticas identificadas en pacientes adultos fueron: fiebre, tos normal o seca, dolor de cabeza, faringalgia, disnea, diarrea, mialgia, vómitos, esputo o expectoración, angustia o dolor en el pecho, fatiga, náuseas, anorexia, dolor abdominal, rinorrea, secreción nasal o congestión nasal, mareos, escalofríos, dolor sistémico, confusión mental, hemoptisis, asma, alteración del gusto, alteración del olfato, eructos y taquicardia.


RESUMO Objetivo Verificar na literatura científica as manifestações sintomáticas da COVID-19 em pessoas adultas. Método Revisão sistemática utilizando as bases Scopus, Web of Science e PubMed com estudos publicados de 1 de dezembro de 2019 a 21 de abril de 2020, a fim de responder à questão norteadora: "Quais as manifestações sintomáticas causada pela COVID-19 em pessoas adultas?" utilizando-se as palavras-chave: "Symptoms", "Clinical Manifestations", "Coronavirus", "COVID-19". Resultados Do total de 105 referências, foram selecionadas 13 que abordaram as manifestações sintomáticas da COVID-19, estando a febre e a tosse normal ou seca presente em todos os estudos. Conclusão As manifestações sintomáticas identificadas nos pacientes adultos foram: febre, tosse normal ou seca, cefaleia, faringalgia, dispneia, diarreia, mialgia, vômito, escarro ou expectoração, angústia ou dor no peito, fadiga, náusea, anorexia, dor abdominal, rinorreia, coriza ou congestão nasal, tontura, calafrios, dor sistêmica, confusão mental, hemoptise, asma, comprometimento do paladar, comprometimento do olfato, arroto e taquicardia.


Subject(s)
Humans , Male , Female , Adult , General Symptoms , SARS-CoV-2 , COVID-19 , Asthma , Vomiting , Anorexia , Databases, Bibliographic , Cough , Ageusia , Diarrhea , Dizziness , Fatigue , Fever , Olfaction Disorders
5.
Rev. argent. salud publica ; 13(Suplemento COVID-19): 1-6, 2021.
Article in Spanish | LILACS, BINACIS, ARGMSAL | ID: biblio-1151491

ABSTRACT

INTRODUCCIÓN: Existen evidencias sobre el deterioro del olfato y el gusto en pacientes con la enfermedad por el nuevo coronavirus (COVID-19). Se hallaron diferencias en la proporción de pacientes afectados por estos síntomas en distintas poblaciones. Con base en el patrón de presentación, a partir de abril de 2020, la definición de caso sospechoso en Argentina incorporó la pérdida parcial o total de olfato o de gusto. El objetivo de este estudio fue evaluar la proporción de pacientes con COVID-19 que presentan pérdida de olfato o de gusto en Argentina. MÉTODOS: Estudio multicéntrico. Participaron pacientes con COVID-19 mayores de 18 años confirmados con reacción en cadena de la polimerasa en tiempo real (RT-PCR, por sus siglas en inglés) en muestras obtenidas por hisopado entre el 15 de mayo y el 31 de agosto de 2020. Los participantes completaron una encuesta en línea, que incluyó preguntas sociodemográficas sobre síntomas de COVID-19, comorbilidades y la percepción de la pérdida del olfato y el gusto. RESULTADOS: Participaron 241 pacientes, 79% informaron pérdida de olfato y 54%, de gusto. En 32% de los casos, la pérdida de olfato fue el primer síntoma. La proporción de hombres y mujeres que informaron pérdida olfativa fue similar y lo mismo ocurrió en relación con la pérdida de gusto. Tampoco se observaron diferencias en relación con la edad. DISCUSIÓN: Una proporción elevada de pacientes con COVID-19 presenta disfunción olfativa y gustativa en la población argentina. Resulta importante la disponibilidad amplia de un test para la evaluación del olfato y el gusto con adaptación sociocultural y que pueda realizarse en el hogar. En el futuro, se implementará la realización de un test masivo desechable y digital


Subject(s)
Rehabilitation , Coronavirus Infections , Ageusia , Olfaction Disorders
6.
Cienc. tecnol. salud ; 7(3): 381-395, 26 de noviembre 2020. ^c27 cmilus
Article in Spanish | LILACS, LIGCSA, DIGIUSAC | ID: biblio-1130181

ABSTRACT

La Enfermedad por Coronavirus 2019 (COVID-19) supone un reto sin precedentes para la salud pública. Los médicos deben fortalecer sus habilidades clínicas para combatir esta nueva enfermedad. El objetivo de esta revisión fue describir los signos, síntomas y complicaciones de pacientes con COVID-19. Se realizó una búsqueda en la literatura en la base de datos PubMed incluyendo publicaciones entre 1 de diciembre 2019 y 15 de agosto 2020, sin restricciones de lenguaje, utilizando las palabras clave 'COVID-19' cruzada con 'manifestaciones clínicas', 'signos y síntomas' y 'complicaciones'. Se incluyeron revisiones sistemáticas y meta-análisis, estudios epidemiológicos y series de casos. Se identificaron 1,066 artículos, de los cuales se seleccionaron 71 de acuerdo a los contenidos previamente definidos por los autores. La COVID-19 presenta un curso de leve a moderado y severo-crítico, específicamente en mayores de 65 años con o sin comorbilidades. Los signos y síntomas no son específicos y usualmente se superponen de acuerdo a la edad y a la fase de la enfermedad. Los síntomas más comunes son fiebre, tos y fatiga. Síntomas menos comunes incluyen escalofríos, dolor de garganta, cefalea, mialgias/artralgias, pérdida del gusto y del olfato, diarrea, nausea, vómitos, congestión nasal, palpitaciones, opresión precordial y dolor pleurítico. La sintomatología en niños difiere de la de los adultos y el curso es usualmente benigno y de baja mortalidad. La evaluación clínica de COVID-19 supone un reto hoy en día. Sin embargo, el conocimiento de la historia natural de la enfermedad permite situar los síntomas comunes e inespecíficos en el contexto clínico correcto.


Coronavirus disease 2019 (COVID-19) presents an unprecedented challenge to public health. Physicians must strengthen clinical skills for this new disease. This review aimed to describe the signs, symptoms and complications of patients with COVID-19. A literature search was conducted in the PubMed database, including publications between December 1, 2019, to August 15, 2020, without language restrictions, using the keywords 'COVID-19' crossed with 'clinical manifestations', 'signs and symptoms', and 'complications'. Systematic reviews, meta-analysis, epidemiological studies, and case report series were included. A total of 1,066 articles were identi¬fied, among 71 were selected according to the contents previously defined by the authors. COVID-19 has a mild to moderate or severe-critical course, specifically in over 65 years of age, with or without comorbidities. Signs and symptoms are not specific and usually overlap according to the age and stage of the disease. The most common symptoms are fever, cough, and fatigue. Less common symptoms include chills, sore throat, headache, myalgia/ arthralgia, loss of taste and smell, diarrhea, nausea, vomiting, nasal congestion, palpitations, chest tightness, and pleuritic pain. The symptomatology in children differs from that of adults, and the course is usually benign and low mortality. Clinical evaluation of COVID-19 is challenging today. However, knowledge of the disease's natural history allows placing common and nonspecific symptoms in the correct clinical context.


Subject(s)
Humans , Male , Female , Child , Adult , Middle Aged , Aged , Signs and Symptoms , Betacoronavirus , COVID-19 , Pharyngitis , Cough , Ageusia , Diarrhea , Fever , Myalgia , Headache , Literature , Olfaction Disorders , Nausea
7.
Rev. méd. Maule ; 35(1): 8-10, oct. 2020.
Article in Spanish | LILACS | ID: biblio-1366362

ABSTRACT

The infection caused by the SARS-CoV-2 virus, recently described in Wuhan, China, has put numerous health systems around the world in check. Given its high contagiousness and the exponential growth of cases, it was declared a pandemic by the world health organization. Although the majority of those infected will present mild symptoms, a smaller percentage will present severe manifestations of the disease, such as acute respiratory distress syndrome, requiring ventilator support measures and stays in intensive care units. The main symptoms described in SARS-CoV-2 infection are fever, fatigue, dry cough and myalgia. Despite this, there is a not insignificant number of patients who present with atypical symptoms of the disease, some described are anosmia, ageusia, gastrointestinal symptoms like diarrhea, dermatological manifestations, among others. In these patients it is particularly where the diagnosis is made late, delaying isolation and prevention measures, thus increasing the risk of contagion within the population.


Subject(s)
Humans , Male , Adult , Pandemics , COVID-19 , Quarantine , Ageusia , COVID-19 Nucleic Acid Testing , Anosmia , Olfaction Disorders/complications
9.
Arq. neuropsiquiatr ; 78(5): 290-300, May 2020. tab, graf
Article in English | LILACS | ID: biblio-1131705

ABSTRACT

ABSTRACT Background: As the COVID-19 pandemic unfolds worldwide, different forms of reports have described its neurologic manifestations. Objective: To review the literature on neurological complications of SARS-CoV-2 infection. Methods: Literature search performed following systematic reviews guidelines, using specific keywords based on the COVID-19 neurological complications described up to May 10th, 2020. Results: A total of 43 articles were selected, including data ranging from common, non-specific symptoms, such as hyposmia and myalgia, to more complex and life-threatening conditions, such as cerebrovascular diseases, encephalopathies, and Guillain-Barré syndrome. Conclusion: Recognition of neurological manifestations of SARS-CoV-2 should be emphasized despite the obvious challenges faced by clinicians caring for critical patients who are often sedated and presenting other concurrent systemic complications.


RESUMO Introdução: À medida que a pandemia da COVID-19 se desenvolve em todo o mundo, diferentes tipos de publicações descreveram suas manifestações neurológicas. Objetivo: Revisar a literatura sobre complicações neurológicas da infecção por SARS-CoV-2. Métodos: A pesquisa bibliográfica foi realizada seguindo diretrizes de revisões sistemáticas, usando palavras-chave específicas baseadas nas complicações neurológicas da COVID-19 descritas até 10 de maio de 2020. Resultados: Foram selecionados 43 artigos, incluindo descrições que variam de sintomas comuns e inespecíficos, como hiposmia e mialgia, a condições mais complexas e com risco de vida, como doenças cerebrovasculares, encefalopatias e síndrome de Guillain-Barré. Conclusão: O reconhecimento das manifestações neurológicas da SARS-CoV-2 deve ser enfatizado apesar dos óbvios desafios enfrentados pelos clínicos que cuidam de pacientes críticos, muitas vezes sedados e apresentando outras complicações sistêmicas concomitantes.


Subject(s)
Humans , Pneumonia, Viral/complications , Coronavirus Infections/complications , Nervous System Diseases/complications , Brain Diseases/complications , Cerebrovascular Disorders/complications , Cerebrovascular Disorders/physiopathology , Coronavirus Infections , Guillain-Barre Syndrome/complications , Ageusia/complications , Pandemics , Myalgia/complications , Olfaction Disorders/complications , Nervous System Diseases/physiopathology
10.
Rev. RENE ; 17(4): 483-489, jul.-ago. 2016.
Article in English, Portuguese | LILACS, BDENF | ID: biblio-835663

ABSTRACT

Avaliar a percepção sensorial de pacientes com Diabetes Mellitus tipo 2, por meio do teste de índicelimiar para o gosto doce. Métodos: estudo transversal, composto por 80 adultos de ambos os sexos, divididosem dois grupos: controle, composto por não diabéticos, e teste, formado por pacientes diabéticos. Avaliação dapercepção sensorial realizada pelo teste de sensibilidade para determinação do índice limiar. Testes conduzidosem cinco sessões, contendo as concentrações diferentes de sacarose. Análise estatística por meio do teste t,adotado p˂0,05. Resultados: ao comparar a média dos limiares para detecção do gosto doce entre diabéticos enão diabéticos foi notório que os diabéticos são menos sensíveis ao estímulo doce. Conclusão: indivíduos comDiabetes Mellitus 2 apresentam valor de índice limiar maior para o gosto doce, o que pode contribuir para oaumento do consumo de açúcar.


Objective: to evaluate the perception of patients with type 2 diabetes through the threshold index test for the sweet taste. Methods: a cross-sectional study with 80 adults of both genders, divided into two groups: control, composed of non-diabetics, and test, with diabetic patients. The evaluation of sensory perception held by the sensitivity test to determine the threshold index. The tests were conducted on five sections containing different concentrations of sucrose. Statistical analysis was held using the t test, adopted P<0.05. Results: when comparing the average of the thresholds to detect sweet taste between diabetics and non-diabetics, it was known that diabetics are less sensitive to sweet stimuli. Conclusion: individuals with Diabetes Mellitus 2 have higher threshold index value for the sweet taste, which may contribute to the increase in sugar consumption.


Subject(s)
Humans , Male , Female , Adult , Ageusia , Sensory Thresholds , Taste Perception
11.
Article in Korean | WPRIM | ID: wpr-206080

ABSTRACT

No abstract available.


Subject(s)
Ageusia , Humans , Myasthenia Gravis , Thymoma
12.
Intestinal Research ; : 317-322, 2013.
Article in Korean | WPRIM | ID: wpr-55521

ABSTRACT

Cronkhite-Canada syndrome (CCS) is a rare, noninherited gastrointestinal polyposis syndrome associated with ectodermal changes such as alopecia, nail dystrophy, and cutaneous hyperpigmentation. The etiology and pathogenesis of CCS are not known, but diarrhea, malnutrition, gastrointestinal bleeding, and infection may occur in the affected patient; moreover, this condition could be fatal. However, previous reports have described several cases of spontaneous remission. We report a 60-year-old man who was incidentally found to have colonic polyposis, alopecia, and hypogeusia and was diagnosed to have CCS. However, this patient experienced spontaneous remission, including regrowth of body hair and alleviation of bowel inflammation, without any specific medications such as steroids, antibiotics, or proton pump inhibitors.


Subject(s)
Ageusia , Alopecia , Anti-Bacterial Agents , Colon , Diarrhea , Ectoderm , Hair , Hemorrhage , Humans , Hyperpigmentation , Inflammation , Intestinal Polyposis , Malnutrition , Middle Aged , Nails , Proton Pump Inhibitors , Remission, Spontaneous , Steroids
14.
JPAD-Journal of Pakistan Association of Dermatologists. 2012; 22 (4): 363-365
in English | IMEMR | ID: emr-155633

ABSTRACT

Terbinafine is an oral antimycotic agent that belongs to the allylamine class. It was introduced in 1991 and is being widely used, both topically and systemically, to treat fungal infections. Nowadays oral terbinafine has become a commonly prescribed drug to treat finger- and toenail fungal infections because of relatively short duration of treatment compared to other oral antifungals like griseofulvin and fluconazole. The common side effects of this drug include nausea, abdominal pain, elevated transaminases and allergic reactions. Loss of taste sensation is a rare side effect occurring in patient taking oral form of this drug. PubMed search showed that very few cases of terbinafineinduced taste loss have been reported worldwide. We report a case series of two patients who complained of taste loss after taking terbinafine


Subject(s)
Humans , Male , Female , Middle Aged , Taste Disorders/chemically induced , Taste , Ageusia
15.
Article in Chinese | WPRIM | ID: wpr-746732

ABSTRACT

OBJECTIVE@#To explore changes of olfactory and gustatory functions in patients with olfactory dysfunction.@*METHOD@#The 284 study subjects included 92 healthy volunteers, 92 with hyposmia and 100 with functional anosmia. Their olfactory and gustatory functions were examined using T&T olfactometer, olfactory event-related potentials (OERPs) and triple drop method, respectively.@*RESULT@#The T&T results showed that the difference between patients with hyposmia and functional anosmia and healthy subjects had statistical significance. The OERPs results showed that patients with olfactory dysfunction had N1 and P2 waves of prolonged latency and reduced amplitude when compared to healthy subjects with the difference of statistical significance. When compared to healthy subjects, patients with olfactory dysfunction had clear hypogeusia and the difference had statistical significance. There was no significant difference between female and male groups.@*CONCLUSION@#It is suggested that the apparently concomitant hypogeusia is in patients with olfactory dysfunction. Decreased of olfactory and gustatory function exhibited little or no relationship with gender. Combined examinations of OERPs, T&T and triple drop method, could make it possible to reflect the overall chemical sensory functions in subjects systematically and provide scientific evidence for clinical diagnosis and treatment early.


Subject(s)
Adolescent , Adult , Aged , Ageusia , Diagnosis , Case-Control Studies , Evoked Potentials , Female , Humans , Male , Middle Aged , Olfaction Disorders , Diagnosis , Smell , Taste , Young Adult
16.
Radiol. bras ; 44(6): 388-395, nov.-dez. 2011. tab
Article in Portuguese | LILACS | ID: lil-611520

ABSTRACT

A radioterapia em região de cabeça e pescoço provoca inúmeras sequelas ao paciente irradiado, afetando o sistema estomatognático e com repercussões sistêmicas importantes. As sequelas da radiação ionizante podem ser extensas e, algumas vezes, permanentes, em especial nas glândulas salivares e no tecido ósseo. É relevante que o cirurgião dentista tenha conhecimento das reações adversas e das formas adequadas de prevenção e tratamento para amenizar o desconforto e melhorar a condição de vida do paciente irradiado. Portanto, a conscientização e motivação deste paciente, com a promoção de saúde oral através da adequação do meio bucal e orientações sobre ações preventivas, são essenciais para se obter o melhor prognóstico.


Head and neck radiotherapy causes countless sequelae in irradiated patients, affecting the stomatognathic system, with significant systemic implications. Sequelae of exposure to ionizing radiation may be extensive and sometimes permanent, particularly in the salivary glands and bone tissue. It is of utmost importance that the surgeon dentist be aware of adverse reactions and appropriate forms of treatment to alleviate discomfort and improve the quality of life of the irradiated patient. Therefore, awareness and motivation of the patient, with promotion of oral health through the adaptation of the oral environment and guidance on preventive measures are essential to get a better prognosis.


Subject(s)
Humans , Head and Neck Neoplasms , Radiobiology , Radiotherapy , Radiotherapy/adverse effects , Ageusia , Dysgeusia , Opportunistic Infections , Osteoradionecrosis , Periodontal Diseases , Stomatitis , Trismus , Xerostomia
17.
Radiol. bras ; 44(5): 297-300, set.-out. 2011. tab
Article in Portuguese | LILACS | ID: lil-612931

ABSTRACT

OBJETIVO: Avaliar os efeitos da radiação ionizante sobre o paladar, em pacientes que foram submetidos a radioterapia na região de cabeça e pescoço. MATERIAIS E MÉTODOS: Foram selecionados 20 pacientes que possuíam diagnóstico de tumor na região de cabeça e pescoço, que iniciaram tratamento no Setor de Radioterapia da Santa Casa de Misericórdia de Belo Horizonte, MG, Brasil. Para testes do paladar, foram manipuladas quatro soluções (salgada - NaCl; doce - sacarose; azeda - ácido cítrico; amarga - ureia) em três concentrações diferentes (fraca, média e forte), administradas por meio de conta-gotas, três gotas de cada solução de maneira aleatória, respeitando a ordem das concentrações fracas, médias e fortes. Após a aplicação de cada solução, o paciente relatava o sabor que sentia. O procedimento foi realizado semanalmente durante as três primeiras semanas de radioterapia. RESULTADOS: Foi observada diferença estatisticamente significante na perda do paladar dos pacientes em tratamento radioterápico, quando se compararam a 1ª e 4ª semanas de tratamento na solução salgada, nas três concentrações, na solução doce nas concentrações fracas e médias e nas soluções azedas e amargas, apenas quando se testaram as concentrações fracas. CONCLUSÃO: A radiação ionizante altera o paladar de pacientes submetidos a radioterapia de cabeça e pescoço.


OBJECTIVE: To evaluate the effects of ionizing radiation on the taste function in patients submitted to radiotherapy in the head and neck region. MATERIALS AND METHODS: Twenty patients diagnosed with head and neck tumors and undergoing treatment in the Division of Radiotherapy at Santa Casa de Misericórdia de Belo Horizonte, MG, Brazil, were selected. For their taste function testing, four solutions were manipulated with salt (NaCl), sugar (sucrose), citric acid (for acidity), and urea (for bitterness), at three different (low, medium and high) concentrations. Weekly tests were performed during the first three weeks of radiotherapy, with random administration of the solutions (three drops each) respecting the order of their concentration levels (low, medium and high). After the application of each solution, the patient reported which flavor he/she tasted. RESULTS: A statistically significant difference was observed in the loss of taste function as the results in the 1st and 4th weeks of treatment were compared, with salty solution at the three concentration levels, with the sweet solution at low and medium concentrations, and with the sour and bitter solutions, only at low concentration. CONCLUSION: Ionizing radiation alters the taste function of patients submitted to head and neck radiotherapy.


Subject(s)
Humans , Adolescent , Young Adult , Middle Aged , Ageusia , Ageusia/complications , Head and Neck Neoplasms/radiotherapy , Head and Neck Neoplasms , Medical History Taking , Radiation, Ionizing , Radiobiology , Radiotherapy/adverse effects , Taste
18.
Article in Korean | WPRIM | ID: wpr-656013

ABSTRACT

BACKGROUND AND OBJECTIVES: Phenylthiocarbamide (PTC) and its chemically related compound,6-n-propylthiouracil (PROP), both produce a taste that is extremely bitter to some subjects (tasters) but tasteless or only slightly bitter to others (non-tasters). Earlier studies had used PTC, but most investigators have switched to PROP because of its several advantages. Recently, three single nucleotide polymorphisms in the TAS2R38 gene were identified and several studies have demonstrated a strong association between these genes with taster status. The aim of this study was to investigate the relationship between taste thresholds of PTC and PROP and their correlation with the TAS2R38 genotype. SUBJECTS AND METHOD: Seventy-five healthy normal volunteers were included. Taster status was determined using successive solutions of PTC and PROP, which comprised a total of 15 grades. All participants were genotyped for polymorphism of the TAS2R38 gene that affects taste sensitivity to PTC and PROP. RESULTS: PTC taste thresholds showed 96% correlation with the taste thresholds for PROP. Non-tasters defined by the PTC threshold test were the exactly the same with those identified as AVI (alanine, valine, isoleucine) homozygous, but taster status determined by the PROP threshold test showed 96% correlation with the genotypes. CONCLUSION: The PTC threshold test was more reliable for determining taste blindness than the PROP threshold test.


Subject(s)
Ageusia , Factor IX , Genotype , Humans , Phenylthiourea , Polymorphism, Single Nucleotide , Research Personnel , Taste Threshold , Valine
19.
Odonto (Säo Bernardo do Campo) ; 16(31): 62-68, jan.-jun. 2008. ilus, tab
Article in Portuguese | LILACS, BBO | ID: lil-542827

ABSTRACT

O paciente sob tratamento oncológico, ao receber atenção do Cirurgião-Dentista (CD), necessita de cuidados especiais, assim, seria relevante que o profissional conhecesse as reações adversas do tratamento radioterápico na boca e nas regiões circunvizinhas, atuando na tentativa de amenizar o desconforto e melhorar a condição de vida do seu paciente. Considerando que a radioterapia de cabeça e pescoço pode trazer seqüelas extensas e, algumas vezes, permanentes, em especial nas glândulas salivares e no tecido ósseo, nosso objetivo é revisar tais efeitos e respectivos tratamentos, propostos na literatura. Ficou evidente após este estudo a significante importância do Cirurgião-Dentista no manejo adequado do paciente submetido à radiação de cabeça e pescoço.


The patient undergoing oncology treatment needs special care when assisted by the dental surgeon. Therefore, it would be quite relevant that the clinician were aware of the adverse reactions of radiotherapy on the mouth and surrounding regions, in order to attempt to minimize discomfort and improve the patient’s life condition. Considering that head and neck radiotherapy can cause extensive sequelae – sometimes permanent ones – particularly on the salivary glands and bone tissue, our aim is to revise these effects and their respective treatments, as proposed in literature. After this study, the significant importance of the dental surgeon became evident for the adequate management of the patient subjected to radiation treatment on the head and neck.


Subject(s)
Mouth Diseases/complications , Mouth Diseases , Radiation Effects , Radiotherapy/adverse effects , Ageusia , Mucositis , Osteoradionecrosis , Periodontal Diseases , Trismus , Xerostomia
20.
Article in English | WPRIM | ID: wpr-83652

ABSTRACT

OBJECTIVE: We studied whether frontal skull base fracture has an impact on the occurrence and recovery of anosmia and/or ageusia following frontal traumatic brain injury (TBI). METHODS: Between May 2003 and April 2005, 102 consecutive patients who had hemorrhage or contusion on the frontal lobe base were conservatively treated. Relevant clinical and radiographic data were collected, and assessment of impaired smell and taste sensation were also surveyed up to at least 12 months post-injury. RESULTS: Among 102 patients, anosmia was noted in 22 (21.6%), of whom 10 had ageusia at a mean 4.4 days after trauma. Bilateral frontal lobe injuries were noted in 20 of 22 patients with anosmia and in all 10 patients with ageusia. Frontal skull base fracture was noted in 41 patients, of whom 9 (21.4%) had anosmia and 4 (9.5%) had ageusia. There was no statistical difference in the occurrence of anosmia and ageusia between patients with or without fracture. Of the 22 patients with anosmia, recovery from anosmia occurred in nine (40.9%) at the interval of 6 to 24 months after trauma, of whom six had frontal skull base fracture and three were not associated with fracture. Recovery of anosmia was significantly higher in patients without fracture than those with fracture (p<0.05). Recovery from ageusia occurred in only two of 10 patients at the interval of 18 to 20 months after trauma and was not eminent in patients without fracture. CONCLUSION: One should be alert and seek possibile occurrence of the anosmia and/or ageusia following frontal TBI. It is suggested that recovery is quite less likely if such patients have fractures on the frontal base, and these patients should wait for at least 6 to 18 months to anticipate such recovery if there is no injury to the central olfactory structures.


Subject(s)
Ageusia , Brain Injuries , Contusions , Frontal Lobe , Hemorrhage , Humans , Incidence , Olfaction Disorders , Sensation , Skull Base , Smell
SELECTION OF CITATIONS
SEARCH DETAIL