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Neumol. pediátr. (En línea) ; 14(3): 180-183, sept. 2019. ilus
Article in Spanish | LILACS | ID: biblio-1087790


Hydatid disease is a zoonosis caused by Echinococcus granulosus, and represents a global public health problem. In children the pulmonary location is the most frequent. The hydatid cyst can be asymptomatic and present symptoms when breaking into the bronchial tree or pleura. We present a case of complicated pulmonary hydatid cyst in a 14-year-old girl from Morocco, where this disease is endemic. The initial clinical picture simulated a lung abscess. The management was surgical, associated with albendazole treatment, with a good clinical evolution.

La enfermedad hidatídica es una zoonosis producida por el Echinococcus granulosus, y representa un problema mundial de salud pública. En niños la localización pulmonar es la más frecuente. El quiste hidatídico puede ser asintomático y presentar síntomas al romperse hacia el árbol bronquial o pleura. Presentamos un caso de quiste hidatídico pulmonar complicado en una niña de 14 años residente en Marruecos, donde esta enfermedad es endémica. El cuadro clínico inicial simuló un absceso pulmonar. El manejo fue quirúrgico, asociado a tratamiento con albendazol, con una buena evolución clínica.

Humans , Female , Adolescent , Echinococcosis, Pulmonary/surgery , Echinococcosis, Pulmonary/drug therapy , Echinococcosis, Pulmonary/diagnostic imaging , Radiography, Thoracic , Tomography, X-Ray Computed , Albendazole/therapeutic use , Anthelmintics/therapeutic use
Gastroenterol. latinoam ; 30(2): 107-112, 2019. ilus
Article in Spanish | LILACS | ID: biblio-1103913


Intestinal parasitic infections cause a not insignificant number of chronic diarrhea in children, however, with the sociodemographic change that our country has experienced, the number of cases and new parasites (immigration from tropical endemic areas) could increase. We report the case of an immunocompetent patient who presents with chronic diarrhea associated with Strongyloides stercoralis infection. The patient migrated two years ago from an endemic area for this helminth. The diagnosis is challenging, and the chances of a successful outcome depend on the administration of the antiparasitic.

Las infecciones parasitarias intestinales provocan un número no despreciable de causas de diarrea crónica en niños, sin embargo, con el cambio sociodemográfico que ha vivido nuestro país se podría incrementar el número de casos y de nuevos parásitos (inmigración de áreas endémicas tropicales). Reportamos el caso de un paciente inmunocompetente, que presenta cuadro de diarrea crónica asociada a infección por Strongyloides stercoralis. El paciente habría migrado hace dos años desde zona endémica para este helminto. El diagnóstico es desafiante y las posibilidades de un resultado exitoso dependen de la administración del antiparasitario.

Humans , Male , Adult , Strongyloidiasis/diagnosis , Strongyloidiasis/drug therapy , Intestinal Diseases, Parasitic/diagnosis , Intestinal Diseases, Parasitic/drug therapy , Strongyloidiasis/parasitology , Tomography, X-Ray Computed , Albendazole/therapeutic use , Strongyloides stercoralis/isolation & purification , Diarrhea/etiology , Immunocompetence , Intestinal Diseases, Parasitic/parasitology
Rev. Soc. Bras. Med. Trop ; 51(6): 861-863, Nov.-Dec. 2018. graf
Article in English | LILACS | ID: biblio-977098


Abstract Cysticercosis is caused by the hematogenous dissemination of the larval form (cysticercus) of Taenia solium. It can affect any organ or tissue in the body but commonly affects the subcutaneous tissue, central nervous system, eyes, and skeletal muscle. Skin lesions can assist as a marker in the diagnosis of asymptomatic neurocysticercosis in endemic areas. A 49-year-old HIV positive man presented with multiple cutaneous nodules confirmed as cysticercomas which led to the diagnosis of asymptomatic neurocysticercosis. He was successfully treated with albendazole and steroids at recommended doses with no adverse effects.

Humans , Male , Cysticercosis/diagnosis , AIDS-Related Opportunistic Infections/diagnosis , Cysticercosis/drug therapy , Prednisone/therapeutic use , Albendazole/therapeutic use , AIDS-Related Opportunistic Infections/ethnology , Neurocysticercosis/drug therapy , Neurocysticercosis/diagnostic imaging , Subcutaneous Tissue/parasitology , Middle Aged
LMJ-Lebanese Medical Journal. 2018; 66 (1): 61-62
in French | IMEMR | ID: emr-170978


Background: Potential irritation and ocular damage can result from topical treatment of phthiriasis palpebrarum

Case: We report the case of a 7-year-old boy who presented a phthiriasis palpebrarum infection showing no response to classic treatments, treated successfully with albendazole per os

Conclusion: Albendazole could be considered a therapeutic option for phthiriasis palpebrarum

Humans , Male , Child , Albendazole/therapeutic use
Rev. méd. Maule ; 33(1): 34-39, jun. 2017. ilus
Article in Spanish | LILACS | ID: biblio-1284406


Cardiac hydatidosis without involvement of extracardiac organs is an uncommun condition. We report a case of a 20 years old female without any prior disease, she consult for progressive dyspnea and palpitations. Echocardiogram and cardiac MRI shows cystic lesion in apical intraventricular septum suggestive of hydatid cyst. No other organs were affected. The patient underwent surgery with successful removal of hydatid cyst and medical treatment with Albendazole, after that, the patient remains asymptomatic.

Humans , Female , Adult , Echinococcosis/complications , Heart Diseases/complications , Heart Diseases/parasitology , Echocardiography , Tomography, X-Ray Computed , Albendazole/therapeutic use , Chile , Echinococcosis/drug therapy
Rev. bras. neurol ; 53(1): 5-14, jan.-mar. 2017. tab
Article in English | LILACS | ID: biblio-832724


Neurocysticercosis (NCC) is the brain infection caused by larval stages of the helminth Taenia solium. The embryos of Taenia travel through the bloodstream and can reach the brain, muscles, eyes, and various organs. In the brain, the psychiatric manifestations are mood disorders, depression and anxiety, which are commonly associated with epilepsy and sensory-motor deficits. Neurocysticercosis is a frequent parasitic disease in the world population; it is endemic in Central and South America, Asia and Sub-Saharan Africa. In the present review, we report the major symptoms and signals of neurocysticercosis common to neurological and psychiatric illnesses. We briefly present Epidemiology of those manifestations and analyze the relationship between pathological changes and NCC symptomatology. OBJECTIVES AND METHODOLOGY: A literature review was conducted to characterize epidemiological, neurological and psychiatric manifestations of NCC. The final 90 papers were selected of a set of 937 publications from 2010 to 2016. RESULTS: NCC is a major cause of epilepsy in endemic areas; further- more, leads to a diversity of motor and sensitive deficits, manifestations vary from headache to severe intracranial hypertension. Potentially fatal conditions include arteritis, encephalitis and hydrocephalus. Depression and cognitive decline remain among the most important psychiatric manifestations. Neuropsychiatric manifestations, Epidemiology, and neuroimaging provide diagnostic criteria. Brain scans may reveal one or diverse cysts filled with fluid within a scolex (parasite's head). CONCLUSION: NCC's diversity of presentations encourage health professionals to consider it in diagnoses, especially in endemic countries, and also in non-endemic areas because migrants and travelers are subject to contagious. Treatment consists in use of antiparasitic drugs (albendazol, praziquantel) and drugs to treat associated conditions (anticonvulsants, corticosteroids). Surgery is reserved to extirpate the parasite from particular locations (eyes, spinal cord, cerebral ventricles) or to differentiate NCC from tumors, tuberculosis, mycosis, etc. Prevention includes treatment of intestinal helminthiasis, sanitation in animal farming, food preparing hygiene, quality control of water and food.

Neurocisticercose é a infecção cerebral causada pelos estágios lar- vais do helminto Taenia solium. Os embriões da Taenia deslocam-se através da corrente sanguínea e podem atingir o cérebro, músculos, olhos e vários órgãos. No cérebro, as manifestações psiquiátricas são transtornos de humor, depressão e ansiedade, as quais estão comumente associados com epilepsia e deficiências sensório-motoras. Neurocisticercose é uma parasitose frequente na população mundial, é endêmica na América Central e do Sul, Ásia e África subsaariana. Na presente revisão, relatamos os principais sintomas e sinais de neurocisticercose pertinentes a doenças neurológicas e psiquiátricas. Nós brevemente apresentamos a Epidemiologia dessas manifestações, e analisamos a relação entre alterações patológicas e sintomatologia da NCC. OBJETIVOS E METODOLOGIA: Uma revisão da literatura foi conduzida para caracterizar a epidemiologia, as manifestações neurológicas e psiquiátricas de NCC. Os 90 artigos finais foram selecionados de um conjunto de 937 publicações entre 2010 a 2016. RESULTADOS: NCC é uma importante etiologia de epilepsia em áreas endêmicas, além disso causa uma diversidade de deficiências motoras e sensoriais, as manifestações variam de cefaleia a severa hipertensão intracraniana. Condições potencialmente fatais incluem arterites, encefalites e hidrocefalia. Depressão e declíneo cognitive permanecem entre as mais importantes manifestações psiquiátricas. Manifestações neuropsiquiátricas, epidemiologia e neuroimagem provêm os critérios de diagnóstico. As imagens cerebrais podem revelar um ou diversos cistos preenchidos com líquido e o escólex (cabeça) do parasito. CONCLUSÕES: A diversidade de apresentações da NCC encoraja os profissionais de saúde a considerá-la dentre os diagnósticos, especialmente em países endêmicos; e também em áreas não-endêmicas, pois migrantes e viajantes estão sujeitos ao contágio. O tratamento consiste no uso de antiparasíticos (albendazol, praziquantel) e medicamentos para tratar condições associadas (anticonvulsivantes, corticosteróides). Cirurgia é reservada para remoção do parasito de locais particulares (olhos, medula espinhal, ventrículos cerebrais) ou para diferenciar NCC de tumores, tuberculose, micose, etc. Prevenção inclui o tratamento de helmintíases intestinais, sanidade animal, higiene ao preparar alimentos, controle da qualidade da água e alimentos.

Humans , Neurocysticercosis/complications , Neurocysticercosis/diagnosis , Neurocysticercosis/epidemiology , Praziquantel/therapeutic use , Albendazole/therapeutic use , Incidence , Cognition Disorders/etiology , Neurocysticercosis/drug therapy , Taenia solium/pathogenicity , Depression/etiology , Epilepsy/etiology , Neuroimaging/methods , Hydrocephalus/etiology
Rev. cuba. med. trop ; 68(3): 255-261, sep.-dic. 2016. ilus
Article in Spanish | LILACS, CUMED | ID: biblio-844989


La infección causada por Strongyloides stercoralis puede permanecer asintomática o con síntomas ligeros en humanos por varios años. Sin embargo, algunos individuos inmunodeprimidos, entre ellos los pacientes tratados con esteroides por tiempo prolongado, pueden presentar hiperinfección con altas tasas de mortalidad. El objetivo es reportar por primera vez en Cuba el caso de una paciente con síntomas de estrongiloidiasis crónica asociada al uso de esteroides orales. Se trata de una paciente de 63 años, asmática con síntomas de estrongiloidiasis crónica y riesgo de hiperinfección por el uso de esteroides orales por tiempo prolongado. Se describen las manifestaciones clínicas y los análisis complementarios. Se discuten los factores predisponentes para la adquisición inicial y el desarrollo de la enfermedad. El laboratorio confirmó la presencia de larvas rabditoides de Strongyloides stercoralis en las heces de la paciente. Aunque existen evidencias de casos fatales de pacientes con strongiloidiasis asociada al uso prolongado de esteroides en la literatura internacional, hay escasez de esos reportes en Cuba. Adicionalmente, es probable que el diagnóstico y el tratamiento oportunos, hayan contribuido a evitar complicaciones fatales en esta paciente(AU)

The infection caused by Strongyloides stercoralis may remain asymptomatic or with slight symptoms in humans for decades. However, immunocompromised patients, particulary those receiving long-term steroid therapy, may face hyperinfection resulting in high mortality rates. The objective was to present the first report in Cuba about a patient with chronic strongyloidiasis associated to use of oral steroids. Here is a 63 years-old asthmatic woman, who showed chronic strongyloidiasis symptoms and hyperinfection risk due to the long-term use of oral steroids. The symptoms and physical examination were described as well as various diagnostic tests. Predisposing factors for the onset and development of the disease were discussed. Laboratory diagnosis confirmed the presence of Strongyloides stercoralis rabditoid larvae in the patient's feces. Although there has been evidence of fatal cases with chronic strongyloidiasis associated with long-term use of steroids in the international literature, such reports are rare in Cuba. Additionally, it is likely that timely diagnosis and treatment have contributed to avoid fatal complications in this patient(AU)

Humans , Female , Middle Aged , Strongyloidiasis/complications , Albendazole/therapeutic use , Helminthiasis/epidemiology , Steroids/adverse effects , Feces/parasitology
Rev. chil. infectol ; 33(5): 584-588, oct. 2016. ilus
Article in Spanish | LILACS | ID: biblio-844410


Strongyloidiasis is an infection caused by the parasite Strongyloides stercoralis, which can be asymptomatic and means a high morbidity and mortality in immunocompromised hosts, severe malnutrition and coinfection with HTLV-1 virus. The parasite has the potential to produce and multiply internal autoinfection in humans, thus an hyperinfection can be developed. A case of pulmonary infection by this parasite is presented in this study, infection which advanced into a respiratory failure and required mechanical ventilation and hemodynamic support in an intensive care unit. The standard treatment combined with ivermectin and albendazole was provided, achieving an appropriate response.

La estrongiloidosis es una infección causada por el parásito Strongyloides stercoralis, la cual puede cursar con una alta morbi-mortalidad en pacientes inmunocomprometidos, con desnutrición grave y coinfección con el virus HTLV-1. Se puede desarrollar una hiperinfección, dado que el parásito tiene el potencial de producir una autoinfección interna. Se presenta un caso de infección pulmonar por S. stercoralis que progresó a una falla respiratoria y requirió soporte ventilatorio y hemodinámico en una unidad de cuidados intensivos, suministrándole el tratamiento estándar combinado de ivermectina y albendazol con una respuesta satisfactoria.

Humans , Animals , Female , Middle Aged , Strongyloidiasis/diagnosis , Strongyloides stercoralis/isolation & purification , Lung Diseases, Parasitic/diagnosis , Strongyloidiasis/drug therapy , Ivermectin/therapeutic use , Albendazole/therapeutic use , Lung Diseases, Parasitic/drug therapy , Antiparasitic Agents/therapeutic use
Rev. chil. infectol ; 33(3): 346-351, jun. 2016. ilus, tab
Article in Spanish | LILACS | ID: lil-791030


La toxocarosis humana es una parasitosis larvaria crónica catalogada dentro de las cinco enfermedades subestimadas más importantes por los CDC. Las larvas pueden diseminarse por vía sistémica y migrar a distintos tejidos (larva migrans visceral) incluyendo el hígado y vesícula biliar. La colecistitis aguda acalculosa (CAA) es una enfermedad rara en niños. El diagnóstico se basa en parámetros clínicos y criterios imagenológicos. Se ha asociado a sepsis, shock, trauma, quemaduras, enfermedades sistémicas graves, anomalías congénitas e infecciones, como también en niños sanos. Presentamos el caso de una toxocarosis infantil con síntomas clínicos y criterios imagenológicos compatibles con una CAA tratado médicamente, y discutir la relación entre ambos cuadros en base a la evidencia publicada.

Human toxocarosis is a chronic larval parasitosis listed as one of the five most important neglected diseases by the CDC. The larvae can spread systemically and migrate to different tissues including liver and gallbladder. Acalculous acute cholecystitis (AAC) is a rare disease in children. The diagnosis is based on clinical parameters and imaging criteria. It has been reported in relation to sepsis, shock, trauma, burns, severe systemic diseases, congenital anomalies, infections and also in healthy children. We report a pediatric case of toxocarosis, with clinical symptoms and imaging criteria compatible with AAC treated medically, and discuss the relationship between toxocarosis and AAC based on published evidence.

Humans , Male , Child , Larva Migrans, Visceral/complications , Acalculous Cholecystitis/diagnosis , Acalculous Cholecystitis/parasitology , Magnetic Resonance Imaging , Tomography, X-Ray Computed , Albendazole/therapeutic use , Acute Disease , Anthelmintics/therapeutic use
J. bras. nefrol ; 38(1): 123-126, jan.-mar. 2016. graf
Article in Portuguese | LILACS | ID: lil-777508


Resumo Introdução: A infecção por Echinococcus ou hidatidose constitui-se em uma zoonose causada pelo parasita Echinococcus granulosus. Apresenta distribuição mundial, sendo Portugal considerado endêmico. A doença hidática do rim é rara, ocorrendo em apenas 2% dos casos. Caso Clínico: Adolescente de 14 anos, do sexo masculino, com doença hidática do rim. O diagnóstico foi efetuado por exames de imagem e por teste sorológico específico. Foi instituída terapêutica com albendazol durante quatro ciclos de quatro semanas cada, tendo-se verificado diminuição significativa do tamanho do cisto e negatividade dos anticorpos específicos. Discussão: Embora a terapêutica recomendada seja a excisão cirúrgica, estudos demonstram que a terapêutica médica pode ser uma alternativa a considerar, permitindo a preservação do órgão.

Abstract Introduction: Hydatid disease is a zoonosis caused by the parasite Echinococcus granulosus. It has a worldwide distribution, being endemic in Portugal. Hydatid disease of the urinary tract is rare, occurring in less than 2% of all cases. Case report: 14-year-old male with hydatid disease of the kidney. The diagnosis was established by imaging studies and specific serologic testing. Treatment consisted of four 4-week cycles of albendazol and resulted in a progressive reduction of the cyst as well as in a negative specific serology. Discussion: Even though the recommended treatment is surgical excision, studies have demonstrated that medical treatment may be an alternative allowing for organ preservation.

Humans , Animals , Male , Adolescent , Echinococcosis/diagnosis , Kidney Diseases/diagnosis , Albendazole/therapeutic use , Echinococcus granulosus , Echinococcosis/therapy , Kidney/parasitology , Kidney Diseases/parasitology
An. Fac. Med. (Perú) ; 76(3): 241-246, jul.-set.2015. tab, graf
Article in Spanish | LIPECS, LILACS, LIPECS | ID: lil-781086


En un estudio previo, los autores estandarizaron una prueba de ELISA IgE para hidatidosis con alta sensibilidad (95,6 por ciento) y especificidad (100 por ciento) para el diagnóstico y seguimiento de pacientes tratados con albendazol, con resultados alentadores. Objetivo. Confirmar la utilidad de la medición de los niveles de los anticuerpos IgE en pacientes con equinococosis quística tratados con albendazol y considerados curados clínica y ecográficamente y en pacientes mejorados o curados que recurrieron. Diseño. Estudio retrospectivo-prospectivo, de tipo cuasi experimental, corte longitudinal, con pre prueba y post prueba en un solo grupo para evaluar el diagnóstico y seguimiento en los casos prospectivos y el seguimiento y recurrencia en ambos grupos. Institución. Instituto de Medicina Tropical "Daniel A. Carrión", Universidad Nacional Mayor de San Marcos, Lima, Perú. Participantes. Pacientes con equinococosis quística. Métodos. Se incluyó 17 pacientes, 15 mujeres y 2 hombres, entre 25 y 80 años de edad (promedio 58 años), con uno más quistes hepáticos y en uno además quistes pulmonares; 16 fueron tratados con albendazol a la dosis de 12-15 mg/kg, en 3 a 5 ciclos de 28 días y uno recibió tratamiento con albendazol y cirugía por una complicación. Todos fueron seguidos entre dos y 12 años postratamiento, con evaluación clínica y ecográfica en 2 a 7 oportunidades y cuantificación de los niveles de anticuerpos IgE para equinococosis en muestras de sangre. La técnica utilizada para la detección de anticuerpos IgE mediante prueba de ELISA para IgE fue estandarizada por los autores. Principales medidas de resultados. Relación de niveles de anticuerpos IgE en sangre y comportamiento de la enfermedad. Resultados. En 10 de los 17 pacientes se mantuvieron los niveles de IgE por debajo del punto de corte, lo que se consideró como evidencia de curación, lo que además coincidía con los cambios en la ecoestructura que iba de CE1 y CE2 a CE4 y CE5, según la...

In a previous study an IgE ELISA test for hydatidosis was standardized and evidenced high sensitivity (95.6 per cent) and specificity (100 per cent) and encouraging results for the diagnosis and follow up of patients treated with albendazole. Objectives: To confirm efficacy of IgE antibody level determination in patients with cystic echinococcosis treated with albendazole and considered clinically cured and ultrasonographically improved, or recurrence in patients considered improved or cured. Design: Longitudinal, retrospective-prospective, quasi-experimental study, longitudinal study, with pre- and post-test for assessing diagnosis and monitoring in the prospective group, and follow-up and recurrence in both groups. Setting: Instituto de Medicina Tropical "Daniel A. Carrión", Universidad Nacional Mayor de San Marcos, Lima, Peru. Participants: Patients with cystic echinococcosis. Methods: Seventeen patients, 15 female and 2 male, 25-80 years old (average 58 years) carrying one or more hepatic cysts and one also lung cysts were treated with albendazole 12-15 mg/kg in 3 or 5 28-day cycles. One had also surgical treatment for a complication. They were followed for 2 to 12 years after treatment, with clinical and ultrasound evaluation 2-7 times and serum quantification of echinococcosis IgE antibody levels. IgE antibody detection method was IgG ELISA test standardized by the authors. Main outcome measures: Relation of serum IgE antibodies and disease outcome. Results: Out of the 17 patients, 10 had serum IgE below cutoff levels considered as evidence of healing. This coincided with eco structural changes from CE1 and CE2 to CE4 and CE5, according to the ultrasound imaging WHO classification, indicating high activity in the firsts and low or no recent activity in the latter. Seven patients evidencing cure or clinical and ultrasound improvement and significant decrease of IgE some below de cut-off level showed sustained increase of these levels...

Humans , Female , Aged , Aged, 80 and over , Albendazole/therapeutic use , Enzyme-Linked Immunosorbent Assay , Echinococcosis , Immunoglobulin E , Longitudinal Studies , Prospective Studies , Retrospective Studies
Article in English | IMSEAR | ID: sea-158472


Background & objectives: One third of the world’s population is infected with one or more of the most common soil-transmitted helminths (STH). Albendazole (ALB) is being administered with diethyl carbamazine (DEC) in filariasis endemic areas to eliminate lymphatic filariasis (LF) and helminth infections. In this study, the cumulative impact of seven annual rounds of mass drug administrations (MDA) of DEC and ALB on STH infection in school children in selected villages in southern India was determined. Methods: During 2001-2010, seven MDAs were implemented by the Tamil Nadu state health department, India. LF and STH infections were monitored in school children from 18 villages of the two treatment arms (viz, DEC alone and DEC+ALB). Kato-Katz cellophane quantitative thick smear technique was employed to estimate STH infections at three weeks, six months and one year post MDA. Results: Prior to treatment, an overall STH prevalence was 60 per cent. After each MDA, infection markedly reduced at three weeks post-treatment in both the arms. The prevalence increased at six months period, which was maintained up to one year. After seven rounds of MDA, the infection reduced from 60.44 to 12.48 per cent in DEC+ALB arm; while the reduction was negligible in DEC alone arm (58.77 to 52.70%). Interpretation & conclusions: Seven rounds of MDA with DEC+ALB reduced the infection load significantly, and further sustained low level of infection for 10 years. However, complete parasite elimination could not be achieved. To curtail STH infection in the community, MDA should be regularized and environmental sanitation measures need to be improved by effective community-based campaigns.

Albendazole/administration & dosage , Albendazole/therapeutic use , Child , Diethylcarbamazine/administration & dosage , Diethylcarbamazine/therapeutic use , Drug Administration Schedule , Drug Therapy, Combination , Helminthiasis/drug therapy , Helminthiasis/epidemiology , Helminthiasis/transmission , Humans , India , Intestinal Diseases, Parasitic/drug therapy , Intestinal Diseases, Parasitic/epidemiology , Intestinal Diseases, Parasitic/transmission , Prevalence , Rural Population , Soil/parasitology
Article in English | WPRIM | ID: wpr-194207


BACKGROUND/AIMS: Visceral larva migrans, caused by Toxocara canis and Toxocara cati, has emerged as a significant cause of eosinophilic liver abscess (ELA). Differentiation of ELA associated with toxocariasis (ELA-T) from metastasis or primary liver malignancy is sometimes difficult. However, the role of albendazole treatment remains uncertain in this condition. The aim of this study was to evaluate whether albendazole can enhance the radiologic resolution of ELA-T. METHODS: We retrospectively reviewed the medical records of the patients diagnosed with ELA-T at our institution between January 2008 and December 2011. ELA-T was diagnosed based on the imaging findings on computed tomography or magnetic resonance imaging and the presence of positive serum IgG antibody for Toxocara canis. Among a total of 163 patients, 32 patients received albendazole (albendazole group) and 131 did not (control group). Baseline characteristics and fate of liver nodules were compared between the two groups. RESULTS: Baseline characteristics (age, sex, number and maximal size of lesions, eosinophil count) were similar between the two groups. Median duration for achieving radiologic resolution in the albendazole group was significantly shorter than in the control group (207 days [range 186-228] vs. 302 days [range 224-380], p=0.023). In Cox regression analysis of the cumulative rates of radiologic resolution, the hazard ratio for albendazole treatment was 1.99 (95% confidence interval, 1.22-3.23). CONCLUSIONS: Radiologic resolution of ELA-T can be accelerated with albendazole treatment. Hence, inconvenience associated with long-term follow-up and unnecessary worries among patients can be eliminated with albendazole treatment.

Adult , Aged , Aged, 80 and over , Albendazole/therapeutic use , Animals , Antiprotozoal Agents/therapeutic use , Eosinophils/immunology , Female , Humans , Immunoglobulin G/blood , Larva Migrans, Visceral/drug therapy , Liver/enzymology , Liver Abscess/etiology , Magnetic Resonance Imaging , Male , Middle Aged , Proportional Hazards Models , Retrospective Studies , Tomography, X-Ray Computed , Toxocara canis/immunology
Article in English | WPRIM | ID: wpr-160912


The objectives of this study was to conduct a survey on schistosomiasis and soil-transmitted helminth (STH) infections in order to come up with feasible control strategies in Lake Victoria basin, Tanzania. Depending on the size of the school, 150-200 schoolchildren were recruited for the study. Duplicate Kato-Katz stool smears were prepared from each child and microscopically examined for Schistosoma mansoni and STHs. Urine specimens were examined for Schistosoma haematobium eggs using the filtration technique. After the survey, mass drug administration was done using praziquantel and albendazole for schistosomiasis and STHs infections, respectively. A total of 5,952 schoolchildren from 36 schools were recruited for the study and had their stool and urine specimens examined. Out of 5,952 schoolchildren, 898 (15.1%) were positive for S. mansoni, 754 (12.6%) for hookworms, 188 (3.2%) for Ascaris lumblicoides, and 5 (0.008%) for Trichuris trichiura. Out of 5,826 schoolchildren who provided urine samples, 519 (8.9%) were positive for S. haematobium eggs. The results revealed that intestinal schistosomiasis, urogenital schistosomiasis, and STH infections are highly prevalent throughought the lake basin. The high prevalence of intestinal and urogenital schistosomisiasis in the study area was a function of the distance from Lake Victoria, the former being more prevalent at localities close to the lake, whilst the latter is more so away from it. Control of schistosomiasis and STHs in the study area requires an integrated strategy that involves provision of health education to communities, regular treatments, and provision of adequate safe water supply and sanitation facilities.

Adolescent , Albendazole/therapeutic use , Animals , Anthelmintics/therapeutic use , Child , Feces/parasitology , Female , Helminthiasis/drug therapy , Helminths/classification , Humans , Intestinal Diseases, Parasitic/drug therapy , Male , Praziquantel/therapeutic use , Prevalence , Schistosomiasis/drug therapy , Schools , Students , Tanzania/epidemiology , Urine/parasitology
Article in English | WPRIM | ID: wpr-160911


The objective of this study was to carry out a community survey on schistosomiais and soil-transmitted helminth (STH) infections in order to suggest feasible and effective intervention strategies in Lake Victoria basin, Tanzania. A total of 37 communities selected from 23 districts of the 4 regions in the Lake Victoria basin of Tanzania were involved in the study. From each of the selected locality, 50 adult community members, 25 males and 25 females, were recruited for the study. Each study participant was requested to submit stool and urine specimens. From each stool specimen, duplicate Kato-Katz thick smears were prepared and microscopically examined for Schistosoma mansoni and STH eggs. Urine specimens were processed by the filtration technique and microscopically examined for Schistosoma haematobium eggs. Ultrasound examination for morbidity due to schistosomiasis was performed. Mass treatment was done using praziquantel and albendazole for schistosome and STHs infections, respectively. Out of 1,606 adults who provided stool specimens, 199 (12.4%) were positive for S. mansoni, 349 (21.7%) for hookworms, 133 (8.3%) for Ascaris lumbricoides, and 33 (2.0%) for Trichuris trichiura. Out of 1,400 participants who provided urine specimens, 25 (1.8%) were positive for S. haematobium eggs. Because of the co-endemicity of these afflictions and their impact on vulnerable population groups, the helminthiasis could be simultaneously treated with 2 drugs, praziquantel for schistosomiasis and albendazole for STHs.

Adult , Albendazole/therapeutic use , Animals , Anthelmintics/therapeutic use , Feces/parasitology , Female , Helminthiasis/drug therapy , Helminths/classification , Humans , Intestinal Diseases, Parasitic/drug therapy , Lakes , Male , Microscopy , Praziquantel/therapeutic use , Prevalence , Schistosomiasis/drug therapy , Tanzania/epidemiology , Urine/parasitology