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1.
Prensa méd. argent ; 107(6): 299-306, 20210000. tab, fig
Article in English | LILACS, BINACIS | ID: biblio-1359089

ABSTRACT

Introducción. El consumo de alcohol daña la mayoría de los órganos y sistemas de nuestro organismo, con un efecto nocivo sobre la diabetes tipo 2. En nuestro país, el consumo de alcohol es tolerado y socialmente bien considerado, lo que provoca que una parte importante de la población tenga una ingesta excesiva de alcohol. Por tanto, quisimos evaluar el efecto de la ingesta excesiva de alcohol en la población trabajadora y su efecto sobre el riesgo de desarrollar diabetes tipo 2. Métodos. Estudio descriptivo y transversal en 55.147 trabajadores españoles en el que se evaluó el efecto del consumo excesivo de alcohol sobre el riesgo de desarrollar diabetes tipo 2. El riesgo de diabetes se evaluó con las escalas Findrisk y QDScore. El consumo de alcohol se evalúa con la unidad de bebida estándar, equivalente a 10 g de alcohol. Se considera consumo excesivo cuando se superan semanalmente 35 unidades de bebida estándar en hombres y 20 en mujeres. Resultados. El consumo excesivo de alcohol en comparación con no beber, beber poco o moderadamente aumenta el riesgo de diabetes tipo 2 en ambas escalas de riesgo. La razón de probabilidades es 12,22 (IC 95 11,51-12,99) para la escala Findrisk y 13,36 (IC 95% 12,04-14,69) para el riesgo relativo con QDScore. Conclusión. El consumo excesivo de alcohol aumenta el riesgo de diabetes tipo 2 con las escalas Findrisk y QDScore en la población laboral española


Introduction. Alcohol consumption damages most of the organs and systems of our organism, with a harmful effect on type 2 diabetes. In our country, alcohol consumption is tolerated and socially well regarded, which causes an important part of the population to have an excessive alcohol intake. Therefore, we want to evaluate the effect of excessive alcohol intake in the working population and its effect on the risk of developing type 2 diabetes. Methods. Descriptive and cross-sectional study in 55,147 Spanish workers in which the effect of excessive alcohol consumption on the risk of developing type 2 diabetes was assessed. Diabetes risk was assessed with the Findrisk and QDScore scales. Alcohol consumption is assessed with the standard drinking unit, equivalent to 10g of alcohol. Excessive consumption is considered when 35 standard drinking unit in men and 20 in women are exceeded weekly. Results. Heavy drinking compared to no, low or moderate drinking increases the risk of type 2 diabetes on both risk scales. The Odds ratio is 12.22 (CI 95 11.51-12.99) for the Findrisk scale and 13.36 (CI 95% 12.04-14.69) for the relative risk with QDScore. Conclusion. Excessive alcohol consumption increases the risk of type 2 diabetes with the Findrisk and QDScore scales in the Spanish working population


Subject(s)
Humans , Alcohol Drinking/adverse effects , Risk Assessment , Diabetes Mellitus/diagnosis , Diabetes Mellitus, Type 2/diagnosis , Binge Drinking/complications , Occupational Groups
2.
Arq. ciências saúde UNIPAR ; 25(1): 43-51, jan-abr. 2021.
Article in Portuguese | LILACS | ID: biblio-1151409

ABSTRACT

Introdução: Usuários do sistema de saúde com doenças crônicas não transmissíveis devem estar em acompanhamento constante para evitar complicações em seu estado de saúde. Objetivo: Analisar os indicadores laboratoriais de saúde em usuários de uma Unidade Básica de Saúde com e sem o diagnóstico para a diabetes e hipertensão. Métodos: A amostra foi de 231 usuários de uma unidade básica de saúde da cidade de Santarém-PA, maiores de idade, que foram agrupados em pacientes com DM/HAS (DM/HAS; n=144), e sem o diagnóstico para DM/HAS (AUS; n=87). As coletas envolveram informações socioeconômicas, clínicas e laboratoriais. Os dados foram tratados com estatística descritiva e inferencial, adotando-se p<0.05. Resultados: Tanto no DM/HAS como no AUS predominou o sexo feminino, estado civil casado, com vínculo empregatício, cor de pele parda, com 4-7 anos de estudo, renda de 1-2 salários, não tabagistas, não etilista e faixa etária de 38-77 anos. A HAS foi a doença mais presente de forma geral, bem como por sexo. Identificou-se no DM/HAS valores menores para a taxa de filtração glomerular (TFG) e maiores valores para a glicemia, triglicerídeos, colesterol total, LDL-c e não HDL-c. Conclusão: De acordo com a proposta desenvolvida, destaca-se que os usuários com DM/HAS apresentam associação positiva para valores alterados de glicemia, colesterol total, não HDL-c, triglicerídeos, TFG e para a presença da síndrome metabólica e risco cardiovascular moderado/alto.


Introduction: Users of the health system with chronic non-communicable diseases must be constantly monitored to avoid complications in their health status. Objective: Analyze laboratory health indicators in users of a Basic Health Unit with and without a diagnosis for diabetes and hypertension. Methods: The sample consisted of 231 users of a basic health unit in the city of Santarém-PA, all of them of age, grouped into patients with DM/SAH (DM/SAH; n=144), and without the diagnosis for DM/SAH (ABS; n=87). The collections involved socioeconomic, clinical, and laboratory information. The data were treated with descriptive and inferential statistics, adopting p <0.05. Results: In both DM/SAH and ABS groups, there was a predominance of female individuals, married status, employed, brown skin color, with 4-7 years of study, income of 1-2 salaries, non-smokers, non-alcoholic drinkers, and aged between 38-77 years. SAH was the most common disease in general, as well as when analyzing by gender. Lower values for the glomerular filtration rate (GFR) were identified in the DM/SAH and higher values for the glycemia, triglycerides, total cholesterol, LDL-c, and non-HDL-c. Conclusion: According to the proposal of this paper, it is noteworthy that users with DM/SAH have a positive association for altered values of blood glucose, total cholesterol, non-HDL-c, triglycerides, GFR, and for the presence of metabolic syndrome and moderate/high cardiovascular risk.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Health Evaluation/statistics & numerical data , Health Centers , Health Status Indicators , Tobacco Use Disorder/complications , Triglycerides/blood , Blood Glucose , Alcohol Drinking/adverse effects , Cardiovascular Diseases/diagnosis , Cholesterol/blood , Chronic Disease/nursing , Metabolic Syndrome/diagnosis , Diabetes Mellitus/diagnosis , Noncommunicable Diseases/prevention & control , Glomerular Filtration Rate , Hypertension/diagnosis , Cholesterol, HDL , Cholesterol, LDL/blood
4.
Braz. j. med. biol. res ; 54(1): 10252-0, 2021. tab, graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS | ID: biblio-1142565

ABSTRACT

Fetuses exposed to alcohol and/or tobacco are at risk for perinatal adversities. However, little is currently known about the association of the separate or concomitant use of alcohol and tobacco with infant motor and cognitive development. Thus, the objective of the present study was to investigate the association between maternal consumption of alcohol and/or tobacco during pregnancy and the motor and cognitive development of children starting from the second year of life. The study included 1006 children of a cohort started during the prenatal period (22-25 weeks of pregnancy), evaluated at birth and reevaluated during the second year of life in 2011/2013. The children were divided into four groups according to the alcohol and/or tobacco consumption reported by their mothers at childbirth: no consumption (NC), separate alcohol consumption (AC), separate tobacco consumption (TC), and concomitant use of both (ACTC). The Bayley Scale of Infant and Toddler Development Third Edition screening tool was used for the assessment of motor and cognitive development. Adjusted Poisson regression models were used to determine the association between groups and delayed development. The results indicated that only the ACTC group showed a higher risk of motor delay, specifically regarding fine motor skills, compared to the NC group (RR=2.81; 95%CI: 1.65; 4.77). Separate alcohol or tobacco consumption was not associated with delayed gross motor or cognitive development. However, the concomitant use of the two substances increased the risk of delayed acquisition of fine motor skills.


Subject(s)
Humans , Male , Female , Pregnancy , Infant, Newborn , Infant , Prenatal Exposure Delayed Effects/epidemiology , Alcohol Drinking/adverse effects , Alcohol Drinking/epidemiology , Child Development , Tobacco Use , Cohort Studies
5.
Rev. Pesqui. (Univ. Fed. Estado Rio J., Online) ; 13: 1354-1360, jan.-dez. 2021. ilus, tab
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1292018

ABSTRACT

Objetivo: avaliar as publicações científicas sobre o alcoolismo e o envelhecimento. Métodos: estudo bibliométrico, realizado por meio da análise de artigos disponíveis na base de dados da LILACS, EBSCOT e MEDLINE, no período de 2010-2016. Resultados: os achados demostram a crescente busca sobre a temática em diversos países, nos últimos anos, aperfeiçoando a importância da contribuição da mesma quando se pensa em saúde pública, bem como os pesquisadores atuam em diversas áreas de conhecimentos; o que possibilita descobertas que podem informar o desenvolvimento e a implementação de ações de prevenção e promoção da saúde, que refletem as necessidades de saúde mental do envelhecimento. Conclusão: é importante que os profissionais de saúde e a população idosa discutam sobre consumo de álcool como componente do manejo da doença crônica. Nos casos de consumo de álcool, os provedores têm a oportunidade de fornecer uma intervenção breve ou oferecer referências, se necessário


Objetivo: Evaluar las publicaciones científicas sobre el alcoholismo y el envejecimiento. Métodos: Estudio bibliométrico, realizado por medio del análisis de artículos disponibles en la base de datos de LILACS, EBSCOT y MEDLINE, en el período 2010-2016. Resultados: Los hallazgos de esta revisión demuestran que la creciente demanda sobre la temática en diversos países, en los últimos años, perfeccionando la importancia de la contribución de la misma cuando se piensa en salud pública, así como los investigadores actúan en diversas áreas de conocimientos; lo que posibilita descubrimientos que pueden informar el desarrollo y la implementación de acciones de prevención y promoción de la salud que reflejan las necesidades de salud mental del envejecimiento. Conclusión: Es importante que los profesionales de salud y la población anciana discutan sobre el consumo de alcohol como componente del manejo de la enfermedad crónica. En los casos de consumo de alcohol, los proveedores tienen la oportunidad de proporcionar una intervención breve o ofrecer referencias. A pesar de la relevancia, todavía son escasos los estudios sobre la temática, en el escenario de investigación nacional, siendo necesario más producción científica


Objective:Tevaluate scientific publications about alcoholism and aging. Methods: It included analysis of items available in the database of the LILACS, EBSCOT and MEDLINE, in the period from 2010 to 2016. Results: The findings of this review show increasing bibliometric search on the subject in several countries, in recent years, enhancing the importance of the contributions on the subject in terms of public health, as well as researchers working in different areas of knowledge. Conclusion: It is important that health professionals and the elderly debate about alcohol consumption as a component of chronic disease management and that the health care network ensures quick intervention or referrals. Despite the relevance, studies on the subject are still scarce in the national research scenario, and more scientific production is needed


Subject(s)
Aging/psychology , Bibliometrics , Alcoholism/prevention & control , Preventive Health Services , Alcohol Drinking/adverse effects , Mental Health , Health Services Needs and Demand
7.
Rev. bras. cancerol ; 66(1)20200129.
Article in Portuguese | LILACS | ID: biblio-1087670

ABSTRACT

Introdução: O carcinoma de células escamosas é o tumor de maior importância na região de cabeça e pescoço, em razão da sua incidência e mortalidade. Sabe-se que fatores como consumo de álcool estão relacionados à diminuição da sobrevida de tumores tanto estimulando a progressão tumoral como causando comorbidades importantes, sendo um fator relevante para estudo. Objetivo: Avaliar a influência do histórico de álcool em características clinicoprognósticas de pacientes com carcinoma de células escamosas de boca e orofaringe (CCEBO). Método: Estudo de coorte, retrospectivo, no qual 156 prontuários de pacientes etilistas e 78 prontuários de pacientes não etilistas com CCEBO diagnosticados no Hospital Haroldo Juaçaba, em Fortaleza, Ceará, foram avaliados, entre 2000 e 2014, para análise de dados como idade, sexo, raça, localização do tumor, estadiamento TNM, tratamentos realizados e sobrevida em 15 anos por meio dos testes X², Long-Rank e modelos de regressão multinomial e de Cox (SPSS 20,0; p<0,05). Resultados: Houve maior prevalência de homens entre os pacientes etilistas (p<0,001), com tumores T3-T4 (p=0,003), linfonodos positivos (p=0,006) que realizaram tratamentos paliativos (p<0,001) e menor prevalência abaixo de 65 anos (p<0,001), quando havia histórico familiar de câncer (p=0,043). A sobrevida dos pacientes etilistas foi menor (p=0,040) e os fatores que diminuíram a sobrevida de maneira independente foram sexo masculino (p=0,042), estadiamento T3-T4 (p=0,004), metástase linfonodal (p=0,012), idade >65 anos (p=0,035) e localização na língua (p=0,042). O sexo masculino foi independentemente associado ao etilismo (p<0,001). Conclusão: O álcool é um fator de prognóstico em pacientes com CCEBO, mostrando maior prevalência em pacientes T3-T4 e, assim, influenciando negativamente no prognóstico.


Introduction: Squamous cell carcinoma is the most important tumor in the head and neck region, due to its incidence and mortality. It is known that factors as alcohol consumption are related to the decrease of the survival of tumors, either stimulating tumor progression or causing considerable comorbidities, being an important study factor. Objective: Evaluate the influence of alcohol history on clinical and prognostic characteristics of patients with mouth oropharynx squamous cell carcinoma (MOSCC). Method: A retrospective cohort study in which 156 charts of alcoholic patients and 78 medical charts of non-alcoholic patients with MOSCC diagnosed at Haroldo Juaçaba Hospital in Fortaleza, state of Ceará were evaluated between 2000 and 2014 for data analysis such as age, gender and race, tumor location, TNM staging, treatments performed and 15-year survival through X², Long-Rank and Cox and multinomial regression models (SPSS 20.0; p <0.05). Results: Men were more prevalent among alcoholic patients (p <0.001), with T3/4 tumors (p = 0.003), positive lymph nodes (p = 0.006) who submitted to palliative treatments (p<0.001) and lower prevalence under 65 years (p <0.001), when there was a family history of cancer (p = 0.043). The survival of alcoholic patients was lower (p = 0.040) and the factors that independently reduced survival were male sex (p = 0.042), T3-T4 staging (p = 0.004), lymph node metastasis (p = 0.012), age> 65 years (p = 0.035) and tumor in the tongue (p = 0.042). Male sex was independently associated with alcohol consumption (p<0.001). Conclusion: Alcohol is a prognostic factor in patients with MOSCC, showing a higher prevalence in T3-T4 patients and, thus, negatively influencing the prognosis.


Introducción: El carcinoma de células escamosas es el tumor de mayor importancia en la región de cabeza y cuello, debido a su incidencia y mortalidad. Se sabe que factores como el consumo de alcohol están relacionado con la disminución de la supervivencia de tumores tanto estimulando la progresión tumoral, como provocando comorbilidades considerables, siendo un factor de estudio importante. Objetivo: Evaluar la influencia del historial del consumo de alcohol en las características clínicas-pronósticas de pacientes con carcinoma de células escamosas oral y orofaringe (CCEOO). Método: Estudio retrospectivo en el que se evaluaron 156 registros médicos de pacientes consumidores de alcohol y 78 de pacientes no alcohólicos con CCEOO diagnosticados en el Hospital Haroldo Juaçaba, en Fortaleza, Ceará, entre 2000 y 2014, para el análisis de datos como edad, sexo raza, escolaridad, los antecedentes familiares, vínculo matrimonial, registro en el servicio, ubicación del tumor, clasificación de TNM, los tratamientos realizados y la supervivencia durante 15 años a través de las pruebas X² Long-Rank y modelos de regresión multinomial y de Cox (SPSS 20.0; p<0,05). Resultados: Hubo una mayor prevalencia de hombres entre pacientes alcohólicos (p<0,001), con tumores T3-T4 (p=0,003), ganglios linfáticos positivos (p=0,006), y realizó tratamientos paliativos (p<0,001) y menor prevalencia en paciente menores de 65 años (p <0,001); cuando se presentaron antecedentes familiares de cáncer (p=0,043). La supervivencia de los pacientes alcohólicos fue menor (p=0,040); y los factores que disminuyeron la supervivencia de forma independiente fueron hombres (p=0,042); estadificación t3-t4 (p=0,004); metástasis a ganglios linfáticos (p=0,012); edad > 65 años (p=0,035); localización de la lengua (p=0,042). El sexo masculino se asoció independientemente con el consumo de alcohol (p<0,001). Conclusión: El alcohol define el pronóstico en pacientes con CCEOO, muestra una mayor prevalencia en pacientes con T3-T4, por lo tanto, influye negativamente en el pronóstico.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Alcohol Drinking/adverse effects , Mouth Neoplasms/epidemiology , Oropharyngeal Neoplasms/epidemiology , Squamous Cell Carcinoma of Head and Neck/epidemiology , Prognosis , Survival , Tobacco Use Disorder , Sex Factors , Retrospective Studies , Risk Factors , Follow-Up Studies , Age Factors
9.
Article in English | LILACS, BBO | ID: biblio-1135533

ABSTRACT

Abstract Objective: To determine the relationship between tobacco and alcohol consumption and staging of head and neck cancer in patients treated at a referral hospital for cancer treatment. Material and Methods: This is a cross-sectional study based on medical records of patients with head and neck cancer treated between 2008 and 2015. The following variables were considered: gender, age, marital status, educational level, place of residence, profession, affected site, clinical staging of neoplasms, histopathological diagnosis, tobacco and alcohol consumption. Results: Of the 154 medical records analyzed, there was a predominance of male patients (72.7%), single (50%), with low education (88.1%), rural workers (38.3%), residents in the state countryside (70.2%) and aged 20-94 years. T3 and T4 size tumors prevailed. A significant correlation was found between alcohol use and tumor size (p=0.03) and presence of nodules (p<0.001), as well as between alcohol use and smoking with tumor size (p=0.04) and presence of nodules (p=0.019). No correlations were observed between tobacco use and injury staging. Conclusion: There was strong significance between tumor size and presence of nodules, both with the use of alcohol alone and with tobacco, thus suggesting the existence of important carcinogenic action of this substance.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Alcohol Drinking/adverse effects , Mouth Neoplasms/pathology , Risk Factors , Tobacco Use/adverse effects , Head and Neck Neoplasms/pathology , Rural Workers , Brazil/epidemiology , Chi-Square Distribution , Medical Records/statistics & numerical data , Epidemiology, Descriptive , Cross-Sectional Studies/methods , Retrospective Studies
10.
In. Zelarayán Noceti, Mario Jorge; Garré Castro, Laura Patricia. Consumo de alcohol y salud. Montevideo, Comisión Honoraria para la Salud Cardiovascular, [2020]. p.11-15, tab.
Monography in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1353696
11.
In. Zelarayán Noceti, Mario Jorge; Garré Castro, Laura Patricia. Consumo de alcohol y salud. Montevideo, Comisión Honoraria para la Salud Cardiovascular, [2020]. p.37-44.
Monography in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1353701
12.
In. Zelarayán Noceti, Mario Jorge; Garré Castro, Laura Patricia. Consumo de alcohol y salud. Montevideo, Comisión Honoraria para la Salud Cardiovascular, [2020]. p.25-35.
Monography in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1353700
13.
In. Zelarayán Noceti, Mario Jorge; Garré Castro, Laura Patricia. Consumo de alcohol y salud. Montevideo, Comisión Honoraria para la Salud Cardiovascular, [2020]. p.47-50.
Monography in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1353702
14.
Rev. bras. enferm ; 72(6): 1692-1698, Nov.-Dec. 2019. tab
Article in English | LILACS, BDENF | ID: biblio-1042179

ABSTRACT

ABSTRACT Objective: To evaluate the relation between the consumption of alcohol and other drugs and school absenteeism in high school students of public schools in the 30 days prior to data collection. Method: Cross-sectional study of quantitative character conducted from May to September 2017, with 282 high school students of public schools of Mossoró-RN. We used a closed questionnaire with questions about drug consumption as our instrument of analysis. We performed hierarchical binary logistic regression by using the SPSS 20.0. Results: In bivariate analysis, the relation between absenteeism and drug consumption patterns proved to be significant to those who engage in heavy episodic drinking of alcohol and in the use of tobacco, inhalants and marijuana. The adjusted regression model only included the variables tobacco and heavy episodic drinking of alcohol. Conclusion: The hierarchical binary logistic regression analysis corroborated with absenteeism outcomes, explaining it in 12.3% of cases.


RESUMEN Objetivo: Evaluar la relación entre el consumo de alcohol y de otras drogas y el absentismo escolar en estudiantes de la enseñanza media pública durante 30 días anteriores a la recolección de datos. Método: Estudio transversal, cuantitativo, realizado entre mayo y septiembre de 2017, en el cual participaron 282 adolescentes, estudiantes de escuelas públicas de enseñanza media de la ciudad de Mossoró (RN, Brasil). Se utilizó un cuestionario cerrado con preguntas sobre el consumo de drogas. Se realizó una regresión logística binaria jerarquizada con el auxilio del SPSS 20.0. Resultados: En el análisis bivariado, la relación entre el absentismo escolar y los patrones de consumo de drogas se mostró significativa para quienes tenían un consumo excesivo episódico de alcohol y un consumo de tabaco, de inhalantes y de marihuana. El modelo de regresión ajustado incluyó solamente las variables consumo excesivo episódico de alcohol y consumo de tabaco. Conclusión: El análisis de la regresión logística binaria jerarquizada se mostró ajustada para el resultado del absentismo escolar, lo que explica el 12,3% de los casos.


RESUMO Objetivo: Avaliar a relação do consumo de álcool e outras drogas com o absenteísmo escolar em estudantes do ensino médio público nos 30 dias anteriores à coleta. Método: Estudo transversal, quantitativo, realizado de maio a setembro de 2017, com 282 adolescentes, estudantes de escolas públicas de ensino médio de Mossoró-RN. Utilizou-se um questionário fechado com questões sobre o uso de drogas. Realizou-se regressão logística binária hierarquizada com o apoio do SPSS 20.0. Resultados: Na análise bivariada, a relação entre o absenteísmo escolar e os padrões de consumo de drogas se mostrou significativa para aqueles com prática de beber pesado episódico de álcool e uso de tabaco, inalantes e maconha. O modelo de regressão ajustado incluiu apenas as variáveis beber pesado episódico de álcool e tabaco. Conclusão: A análise da regressão logística binária hierarquizada se mostrou ajustada para o desfecho do absenteísmo escolar, explicando-o em 12,3% dos casos.


Subject(s)
Humans , Male , Female , Adolescent , Alcohol Drinking/adverse effects , Substance-Related Disorders/complications , Absenteeism , Schools/organization & administration , Schools/statistics & numerical data , Students/psychology , Students/statistics & numerical data , Brazil , Alcohol Drinking/psychology , Cross-Sectional Studies , Surveys and Questionnaires , Substance-Related Disorders/psychology
15.
Rev. cuba. reumatol ; 21(3): e105, sept.-dic. 2019. tab
Article in English | LILACS-Express | LILACS, CUMED | ID: biblio-1093831

ABSTRACT

Introduction: gouty arthritis is a persistent metabolic disease that produces an increase of the circulating uric acid, with the resulting deposit of monosodic urate crystals in the tissues. Objective: to characterize patients with gouty arthritis clinically and epidemiologically. Methods: a descriptive investigation of 72 patients with a diagnosis of gouty arthritis, assisted at Arnaldo Milián Castro Clinical Surgical University Hospital was carried out from January 2008 to December 2017. Results: patients between 40 and 49 years of age were the most representative group with a highest incidence in not white patients and the male sex. Obesity and hypertension prevailed as previous personal antecedents. Alcohol intake was the most represented toxic habit. A crisis of inflammation of the big toe was the more frequent starting manifestation. Swelling of soft tissues was the main radiologic alteration. Conclusion: gouty arthritis is present with a highest frequency in the male sex with a peak of incidence in the fourth decade of life. It is associated to bad diet habits and alcohol intake that could cause joint damage(AU)


Introducción: la artritis gotosa es una enfermedad metabólica persistente, que produce un aumento del ácido úrico circulante, con el consiguiente depósito de cristales de uratos monosódicos en los tejidos. Objetivo: caracterizar clínica y epidemiológicamente a los pacientes con artritis gotosa. Método: se realizó una investigación descriptiva de 72 pacientes con diagnóstico de artritis gotosa, atendidos en el Hospital Universitario Clínico Quirúrgico Arnaldo Milián Castro, entre enero del 2008 y diciembre del 2017. Resultados: los pacientes entre 40 y 49 años de edad fueron los más representativos, con mayor incidencia en no blancos y del sexo masculino. Predominó la obesidad y la hipertensión arterial como antecedentes patológicos personales. El alcohol fue el hábito tóxico mayoritariamente representado. La crisis de podagra resulto ser la manifestación inicial más usual. El aumento de partes blandas fue la principal alteración radiológica. Conclusiones: La gota se presenta con mayor frecuencia en el sexo masculino con un pico de incidencia en la cuarta década de la vida. Está asociada a malos hábitos dietéticos y al consumo de bebidas alcohólicas pudiendo ocasionar daño articular(AU)


Subject(s)
Humans , Alcohol Drinking/adverse effects , Arthritis, Gouty/epidemiology , Feeding Behavior/physiology , Metabolic Diseases
16.
J. bras. nefrol ; 41(2): 266-274, Apr.-June 2019. tab, graf
Article in English | LILACS | ID: biblio-1012534

ABSTRACT

Abstract Refractory hypertension (RfH) is an extreme phenotype of resistant hypertension (RH), being considered an uncontrolled blood pressure besides the use of 5 or more antihypertensive medications, including a long-acting thiazide diuretic and a mineralocorticoid antagonist. RH is common, with 10-20% of the general hypertensives, and its associated with renin angiotensin aldosterone system hyperactivity and excess fluid retention. RfH comprises 5-8% of the RH and seems to be influenced by increased sympathetic activity. RH patients are older and more obese than general hypertensives. It is strongly associated with diabetes, obstructive sleep apnea, and hyperaldosteronism status. RfH is more frequent in women, younger patients and Afro-americans compared to RFs. Both are associated with increased albuminuria, left ventricular hypertrophy, chronic kidney diseases, stroke, and cardiovascular diseases. The magnitude of the white-coat effect seems to be higher among RH patients. Intensification of diuretic therapy is indicated in RH, while in RfH, therapy failure imposes new treatment alternatives such as the use of sympatholytic therapies. In conclusion, both RH and RfH constitute challenges in clinical practice and should be addressed as distinct clinical entities by trained professionals who are capable to identify comorbidities and provide specific, diversified, and individualized treatment.


Resumo A Hipertensão Arterial Refratária (HARf) representa um fenótipo extremo da hipertensão arterial resistente (HAR), sendo considerada a falência ao tratamento apesar do uso de 5 ou mais classes de anti-hipertensivos, incluindo um diurético tiazídico de longa ação e um antagonista mineralocorticoide. A HAR é comum (10-20%) entre os hipertensos em geral, sendo decorrente de hiperatividade do Sistema Renina Angiotensina Aldosterona e retenção hidrossalina. Aqueles com HARf correspondem a 5-8% dos resistentes e parecem sofrer maior influência catecolaminérgica. Os resistentes tendem a ter maior idade, ao sobrepeso e à obesidade. Comorbidades incluem diabetes, apneia obstrutiva do sono e status de hiperaldosteronismo. Refratários são afro-americanos em maior proporção, mais jovens e, predominantemente, mulheres. Ambos são fortemente associados à elevada albuminúria, HVE, doenças cardio e cerebrovasculares, além da doença renal crônica. O fenômeno do jaleco branco parece ser mais evidente nos resistentes. Quanto ao tratamento, a intensificação da terapia diurética está indicada nos resistentes, enquanto na HARf, a falência à terapia impôs novas alternativas de tratamento ("simpaticolíticas"). Em conclusão, tanto a HAR quanto a HARf constituem-se desafios na prática clínica e devem ser abordadas como entidades clínicas distintas por profissionais especialistas que identifiquem comorbidades e venham a prover um tratamento específico, diversificado e individualizado.


Subject(s)
Humans , Drug Resistance , Hypertension/drug therapy , Hypertension/epidemiology , Phenotype , Sympatholytics/therapeutic use , Blood Pressure/drug effects , Complementary Therapies , Alcohol Drinking/adverse effects , Exercise , Smoking/adverse effects , Prevalence , Blood Pressure Monitoring, Ambulatory , Diet, Sodium-Restricted , Diuretics/pharmacology , Dietary Approaches To Stop Hypertension , Hypertension/diagnosis , Hypertension/physiopathology , Antihypertensive Agents/pharmacology
17.
Int. j. cardiovasc. sci. (Impr.) ; 32(3): 261-268, May-June 2019. tab
Article in English | LILACS | ID: biblio-1002231

ABSTRACT

Smoking is the most important risk factor for coronary heart disease (CHD) and ischemic events; alcohol consumption, on the other hand, appears to have a protective role. Objective: Assess the association between smoking and alcohol consumption with the severity of coronary artery injuries in patients with acute myocardial infarction (AMI). Methods: Cross-sectional study, performed in Santa Catarina. Variables were evaluated using the Chi-squared T/Fisher's exact test, Kendall's correlation coefficient, Student's t test or Mann-Whitney U test. Values of p < 0.05 were considered significant. Results: Between August 2016 to June 2017, 226 patients were evaluated with first episode of AMI. There was a difference in sex distribution, showing that 59.7% of men and 85.4% of women were not alcoholic (p < 0.001). There was a higher prevalence of non-hypertensive patients who consumed alcohol than hypertensive ones (40.7% vs. 24.4% and p = 0.010) and patients without diabetes who had drinking habits than those diabetic (36.4% vs. 12.0% and p = 0.001). There was also a higher prevalence of non-diabetic patients who smoked than diabetic ones (38.1% vs. 22.0% and p = 0.035). A weak and negative correlation was found between the number of cigarettes per day and the pack-year with the TIMI frame count (r = -0.174 and p = 0.041 and r = -0.192 and p = 0.027, respectively). The other associations did not show statistical significance. Conclusion: The study showed that the number of cigarettes consumed per day and the pack-year is related to a smaller TIMI frame count, i.e., to a better coronary flow, which may be related to the Smoker's Paradox. There was no correlation between the beverage type and quantity with the SYNTAX score, Ejection fraction and TIMI frame count


Subject(s)
Humans , Male , Female , Tobacco Use Disorder/complications , Coronary Artery Disease/mortality , Alcohol Drinking/adverse effects , Myocardial Infarction , Stroke Volume , Cardiovascular Diseases/mortality , Sex Factors , Prevalence , Cross-Sectional Studies , Statistical Analysis , Risk Factors , Diabetes Mellitus , Hospitals, Public
18.
Rev. bras. ginecol. obstet ; 41(5): 333-347, May 2019. tab, graf
Article in English | LILACS | ID: biblio-1013618

ABSTRACT

Abstract Objective To investigate the relationship between maternal exposure to alcohol and low birthweight (LBW). Methods The literature search was performed in January 2017 using the following electronic databases: Medline, Embase, LILACS, SciELO, Web of Science, Scopus, CINHAL, Proquest, and PsychInfo. The search strategy used the following terms: alcohol drinking, binge drinking, alcohol-related disorders, alcoholism, alcohol addiction/ use/abuse/consumption, light/moderate/social/low drinking, low birthweight, case-control studies, retrospective studies, and cohort studies. No restrictions regarding language or publication date were considered. The literature search yielded 2,383 articles, and after screening and eligibility assessment, 39 articles were included in the systematic review, and 38 studies were included in the meta-analysis. Results Maternal alcohol consumption was associated with LBWamong retrospective cohort studies (relative risk [RR] = 1.37; 95%CI [confidence interval]:1.10-1.77; I2 = 98.4%; p < 0.01). Prospective cohort studies (RR = 1.11; 95%CI: 0.98-1.25; I2 = 81.5%; p < 0.01), and case-control studies (odds ration [OR] = 1.16; 95%CI: 0.68-1.97; I2 = 61.2%; p = 0.05) showed no association between alcohol and LBW.No publication bias was identified, and the meta-regression showed that the sample size influenced the high heterogeneity among retrospective cohort studies. The subgroup analysis showed differences in association between groups when compared by sample size, type of adjustment, or crude measures and publication year. Conclusions We have not found an association between alcohol consumption during gestation and LBW in the analysis in all of the subgroups. In addition, we have found a high heterogeneity between the primary studies, which is related to methodological differences in the conduction of these studies.


Resumo Objetivo Investigar a associação entre a exposição maternal ao álcool e o baixo peso ao nascer. Método A busca na literatura ocorreu em janeiro de 2017 nas seguintes bases de dados eletrônicas: Medline, Embase, LILACS, SciELO, Web of Science, Scopus, CINHAL, Proquest, e PsychInfo. A estratégia de busca utilizou os seguintes termos: alcohol drinking, binge drinking, alcohol-related disorders, alcoholism, alcohol addiction/use/ abuse/consumption, light/moderate/social/low drinking, low birthweight, case-control studies, retrospective studies, e cohort studies. Não houve restrição de idioma e ano de publicação. A busca na literatura identificou 2.383 artigos, e depois de analisados conforme os critério de elegibilidade, foram incluídos na revisão sistemática 39 estudos, e 38 estudos foram incluídos na metanálise. Resultados A amostra foi composta por 497.023 gestantes. O consumo materno de álcool foi associado ao baixo peso ao nascer entre os estudos de coorte retrospectiva (risco relativo [RR] = 1,37; IC [intervalo de confiança] 95%: 1,10-1,77; I2 = 98,4%; p < 0,01). Os estudos de coorte prospectiva (RR = 1,11; IC95%: 0,98-1,25; I2 = 81,5%; p < 0,01) e caso-controle (razão de chances [OR, na sigla em inglês] = 1,16; IC95%: 0,68-1,97; I2 = 61,2%; p = 0,05) não apresentaram associação entre o consumo e o desfecho. Não foi identificado viés de publicação, e a metarregressão mostrou que o tamanho da amostra influenciou a heterogeneidade entre os estudos de coorte prospectiva. Na análise por subgrupo, houve diferenças entre os grupos por tamanho de amostra, por tipo de ajuste e por ano de publicação. Conclusão Não encontramos associação entre o consumo e o baixo peso ao nascer em todas as análises por subgrupo. Além disso, encontramos alta heterogeneidade entre os estudos primários, e isto se deve possivelmente às diferenças metodológicas na condução destes estudos.


Subject(s)
Humans , Female , Pregnancy , Alcohol Drinking/adverse effects , Infant, Low Birth Weight , Maternal Exposure/adverse effects , Prenatal Care , Birth Weight
19.
Rev. saúde pública (Online) ; 53: 86, jan. 2019. tab
Article in English | LILACS | ID: biblio-1043330

ABSTRACT

ABSTRACT OBJECTIVE To estimate the co-occurrence of the major risk factors for chronic diseases in adults (18-59 years old) and older people (≥ 60 years old) living in Brazilian state capitals and the Federal District. METHODS Cross-sectional study with population-based data from 35,448 adults and 18,726 older people collected in the Sistema de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por Inquérito Telefônico (System of Surveillance of Risk and Protective Factors for Chronic Diseases by Telephone Survey - Vigitel) in 2015. The prevalence of each of the five risk factors (smoking, overweight, physical inactivity, alcohol and unhealthy diet) was estimated, as well as their co-occurrence for the different possible combinations, according to socioeconomic and health self-assessment variables. The independent associations were verified via multinomial logistic regression to obtain the estimates of the odds ratio (OR) and corresponding 95% confidence intervals. RESULTS At least two risk factors were present in 38.5% of the adults and 37.0% of the older participants. The male adults and older participants who did not have private health insurance and classified their health as average or poor/very poor were more likely to have two or more concurrent risk behaviors. The greater chance of co-occurrence of smoking and alcohol abuse in adults (adjusted OR = 3.52) and older people (adjusted OR = 2.94) stands out. CONCLUSIONS The subgroups with increased risk of developing multiple unhealthy behaviors and the most prevalent behaviors were identified. These findings are expected to contribute to the better targeting of health promotion and preventive care. It is worth noting that, for the adoption of healthy lifestyle habits, macro-social and inter-sectoral policies are more effective.


RESUMO OBJETIVO Estimar a coocorrência dos principais fatores de risco para doenças crônicas não transmissíveis em adultos (18 a 59 anos) e idosos (≥ 60 anos) residentes nas capitais dos estados brasileiros e Distrito Federal. MÉTODOS Estudo transversal de base populacional com dados de 35.448 adultos e 18.726 idosos coletados no Sistema de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por Inquérito Telefônico (Vigitel) em 2015. Estimaram-se as prevalências de cada um dos cinco fatores de risco (tabagismo, excesso de peso, inatividade física, uso de álcool e alimentação não saudável), assim como sua coocorrência para as diferentes combinações possíveis, segundo variáveis socioeconômicas e autoavaliação da saúde. As associações independentes foram verificadas por meio de regressão logística multinomial para obter as estimativas do odds ratio (OR) e respectivos intervalos de confiança de 95%. RESULTADOS Ao menos dois fatores de risco estavam presentes em 38,5% dos adultos e 37,0% dos idosos. Adultos e idosos do sexo masculino, que não possuíam plano de saúde privado e que avaliaram sua saúde como regular ou ruim/muito ruim apresentaram maiores chances de ter dois ou mais comportamentos de risco simultâneos. Destaca-se a maior chance de coocorrência de tabagismo e uso abusivo de álcool em adultos (OR ajustado = 3,52) e idosos (OR ajustado = 2,94). CONCLUSÕES Foram identificados subgrupos com maior risco de desenvolver múltiplos comportamentos não saudáveis e os comportamentos mais prevalentes. Almeja-se que esses resultados contribuam para o melhor direcionamento de ações de promoção de saúde e assistência preventiva. Destaca-se que, para a adoção de hábitos de vida saudáveis, as políticas macrossociais e intersetoriais são mais efetivas.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , Chronic Disease/epidemiology , Risk Assessment/methods , Socioeconomic Factors , World Health Organization , Brazil/epidemiology , Alcohol Drinking/adverse effects , Alcohol Drinking/epidemiology , Smoking/adverse effects , Smoking/epidemiology , Comorbidity , Prevalence , Cross-Sectional Studies , Risk Factors , Age Factors , Sex Distribution , Age Distribution , Overweight/complications , Overweight/epidemiology , Sedentary Behavior , Health Risk Behaviors , Middle Aged
20.
Rev. bras. epidemiol ; 22(supl.1): e190009, 2019. tab, graf
Article in English | LILACS | ID: biblio-1042215

ABSTRACT

ABSTRACT Introduction: Knowledge about risky sexual behavior among young people has been widely acknowledged as a key tool to controlling the spread of HIV. This article aimed at presenting the risk behavior of Brazilian Army conscripts toward HIV infection according to the country's geographic regions. . Method: We collected data from 37,282 conscripts, aged 17 to 22, during enlistment in the Brazilian Army in 2016. The prevalence of HIV infection, both self-reported and measured through laboratory results, and risk behavior factors were estimated by region. Results: 75% of the sample of conscripts reported to have already started sexual activity, and the average age of their sexual initiation was 15. Condom use varied according to the type of sexual relationship, being lower among steady partners and greater among less stable relationships. HIV prevalence assessed by laboratory tests was 0.12% across the country and the highest prevalence was observed in the North region (0.24%). Alcohol and illicit drug usage was higher in the South region. Discussion: The study allowed the observation of risk behavior monitoring for HIV infection among young Brazilians. Lower condom usage among steady partners may be contributing to an increase in the number of HIV-infected individuals. Conclusion: Results suggest the need to intensify prevention campaigns to disseminate safe sex practices among young people, in addition to the expansion of testing offer to this population.


RESUMO Introdução: O conhecimento do comportamento sexual de risco entre jovens tem sido amplamente reconhecido como ferramenta-chave para controlar a propagação do HIV. Este artigo tem o objetivo de retratar o comportamento de risco dos conscritos do Exército brasileiro à infecção pelo HIV segundo as macrorregiões brasileiras. Métodos: Foram utilizados dados de 37.282 conscritos, entre 17 e 22 anos, durante apresentação ao Exército em 2016. Estimaram-se as prevalências de HIV autorreferida e medida por exame laboratorial, além de indicadores de comportamento de risco, por macrorregiões geográficas. Resultados: Dos conscritos que compuseram a amostra, 75% relatou já ter iniciado atividade sexual, e a média de idade de início foi de aproximadamente 15 anos. O uso do preservativo variou de acordo com o tipo de parceria sexual, sendo menor na relação com parceiros(as) fixos(as) e maior nas parcerias menos estáveis. A prevalência da infecção pelo HIV medida através do diagnóstico laboratorial foi de 0,12% no Brasil, sendo mais prevalente na região Norte (0,24%). O consumo de álcool e drogas ilícitas foi maior na região Sul. Discussão: O estudo permitiu observar o monitoramento do comportamento de risco à infecção pelo HIV entre os jovens brasileiros. O menor uso de preservativo quando a parceria sexual é considerada estável pode estar contribuindo para aumentar o número de indivíduos infectados pelo HIV. Conclusão: Os resultados sugerem a necessidade de campanhas de divulgação para os jovens sobre práticas de sexo seguro, além da ampliação da oferta de testagem nessa população.


Subject(s)
Humans , Male , Adolescent , Adult , Young Adult , HIV Infections/etiology , Health Risk Behaviors , Military Personnel/statistics & numerical data , Sexual Behavior/statistics & numerical data , Brazil/epidemiology , Alcohol Drinking/adverse effects , Alcohol Drinking/epidemiology , HIV Infections/epidemiology , Prevalence , Cross-Sectional Studies , Risk Factors , Condoms/statistics & numerical data , Risk Assessment , Substance-Related Disorders/complications , Substance-Related Disorders/epidemiology , Geography
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