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1.
São Paulo; SMS; 20250000. 42 p. (USO DE ÁLCOOL E SUBSTÂNCIAS PSICOATIVAS NA PERIFERIA(DE SÃO PAULO (2022-2024): ANÁLISE DO PERFIL DE CASOS(PSIQUIÁTRICOS INTERNADOS NO HOSPITAL MUNICIPAL DR.(FERNANDO MAURO PIRES DA ROCHA).
Thesis in Portuguese | LILACS, SMS-SP | ID: biblio-1589555

ABSTRACT

Esta pesquisa analisa a amostra populacional composta pela totalidade de pacientes internados no Hospital Municipal Dr. Fernando Mauro Pires da Rocha ou Hospital Municipal do Campo Limpo (HMCL), homens e mulheres, de 14 a 60+, que fizeram uso dos serviços de psiquiatria no período de janeiro de 2022 a julho de 2024, e cujo CID abarque algum ou múltiplos Transtornos Relacionados ao Uso de Substâncias (TUS), especialmente álcool e substâncias psicoativas (F-10, F-11, F-12, F13, F-14, F-16 e F-19 e suas subvariações)10. O hospital possui 15 leitos na enfermaria e sem determinação máxima no Pronto Socorro. A presente pesquisa apresenta-se como um estudo observacional retrospectivo seccional, realizado por meio da análise dos prontuários dos pacientes internados no HMCL que utilizaram o serviço de Psiquiatria do Hospital cujo CID se insira na classificação supramencionada. A coleta de dados foi realizada por meio na análise dos prontuários médicos, já anteriormente elaborados, quando da internação constante do banco de dados do SAME (Serviço de Arquivos Médicos). A pesquisa foi submetida e aprovado pelo Comitê de Ética do Hospital ­ CEP sob CAAE 85771125.4.0000.5452, antes do início da coleta de dados, e cadastrada a autorização emitida na Plataforma Brasil. A relevância desse estudo se fundamenta na necessidade de compreender as dinâmicas locais para desenvolver estratégias eficazes de prevenção e intervenção em casos de Transtornos Relacionados ao Uso de Substâncias, tal como alcoolismo, uso de drogas Ilícitas, uso de psicotrópicos, associados muitas vezes ao tabagismo, por meio da identificação do perfil epidemiológico da população que compõe a amostra. A amostra foi subdividida por faixa etária, até 19 anos de idade e depois por décadas até atingir 60+. Os objetivos específicos são (i) descrever o perfil epidemiológico dos pacientes internados no Hospital Municipal Dr. Fernando Mauro Pires da Rocha, e (ii) estudar quais tipos de substância(s) utilizada(s) e diagnóstico psiquiátrico correlacionado.


Subject(s)
Humans , Psychiatry , Psychotropic Drugs , Illicit Drugs , Substance-Related Disorders , Alcoholism
2.
Pesqui. bras. odontopediatria clín. integr ; 24: e230065, 2024. tab, graf
Article in English | LILACS, BBO | ID: biblio-1550588

ABSTRACT

ABSTRACT Objective: To assess the level of oral cancer awareness and risk factors perception and the relationship between this awareness and the sociodemographic and behavioral characteristics. Material and Methods: This descriptive study was conducted among rural and urban residents in Lagos State, Nigeria. A multi-stage random sampling method was utilized. The sociodemographic and behavioral characteristics of respondents, as well as their knowledge about oral cancer risk factors, were assessed with a validated questionnaire. The bivariate association was done using an independent t-test and one-way ANOVA. Multivariate regression was used to determine the association between predictor variables and oral cancer knowledge scores. The statistical significance level is set at p<0.05. Results: 590 participants between 18 and 82 years (mean age 34.5 ±13.7) completed the survey. The prevalence of cigarette smoking was 25.7%, of which 16 (1.5%) were heavy smokers (20+ cigarettes per day). The prevalence of alcohol consumption was 66.1%, with 57 (9.7%) being heavy drinkers, consuming drinks for 5-7 days of the week. A high proportion of the respondents (>60%) exhibited gaps in their knowledge of oral cancer. Uneducated participants had lower oral cancer knowledge than those with >12 years of formal education (aOR = 5.347; 95% CI: 4.987-6.240). Participants who were smokers had lower oral cancer knowledge compared with non-smokers (aOR = 3.341; 95% CI: 2.147-4.783); Participants who consumed alcohol had more deficient oral cancer knowledge compared with non-drinkers (aOR = 1.699; 95% CI: 1.087-2.655); While heavy smokers aOR = 4.023; 95% CI: 3.615-4.825) and heavy drinkers aOR = 4.331; 95% CI: 3.158-5.939) had lower oral cancer knowledge compared with those who did not abuse both substances. Conclusion: A high proportion of the respondents exhibited gaps in their knowledge of oral cancer in their responses. Delayed diagnosis of oral cancer can be reduced by increasing the awareness and knowledge of the populace about risk factors and also in the recognition of its signs and symptoms.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Tobacco Use Disorder , Mouth Neoplasms/diagnosis , Health Knowledge, Attitudes, Practice , Risk Factors , Alcoholism , Sociodemographic Factors , Epidemiology, Descriptive , Cross-Sectional Studies/methods , Multivariate Analysis , Surveys and Questionnaires , Analysis of Variance , Evaluation Studies as Topic , Nigeria/epidemiology
3.
Psicol. ciênc. prof ; 44: e258946, 2024.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1558745

ABSTRACT

Este trabalho tem o objetivo de analisar as concepções de maternidade para mulheres inférteis de diferentes níveis socioeconômicos que estão em tratamento de reprodução assistida. Trata-se de um estudo qualitativo, descritivo, que utilizou como instrumento uma entrevista semiestruturada e contemplou temas como o significado de família, desejo/expectativas sobre filho e gestação e expectativas sobre a maternidade. Participaram da pesquisa 48 mulheres inférteis acima de 35 anos que usam tecnologias de reprodução assistida de alta complexidade em instituições privada e pública. Os dados foram tratados pela análise de conteúdo em que emergiram os temas: representações sociais da família; representações sociais da maternidade; expectativas com a gestação e os modelos maternos; e o filho imaginado. As participantes representaram a família de forma positiva, como um sistema de suporte, de fundação e origem de amor, configurando-a como um laço social. Por outro lado, as concepções de família com base na consanguinidade também estiveram presentes, representando a família pela perpetuação da espécie e pela importância do laço biológico. A maternidade foi marcada por significativa idealização, sendo vista como um papel gratificante e de realização da feminilidade. O peso da cobrança social para procriar também foi sentido como um dever a cumprir e que, na impossibilidade de se realizar, gera sentimentos de inferioridade, menos-valia, impotência e inadequação perante a sociedade, o que reforça o estigma da infertilidade. Tais resultados apontam a importância de reflexões sobre o papel da mulher na nossa cultura, visto que a maternidade é ainda utilizada como medida para o sucesso ou fracasso feminino. Faz-se necessário também refletir sobre a possibilidade da maior inserção do trabalho psicológico na reprodução assistida, visto a carga emocional e social envolvidas nesse processo.(AU)


This study aimed to analyze the conceptions of motherhood for infertile women from different socioeconomic levels who are undergoing assisted reproduction treatment. This is a qualitative and descriptive study that used a semi-structured interview as an instrument and included topics such as the meaning of family and desires/expectations about the child, pregnancy, and motherhood. A total of 48 infertile women over 35 years of ages using high-complexity assisted reproductive technologies in private and public institutions participated in this research. The data were treated by content analysis in which the following themes emerged: family social representations; social representations of motherhood; expectations with pregnancy and maternal models; and the imagined son. Participants represented the family in a positive way as a support system and the foundation and origin of love, embracing the family as a social bond. On the other hand, the family concepts based on inbreeding were also present, representing the family by perpetuation of the species and the importance of biological bonds. Motherhood was marked by significant idealization, being seen as a gratifying role and the fulfillment of femininity. The weight of the social demand to procreate was also felt as a duty to be fulfilled that, in the impossibility of carrying it out, generates feelings of inferiority, worthlessness, impotence, and inadequacy toward society, which reinforce the stigma of infertility. Results point to the necessary reflections on the role of women and our culture since Motherhood is still used as a measure of female success or failure. They also point to a reflection on the possibility of greater inclusion of psychological work in assisted reproduction given the emotional and social burden involved in this process.(AU)


Este estudio tuvo como objetivo analizar las concepciones de maternidad de mujeres infértiles, de diferentes niveles socioeconómicos, que se encuentran en tratamiento de reproducción asistida. Se trata de un estudio cualitativo, descriptivo, que utilizó como instrumento una entrevista semiestructurada e incluyó temas como el sentido de la familia, deseos/expectativas sobre el hijo y el embarazo y expectativas sobre la maternidad. Participaron en la investigación un total de 48 mujeres infértiles, mayores de 35 años, usuarias de tecnologías de reproducción asistida de alta complejidad en instituciones públicas y privadas. Los datos se sometieron a análisis de contenido del cual surgieron los temas: representaciones sociales familiares; representaciones sociales de la maternidad; expectativas con el embarazo y modelos maternos; hijo imaginado. Las participantes representaron a la familia de manera positiva, como sistema de apoyo, fundamento y origen del amor, configurándola como vínculo social. Por otro lado, también estuvieron presentes las concepciones familiares basadas en la consanguinidad, representando a la familia para la perpetuación de la especie y la importancia del vínculo biológico. La maternidad estuvo marcada por una importante idealización, vista como un rol gratificante y de realización de la feminidad. También se sintió el peso de la demanda social de procrear como un deber que cumplir y que, ante la imposibilidad de realizarlo, genera sentimientos de inferioridad, desvalorización, impotencia e inadecuación en la sociedad, lo que refuerza el estigma de la infertilidad. Por tanto, son necesarias reflexiones sobre el papel de la mujer en nuestra cultura, ya que la maternidad se sigue utilizando como medida del éxito o fracaso femenino. También se reflexiona sobre la posibilidad de una mayor inclusión del trabajo psicológico en la reproducción asistida dada la carga emocional y social que implica este proceso.(AU)


Subject(s)
Humans , Female , Pregnancy , Reproduction , Family , Parenting , Social Representation , Infertility, Female , Anxiety , Ovulation Detection , Ovulation Induction , Ovum , Ovum Transport , Parent-Child Relations , Patient Care Team , Patients , Pregnancy Maintenance , Pregnancy, Multiple , Prejudice , Psychology , Quality of Life , Self Concept , Sex , Sexual Abstinence , Shame , Achievement , Social Identification , Sperm Transport , Spermatozoa , Taboo , Time , Tobacco Use Disorder , Urogenital System , Uterus , Population Characteristics , National Health Strategies , Labor, Obstetric , Pregnancy , Pregnancy Outcome , Pharmaceutical Preparations , Adoption , Divorce , Marriage , Fertilization in Vitro , Sexually Transmitted Diseases , Child Rearing , Family Characteristics , Risk Factors , Pelvic Inflammatory Disease , Reproductive Techniques , Gestational Age , Coitus , Pregnancy, High-Risk , Oocyte Donation , Consanguinity , Contraception , Sexuality , Couples Therapy , Affect , Abortion, Threatened , Pelvic Infection , Heredity , Inheritance Patterns , Ovulation Prediction , Depression , Reproductive Rights , Diagnosis , Dreams , Alcoholism , Embryo Transfer , Endometriosis , Conjugal Status , Job Market , Fallopian Tube Patency Tests , Family Conflict , Family Relations , Fantasy , Fear , Female Urogenital Diseases and Pregnancy Complications , Masculinity , Sedentary Behavior , Binge Drinking , Hope , Social Norms , Delay Discounting , Contraceptive Prevalence Surveys , Psychological Trauma , Donor Conception , Healthy Lifestyle , Contraceptive Effectiveness , Long-Acting Reversible Contraception , Social Construction of Gender , Gender Expression , Gender-Specific Needs , Frustration , Embarrassment , Sadness , Emotional Regulation , Psychological Distress , Empowerment , Varicocele , Belonging , Family Support , Emotional Exhaustion , Guilt , Happiness , Imagination , Infertility, Male , Insemination, Artificial, Homologous , Laboratories , Life Style , Loneliness , Maternal-Fetal Exchange , Medicine , Obesity
4.
Rev. Baiana Enferm. (Online) ; 38: e48604, 2024. tab
Article in Portuguese | LILACS, BDENF | ID: biblio-1559303

ABSTRACT

Objetivo: avaliar as percepções, conhecimentos e atitudes antes e após a realização de um treinamento aos Agentes Comunitários de Saúde (ACS). Método: estudo quase experimental e quantitativo, realizado no interior do estado de São Paulo. Para a coleta de dados foi utilizado ficha de identificação sociodemográfica, Seaman & Manello e Short Alcohol and Alcohol Problems Perception Questionnaire, aplicados em 31 ACS de serviços de Atenção Primária à Saúde. O estudo foi submetido e aprovado pelo Comitê de Ética. Resultados: as percepções foram positivas, mas ainda existem dificuldades para trabalhar na prática, os conhecimentos apresentaram mudanças em relação aos sinais e sintomas relacionados ao uso de álcool e as atitudes. Não foram observadas mudanças significativas após o treinamento. Conclusão: o treinamento é uma estratégia que possibilita mudanças nas práticas de saúde para a assistência integral e que deve ser incorporada nas rotinas das unidades de Atenção Primária à Saúde (APS).


Objetivo: evaluar percepciones, conocimientos, y actitudes antes y después de un entrenamiento de Agentes Comunitarios de Salud (ACS). Método: estudio cuasiexperimental y cuantitativo, realizado en el interior del estado de São Paulo. Para colectar a los datos se utilizó un formulario de identificación sociodemográfica, el Seaman & Manello y el Short Alcohol and Alcohol Problems Perception Questionnaire, aplicados a 31 ACS en servicios de atención primaria a la salud. El estudio fue aprobado por el comité de ética. Resultados: las percepciones fueran positivas, pero hay dificultades en la práctica del trabajo. Los conocimientos cambiaron con respecto a las señales y síntomas relacionados al uso de alcohol y a las actitudes. No se observó cambios significativos después del entrenamiento. Conclusión: el entrenamiento posibilita cambios en las prácticas de salud para la asistencia integral, y debe ser incorporado en las rutinas de las unidades de atención primaria a la salud (APS).


Objective: To evaluate the perceptions, knowledge, and attitudes, before and after a training session provided to community health workers (CHW). Method: Quasi-experimental, quantitative study, carried out in the countryside of the state of São Paulo. For data collection, we used Seaman and Manello's sociodemographic identification form and the Short Alcohol and Alcohol Problems Perception Questionnaire, applied to 31 CHWs of primary health care services. The study was submitted and approved by the research ethics committee. Results: Perceptions were positive, but there are still practical obstacles regarding the actual work. The knowledge related to signs and symptoms of alcohol use and related attitudes was changed, as were the attitudes. There were no significant changes after training. Conclusion: training is a strategy that enables changes in health practices for integral care. It should be incorporated in the routine of Primary Health Care (PHC) units.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Primary Health Care/organization & administration , Community Health Workers/education , Alcoholism/prevention & control , Health Human Resource Training , Mentoring/methods
5.
Cogitare Enferm. (Online) ; 29: e93922, 2024. tab
Article in Portuguese | LILACS, BDENF | ID: biblio-1582120

ABSTRACT

RESUMO Objetivo: analisar os fatores associados ao uso do álcool entre adolescentes escolares brasileiros. Método: trata-se de um estudo transversal analítico utilizando dados secundários da Pesquisa Nacional de Saúde do Escolar edição 2019, conduzida pelo Instituto Brasileiro de Geografia e Estatística. A pesquisa avaliou 125.123 adolescentes por meio da aplicação de um questionário. Para o modelo final foi utilizada a regressão logística múltipla. Resultados: o uso de cigarro na vida foi fortemente associado ao uso de álcool (Odds Ratio=3,25; Intervalo de Confiança 95% 2,28-4,62), seguido do uso de álcool por amigos nos últimos 30 dias (Odds Ratio=2,15; Intervalo de Confiança 95% 1,52-3,05) e ter pai e mãe que fumam (Odds Ratio=1,29; Intervalo de Confiança 95%1,13-148). Conclusão: são importantes ações integradas e políticas públicas envolvendo jovens e adolescentes para garantir a saúde e o bem-estar de adultos saudáveis.


ABSTRACT Objective: To analyze the factors associated with alcohol use among Brazilian school adolescents. Method: This analytical cross-sectional study uses secondary data from the 2019 National School Health Survey edition conducted by the Brazilian Institute of Geography and Statistics. The research evaluated 125,123 adolescents through the application of a questionnaire. For the final model, multiple logistic regression was used. Results: Lifetime cigarette use was strongly associated with alcohol use (Odds Ratio=3.25; 95% Confidence Interval 2.28-4.62), followed by friends' alcohol use in the last 30 days (Odds Ratio=2.15; 95% Confidence Interval 1.52-3.05) and having parents who smoke (Odds Ratio=1.29; 95% Confidence Interval 1.13-1.48). Conclusion: Integrated actions and public policies involving young people and adolescents are important to ensure the health and well-being of healthy adults.


RESUMEN Objetivo: analizar los factores asociados con el consumo de alcohol entre adolescentes escolares brasileños. Método: se trata de un estudio transversal analítico utilizando datos secundarios de la Encuesta Nacional de Salud del Escolar edición 2019, conducida por el Instituto Brasileño de Geografía y Estadística. La investigación evaluó a 125.123 adolescentes mediante la aplicación de un cuestionario. Para el modelo final se utilizó la regresión logística múltiple. Resultados: el uso de cigarrillo en la vida estuvo fuertemente asociado al uso de alcohol (Odds Ratio=3,25; Intervalo de Confianza 95% 2,28-4,62), seguido del uso de alcohol por amigos en los últimos 30 días (Odds Ratio=2,15; Intervalo de Confianza 95% 1,52-3,05) y tener padre y madre que fuman (Odds Ratio=1,29; Intervalo de Confianza 95%1,13-148). Conclusión: son importantes acciones integradas y políticas públicas que involucren a jóvenes y adolescentes para garantizar la salud y el bienestar de adultos saludables.


Subject(s)
Humans , Adolescent , Students , Alcohol Drinking , Cross-Sectional Studies , Adolescent , Alcoholism , Underage Drinking , School Health Services
6.
Cogitare Enferm. (Online) ; 29: e93340, 2024. tab
Article in Portuguese | LILACS, BDENF | ID: biblio-1582123

ABSTRACT

RESUMO: Objetivo: compreender as representações sociais sobre alcoolismo entre alcoolistas abstêmios em um grupo terapêutico e suas repercussões para o cuidado no Centro de Atenção Psicossocial de Álcool e outras Drogas. Método: estudo qualitativo com a participação de 20 depoentes, empregada a técnica de livre associação de palavras; estudo realizado no CAPS-AD III na cidade de Belém - Pará - Brasil, em 2023. Dados analisados por análise temática seguida de seis etapas. Resultados: desvelou-se a trajetória do consumo problemático de álcool, por meio de suas representações sociais, nas quais construíram formas de cuidado ligadas primeiramente ao senso comum. Infere-se que eles, sofrendo com males do alcoolismo, buscam a dignidade e retorno à vida cotidiana. Considerações finais: o estudo evidencia que desvelar as representações sociais favorece o acolhimento da família e profissionais de saúde mental, logo o Centro de Atenção Psicossocial se revela como uma nova chance aos usuários abstêmios.


ABSTRACT OBJECTIVE: to understand the social representations of alcoholism among abstinent alcoholics in a therapeutic group and their impact on care at the Psychosocial Care Center for Alcohol and Other Drugs. Method: a qualitative study with the participation of 20 interviewees, using the technique of free association of words; a study carried out at CAPS-AD III in the city of Belém - Pará - Brazil, in 2023. Six stages follow thematic analysis to analyze data. Results: the trajectory of problematic alcohol consumption was revealed through their social representations, in which they constructed forms of care linked primarily to common sense. It is inferred that they, suffering from alcoholism, seek dignity and a return to everyday life. Final considerations: the study shows that unveiling social representations favors welcoming the family and mental health professionals. Hence, the Psychosocial Care Center reveals itself as a new chance for abstinent users.


RESUMEN OBJETIVO: comprender las representaciones sociales del alcoholismo entre alcohólicos abstinentes de un grupo terapéutico y sus repercusiones en la atención en el Centro de Atención Psicosocial de Alcohol y Otras Drogas. Método: estudio cualitativo con la participación de 20 entrevistados, utilizando la técnica de asociación libre de palabras; estudio realizado en el CAPS-AD III de la ciudad de Belém - Pará - Brasil, en 2023. Datos analizados mediante análisis temático seguido de seis etapas. Resultados: la trayectoria de consumo problemático de alcohol fue revelada a través de sus representaciones sociales, en las que construyeron formas de cuidado vinculadas principalmente al sentido común. Se puede inferir que, sufriendo de alcoholismo, buscan la dignidad y el retorno a la vida cotidiana. Consideraciones finales: el estudio muestra que el desvelamiento de las representaciones sociales favorece la acogida de la familia y de los profesionales de salud mental, por lo que el Centro de Atención Psicosocial se revela como una nueva oportunidad para los usuarios abstinentes. seguido de seis etapas.


Subject(s)
Humans , Mental Health , Alcoholism , Rehabilitation Services , Social Representation , Mental Health Services
7.
Front. med. (En línea) ; 18(4): 0229-0234, Oct.-Dic. 2023.
Article in Spanish | LILACS | ID: biblio-1568496

ABSTRACT

Introducción. En los estadios avanzados de la cirrosis se pueden presentar coagulopatías, las cuales se definen como los trastornos en el sistema de coagulación y se identifican por la prolongación del tiempo de protrombina, INR elevado, tiempo de tromboplastina parcial activado prolongado y trombocitopenia. El objetivo del estudio fue determinar la prevalencia de alteraciones de coagulación en los pacientes con cirrosis hepática. Materiales y métodos. Se realizó un estudio observacional, descriptivo, retrospectivo de corte transversal, en mayores de 18 años de edad atendidos en el Hospital Universitario San Rafael de Tunja entre el 01 de enero del 2016 al 31 de diciembre del 2021 con diagnóstico de cirrosis hepática, identificados a partir del sistema de información de la institución, mediante el código internacional de enfermedades (CIE-10). Resultados. De 289 pacientes, 74.4% presentaba coagulopatías, predominando el género masculino. La etiología más relacionada al desarrollo de coagulopatías fue el enolismo (62.98%). Los antecedentes comúnmente relacionados fueron: hipertensión arterial 19.38%, diabetes 11.43% y litiasis biliar 11.76%. El 38.75% de pacientes categorizados en clase C (Child Pugh) presentó predisposición al desarrollo de coagulopatías. Conclusiones. La prevalencia de coagulopatías en los pacientes con cirrosis hepática es alta, presentándose con mayor frecuencia en los pacientes de sexo masculino, alcohólicos. En valores pronósticos, la escala de Child Pugh ayuda a categorizar al paciente con mayor riesgo de coagulopatías.


Subject(s)
Blood Coagulation Disorders , Alcoholism , Liver Cirrhosis , Thrombosis , Hemostasis
8.
Rev. cient. Esc. Univ. Cienc. Salud ; 10(2): 42-50, jul.-dic. 2023. tab.
Article in Spanish | LILACS, BIMENA | ID: biblio-1567403

ABSTRACT

la gangrena de Fournier es una fascitis necrosante tipo I que afecta a los hombres y mujeres en cualquier edad, se origina por una infección de la región perianal, genital y del tercio inferior del abdomen, es de etiología polimicrobiana y puede ocurrir propagación hasta la clavícula; esta patología, presenta una alta tasa de mortalidad, por lo que requiere tratamiento rápido y agresivo. Objetivo: identificar las necesidades de paciente Gangrena de Fournier, e implementar el proceso de atención de enfermería (PAE), realizando valoración y elaboración de los diagnósticos según la Taxonomía de North American Nursing Diagnosis Association (NANDA). Se presenta caso de paciente masculino de 38 años de edad, el cual presentaba lesión ulcerada de aproximadamente 8 cm de longitud en área perianal, con bordes irregulares, endurecidos, fétido, acompañado de dolor a la palpación, caliente al tacto, presencia de afectación muscular (esfinteranal externo), localizado en región perianal anterior, que se comunica con región contralateral del glúteo derecho, acompañado de cambios inflamatorios, aproximadamente 5cc de secreción purulenta. Paciente fue sometido a desbridamiento y limpieza en región afectada; en el proceso de atención de enfermería (PAE), se realizó valoración y elaboración de los diagnósticos según la Taxonomía NANDA: 1) Dolor agudo 2) Deterioro de la integridad tisular 3) Riesgo de infección 4) inestabilidad emocional. Además, se elaboró el plan de intervención con Nursing Outcomes Classification (NOC) y Nursing Interventions Classification (NIC)...(AU)


Subject(s)
Humans , Male , Aged , Fasciitis, Necrotizing , Alcoholism , Back Muscles
9.
Rev. latinoam. enferm. (Online) ; 31: e3980, Jan.-Dec. 2023. tab
Article in Spanish | LILACS, BDENF | ID: biblio-1515333

ABSTRACT

Objetivo: identificar la prevalencia y los factores asociados a la ideación suicida pasiva y activa a lo largo de la vida en estudiantes ingresantes de posgrado. Método: estudio analítico y de diseño transversal, con una muestra compuesta por 321 estudiantes ingresantes de posgrado. Se realizó análisis estadístico descriptivo e inferencial múltiple. Resultados: los análisis multivariados indican que la ideación suicida pasiva y activa tuvieron una prevalencia mayor y similar en los estudiantes de orientación sexual minoritaria, del sexo femenino, que realizaban actividad física diaria ≤ 30 minutos/día y sufrieron victimización por violencia psicológica en los últimos 12 meses. Los factores abuso de alcohol, las exigencias del posgrado stricto sensu no afectaron las relaciones familiares y baja autoestima se asociaron solo con la ideación suicida pasiva. A su vez, el consumo de marihuana en los últimos 30 días, no tener una buena relación interpersonal con sus pares académicos, ejercer la actividad profesional junto con las exigencias del posgrado se asociaron únicamente con ideación suicida activa. Conclusión: se identificó una alta prevalencia de ideación suicida pasiva y activa a lo largo de la vida en los estudiantes ingresantes de posgrado y se comprobó que hubo similitudes y diferencias entre algunos de los factores asociados a ambos resultados.


Objective: to identify the prevalence and factors associated with passive and active suicidal ideation throughout life among students entering graduate courses. Method: an analytical and cross-sectional study with a sample comprised of 321 students entering graduate courses. Multiple descriptive and inferential statistical analyses were performed. Results: the multivariate analyses indicated that passive and active suicidal ideation were similarly more prevalent among female students belonging to minority sexual orientations who engaged in daily physical activity ≤ 30 minutes/day and were victims of psychological violence in the past 12 months. Alcohol abuse, family relationships not impaired due to the demands imposed by stricto sensu graduate studies and low self-esteem were only associated with passive suicidal ideation. In turn, recent marijuana use in the last 30 days, poor interpersonal relationships with academic peers, and engagement in professional activities concomitantly with the demands imposed by graduate studies were only associated with active suicidal ideation. Conclusion: high prevalence of lifetime passive and active suicidal ideation was identified among graduate students, and similarities and differences were verified between some associated factors for both outcomes.


Objetivo: identificar a prevalência e fatores associados à ideação suicida passiva e ativa ao longo da vida em estudantes ingressantes na pós-graduação. Método: estudo analítico e de delineamento transversal, amostra composta por 321 estudantes ingressantes da pós-graduação. Realizou-se análise estatística descritiva e inferencial múltipla. Resultados: análises multivariadas apontaram que ideação suicida passiva e ativa foram similarmente mais prevalentes entre estudantes de orientações sexuais minoritárias, do sexo feminino, que realizavam atividade física diária ≤ 30 minutos/dia e sofreram vitimização por violência psicológica nos últimos 12 meses. O abuso de álcool, o não prejuízo no relacionamento familiar por demandas da pós-graduação stricto sensu e a baixa autoestima foram associadas unicamente com ideação suicida passiva. Por sua vez, o consumo de maconha ocorrido nos últimos 30 dias, a falta de um relacionamento interpessoal satisfatório com seus pares acadêmicos e a prática da atividade profissional em concomitância com as demandas da pósgraduação foram associadas apenas com ideação suicida ativa. Conclusão: identificou-se alta prevalência de ideação suicida passiva e ativa ao longo da vida entre estudantes ingressantes na pós-graduação e verificou-se a ocorrência de similitudes e diferenças entre alguns fatores associados para ambos os desfechos.


Subject(s)
Humans , Male , Female , Students , Prevalence , Cross-Sectional Studies , Alcoholism , Suicidal Ideation
10.
Article in Spanish | CUMED, LILACS | ID: biblio-1583660

ABSTRACT

Estimado editor: Luego de revisar con mucho interés el artículo original Intervención educativa sobre alcoholismo en pobladores del policlínico Fermín Valdés Domínguez, Baracoa,1 que realiza un estudio preexperimental de tipo antes-después sobre aplicación de un programa de intervención educativa para modificar el nivel de conocimientos sobre alcoholismo en pobladores de la comunidad de Santa Rosa. El estudio estuvo compuesto por pacientes mayores de 18 años de edad, de los cuales, antes de la intervención educativa, el 76,7 por ciento no tenía conocimientos sobre las consecuencias que provoca el consumo de alcohol; compartimos algunas observaciones que creemos enriquecerían el análisis de la información, especialmente dirigida a los adolescentes: La baja percepción de riesgo es uno de los factores que en mayor medida promueve o favorece el consumo de alcohol en los adolescentes y, por ello, incrementar dicha percepción es uno de los objetivos fundamentales de las campañas de prevención. Estas campañas se llevan a cabo en los centros educativos y a través de los medios de comunicación, y se fundamentan en ofrecer información a los adolescentes sobre los distintos peligros asociados a la ingestión...(AU)


Subject(s)
Humans , Male , Female , Alcoholism/epidemiology , Underage Drinking/prevention & control , Education/methods
11.
Psico USF ; 28(3): 449-459, jul.-set. 2023. tab, il
Article in English | LILACS, INDEXPSI | ID: biblio-1521371

ABSTRACT

Risk behaviors are common in adolescence and demonstrates an association with depressive symptoms. Considering the psychological health implications of this phase in adult life, the aim of this study was to verify associations between depressive symptoms and consumption of alcohol and marijuana, self-injurious behavior, health self-perception, life satisfaction, anxiety symptoms and suicidal ideation in adolescents. A total of 298 adolescents, aged 12 to 14 years (61.1% girls), participated in the study. The measures were the translated Health Behavior in School-aged Children questionnaire (HBSC - BR) and the Children's Depression Inventory (CDI). The chi-square test, student's t test and binomial logistic regression (p<0.05) were used. Depressive symptoms were associated with anxiety symptoms and self-injury. Higher risk for alcohol use and consumption, self-injury, negative health self-perception, anxiety and depression related to females. The findings of this population suggest worrying health outcomes, especially for girl. (AU)


Comportamentos de risco são comuns na adolescência e demonstram associação com sintomas depressivos. Considerando as implicações da saúde psicológica dessa fase na vida adulta, o objetivo deste trabalho foi verificar associações entre sintomas depressivos e consumo de álcool e maconha, comportamento autolesivo, autopercepção de saúde, satisfação com a vida, sintomas ansiosos e ideação suicida em adolescentes. Participaram 298 adolescentes, de 12 a 14 anos (61,1% meninas). Os instrumentos utilizados foram o questionário traduzido Health Behavior in School-aged Children (HBSC - BR) e o Inventário de Depressão Infantil (CDI). Utilizou-se os teste Qui-Quadrado, t de student e regressão logística binomial (p<0,05). Sintomas depressivos associaram-se com sintomas ansiosos e autolesão. Maior risco para uso e consumo de álcool, autolesão, autopercepção de saúde negativa, ansiedade e depressão em relação ao sexo feminino. Os achados desta população sugerem resultados preocupantes de saúde, sobretudo para o sexo feminino. (AU)


Las conductas de riesgo son comunes en la adolescencia y demuestran una asociación con síntomas depresivos. Considerando las implicaciones psicológicas para la salud de esta fase en la vida adulta, el objetivo de este estudio fue verificar asociaciones entre síntomas depresivos y consumo de alcohol y marihuana, autolesión, autopercepción de salud, satisfacción con la vida, ansiedad e ideación suicida en adolescentes. Participaron 298 adolescentes de 12 a 14 años (61,1% niñas). Los instrumentos utilizados fueron el cuestionario traducido Health Behavior in School-aged Children (HBSC - BR) y el Inventario de Depresión Infantil (CDI). Se utilizaron las pruebas de chi-cuadrado, t de Student y regresión logística binomial (p<0,05). Los síntomas depresivos se asociaron con síntomas de ansiedad y autolesiones. Mayor riesgo de uso y consumo de alcohol, autolesiones, autopercepción negativa de la salud, ansiedad y depresión en relación con el sexo femenino. Los hallazgos de esta población sugieren resultados de salud preocupantes, especialmente para las mujeres. (AU)


Subject(s)
Humans , Male , Female , Child , Adolescent , Anxiety/psychology , Cannabis , Mental Health , Depression/psychology , Alcoholism/psychology , Health Risk Behaviors , Personal Satisfaction , Chi-Square Distribution , Logistic Models , Cross-Sectional Studies , Surveys and Questionnaires
12.
Medisan ; 27(4)ago. 2023. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1514567

ABSTRACT

Introducción: Hoy en día las enfermedades no transmisibles constituyen un grave problema que afecta el estado de salud de la población, con una tendencia ascendente preocupante. Objetivo: Identificar los factores predisponentes a las enfermedades no transmisibles en pacientes de un área de salud. Métodos: Se realizó un estudio observacional, descriptivo y transversal de 286 individuos, escogidos a través de un muestreo aleatorio bietápico en el área de salud Josué País García del municipio de Santiago de Cuba, durante el 2021. Las variables analizadas fueron antecedentes patológicos personales, consumo de productos del tabaco y alcohol, hábitos dietéticos y evaluación nutricional. Se utilizaron como medidas de resumen las frecuencias absolutas, el porcentaje y la tasa de prevalencia para variables cualitativas; la media aritmética y el mínimo e intervalo de confianza para variables cuantitativas. Resultados: El mayor riesgo de presentar hipertensión arterial figuró en las féminas (35,6 %) y existió alta prevalencia de fumadores en hombres (30,5 %) y mujeres (27,7 %). Asimismo, predominaron la exposición al humo de tabaco (fumadores pasivos) y el consumo de alcohol en edades tempranas (25-34 años). De los encuestados, 33,3 % resultó estar sobrepeso u obeso. Conclusiones: Los factores predisponentes a las enfermedades no transmisibles pudieran estar asociados con estilos de vida no saludables como el consumo de productos del tabaco y el alcohol, los hábitos dietéticos inadecuados y el sobrepeso.


Introduction: Nowadays non-communicable diseases are a serious problem that affects the health of the population, with a worrying upward tendency. Objective: To identify the predisposing factors to non-communicable diseases in patients from a health area. Methods: An observational, descriptive and cross-sectional study of 286 individuals, chosen by a two-stage random sampling in Josué País García health area from Santiago de Cuba municipality, was carried out during 2021. The analyzed variables were personal pathological history, consumption of tobacco and alcohol products, dietary habits and nutritional evaluation. The absolute frequencies, percentage and prevalence rate were used as summary measures for qualitative variables; the arithmetic mean and the minimum and interval of confidence were used for quantitative variables. Results: The highest risk of presenting hypertension was in females (35.6%) and there was a high prevalence of smokers in men (30.5%) and women (27.7%). Also, the exposure to tobacco smoke (passive smokers) and alcohol consumption at an early age (25-34 years) prevailed. Of those interviewed, 33.3% was overweight and obese. Conclusions: The predisposing factors to non-communicable diseases could be associated with the non healthy lifestyle as the consumption of tobacco and alcohol products, inadequate dietary habits and overweight.


Subject(s)
Tobacco Use Disorder , Alcoholism , Noncommunicable Diseases , Nutrition Assessment , Diet
13.
Estud. Pesqui. Psicol. (Online) ; 23(2): 689-706, julho 2023.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1532758

ABSTRACT

Familiares de dependentes de álcool vivem intenso sofrimento emocional que os vulnerabiliza a ponto de necessitarem cuidado profissional. No Brasil, o Centro de Atenção Psicossocial Álcool e Drogas (CAPs AD) é o serviço público de referência no atendimento psicossocial a usuários de álcool e outras drogas. A partir da constatação da inexistência de artigos científicos sobre intervenções com familiares dos dependentes de álcool no CAPs AD, dada a profusão de trabalhos que tratam do dependente ou das políticas públicas que fundamentam o serviço, elaboramos três hipóteses sobre essa lacuna. A primeira propõe que na base dessa ausência de modalidades terapêuticas específicas esteja a concepção de que o cuidado aos familiares no CAPs AD é o mesmo e independe das peculiaridades de cada substância psicoativa. A segunda hipótese parte do fato de que a constante ameaça de aniquilamento dos próprios CAPs AD e a consequente luta para sua sobrevivência comprometeria pesquisas para o desenvolvimento de intervenções cada vez mais especializadas. E, finalmente, a hipótese de que a maior demanda de atendimento de usuários de mais de uma substância desarticularia a proposição de intervenções com familiares de dependentes de álcool. Esperamos que este estudo contribua para a elaboração de intervenções mais afinadas às necessidades desse público.


Family members of alcohol dependents live intense emotional suffering that makes them vulnerable to the point of needing professional care. In Brazil, the Psychosocial Care Center for Alcohol and Drugs (CAPSad) is the public service of reference in psychosocial care for users of alcohol and other drugs. Based upon the lack of studies on interventions for family members of alcohol dependents in the CAPSad, contrasting with the profusion of works that deal with the dependent or the public policies that support the service, we elaborated three hypotheses about this gap. The first one proposes that at the center of this abscense of specific therapeutic modalities there is the idea that care for family members in the CAPSad is the same and does not depend on the peculiarities of each psychoactive substance. The second hypothesis derives from the fact that the constant threat of annihilation of the CAPSad themselves and the struggle for their survival would compromise the development of increasingly specialized interventions. At last, the hypothesis that the greater demand for assistance from multiple substance users would dismantle the proposal of interventions with family members of alcohol dependents. We expect that this study will contribute to the development of interventions in accord with the needs of this audience.


Familiares de dependientes de alcohol viven intenso sufrimiento emocional que los vulnera hasta que necesiten cuidado profesional. En Brasil, el Centro de Atención Psicosocial Alcohol y Drogas (CAPs AD) es el servicio público referencial a la atención psicosocial a usuarios de alcohol y drogas. Desde la constatación de la inexistencia de ensayos sobre intervenciones con familiares de dependientes de alcohol en CAPs AD, dada la profusión de trabajos que tratan del dependiente o de las políticas públicas que fundamentan el servicio, se elaboró tres hipótesis sobre esa brecha. La primera propone que en la base de esa ausencia de modalidades terapéuticas específicas esté una concepción de que el cuidado a los familiares en CAPs AD es lo mismo y no depende de las peculiaridades de cada material psicoactivo. La segunda hipótesis parte del hecho de que la constante amenaza de aniquilación de los CAPs AD y consecuente lucha para su sobrevivencia comprometería investigaciones al desarrollo de intervenciones todavía más especializadas. Finalmente, la hipótesis de que la mayor demanda de atención a usuarios de más de una sustancia desestructuraría la proposición de intervenciones con familiares de dependientes de alcohol. Se espera que este estudio contribuya a la elaboración de intervenciones específicas a las necesidades de ese público.


Subject(s)
Family , Alcoholism , Family Therapy , Mental Health Services , Psychological Distress
14.
Rev. fac. cienc. méd. (Impr.) ; 20(1): 8-16, ene.-jul 2023. tab
Article in Spanish | LILACS, BIMENA | ID: biblio-1580226

ABSTRACT

En los últimos seis años, datos policiales han apuntado un alza en la tasa de suicidios en Honduras, encontrándose para el 2018 en tercer lugar el municipio de Danlí, departamento de El Paraíso, precedido únicamente por las dos zonas metropolitanas más densamente pobladas, Tegucigalpa y San Pedro Sula. Objetivo: caracterizar clínica y epidemiológicamente los casos de pacientes con diagnóstico de intento suicida recibidos en los servicios de medicina interna, pediatría, y cirugía del Hospital Básico Gabriela Alvarado. Material y métodos: estudio retrospectivo, descriptivo, transversal. Se revisaron expedientes de 15 casos con diagnóstico de intento suicida atendidos en el Hospital Básico Gabriela Alvarado, ubicado en el municipio de Danlí, departamento de El Paraíso durante el período Mayo-Agosto 2019. Resultados: Predominó el sexo masculino 12(80%), edad media 25 años, la mayoría procedentes del municipio de Danlí 6(40%), sobrevivieron 14(93.34%). El mecanismo más frecuente utilizada fue intoxicación por substancias no medicamentosas 11(73.33%), especialmente plaguicidas como cipermetrina 5(28.57%) y herbicidas como glifosato 2(14.29%), y paraquat 2(14.29%). Conclusión: se estimó una prevalencia de intento suicida de 0.44%. El perfil del paciente parasuicida es hombre joven, edad promedio 25 años que se desempeña como agricultor, antecedente de alcoholismo, sin comorbilidades. Se evidenció falta de conocimiento y escasos recursos de atención en Salud Mental en el Hospital Básico Gabriela Alvarado. Programas de prevención y educación pueden ser de beneficio inmediato a nivel poblacional, así como el fortalecimiento institucional para lograr la cobertura adecuada de la demanda en materia de salud mental...(AU)


Subject(s)
Humans , Male , Female , Adolescent , Adult , Suicide , Suicide, Attempted , Alcoholism , Mental Health Assistance
15.
Subj. procesos cogn ; 27(1): 75-91, jun. 05, 2023.
Article in Spanish | LILACS, UNISALUD, BINACIS | ID: biblio-1437854

ABSTRACT

El uso de sustancias psicoactivas contribuye a la aparición de diferentes trastornos cuando se asocia con variaciones sociales y la fisiopatología del individuo, como aspectos genéticos, ambientales y neurológicos. Así, surge la necesidad de producir métodos de revisión de la literatura, entre los cuales destacamos la revisión integradora. Las palabras clave "alcohol" Y "estrategias de afrontamiento" Y "terapia cognitiva" fueron cruzadas en las bases de la Biblioteca Virtual en Salud (BVS) y SciELO, resultando en 200 artículos publicados en portugués, inglés y español, de 2018 a 2022. La inclusión los criterios fueron: ser un artículo de investigación completo; publicado en portugués, inglés y español; estar disponible electrónicamente y abordar el tema en estudio. Los resultados indicaron avances en prácticas que involucran la práctica de la TC y que, asociadas a otras técnicas de intervención, modifican el perfil tradicional de atención al paciente. Así, la literatura apunta para una mayor demanda de rehabilitación en la que se inserta la Terapia Cognitivista AU


O uso de substâncias psicoativas contribuem para o aparecimento de diferentes transtornos quando associadas a variações sociais e à fisiopatologia do indivíduo, como aspectos genéticos, ambientais e neurológicos. Desta forma, há necessidade de produção demétodos de revisão de literatura, dentre estes, destacamos a revisão integrativa. Foram cruzados os unitermos "álcool" AND "estratégias de enfrentamento" AND "terapia cognitiva" nas bases da Biblioteca Virtual em Saúde (BVS) e SciELO, resultando em 200 artigos publicados em português, inglês e espanhol, no período de 2018 a 2022. Os critérios de inclusão foram: ser artigo de pesquisa completo; publicado nos idiomas português, inglês e espanhol; estar disponível eletronicamente e abordar o tema em estudo. Os resultados indicaram avanços nas práticas que envolvem a prática da TC e que associadas a outras técnicas de intervenção, modificam o perfil tradicional de atenção aos pacientes. Assim a literatura aponta uma maior demanda de reabilitação na qual a Terapia Cognitivista está inserida AU


The use of psychoactive substances contributes to the appearance of different disorders when associated with social variations and the pathophysiology of the individual, such as genetic, environmental and neurological aspects. Thus, there is a need to produce literature review methods, among which we highlight the integrative review. The keywords "alcohol" AND "coping strategies" AND "cognitive therapy" were crossed in the bases of the Virtual Health Library (VHL) and SciELO, resulting in 200 articles published in Portuguese, English and Spanish, from 2018 to 2022. The inclusion criteria were: being a complete research article; published in Portuguese, English and Spanish; be electronically available and address the topic under study. The results indicated advances in practices that involve the practice of CT and that, associated with other intervention techniques, modify the traditional profile of patient care. Thus, the literature points to a greater demand for rehabilitation in which Cognitivist Therapy is inserted AU


Subject(s)
Humans , Male , Female , Cognitive Behavioral Therapy , Alcohol-Related Disorders/psychology , Health Strategies , Alcoholism/therapy
16.
Biomédica (Bogotá) ; Biomédica (Bogotá);43(1): 37-43, mar. 2023. tab, graf
Article in Spanish | LILACS | ID: biblio-1533916

ABSTRACT

La nocardiosis es una enfermedad de distribución mundial; de forma habitual se encuentra en zonas tropicales y afecta principalmente a pacientes inmunocomprometidos, sin embargo, también existen casos reportados de infección en personas inmunocompetentes. Esta infección es causada por actinomicetos del género Nocardia spp. que son bacterias Gram positivas, saprófitos ambientales. Aunque la exposición a Nocardia spp. es casi universal, solo una pequeña fracción de las personas expuestas desarrollan la enfermedad. Se presenta el caso de un hombre de 47 años, sin dato de inmunosupresión, procedente de un área rural de Boyacá, que consultó por un cuadro clínico de cefalea intensa e intermitente, con parestesias y, finalmente, alteración del estado de conciencia. Se practicó una resonancia magnética cerebral, en la que se evidenció una lesión que ocupaba espacio de localización córtico-subcortical en la región fronto-témporo-parietal izquierda, con efecto compresivo y desplazamiento de las cavidades del sistema ventricular. Se sospechó, inicialmente, una lesión neoplásica o un absceso cerebral. El paciente fue sometido a una resección quirúrgica, y el cultivo de la lesión documentó Nocardia africana/nova; en estudios posteriores, se evidenció un posible foco pulmonar primario. Como único factor de riesgo en el paciente, se documentó alcoholismo. Completó seis semanas de tratamiento antibiótico intrahospitalario con evolución clínica y radiológica, y egresó con plan de un año de terapia antibiótica ambulatoria. Aunque la enfermedad por Nocardia spp. afecta principalmente a pacientes inmunocomprometidos, la "evidencia" clínica demuestra que este microorganismo también puede ser una amenaza para individuos sin los factores de riesgo tradicionales para inmunosupresión.


Nocardiosis is a disease with worldwide distribution. It is usually found in tropical areas and mainly affects immunocompromised patients, however, there are also cases where its infection has been reported in immunocompetent patients. This pathology is caused by bacteria known as Nocardia spp., which are gram-positive microorganisms and environmental saprophytes, and although exposure to Nocardia spp. is almost universal, only a small fraction of exposed people develops the disease. We present the case of a 47-year-old man, with no evidence of immunosuppression, from a rural area of Boyacá, who was admitted due to intense and intermittent headache accompanied by paresthesia and, finally, a decrease in consciousness. A brain magnetic resonance was performed and evidenced a fronto-temporo- occipital space-occupying lesion in the cortico-subcortical region with a compressive effect and displacement of the ventricular system cavities. It was suspected at first a neoplastic lesion or a brain abscess. The lesion was surgically resected, and its culture showed Nocardia africana/nova. In later studies a possible primary pulmonary focus was evidenced. Alcoholism was the only risk factor documented. The patient completed 6 weeks of hospital antibiotic treatment with favorable clinical and radiological evolution and was discharged with a 1-year plan of outpatient antibiotic therapy. Although Nocardia spp. mainly affects immunocompromised patients, evidence shows that this microorganism can also be a threat to individuals without traditional immunosuppression risk factors.


Subject(s)
Nocardia Infections , Brain Abscess , Immunocompromised Host , Alcoholism , Immunocompetence , Nocardia
17.
Article in English | WPRIM | ID: wpr-971481

ABSTRACT

A series of chemotherapeutic drugs that induce DNA damage, such as cisplatin (DDP), are standard clinical treatments for ovarian cancer, testicular cancer, and other diseases that lack effective targeted drug therapy. Drug resistance is one of the main factors limiting their application. Sensitizers can overcome the drug resistance of tumor cells, thereby enhancing the antitumor activity of chemotherapeutic drugs. In this study, we aimed to identify marketable drugs that could be potential chemotherapy sensitizers and explore the underlying mechanisms. We found that the alcohol withdrawal drug disulfiram (DSF) could significantly enhance the antitumor activity of DDP. JC-1 staining, propidium iodide (PI) staining, and western blotting confirmed that the combination of DSF and DDP could enhance the apoptosis of tumor cells. Subsequent RNA sequencing combined with Gene Set Enrichment Analysis (GSEA) pathway enrichment analysis and cell biology studies such as immunofluorescence suggested an underlying mechanism: DSF makes cells more vulnerable to DNA damage by inhibiting the Fanconi anemia (FA) repair pathway, exerting a sensitizing effect to DNA damaging agents including platinum chemotherapy drugs. Thus, our study illustrated the potential mechanism of action of DSF in enhancing the antitumor effect of DDP. This might provide an effective and safe solution for combating DDP resistance in clinical treatment.


Subject(s)
Female , Male , Humans , Cisplatin/pharmacology , Disulfiram/pharmacology , Testicular Neoplasms/drug therapy , Fanconi Anemia/drug therapy , Alcoholism/drug therapy , Drug Resistance, Neoplasm , Cell Line, Tumor , Substance Withdrawal Syndrome/drug therapy , Apoptosis , Antineoplastic Agents/therapeutic use , Cell Proliferation
18.
Beijing Da Xue Xue Bao ; (6): 315-323, 2023.
Article in Chinese | WPRIM | ID: wpr-986854

ABSTRACT

OBJECTIVE@#To establish a model of long-term free drinking mouse by feeding mice with alcohol to simulate the state of human voluntary long-term drinking, and on this basis, to further discuss the evaluation criteria of long-term free drinking mice model in sports, anxiety and cognitive behavior.@*METHODS@#Forty six-week-old SPF C57BL/6 male mouse were randomly divided into two groups: Long-term free drinking group (n=20) and normal control group (n=20). The two groups were given solid feed normally. The long-term free drinking group was free to take 10% alcohol and water every day, while the normal drinking group only took water every day. The mice were fed for 7 months, and were evaluated by a series of behavioral methods, including Rota-rod test, balance beam test, open filed test, the elevated plus maze, two-box social behavior, new object recognition, Y maze and water maze.@*RESULTS@#With the increase of drinking days, the mice showed significant alcohol addiction in the alcohol preference test. With the increase of alcohol intake, the mice in the long-term free choice drinking group had slightly shiny fur and reduced diet. Compared with the control group, the weight gain began to slow down from the third month, and the weight decreased significantly by the sixth and seventh months (P=0.006, P < 0.001). The mice showed reduced balance locomotion ability (P=0.003, P=0.001) in the rotary bar and balance beam test. In the open field and elevated cross test, the mice had obvious anxiety-like behavior (P < 0.001). The mice showed decreased social ability in the two boxes of social behavior (P < 0.016). In the experiment of new object recognition and Y maze, the exploration of new object decreased (P=0.018, P=0.040). In the water maze, cognitive functions, such as learning and spatial memory were reduced (P < 0.001).@*CONCLUSION@#The successful establishment of the long-term free drinking mouse model is more convenient for us to carry out further research on the neural mechanism of alcohol addiction, and lays an experimental foundation for exploring the neural mechanism of alcohol addiction and related new targets.


Subject(s)
Mice , Male , Humans , Animals , Alcoholism , Mice, Inbred C57BL , Alcohol Drinking/psychology , Anxiety , Disease Models, Animal , Ethanol
19.
Chinese Critical Care Medicine ; (12): 714-718, 2023.
Article in Chinese | WPRIM | ID: wpr-982660

ABSTRACT

OBJECTIVE@#To explore the risk factors of acute respiratory distress syndrome (ARDS) in patients with sepsis and to construct a risk nomogram model.@*METHODS@#The clinical data of 234 sepsis patients admitted to the intensive care unit (ICU) of Tianjin Hospital from January 2019 to May 2022 were retrospectively analyzed. The patients were divided into non-ARDS group (156 cases) and ARDS group (78 cases) according to the presence or absence of ARDS. The gender, age, hypertension, diabetes, coronary heart disease, smoking history, history of alcoholism, temperature, respiratory rate (RR), mean arterial pressure (MAP), pulmonary infection, white blood cell count (WBC), hemoglobin (Hb), platelet count (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer, oxygenation index (PaO2/FiO2), lactic acid (Lac), procalcitonin (PCT), brain natriuretic peptide (BNP), albumin (ALB), blood urea nitrogen (BUN), serum creatinine (SCr), acute physiology and chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA) were compared between the two groups. Univariate and multivariate Logistic regression were used to analyze the risk factors of sepsis related ARDS. Based on the screened independent risk factors, a nomogram prediction model was constructed, and Bootstrap method was used for internal verification. The receiver operator characteristic curve (ROC curve) was drawn, and the area under the ROC curve (AUC) was calculated to verify the prediction and accuracy of the model.@*RESULTS@#There were no significant differences in gender, age, hypertension, diabetes, coronary heart disease, smoking history, alcoholism history, temperature, WBC, Hb, PLT, PT, APTT, FIB, PCT, BNP and SCr between the two groups. There were significant differences in RR, MAP, pulmonary infection, D-dimer, PaO2/FiO2, Lac, ALB, BUN, APACHE II score and SOFA score (all P < 0.05). Multivariate Logistic regression analysis showed that increased RR, low MAP, pulmonary infection, high Lac and high APACHE II score were independent risk factors for sepsis related ARDS [RR: odds ratio (OR) = 1.167, 95% confidence interval (95%CI) was 1.019-1.336; MAP: OR = 0.962, 95%CI was 0.932-0.994; pulmonary infection: OR = 0.428, 95%CI was 0.189-0.966; Lac: OR = 1.684, 95%CI was 1.036-2.735; APACHE II score: OR = 1.577, 95%CI was 1.202-2.067; all P < 0.05]. Based on the above independent risk factors, a risk nomograph model was established to predict sepsis related ARDS (accuracy was 81.62%, sensitivity was 66.67%, specificity was 89.10%). The predicted values were basically consistent with the measured values, and the AUC was 0.866 (95%CI was 0.819-0.914).@*CONCLUSIONS@#Increased RR, low MAP, pulmonary infection, high Lac and high APACHE II score are independent risk factors for sepsis related ARDS. Establishment of a risk nomograph model based on these factors may guide to predict the risk of ARDS in sepsis patients.


Subject(s)
Humans , Retrospective Studies , Alcoholism , Prognosis , Respiratory Distress Syndrome, Newborn , Pneumonia , Sepsis , Intensive Care Units , Procalcitonin , Fibrinogen , ROC Curve
20.
Ethiop. Med. j ; Ethiop. med. j. (Online);61(2): 121-129, 2023. tables, figures
Article in English | AIM | ID: biblio-1426877

ABSTRACT

Background: Daily alcohol consumption above recommended limits is an important cause of Alcoholic Lher Disease. Hence, this study aimed to assess the knowledge of Alcoholic Liver Disease among alcohol consumers and screenfor alcohol misuse, dependence, and disorder. Methods: A community-based cross-sectional survey using simple random sampling technique was conducted on residents ofÅfikpo age 15 and above who consume alcohol using a structured questionnaire to obtain information on alcoholic use disorder and alcohol dependence. The sample size Itas determined Il'ith the aid of a Raosoft sample size calculator. Data obtained was entered into an excel spreadsheetfor data cleaning. The frequency, percentages and mean and Standard deviation was also obtained. Data was exported into IBM SPSS to determine the relationship behre.en knou:ledge of Alcoholic Liver Disease and demographic variables using One-way ANOL4 and Chi-Square Il'here appropriate at P-value <0.05 and 5% significance level. Results: The total number of study participants was 435 with a response rate of 97%. Out of which had a good knowledge of Alcoholic Liver Disease. Adults above the age of 60 had a mean audit score of 12.808 Il'hile male respondents had a mean audit score of 11.395. Adolescents had a mean CAGE test score of 1.89 while adults above 60 scored 2.48. Hou•ever, participants with no education had the highest mean CAGE score of2.27. The males had good knowledge ofAlcoholic Liver Disease. (P 0.006). Conclusion: The residents ofÅfikpo community have a good knowledge ofAlcoholic Lher Disease though there is alcohol use disorder, alcohol misuse and dependence amongst residents in the community. Gender is the only demographic characteristics that influenced the knowledge ofAlcoholic Liver Disease


Subject(s)
Humans , Alcohol Amnestic Disorder , Liver Diseases, Alcoholic , Therapeutics , Alcoholism , Diet, Healthy
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