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1.
Braz. j. biol ; 83: e249209, 2023.
Article in English | MEDLINE, LILACS, VETINDEX | ID: biblio-1339360

ABSTRACT

Abstract Alo vera is a centenary remedy use for minor wounds and burns, but its mechanism of wound healing has not been know since. This article will evaluate and gather evidence of the effectiveness and safety of the use of aloe vera in the treatment of burns. A systematic review was carried out on the databases: MEDLINE, LILACS, DECS, SCIELO, in the last 7 years, with the descriptors: "Aloe", "Burns" and "treatment". 16 articles were found. After using the exclusion criteria; research in non-humans and literature review; 5 articles were selected. The article Teplick et al. (2018) performed an in vitro clinical experiment in A. Vera solution, and demonstrated that there was proliferation and cell migration of human skin fibroblasts and keratinocytes, in addition to being protective in the death of keratonocytes. That is, it accelerates the healing of wounds. Muangman et al. (2016), evaluated 50 patients with 20% of the total body surface area burned with second-degree burns, between 18-60 years old, with half of the group receiving gauze dressings with soft paraffin containing 0.5% chlorhexidine acetate and the other half receiving polyester dressings containing extracts of medicinal plants mainly Aloe Vera. It had positive results, a higher healing speed and shorter hospital stay compared to the control group. Hwang et al. (2015) investigated the antioxidant effects of different extracts from 2,4,6,8,12 months of Aloe Vera. And the 6-month concentrated extract of 0.25 mg / mL had a higher content of flavonoids (9.750 mg catechin equivalent / g extract) and polyphenols (23.375 mg gallic acid equivalent / g extract) and the greater ferric reducing antioxidant power (0.047 mM equivalent ferrous sulfate / mg extract), that is, greater potential for free radical scavenging and also a protective effect against oxidative stress induced by tert-butyl hydroperoxide (t-BHP), suggesting evidence of a bioactive potential of A. vera . However, in the article Kolacz et al. (2014) suggested as an alternative treatment the use of Aloe Vera dressing in combination with honey, lanolin, olive oil, wheat germ oil, marshmallow root, wormwood, comfrey root, white oak bark, lobelia inflata, glycerin vegetable oil, beeswax and myrrh, without obtaining significant and conclusive results that would allow the conventional treatment of burns to be subsidized. Finally, in the article by Zurita and Gallegos (2017), it carried out a descriptive cross-sectional study with 321 people, both sexes between 17-76 years of age, of an inductive nature, exploring the experience of this population and their behavioral attitudes regarding the treatment of dermatoses. Aloe vera had 13.8% cited by individuals in the treatment of acne and 33.6% in the treatment of burns. Even with evidence that suggests the efficacy in the treatment of burns with the use of Aloe Vera extract, further clinical trials with larger sample space on the use of Aloe vera dressings in medium burns are suggested for further conclusions.


Resumo Alo vera é um remédio centenário usado para pequenas feridas e queimaduras, mas seu mecanismo de cicatrização de feridas não foi conhecido desde então. Este artigo avaliará e reunirá evidências da eficácia e segurança do uso de aloe vera no tratamento de queimaduras. Realizada revisão Sistemática nas bases de dados: MEDLINE, LILACS, DECS, SCIELO, nos últimos 7 anos, com os descritores: "Aloe", "Burns" and "treatment". Foram encontrados 16 trabalhos. Após utilizarmos os critérios de exclusão; pesquisa em nao humanos e revisão da literatura ; foram selecionados 5 artigos. O artigo Teplick et al. (2018) realizou um experimento clinico in vitro em solução de A. Vera, e demonstrou que houve proliferação e migração celular de fibroblastos e queratinócitos de pele humana, além de ser protetor na morte de queratonócitos. Ou seja, acelera a cicatrização das feridas. Já Muangman et al. (2016), avaliou 50 pacientes com 20% do total da área superficial corporal queimada com queimaduras de segundo grau, entre 18-60 anos, tendo metade do grupo como controle recebendo curativos de gaze com parafina mole contendo 0,5% acetado de clorexidina e a outra metade recebendo curativos com poliéster contendo extratos de plantas medicinais principalmente Aloe Vera. Teve resultados positivos, uma maior velocidade de cicatrização e menor tempo de internação comparado ao grupo controle. Já Hwang et al. (2015) investigou os efeitos antioxidante de diferentes extratos de 2,4,6,8,12 meses da Aloe Vera. E o extrato com 6 meses concentrado de 0,25 mg/mL teve maior teor de flavanóides (9,750 mg equivalente catequina / g extrato) e polifenóis (23,375 mg equivalente ácido gálico / g extrato) e o maior poder antioxidante redutor férrico (0,047 mM de sulfato ferroso equivalente / extrato mg), ou seja, maior potencial de eliminação de radicais livres e também efeito proteror contra o estresse oxidativo induzido por hidroperóxido de terc-butila (t-BHP), sugerindo indícios de um potencial bioativo da A. vera. Porém, no artigo Kolacz et al. (2014) sugeriu como tratamento alternativo o uso do curativo com Aloe Vera em conjunto de mel, lanolina, azeite de oliva, óleo de gérmen de trigo, raiz de marshmallow, absinto, raiz de confrei, casca de carvalho branco, lobelia inflata, glicerina vegetal, cera de abelha e mirra, não obtendo resultados significativos e conclusivos que permitam subsidiar o tratamento convencional das queimaduras. Por fim, no artigo de Zurita and Gallegos (2017), realizou um estudo descritivo transversal com 321 pessoas, ambos os sexos entre 17-76 anos, de natureza indutiva, explorando a vivência dessa população e suas atitudes comportamentais quanto ao tratamento de dermatoses. Aloe vera teve 13,8% citada pelos indivíduos no tratamento de acne e 33,6% no tratamento de queimaduras. Mesmo tendo evidências que sugerem a eficácia no tratamento de queimaduras com o uso do extrato da Aloe Vera, sugere-se mais ensaios clínicos com espaço amostral maior sobre o uso de curativos de Aloe vera em médio queimados para maiores conclusões.


Subject(s)
Humans , Plants, Medicinal , Burns/drug therapy , Aloe , Wound Healing , Plant Extracts/therapeutic use , Plant Extracts/pharmacology , Cross-Sectional Studies
2.
Odontol. Clín.-Cient ; 20(3): 47-53, jul.-set. 2021. ilus, tab
Article in Portuguese | LILACS, BBO | ID: biblio-1369857

ABSTRACT

A mucosite oral (MO) é uma grave complicação dos tratamentos antineoplásicos, caracterizada pela presença de lesões erosivas e ulcerativas na mucosa oral, que podem causar uma diminuição significativa na qualidade de vida do paciente. Realizar uma revisão de literatura sobre o uso de agentes naturais na prevenção e tratamento da MO induzida por quimioterapia e/ou radioterapia. Artigos científicos foram pesquisados nas bases de dados SciELO, LILACS e Medline/PubMed, utilizando-se os descritores chamomile, propolis, honey, aloe, chemotherapy-induced oral mucositis e phytotherapeutic drug. A partir dessa busca e dos critérios de inclusão adotados, 22 artigos foram selecionados. Na maioria dos estudos analisados, o uso de produtos naturais, como camomila, própolis, mel e aloe vera, foi capaz de diminuir a incidência da MO e a severidade dessas lesões e, além disso, permitiu um melhor controle da dor local, sendo considerada uma boa opção terapêutica. O uso de produtos naturais tornou-se um importante método alternativo para tratamento e prevenção da MO, pois é uma terapia de baixo custo, que apresenta menos reações adversas e que podem ser implementadas pelos profissionais da saúde bucal... (AU)


Oral mucositis (OM) is a serious complication of antineoplastic treatments, characterized by the presence of erosive and ulcerative lesions in the oral mucosa, which may cause a significant decrease in the quality of life of the patient. To perform a literature review about the use of natural agents in the prevention and treatment of OM induced by chemotherapy and/or radiotherapy. Scientific articles were searched in the Scielo, Lilacs and Medline / PubMed databases using the descriptors chamomile, propolis, honey, aloe, chemotherapy-induced oral mucositis and phytotherapeutic drugs. From that research and according to the inclusion criteria, 22 articles were selected to compose this literature review. In most of the analyzed studies, the use of natural products, such as chamomile, propolis, honey and aloe vera was able to decrease the incidence of OM and the severity of these leions, and also allowed a better control of local pain, thus being considered a good therapeutic option. The use of natural products became an important alternative method for the treatment and prevention of OM, since it is a low-cost treatment, which presents less adverse effects and that can be implemented by oral health professionals... (AU)


La mucositis oral (MO) es una complicación grave de los tratamientos antineoplásicos, caracterizada por la presencia de lesiones erosivas y ulcerativas en la mucosa oral, que pueden provocar una disminución significativa de la calidad de vida del paciente. Realizar una revisión de la literatura sobre el uso de agentes naturales en la prevención y el tratamiento de la MO inducida por quimioterapia y / o radioterapia. Se realizaron búsquedas de artículos científicos en las bases de datos SciELO, LILACS y Medline/PubMed, utilizando los descriptores Manzanilla; Própolis; Miel; Aloe; Estomatitis; Medicamentos Fitoterápicos. De esta búsqueda y de los criterios de inclusión adoptados se seleccionaron 22 artículos. En la mayoría de los estudios analizados, el uso de productos naturales, como manzanilla, própolis, miel y aloe vera, consiguió reducir la incidencia de MO y la gravedad de estas lesiones y, además, permitió un mejor control del dolor local, siendo considerada una buena opción terapéutica. El uso de productos naturales se ha convertido en un método alternativo importante para el tratamiento y prevención de la MO, por ser una terapia de bajo costo, que tiene menos reacciones adversas y que puede ser implementada por profesionales de la salud bucal... (AU)


Subject(s)
Humans , Male , Female , Propolis , Stomatitis , Chamomile , Drug Therapy , Aloe , Phytotherapeutic Drugs , Antineoplastic Agents , Oral Health , Mouth Mucosa
3.
Braz. dent. sci ; 24(1): 1-7, 2021. tab, ilus
Article in English | LILACS, BBO | ID: biblio-1145548

ABSTRACT

Though aloe vera extract, green tea extract and coriander oil are proven antimicrobial agents, very little information is available regarding its effects on oral bacteria, Streptococcus mutans, which is responsible for initiating caries and Enterococcus faecalis, responsible for failure of root canal treatment. Objective: To find the antimicrobial activity of aloe vera extract, black tea extract and coriander oil against S. mutans and E. faecalis. Materials and Methods: The agar well diffusion method was used to determine the antibacterial activity of Aloe vera extract, black tea extract and coriander oil. Different concentration of prepared plant extracts and coriander seed oil (50 & 100 µl) was incorporated into the wells and the plates containing S. mutans and E. faecalis were incubated at 37 °C for 24 h. The antibiotic (amoxicillin 30 µl) was used as positive control. Zone Of Inhibition (ZOI) was recorded in each plate. Results: For S. mutans, the maximum ZOI was created by coriander oil with a diameter of 25.00±0.58 mm at 50 µl and for E. faecalis, maximum ZOI was created by aloe vera extract 16.00±0.58 mm at 100 µl concentration which were far better than the control: amoxicillin 30 µl concentration. Conclusion: The extracts of Aloe vera, black tea and coriander oil, showed significant activity against the investigated microbial strains, Streptococcus mutans and Enterococcus faecalis which further helps in the development of new topical agents that help in reducing the numbers of these organisms present in the oral cavity. (AU)


Embora o extrato de aloe vera, extrato de chá verde e óleo de coentro sejam agentes antimicrobianos comprovados, há pouca informação disponível sobre seus efeitos nas bactérias orais, Streptococcus mutans, que é responsável por iniciar cáries e Enterococcus faecalis, responsável pela falha do tratamento de canal radicular. Objetivo: Avaliar a atividade antimicrobiana do extrato de aloe vera, extrato de chá preto e óleo de coentro contra S. mutans e E. faecalis. Materiais e Métodos: O método de difusão em agar foi usado para determinar a atividade antibacteriana do extrato de Aloe vera, extrato de chá preto e óleo de coentro. Diferentes concentrações dos extratos de plantas e óleo de semente de coentro (50 e 100 µl) foram preparados e colocados nos poços e nas placas contendo S. mutans e E. faecalis e foram incubadas a 37°C por 24 h. O antibiótico (amoxicilina 30 µl) foi utilizado como controle positivo. A zona de inibição (ZOI) foi registrada em cada placa. Resultados: Para S. mutans, a ZOI máxima foi obtida com o óleo de coentro com um diâmetro de 25,00 ± 0,58 mm a 50 µl e para E. faecalis, a ZOI máxima foi obtiada pelo extrato de aloe vera 16,00 ± 0,58 mm na concentração de 100 µl, as quais foram melhores do que o controle: concentração de 30 µl de amoxicilina. Conclusão: Os extratos de Aloe vera, chá preto e óleo de coentro apresentaram atividade significativa contra as cepas microbianas investigadas, Streptococcus mutans e Enterococcus faecalis auxiliando no desenvolvimento de novos agentes tópicos visando a redução do número desses organismos presentes no cavidade oral. (AU)


Subject(s)
Streptococcus mutans , Tea , Enterococcus faecalis , Aloe , Microbiota
4.
Cienc. tecnol. salud ; 7(3): 412-441, 26 de noviembre 2020. ^c27 cmilus
Article in Spanish | LILACS, LIGCSA, DIGIUSAC | ID: biblio-1141472

ABSTRACT

Las infecciones respiratorias constituyen una importante causa de morbilidad y mortalidad a nivel mundial, incrementándose su relevancia ante la reciente infección por SARS-CoV-2, causante de la pandemia de COVID-19. Las opciones terapéuticas para esta infección respiratoria son escasas y sin eficacia comprobada. El objetivo de esta revisión fue buscar la información sobre plantas con actividad antiviral o viricida publicada en los últimos 10 años, en las bases de datos de Google Scholar, Scopus y PubMed. La búsqueda priorizó aquellas especies disponibles en Guatemala, la cual se complementó con la búsqueda de moléculas con actividad antiviral para finalmente postular aquellas que puedan prevenir la infección o aminorar la patogénesis del SARS-CoV-2. Se detectaron más de 170 especies con actividad antiviral y se organizó la información por país o región y tipo de actividad antiviral contra virus específicos. De las especies de mayor disponibilidad en Guatemala se seleccionaron 20. La revisión culmina con 15 artículos que proponen plantas o moléculas con potencial actividad específica en el manejo de la pandemia por SARS-CoV-2. Se concluye que existen especies vegetales (Curcuma longa, Echinacea purpurea, Psidium guajava, Allium sativum, Salvia officinalis y Eucalyptus globulus) y fitocompuestos vegetales (hesperidina, rutina, diosmina, apiina, aloe-emodina, piperina, capsaicina, curcumina, oleuropeina, rhamnetina y gallato de epicatequina) que podrían contribuir al manejo de la enfermedad. Se insta a académicos y autoridades a poner más atención a estas opciones terapéuticas que nos ofrece la naturaleza y que podrían contribuir a aliviar el colapso de los sistemas de salud prevalentes.


Respiratory infections are an important cause of morbidity and mortality worldwide, increasing their relevance by the recent SARS-CoV-2 infection causing the COVID-19 pandemic. Therapeutic options for this respiratory infection are scarce and without proven effectiveness. The objective of this review was the search for information on plants with antiviral or viricidal activity published in the last 10 years in the Google Scholar, Scopus, and PubMed databases. The search prioritized those species available in Guatemala, was completed with the search of molecules with potential to prevent infection or reduce the activity of SARS-CoV-2 infection. More than 170 species with antiviral activity were detected and the information organized in surveys by country or region, activity against specific viruses and antiviral information on the 20 most commonly available species in the country. It is complemented with a summary of 15 articles that proposed plants or molecules with potential specific activity in the management of the SARS-CoV-2 pandemic. It is concluded there are plant species (Curcuma longa, Echinacea purpurea, Psidium guajava, Allium sativum, Salvia officinalis and Eucalyptus globulus) and phytocompounds isolated from these species (hesperidin, rutin, diosmin, apiine, aloe-emodin, piperine, capsaicin, curcumin, oleuropein and epicatechin gallate) that could contribute to the management of the disease. Academics and authorities are urged to pay more attention to these therapeutic options that nature offer to us and could contribute to alleviate the collapse of the prevailing health systems in the country.


Subject(s)
Humans , Plants, Medicinal/drug effects , Respiratory Tract Infections , Therapeutics , Catechin/therapeutic use , Echinacea , Curcumin/therapeutic use , Salvia officinalis , Psidium , Diosmin , Aloe , Eucalyptus , Betacoronavirus , Garlic , COVID-19 , Guatemala , Hesperidin
5.
Rev. Ciênc. Méd. Biol. (Impr.) ; 19(2): 347-352, set 24, 2020. fig, ilus
Article in Portuguese | LILACS | ID: biblio-1358426

ABSTRACT

Introdução: aloe vera é uma planta medicinal que apresenta diversas propriedades biológicas, dentre elas atividade cicatrizante. Objetivo: realizar uma revisão de literatura com o intuito de observar a atividade pró-cicatrizante de A. vera em diferentes formas farmacêuticas. Metodologia: trata-se de uma revisão de literatura do tipo integrativa, realizada nas bases de dados Lilacs e SciElo. Resultados: dentre os 115 estudos encontrados, somente 7 artigos, publicados entre os anos de 1999 a 2018, foram utilizados para a construção dos resultados. A. vera apresentou atividade cicatrizante em modelos humanos e animais, sendo a forma farmacêutica gel a mais utilizada (42,8%), seguida de extratos (28,6%). A atividade cicatrizante pode estar associada a presença de polissacarídeos que atuam diretamente sobre fibroblastos contribuindo para o processo de cicatrização. Conclusão: a. vera em géis, extratos, unguento e nanopartículas demonstrou apresentar não somente atividade cicatrizante, mas também relacionada a inibição de processos inflamatórios.


Introduction: aloe vera, is a medicinal plant that has several biological properties, including healing activity. Objective: to perform a review of the literature with the intention of observing the pro-healing activity of Aloe vera in different presentations. Methodology: it was a literature review of the integrative type, carried out in Lilacs and SciElo databases. Results: among the 115 studies found, only 7 articles, published between 1999 and 2018, were used to construct the results. A. vera presented healing activity in human and animal models, with the most used gel form (42.8%), followed by extracts (28.6%). The cicatrizant activity may be associated with the presence of polysaccharides that act directly on fibroblasts contributing to the cicatrization process. Conclusion: a. vera in gels, extracts, ointment and nanoparticles has shown not only healing activity, but also related to inhibition of inflammatory processes.


Subject(s)
Humans , Animals , Pharmacology , Plants, Medicinal , Aloe , Phytotherapy , Review , Database
6.
Rev. chil. nutr ; 47(3): 390-395, jun. 2020. tab, graf
Article in English | LILACS | ID: biblio-1126136

ABSTRACT

The aim of this research was to characterize a fermented yogurt-type milk drink that was elaborated from whey with the addition of aloe vera crystals and granadilla (Passiflora ligularis Juss). Four formulations for characterization were obtained: F1 (control), F2 (5% aloe vera and 15% granadilla), F3 (10% aloe vera and 10% granadilla) and F4 (15% aloe vera and 5% granadilla). Next, a sensory evaluation through a hedonic test was conducted to choose the formulation with the highest acceptance. After the best formulation was chosen, a bromatological and syneresis characterization was performed. The F4 sample had the best results in the sensory evaluation. Compared to the F1 sample, statistically significant differences (p<0.05) in all parameters except in total carbohydrates was observed for the bromatological analysis. In the percentage of syneresis, at the end of the 15 days, F4 presented a lower value in this parameter with respect to the control sample. It could be determined that the higher percentage of aloe vera and the lower percentage of granadilla had a big influence on the parameters evaluated, where it presented the best results compared to the other samples evaluated.


El objetivo de esta investigación fue caracterizar una bebida láctea fermentada tipo yogur que se elaboró a partir de lactosuero con la adición de cristales de aloe vera y granadilla (Passiflora ligularis Juss). Se obtuvieron cuatro formulaciones para la caracterización: F1 (control), F2 (5% de aloe vera y 15% de granadilla), F3 (10% de aloe vera y 10% de granadilla) y F4 (15% de aloe vera y 5% de granadilla). A continuación, se realizó una evaluación sensorial mediante una prueba hedónica para elegir la formulación de mayor aceptación. Una vez elegida la mejor formulación, se realizó una caracterización bromatológica y de sinéresis. La muestra F4 obtuvo los mejores resultados en la evaluación sensorial. En comparación con la muestra F1, se observaron diferencias estadísticamente significativas (p<0,05) en todos los parámetros, excepto en los carbohidratos totales. En el porcentaje de sinéresis, al final de los 15 días, F4 presentó un valor inferior en este parámetro con respecto a la muestra de control. Se pudo determinar que el mayor porcentaje de aloe vera y el menor porcentaje de granadilla influyeron mucho en los parámetros evaluados, en los que presentó los mejores resultados en comparación con las otras muestras evaluadas.


Subject(s)
Passiflora , Milk , Aloe , Food Analysis , Fermented Foods and Beverages , Taste , Whey
7.
J. coloproctol. (Rio J., Impr.) ; 40(1): 67-72, Jan.-Mar. 2020. tab, ilus
Article in English | LILACS | ID: biblio-1090840

ABSTRACT

Abstract Rationale: Considering that anal fistulae are still challenging regarding their treatment due to the risk of fecal incontinence in the most complex cases and the increasing use of phytotherapeutic drugs such as Aloe Vera in medicine, even with proven healing effectiveness, there is interest in researching this drug in the treatment of anal fistulae. Objective: To evaluate the efficacy of Aloe Vera extract in the treatment of anal fistulae in rats. Method: Thirty male Wistar rats weighing 250-300 g were submitted to anal fistula and after 30 days were divided into three groups: Control Group (GCo) (n = 5), Carbopol Group (GCa) (n = 5), and Aloe Vera Group (GAV) (n = 10). In the GCo no treatment was performed, while in the others a daily infusion of 0.3 mL of solution (Carbopol only in GCa and Carbopol plus Aloe Vera extract in the GAV) was performed through the external orifice of the fistula for 30 days. Afterwards, euthanasia was performed and specimens were removed for histological study. It was evaluated the closure of the fistulous tract, the area of the remaining tract, the inflammatory infiltrate and the degree of vascular congestion. The results were submitted to statistical treatment by Kruskall-Wallis test, considering p<0.05. Results: There was no complete closure of the fistulous tract in any of the animals. The mean area of the remaining tract was 847.2 µm in the GCo, 565.6 µm in the GCa and 377.8 µm in the GAV (p<0.05). The mean of the inflammatory infiltrate score was 2.4 in the GCo, 2.4 in the GCa and 2.3 in the GAV (p<0.05), while in the evaluation of vascular congestion, we observed a mean of 1.6 in the GCo, 1.4 in GCa and 1.1 in GAV (p<0.05). Conclusion: The extract of Aloe vera was able to reduce the lumen of the fistulous tract and reduce the degree of vascular congestion; however, it did not allow the complete closure of the fistulous tract nor diminished the inflammatory process.


Resumo Racional: Considerando que o tratamento das fístulas anais tem risco de incontinência fecal e o crescente uso do Aloe Vera na medicina, há interesse em se pesquisar este fármaco. Objetivo: Avaliar a eficácia do extrato de Aloe vera no tratamento das fístulas anais em ratos. Método: Utilizou-se 30 ratos Wistar, os quais foram submetidos à criação de fístula anal e após 30 dias distribuídos em três grupos: Controle (GCo), Carbopol (GCa) e Aloe Vera (GAV). No GCo nenhum tratamento foi realizado, enquanto nos outros realizou-se infusão diária de 0,3 mL de Carbopol GCa e Carbopol mais extrato de Aloe Vera no GAV por 30 dias. Foram retirados os espécimes para estudo histológico, avaliou-se o fechamento do trajeto fistuloso, a área do trajeto remanescente, o infiltrado inflamatório e o grau de congestão vascular. Resultados: Não houve fechamento completo do trajeto fistuloso em nenhum dos animais. A média da área do trajeto remanescente foi 847,2 µm no GCo; 565,6 µm no GCa e 377,8 µm no GAV (p<0,05). A média do escore de infiltrado inflamatório foi 2,4 no GCo; 2,4 no GCa e 2,3 no GAV (p<0.05), enquanto na avaliação da congestão vascular observou-se média 1,6 no GCo; 1,4 no GCa e 1,1 no GAV (p<0,05). Conclusão: O extrato de Aloe Vera foi capaz de diminuir o lumen dos trajetos fistulosos e reduzir o grau de congestão vascular, porém, não permitiu o fechamento completo dos trajetos fistulosos nem diminuiu o processo inflamatório.


Subject(s)
Animals , Rats , Rectal Fistula/drug therapy , Plant Preparations , Aloe , Aloe/drug effects , Phytotherapy , Plants, Medicinal , Rectal Fistula , Rats, Wistar
8.
Braz. J. Pharm. Sci. (Online) ; 56: e18601, 2020. tab, graf
Article in English | LILACS | ID: biblio-1249143

ABSTRACT

The objective of this work was to develop and characterize liposomes loaded with silver nanoparticles (LAgNPs) to show improvement in stability characteristics. AgNPs were prepared by the green synthesis method with Aloe vera gel extract and exposure to sunlight. Liposomes were prepared by the modified reverse phase method. Particle size, polydispersity index, zeta potential, as well as the scanning electron microscopy (SEM) morphological aspects of AgNPs and LAgNPs were evaluated. In addition, was used flame atomic absorption spectroscopy to determine the amount of AgNP that was encapsulated in liposomes. The AgNPs presented as amorphous and polydisperse structures, with a mean diameter of 278.46 nm and zeta potential of -18.3 mV. LAgNPs had a mean diameter between 321 and 373 nm, the polydispersity index close to 0.2 and a zeta potential around -40 mV, which indicates greater stability to the AgNPs. The images obtained by SEM show semicircular structures for AgNPs and well-defined spherical shape for LAgNPs. The percentage of encapsulation was between 51.81 to 58.83%. These results showed that LAgNPs were obtained with adequate physicochemical characteristics as a release system.


Subject(s)
Silver , Nanoparticles/analysis , Liposomes/analysis , Sunlight/adverse effects , Microscopy, Electron, Scanning/methods , Atomic Absorption Spectroscopy/methods , Aloe/classification , Methods
9.
Braz. j. oral sci ; 19: e208189, jan.-dez. 2020. ilus
Article in English | LILACS, BBO | ID: biblio-1152223

ABSTRACT

Aim: The aim of this study was to investigate the effect of different mouth washes and to study the effect of text message reminder on the oral health status of orthodontic patients treated with fixed appliances. Methods: This study was a clinical trial with pre-test and post-test control group design, conducted on 24 patients undergoing fixed orthodontic treatment aged 15-30 years. The patients randomly divided into two groups; one received a weekly telephone text massage reminder for the instructions of brushing and rinsing while the second group did not receive any messages. Ortho-plaque index and gingival index were used to evaluate the patient's oral hygiene status. The reading indices after brushing only were regarded as a control, then the patients were instructed to use two mouth washes, one containing sodium fluoride with cetylpyridinium chloride, the second containing chlorhexidine digluconate with cetylpyridinium chloride and Aloe Vera. Each one was used routinely for 4 weeks with the same amount and method. The washout period between the two types mouth washes was 4 weeks with a standardized toothbrush and paste. Results: Ortho-plaque index values decreased over the time between first, second and third visits. However, this index raised up at the fourth visit and again dropdown at the fifth visit. Similar results were detected for gingival index. Also, significant interaction between messages and the assessments was recorded for gingival index with a significant difference between the group of text messages and without text messages group (p<0.05). Conclusions: The results of this study showed that the combination of sodium fluoride with cetylpyridinium chloride was more potent for plaque control, while chlorhexidine digluconate with cetylpyridinium chloride and Aloe Vera combination showed a better gingival improvement. Moreover, the text messages reminder could enhance, but not replace direct oral hygiene instruction in orthodontic patients


Subject(s)
Humans , Male , Female , Cetylpyridinium , Chlorhexidine , Aloe , Text Messaging
10.
J. coloproctol. (Rio J., Impr.) ; 39(1): 33-40, Jan.-Mar. 2019. tab
Article in English | LILACS | ID: biblio-984633

ABSTRACT

ABSTRACT Background: Although herbal medicinal products are being used widely throughout the World, beneficial and harmful effects have not been well documented. Our aim was to evaluate the effects of Aloe Vera (AV) on colonic anastomosis healing. Material and methods: 112 albino Wistar rats were randomly assigned into five main groups: preoperative Aloe Vera Group (P), pre- and postoperative Aloe Vera Group (PP), Control Group (C), sham Aloe Vera Group (SA) and Sham Control Group (SC). Groups P, PP, and SA received 1.6 mL/kg per day Aloe Vera by orogastric feeding catheter for 1 month prior to the experiment. Groups P, PP, and C underwent anastomosis of the distal colon, and subgroups (n = 4) of each were sacrificed on postoperative day 3, 7, 14 and 21. Anastomotic bursting pressure, perianastomotic collagen content and histopathological changes were studied. Results: The SC Group had significantly higher ABP when compared with the SA Group (p = 0.0002), although hydroxyproline content showed no difference. When ABP was compared between anastomosis groups, it was found significantly lower in Aloe Vera groups on Day 3 (P3 vs. C3, p = 0.003 and PP3 vs. C3, p = 0.007). Hydroxyproline content was significantly lower in Group PP than Group C, also on Day 3 (p = 0.05). Significant difference was not detected after Day 3 in any of the study parameters. Conclusion: Aloe Vera decreased tissue collagen content in the early postoperative period. It is advisable to call into question the concomitant usage of conventional medicine and the herbal supplements for the surgeons in their clinical practice.


RESUMO Fundamentação: Embora os medicamentos à base de plantas sejam amplamente utilizados no mundo inteiro, seus efeitos (benéficos e prejudiciais) não estão bem documentados. Este estudo teve como objetivo avaliar os efeitos da Aloe vera (AV) na cicatrização de anastomoses colônicas. Material e métodos: 112 ratos Wistar albinos foram distribuídos aleatoriamente em cinco grupos principais: AV pré-operatório (P), AV pré e pós-operatório (PP), controle (C), sham AV (SA) e sham controle (SC). Os grupos P, PP e SA receberam AV em uma dose de 1,6 mL/kg por dia por sonda de alimentação orogástrica por 1 mês antes do experimento. Os grupos P, PP e C foram submetidos a anastomose do cólon distal. Subgrupos (n = 4) de cada grupo foram sacrificados no terceiro, sétimo, 14° e 21° dias pós-operatórios. Os seguintes parâmetros foram avaliados: pressão de ruptura anastomótica (PRA), conteúdo de colágeno perianastomótico e alterações histopatológicas. Resultados: O grupo SC apresentou PRA significativamente maior quando comparado ao grupo SA (p = 0,0002), embora o conteúdo de hidroxiprolina não tenha apresentado diferença. Ao comparar a PRA entre os grupos de anastomose, ela foi significativamente menor no terceiro dia nos grupos que usaram AV (P3 vs. C3, p = 0,003 e PP3 vs. C3, p = 0,007). No terceiro dia, o teor de hidroxiprolina foi significativamente menor no grupo PP do que no grupo C (p = 0,05). Após o terceiro dia, não se observou diferença significativa em nenhum dos parâmetros do estudo. Conclusão: O uso de AV diminuiu o conteúdo de colágeno tecidual no período pós-operatório imediato. É aconselhável questionar o uso concomitante da medicina convencional e suplementos fitoterápicos na prática clínica.


Subject(s)
Animals , Rats , Anastomosis, Surgical/rehabilitation , Aloe , Wound Healing , Rats, Wistar , Colon/pathology , Phytotherapeutic Drugs , Hydroxyproline
11.
Pesqui. bras. odontopediatria clín. integr ; 19(1): 4537, 01 Fevereiro 2019. graf, tab
Article in English | LILACS, BBO | ID: biblio-998237

ABSTRACT

Objective: To analyze the effect of immediate placement of implants with extract from the new bone formation histometically. Material and Methods: In this true-experimental design with randomized post test control group, 9 mongrel dogs weighing 10 to 12 kg were used, which were divided into 3 groups, based on observation time of 14 days, 28 days and 56 days. On the installation of implants (∅3.5x10 mm) sequentially, the former socket extraction of the lower jaw's right second premolar tooth in the study sample injected 10% Aloe vera gel extract and left second left premolar tooth without injection of 10% Aloe vera extract. To compare independent groups use the Mann-Whitney test. All analysis were carried out using SPSS version 20. Results: There was an increase in the number of osteoblast cells in both treatment and control groups, but the value of the treatment group was greater. There were significant differences in the number of osteoblast cells between the treatment and control groups 14 days (p=0.019), 28 days: (p=0.018), and 56 days (p=0.009). There were no significant differences in the number of fibroblast cells between the treatment and control groups (p>0.05). But at observations 28 and 56 days, it was showed a significant difference in the number of fibroblast cells between the treatment and control groups (p=0.353 and p=0.024, respectively). Conclusion: Immediate placement of implants with 10% Aloe vera extract gel on extracted socket increases the number of osteoblasts and suppresses the number of osteoclasts and fibroblasts.


Subject(s)
Animals , Dogs , Osteoclasts , Connective Tissue Cells , Dental Implantation, Endosseous , Aloe , Statistics, Nonparametric , Fibroblasts , Indonesia , Odontoblasts
12.
J. appl. oral sci ; 27: e20180103, 2019. graf
Article in English | LILACS, BBO | ID: biblio-1002400

ABSTRACT

Abstract Objective This study aimed to evaluate the inflammatory effect and bone formation in sterile surgical failures after implantation of a collagen sponge with mesenchymal stem cells from human dental pulp (hDPSCs) and Aloe vera. Material and Methods Rattus norvegicus (n=75) were divided into five experimental groups according to treatment: G1) control (blood clot); G2) Hemospon®; G3) Hemospon® in a culture medium enriched with 8% Aloe vera; G4) Hemospon® in a culture medium containing hDPSCs and G5) Hemospon® in a culture medium enriched with 8% Aloe vera and hDPSCs. On days 7, 15 and 30, the animals were euthanized, and the tibia was dissected for histological, immunohistochemistry and immunofluorescence analyses. The results were analyzed using nonparametric Kruskal-Wallis test and Dunn's post-test. Results On days 7 and 15, the groups with Aloe vera had less average acute inflammatory infiltrate compared to the control group and the group with Hemospon® (p<0.05). No statistically significant difference was found between the groups regarding bone formation at the three experimental points in time. Osteopontin expression corroborated the intensity of bone formation. Fluorescence microscopy revealed positive labeling with Q-Tracker® in hDPSCs before transplantation and tissue repair. Conclusion The results suggest that the combination of Hemospon®, Aloe vera and hDPSCs is a form of clinical treatment for the repair of non-critical bone defects that reduces the inflammatory cascade's effects.


Subject(s)
Humans , Animals , Male , Rats , Bone Regeneration/drug effects , Bone Regeneration/physiology , Plant Extracts/pharmacology , Dental Pulp/cytology , Mesenchymal Stem Cell Transplantation/methods , Aloe/chemistry , Osteogenesis/drug effects , Osteogenesis/physiology , Tibia/drug effects , Tibia/physiology , Tibia/pathology , Time Factors , Immunohistochemistry , Hemostatics/pharmacology , Cell Survival/drug effects , Cell Survival/physiology , Cells, Cultured , Reproducibility of Results , Collagen/pharmacology , Treatment Outcome , Osteopontin/analysis , Flow Cytometry , Microscopy, Fluorescence
13.
J. coloproctol. (Rio J., Impr.) ; 38(4): 283-289, Oct.-Dec. 2018. tab, ilus
Article in English | LILACS | ID: biblio-975973

ABSTRACT

ABSTRACT Rationale: There is a need for a low cost treatment for complex anal fistulas that can heal without causing fecal incontinence, with room for the study of herbal medicines. Objective: To evaluate the effect of the glycerin Aloe barbadensis Miller extract in the treatment of anal fistula in rats. Method: Thirty Wistar rats underwent peritoneal anesthesia with ketamine and Xylasine, followed by transfixation of the anal sphincter with a steel wire, which remained for 30 days to develop the anal fistula. After this period, the steel wire was removed and three groups with 10 animals were formed: A (control), without treatment; B (seton), in which a cotton seton was introduced; C (therapeutic seton), in which a cotton thread was introduced as a seton, and Aloe barbadensis Miller extract was daily dripped in the seton; after 30 days, the setons of groups B and C were removed, and after two weeks without a seton euthanasia and removal of specimens was conducted, and the fistula closure and the inflammatory process were analyzed. Results: Fistula persistence was observed in all animals in Group A, six in Group B and three in Group C (p = 0.015). The mean local inflammation levels were 0.9 in Group A; 0.8 in Group B, and 0 in Group C (p = 0.015). Conclusion: The use of a seton soaked in a glycerin Aloe barbadensis Miller extract was effective in the healing of anal fistulas in rats, in addition to causing less inflammatory process than the non-phytotherapeutic seton.


RESUMO Racional: Há necessidade de um tratamento de baixo custo para as fístulas anais complexas que possa curar sem causar incontinência fecal, havendo espaço para o estudo de fitoterápicos. Objetivo: Avaliar o efeito do extrato glicerinado de Aloe barbadensis Miller no tratamento de fístula anal em ratos. Método: Utilizou-se 30 ratos Wistar, submetidos à anestesia peritoneal com Cetamina e Xilasina, seguida de transfixação do esfíncter anal com fio de aço, que permaneceu por 30 dias para desenvolvimento da fístula anal. Após este período, o fio de aço foi removido e foram formados três grupos com 10 animais: A (controle), sem tratamento; B (sedenho), em que foi introduzido sedenho de algodão; C (sedenho terapêutico), em que foi introduzido fio de algodão como sedenho, e diariamente foi gotejado no sedenho extrato de Aloe barbadensis Miller; após 30 dias os sedentos dos Grupos B e C foram removidos, e, após duas semanas sem sedenho foi praticada a eutanásia e remoção dos espécimes, analisando-se fechamento da fístula e processo inflamatório. Resultados: Houve persistência da fístula em todos os animais do Grupo A, em seis do Grupo B e três do Grupo C (p = 0,015). As médias do grau de inflamação local foram 0,9 no Grupo A; 0,8 no Grupo B e 0 no Grupo C (p = 0,015). Conclusão: O uso de sedenho embebido em extrato glicerinado de Aloe barbadensis Miller foi efetivo na cicatrização de fístulas anais em ratos, além de ter causado menor processo inflamatório que o sedenho sem fitoterápico.


Subject(s)
Animals , Rats , Rectal Fistula , Aloe , Fecal Incontinence , Phytotherapy , Plants, Medicinal , Plant Extracts
15.
Int. j. odontostomatol. (Print) ; 12(3): 320-326, Sept. 2018. tab
Article in Spanish | LILACS | ID: biblio-975751

ABSTRACT

RESUMEN: La gingivitis implica una inflamación de las encías debido a la acumulación de placa, factores anatómicos, por la microbiota subgingival entre otros factores de riesgos, infectando los tejidos que rodean el diente. La utilización de colutorios colabora al cepillado en la prevención, control y reducción de esta condición, por lo que la generación de nuevos productos resulta primordial en el tratamiento de patologías periodontales. El objetivo de este estudio fue establecer la eficacia del colutorio de Aloe Vera comparado con colutorios de clorhexidina en pacientes adultos que presenten gingivitis, en la comuna de Concepción, Chile. El diseño fue una serie de casos. Se evaluó la eficacia del colutorio de aloe vera sobre la gingivitis comparado con colutorio de clorhexidina pacientes entre 18 y 25 años a los diez días de uso en dos grupos con una relación 1:1. Las variables analizadas fueron el índice gingival e índice de placa. El universo fue de 87 sujetos. La muestra se calculó mediante análisis de varianzas arrojando 18 sujetos. Se aprobó por un comité de bioética. Se utilizó estadística descriptiva, además de la t de Student para las asociaciones. Los resultados mostraron una significativa reducción del índice de placa para clorhexidina (IPI de 57,8 a IPF de 27,7), Aloe vera (IPI de 64,3 a IPF de 42,1) y en el índice gingival para clorhexidina (IGI de 0,26 a IGF de 0,11), aloe vera (IGI de 0,95 a IGF de 0,42). El colutorio de aloe vera disminuye significativamente la concentración de placa y la inflamación gingival.


ABSTRACT: Gingivitis correspond to inflammation of the gums as a result of plaque deposits, a material composed of bacteria attached to the tooth, infecting surrounding tissues, in addition to microorganisms of the subgingival microbiota. The use of mouthwash in addition to brushing, helps in the prevention, control and reduction of this condition, so that the generation of new products is paramount in the treatment of periodontal diseases. The aim of this study was to establish the efficacy of Aloe Vera Mouthwash compared with Chlorhexidine mouthwash in adults and patients with gingivitis, in the municipality of Concepción, Chile. The design was a clinical pilot study. The effectiveness of Aloe Vera mouthwash on Gingivitis mouthwash versus chlorhexidine between 18 and 25 on the tenth day of use was evaluated. The variables analyzed were the plaque index and gingival index. A total of 87 subjects were analyzed. The sample was calculated by analysis of variance yielding 18 subjects. It was approved by a committee of bioethics. Descriptive statistics were used in addition to the Student t test for associations. Results showed a significant reduction in the rate of Plaque for chlorhexidine (ICI IPF 57.8 to 27.7), Aloe Vera (IPI IPF 64.3 to 42.1) and Gingival Index for chlorhexidine (IGI 0.26 0.11 IGF), aloe Vera (IGI 0.95 0.42 IGF). Aloe Vera mouthwash significantly decreases the concentration of plaque and gingival inflammation.


Subject(s)
Humans , Adolescent , Adult , Dental Plaque , Aloe , Gingivitis/prevention & control , Chile , Chlorhexidine , Statistical Analysis , Informed Consent , Mouthwashes
16.
Rev. medica electron ; 40(3): 744-754, may.-jun. 2018. ilus
Article in Spanish | LILACS, CUMED | ID: biblio-961261

ABSTRACT

RESUMEN El Aloe vera estimula la proliferación celular, poseeactividad antibacteriana, antifúngica, antiinflamatoria y cicatrizante, entre otras propiedades. Con el objetivo de describir el uso los productos derivados de esta planta en el tratamiento de la enfermedad periodontal inflamatoria crónica, se realizó una revisión de la bibliografía actualizada relacionada con el tema. Los artículos se identificaron a través de la búsqueda automatizada en las bases de datos Scielo, PubMed y EBSCO, de enero a abril del 2017. Fueron seleccionados 32 materiales, escritos en idioma español e inglés, publicados entre los años 2006 y 2017. Co esta revisión se constató que la actividad biológica de los compuestos bioactivos del gel, son útiles para relacionar el efecto terapéutico del Aloe vera en la enfermedad periodontal (AU).


ABSTRACT Aloe vera stimulates cellular proliferation and has antibacterial, antifungal, anti-inflammatory and healing activity, among other properties. With the aim of describing the usage of products prepared with this plant in the treatment of the chronic inflammatory periodontal disease, a review of updated bibliography related with the theme was carried out. The articles were found through the automatic search in SciELO, PubMed and EBSCO databases, from January to April 2017. There were chosen 32 items, written in Spanish and English, published in the period 2006-2017. It was stated with the search that the biological activity of the gel bioactive components are useful to relate the Aloe vera therapeutic effect in the periodontal disease (AU).


Subject(s)
Humans , Animals , Periodontal Diseases , Therapeutic Uses , Aloe , Periodontics , Periodontitis , Research , Cuba , Gingivitis , Phytotherapy
17.
Rev. odontol. UNESP (Online) ; 47(2): 98-105, Mar.-Apr. 2018. tab, ilus
Article in Portuguese | LILACS, BBO | ID: biblio-902704

ABSTRACT

Introdução : O hidróxido de cálcio é considerado uma medicação intracanal padrão ouro e diferentes substâncias podem ser empregadas como veículo para melhorar suas propriedades. O Aloe vera é um fitoterápico popularmente conhecido por babosa e que se destaca pela sua capacidade imunorreguladora, antimicrobiana, cicatrizante e pela biocompatibilidade celular. Objetivo: Avaliar a dissociação iônica do hidróxido de cálcio, tendo o Aloe vera como veículo. Material e método: O extrato de Aloe vera foi obtido diretamente da folha, submetido à filtração e armazenado em tubo Falcon estéril. Foram preparados dois grupos de medicação intracanal: o grupo controle, com hidróxido de cálcio e soro fisiológico, e o grupo experimental, com hidróxido de cálcio e Aloe vera como veículo. Resultado: Não foi verificada uma diferença estatisticamente significativa entre as médias de liberação de cálcio dos grupos (p=0,944). Quando comparados os valores de forma pareada, considerando as diferentes avaliações ao longo do tempo, foi identificada uma diferença estatisticamente significativa (p=0,015) para o grupo experimental, de modo que os valores médios da liberação de cálcio foram superiores até o 21º dia do estudo. Conclusão: O hidróxido de cálcio, quando associado ao Aloe vera, apresentou maior dissociação iônica que quando utilizado com água destilada. Tal resultado, associado às propriedades inerentes deste fitoterápico, sugerem que a pasta de hidróxido de cálcio e Aloe vera pode ser uma alternativa viável e promissora como medicação intracanal, e melhorar o reparo apical e periapical.


Introduction: Calcium hydroxide is considered an intracanal medication gold standard, and different substances can be employed as a vehicle to improve its properties. Aloe vera is a herbal remedy popularly known as babosa and is notable for its immunoregulatory, antimicrobial, healing and cellular biocompatibility. Objective: To evaluate the ionic dissociation of calcium hydroxide, with the Aloe vera as vehicle. Material and method: The extract of Aloe vera was obtained directly from the leaf, submitted to filtration and stored in a sterile falcon tube. Two groups of intracanal medication were prepared; the control group, with calcium hydroxide and saline; and the experimental group, with calcium hydroxide and Aloe vera as vehicle. Result: There was no statistically significant difference between the means of calcium release from the groups (p = 0.944). When comparing the paired values, considering the different evaluations over time, a statistically significant difference (p = 0.015) was identified for the experimental group, so that mean values of calcium released were higher up to the 21st day of the study. Conclusion: Calcium hydroxide, when associated with Aloe vera, presented higher ionic dissociation than when used with distilled water. This result, combined with the inherent properties of this herbal remedy, suggests that the paste of calcium hydroxide and Aloe vera can be a viable and promising alternative as intracanal medication and improve apical and periapical repair.


Subject(s)
Calcium Hydroxide , Distilled Water , Endodontics , Aloe , Phytotherapeutic Drugs
18.
Pesqui. bras. odontopediatria clín. integr ; 18(1): 3959, 15/01/2018. tab
Article in English | LILACS, BBO | ID: biblio-967103

ABSTRACT

Objective: To determine the effectiveness effectivity of mouthwash from Aloe vera juice after scaling treatment on patient with gingivitis. Material and Methods: This was an experimental research using pretest and posttest design with control group. The number of samples of 30 people selected using sampling method quota sampling. Samples were divided into two groups: test (n = 15 skeletons with Aloe vera juice) and control (n = 15 just scaling). Gingival inflammation is measured using a gingival index according to Loe and Sillness on the first day before scaling treatment and 7th day after scaling. Data analysis was conducted using SPSS version 20. Independent-samples t-test and paired-samples t-test were used for data analysis. The statistical test performed has a significance level of 0.05 (p = 0.05) and confidence level of 95% (α = 0,05). Results: There was a significant decrease in the mean score of the gingival index in the control group (1.1 to 0.5) and the test group (1.2 to 0.4) significantly (p<0.05). Conclusion: The use of mouthwash from Aloe vera juice can decrease gingival inflammation, which can be seen from the gingival index score on all test subjects. The decrease in gingival index in the test group using the Aloe vera juice was greater than that of the control group, which was not given the mouthwash.


Subject(s)
Humans , Male , Female , Adult , Plant Extracts/therapeutic use , Dental Plaque , Aloe/immunology , Gingivitis/diagnosis , Mouthwashes/analysis , Case-Control Studies , Epidemiology, Experimental , Data Interpretation, Statistical
19.
Pesqui. bras. odontopediatria clín. integr ; 18(1): 4101, 15/01/2018. tab, ilus, graf
Article in English | LILACS, BBO | ID: biblio-966927

ABSTRACT

Objective: To examine the effect of aloe vera that containing bioactive materials on the levels of calcium (Ca) and phosphorus (P) minerals and their ratios around the immediate implanted in alveolar bone. Material and Methods: Research method by conducting experimental test on experimental animals: 9 male mongrel dogs are divided into 3 groups each 3 tails. In each animal was pulled the second premolar teeth on right side and left side, and immediately inserted titanium implant (3mm x 10mm diameter) after the socket filled with 10% aloevera extract on the right side and control on the left side. Analysis of calcium and phosphorus minerals content formed by examination of Energy Dispersive Spectroscopy (EDS) on Scanning Electron Microscope on implant and around bone tissue was done on days 14, 28 and 56. The result of statistical analysis using repeated ANOVA with independent t test. The level of significance was set at 5%. Results: There was a significant difference on calcium level between control and treatment groups on days 14, 28 and 56 (p<0.05). There was no significant difference on phosphorus level between control and treatment groups (p>0.05). The ratio of Ca / P in both control and treatment groups was also significantly different in every observation day (p<0.05). Conclusion: The addition of aloe vera extract that containing bioactive materials has an effect on increasing levels of mineral elements calcium and calciumphosphorus ratio after immediate implant insertion.


Subject(s)
Animals , Dogs , Phosphorus , Spectrum Analysis/methods , Calcium , Aloe , Immediate Dental Implant Loading , Microscopy, Electron, Scanning/methods , Epidemiology, Experimental , Analysis of Variance , Osseointegration , Indonesia
20.
Braz. oral res. (Online) ; 32: e004, 2018. tab, graf
Article in English | LILACS | ID: biblio-889501

ABSTRACT

Abstract Radiation combined injury, a life-threatening condition, has higher mortality than simple radiation injury. The aim of the present study was to analyze the efficiency of Aloe vera and silver nanoparticles in improving the healing of ulcerated oral mucosa after irradiation. Thirty male Albino mice were divided into five groups: control, radiation, Aloe vera (AV), silver nanoparticles (NS), and AV+NS. The mice were exposed to whole body 6Gy gamma-radiation. After one hour, 20% acetic acid was injected into the submucosal layer of the lower lip for ulcer induction. The animals received topical treatment with the assigned substances for 5 days. Lip specimens were subjected to hematoxylin and eosin and anti alpha-smooth muscle actin immunohistochemical staining. Results demonstrated occurance of ulcer three days post irradiation in all groups except in the AV+NS group where only epithelial detachment was developed. After seven days, data revealed persistent ulcer in radiation group, and almost normal epithelium in the AV+NS group. A significant reduction of epithelial thickness was detected in all groups at the third day as compared to control. At the seventh day, only the AV+NS group restored the epithelial thickness. Area percent of alpha-smooth muscle actin expression was significantly decreased in radiation group at the third day followed by significant increase at the seventh day. However, all treatment groups showed significant increase in alpha-smooth muscle actin at the third day, which decreased to normal level at the seventh day. Our study demonstrated the efficiency of Aloe vera and silver nanoparticles in enhancing ulcer healing after irradiation.


Subject(s)
Animals , Male , Mice , Aloe/chemistry , Gamma Rays/adverse effects , Metal Nanoparticles/therapeutic use , Oral Ulcer/drug therapy , Oral Ulcer/etiology , Radiation Injuries, Experimental/drug therapy , Silver/therapeutic use , Acetic Acid , Actins/analysis , Administration, Topical , Epithelial Cells/drug effects , Epithelial Cells/radiation effects , Fibroblasts/drug effects , Immunohistochemistry , Microscopy, Electron, Transmission , Oral Ulcer/pathology , Radiation Injuries, Experimental/pathology , Reference Values , Reproducibility of Results , Time Factors , Treatment Outcome , Wound Healing/drug effects
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