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1.
J. appl. oral sci ; 27: e20180700, 2019. tab, graf
Article in English | LILACS, BBO | ID: biblio-1012509

ABSTRACT

Abstract Alternatives for the treatment of caries disease, such as minimally invasive approaches, have been developed in recent years. Objective: To carry out clinical and radiographic evaluations of three cavity liners after selective caries removal. Methodology: Thirty-six primary molars with deep occlusal caries lesions without pulp involvement (from children of both genders, aged between 5 and 8 years) were randomly divided into the following groups: calcium hydroxide cement (CHC) group; mineral trioxide aggregate (MTA) group and Portland cement with added zirconium oxide (PCZ) group. The following-up period was 6- and 12-month. The clinical and radiographic success rates were evaluated through chi-square test. The radiographic measurements were compared by ANOVA followed by Tukey's test (p<0.05). Results: Thirty-six patients were included, but thirty-four returned for 12-month follow-up. The overall success rate of the therapy for the three groups was 94.11% and no statistically significant differences occurred in the comparison among groups (p>0.05). Nineteen radiographs were selected to measure the dentin barrier thickness. The intragroup comparison presented a statistically significant increase of the dentin barrier for all groups, at 12-month follow-up. However, the MTA group showed increase of the dentin barrier, over time, 6- to 12-month follow-up. The intergroup comparison revealed no statistically significant differences (p>0.05). Conclusion: The clinical and radiographic data showed that all cavity liners provided effective treatment of primary teeth after selective caries removal.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Oxides/therapeutic use , Zirconium/therapeutic use , Silicates/therapeutic use , Calcium Compounds/therapeutic use , Aluminum Compounds/therapeutic use , Dental Caries/therapy , Dental Cavity Lining/methods , Time Factors , Tooth, Deciduous , Radiography, Dental , Analysis of Variance , Follow-Up Studies , Treatment Outcome , Dental Caries/diagnostic imaging , Dental Cements/therapeutic use , Dental Pulp Cavity/anatomy & histology , Dental Pulp Cavity/drug effects , Dental Restoration, Permanent/methods , Drug Combinations
2.
J. appl. oral sci ; 27: e20180030, 2019. tab, graf
Article in English | LILACS, BBO | ID: biblio-1002410

ABSTRACT

Abstract Objectives: To evaluate the effect of calcium hydroxide (CH) associated with two different vehicles as a capping material for pulp tissue in primary molars, compared with mineral trioxide aggregate (MTA). Methodology: Forty-five primary mandibular molars with dental caries were treated by conventional pulpotomy using one of the following materials: MTA only (MTA group), CH with saline (CH+saline group) and CH with polyethylene glycol (CH+PEG group) (15 teeth/group). Clinical and periapical radiographic examinations of the pulpotomized teeth were performed 3, 6, and 12 months after treatment. Data were tested by chi-squared analysis and a multiple comparison post-test. Results: The MTA group showed both clinical and radiographic treatment success in 14/14 teeth (100%), at all follow-up appointments. By clinical evaluation, no teeth in the CH+saline and CH+PEG groups had signs of mobility, fistula, swelling or inflammation of the surrounding gingival tissue. However, in the CH+saline group, radiographic analysis detected internal resorption in up to 9/15 teeth (67%), and inter-radicular bone resorption and furcation radiolucency in up to 5/15 teeth (36%), from 3 to 12 months of follow-up. In the CH+PEG group, 2/11 teeth (18%) had internal resorption and 1/11 teeth (9%) presented bone resorption and furcation radiolucency at all follow-up appointments. Conclusion: CH with PEG performed better than CH with saline as capping material for pulpotomy of primary teeth. However, both combinations yielded clinical and radiographic results inferior to those of MTA alone.


Subject(s)
Humans , Child, Preschool , Child , Oxides/therapeutic use , Pulpotomy/methods , Tooth, Deciduous/surgery , Calcium Hydroxide/therapeutic use , Silicates/therapeutic use , Calcium Compounds/therapeutic use , Aluminum Compounds/therapeutic use , Pulp Capping and Pulpectomy Agents/therapeutic use , Time Factors , Tooth, Deciduous/diagnostic imaging , Calcium Hydroxide/chemistry , Radiography, Dental , Prospective Studies , Follow-Up Studies , Treatment Outcome , Drug Combinations , Pulp Capping and Pulpectomy Agents/chemistry , Saline Solution/therapeutic use , Saline Solution/chemistry
3.
Braz. oral res. (Online) ; 33: e084, 2019. graf
Article in English | LILACS | ID: biblio-1019612

ABSTRACT

Abstract This study aimed to evaluate the role of photobiomodulation (PBM) in apexification and apexogenesis of necrotic rat molars with an open apex. Rat molars were exposed to the oral environment for 3 weeks. Canals were rinsed with 2.5% NaOCl and 17% EDTA, filled with antibiotic paste and sealed. After 7 days, canals were rinsed and divided into six groups (n=6): mineral trioxide aggregate (MTA); blood clot (BC); human dental pulp stem cells (hDPSC); MTA+PBM; BC+PBM; and hDPSC+PBM. In hDPSC groups, a 1% agarose gel scaffold was used. Two groups were not exposed: healthy tooth+PBM (n = 6), healthy tooth (n = 3); and one was exposed throughout the experiment: necrotic tooth (n = 3). In PBM groups, irradiation was performed with aluminum gallium indium phosphide (InGaAlP) diode laser for 30 days within 24-h intervals. After that, the specimens were processed for histological and immunohistochemical analyses. Necrotic tooth showed greater neutrophil infiltrate (p < 0.05). Necrotic tooth, healthy tooth, and healthy tooth+PBM groups showed absence of a thin layer of fibrous condensation in the periapical area. All the other groups stimulated the formation of a thicker layer of fibers (p < 0.05). All groups formed more mineralized tissue than necrotic tooth (p < 0.05). PBM associated with MTA, BC, or hDPSC formed more mineralized tissue (p < 0.05). MTA+PBM induced apexification (p < 0.05). Rabbit polyclonal anti-bone sialoprotein (BSP) antibody confirmed the histological findings of mineralized tissue formation, and hDPSC groups exhibited higher percentage of BSP-positive cells. It can be concluded that PBM improved apexification and favored apexogenesis in necrotic rat molars with an open apex.


Subject(s)
Animals , Tooth Diseases/radiotherapy , Dental Pulp Necrosis/radiotherapy , Tooth Apex/radiation effects , Low-Level Light Therapy/methods , Dental Pulp Cavity/radiation effects , Lasers, Semiconductor/therapeutic use , Apexification/methods , Oxides/therapeutic use , Stem Cells , Tooth Diseases/pathology , Immunohistochemistry , Random Allocation , Reproducibility of Results , Treatment Outcome , Rats, Wistar , Silicates/therapeutic use , Calcium Compounds/therapeutic use , Aluminum Compounds/therapeutic use , Dental Pulp Necrosis/pathology , Tooth Apex/pathology , Dental Pulp/cytology , Dental Pulp Cavity/pathology , Drug Combinations , Integrin-Binding Sialoprotein/analysis
4.
Braz. oral res. (Online) ; 32(supl.1): e73, 2018.
Article in English | LILACS | ID: biblio-974476

ABSTRACT

Abstract: Root perforation results in the communication between root canal walls and periodontal space (external tooth surface). It is commonly caused by an operative procedural accident or pathological alteration (such as extensive dental caries, and external or internal inflammatory root resorption). Different factors may predispose to this communication, such as the presence of pulp stones, calcification, resorptions, tooth malposition (unusual inclination in the arch, tipping or rotation), an extra-coronal restoration or intracanal posts. The diagnosis of dental pulp and/or periapical tissue previous to root perforation is an important predictor of prognosis (including such issues as clinically healthy pulp, inflamed or infected pulp, primary or secondary infection, and presence or absence of intracanal post). Clinical and imaging exams are necessary to identify root perforation. Cone-beam computed tomography constitutes an important resource for the diagnosis and prognosis of this clinical condition. Clinical factors influencing the prognosis and healing of root perforations include its treatment timeline, extent and location. A small root perforation, sealed immediately and apical to the crest bone and epithelial attachment, presents with a better prognosis. The three most widely recommended materials to seal root perforations have been calcium hydroxide, mineral trioxide aggregate and calcium silicate cements. This review aimed to discuss contemporary therapeutic alternatives to treat root canal perforations. Accordingly, the essential aspects for repairing this deleterious tissue injury will be addressed, including its diagnosis, prognosis, and a discussion about the materials actually suggested to seal root canal perforation.


Subject(s)
Humans , Root Canal Filling Materials/therapeutic use , Dental Pulp Cavity/injuries , Dental Pulp Cavity/diagnostic imaging , Dental Pulp Diseases/therapy , Dental Pulp Diseases/diagnostic imaging , Oxides , Prognosis , Calcium Hydroxide/therapeutic use , Silicates/adverse effects , Calcium Compounds/therapeutic use , Aluminum Compounds/therapeutic use , Root Canal Preparation/adverse effects , Drug Combinations
5.
Rev. chil. dermatol ; 33(1): 7-14, 2017. tab, ilus
Article in Spanish | LILACS | ID: biblio-964619

ABSTRACT

La hiperhidrosis es un aumento patológico de la sudoración, que puede asociarse a patologías médicas y fármacos, afectando en forma significativa la calidad de vida. La hiperhidrosis focal primaria es una patología común, cuyo manejo es un desafío. Están disponibles múltiples terapias para el tratamiento de hiperhidrosis, incluyendo productos tópicos, iontoforesis, toxina botulínica, fármacos sistémicos, cirugía y nuevos equipos para destrucción selectiva de las glándulas sudoríparas. El propósito de este artículo es revisar la literatura, enfocándose en las terapias no quirúrgicas y opciones de tratamiento emergentes.


Hyperhidrosis is a pathological excessive sweating. It can be associated with medical conditions or drugs and affect significantly the quality of life. Primary focal hyperhidrosis is a common disorder for which treatment is often a therapeutic challenge. Multiple therapies are available for the treatment of hyperhidrosis, including topical products, iontophoresis, botulinum toxin, systemic medications, surgery and new devices aimed at the destruction of ecrine glands. The purpose of this article is to review the literature, with a focus on non-surgical therapies and emerging treatment options.


Subject(s)
Humans , Hyperhidrosis/therapy , Severity of Illness Index , Iontophoresis , Aluminum Compounds/therapeutic use , Botulinum Toxins, Type A/therapeutic use , Acetylcholine Release Inhibitors/therapeutic use , Hyperhidrosis/diagnosis
6.
Acta cir. bras ; 31(6): 422-427, graf
Article in English | LILACS | ID: lil-785019

ABSTRACT

ABSTRACT PURPOSE: To evaluate the clinical applicability of Pozzolana Biologic Silva cement (PBS(r)) in endodontic surgery. METHODS: Persistent apical periodontitis was diagnosed in 30 teeth of 12 patients by cone-beam computed tomography (CT). All patients had 2 or 4 affected teeth and underwent endodontic surgery with root-end filling. Patients with 2 affected teeth had one tooth (control) treated with mineral trioxide aggregate (MTA-Angelus(r)) as a root-end filling material, and the other tooth treated with PBS (experiment). When the patient had four affected teeth, two of them were treated with MTA and two with PBS. Six months after surgery, all patients were assessed by CT scan. Between-group comparisons of measurements were performed using the Wilcoxon test. RESULTS: Periradicular tissue regeneration was observed in all cases. Significant within-group differences in long axes of the lesion were found in the bucco-palatal direction (PBS group, p=0.0012; MTA group, p=0.024) and coronal-apical direction (PBS group, p=0.0007; MTA group, p=0.0015) between pre- and postoperative measurements. CONCLUSIONS: Pozzolana Biologic Silva cement can be used in the treatment of persistent periradicular lesions. The clinical use of PBS as a root-end filling material may be an alternative to MTA. PBS has additives, which provide enhanced strength.


Subject(s)
Humans , Adolescent , Adult , Middle Aged , Young Adult , Oxides/therapeutic use , Periapical Periodontitis/surgery , Biocompatible Materials/therapeutic use , Calcium Compounds/therapeutic use , Aluminum Compounds/therapeutic use , Dental Cements/therapeutic use , Apicoectomy/methods , Periapical Periodontitis/diagnostic imaging , Postoperative Period , Regeneration/physiology , Tooth Root/surgery , Tooth Root/diagnostic imaging , Prospective Studies , Drug Combinations , Cone-Beam Computed Tomography
7.
Acta cir. bras ; 30(2): 160-164, 02/2015. tab, graf
Article in English | LILACS | ID: lil-741024

ABSTRACT

PURPOSE: To assess periradicular lesions clinically and by computed tomography (CT) after endodontic surgery using either Portland cement or mineral trioxide aggregate (MTA) as a root-end filling material. METHODS: Three patients diagnosed with periradicular lesions by cone-beam CT underwent endodontic surgery with root-end filling. Patient A was treated with MTA as the root-end filling material, patient B was treated with Portland cement and patient C had two teeth treated, one with MTA and the other with Portland cement. Six months after surgery, the patients were assessed clinically and by CT scan and the obtained results were compared. RESULTS: Periradicular tissue regeneration was observed in all cases, with no significant differences in bone formation when comparing the use of MTA and Portland cement as root-end filling materials. CONCLUSION: Both mineral trioxide aggregate and Portland cement were successful in the treatment of periradicular lesions. .


Subject(s)
Adult , Female , Humans , Male , Young Adult , Aluminum Compounds/therapeutic use , Calcium Compounds/therapeutic use , Dental Cements/therapeutic use , Oxides/therapeutic use , Periapical Diseases/surgery , Root Canal Filling Materials/therapeutic use , Root Canal Therapy/methods , Silicates/therapeutic use , Tooth Root/surgery , Drug Combinations , Materials Testing , Pilot Projects , Postoperative Period , Prospective Studies , Periapical Diseases , Reproducibility of Results , Time Factors , Treatment Outcome , Tomography, X-Ray Computed/methods , Tooth Root
8.
Bauru; s.n; 2015. 183 p. ilus, tab, graf.
Thesis in Portuguese | LILACS | ID: lil-756760

ABSTRACT

O objetivo deste estudo foi avaliar as propriedades físico-químicas, antimicrobianas e biocompatibilidade do MTA branco manipulado com extratos aquoso e/ou em propilenoglicol da Arctium lappa L., Casearia sylvestris Sw. e própolis. Dentre os testes físico-químicos foram avaliados o tempo de presa, escoamento, pH, liberação de íons cálcio e alteração volumétrica. Para verificar o efeito antimicrobiano foram aplicadas as metodologias do contato direto (Enterococcus faecalis e a Cândida albicans) e da descontaminação dentinária, empregando a microscopia confocal de varredura laser para verificar a viabilidade de Enterococcus faecalis. Para a avaliação da biocompatibilidade, 162 ratos Wistar foram utilizados, onde cada animal recebeu dois implantes subcutâneos e um alveolar. Após os períodos experimentais de 15, 30 e 60 dias foram realizadas análises microtomográfica, histológica descritiva e histomorfométrica. Adicionalmente amostras do tecido alveolar foram processadas para dosagem das citocinas TNF-α e IL-10 por meio do ensaio imunoenzimático (ELISA). Os dados obtidos foram analisados estatisticamente com os testes ANOVA e Tukey ou Kruskal-Wallis e Dunn. Os resultados revelaram que a variação do veículo associado ao MTA aumentou significativamente o tempo de presa, no entanto, não houve influência na alteração volumétrica (P>0,05) e na capacidade do cimento em manter o meio alcalino e liberar íons cálcio. Os cimentos manipulados com extratos em propilenoglicol apresentaram maior escoamento (P<0,05). Apenas o extrato da própolis agregou ao MTA efeito contra o Enterococcus faecalis após 24 e 48 horas (descontaminação dentinária e contato direto respectivamente) e contra a Cândida albicans após 10 horas (P<0,05). De acordo com as avaliações histológica e histomorfométrica dos implantes em tecidos subcutâneo e alveolar não foi constatada diferença significativa entre os grupos experimentais quando comparados com o grupo no qual o MTA foi manipulado...


The aim of this study was to evaluate the physicochemical, antimicrobial properties and biocompatibility of white MTA mixed with aqueous or propylene glycol extracts of Arctium lappa L., Casearia sylvestris Sw. and propolis. Among physicochemical tests were evaluated the setting time, flowability, pH, ion calcium release and volumetric change. To verify the antimicrobial effects were applied the methods of direct contact (Enterococcus faecalis and Candida albicans) and dentin decontamination by using the confocal laser scanning microscopy to verify the Enterococcus faecalis viability. To evaluate the biocompatibility were used 162 Wistar rats. Each animal received one alveolar and two subcutaneous implants. After the experimental periods of 15, 30 and 60 days were performed the microtomography, histological description and histomorphometric analyses. Additionally alveolar tissue samples were processed for the measurement of TNF-α e IL-10 cytokines by enzyme-linked immunosorbent assay (ELISA). The data were statistically analyzed by the ANOVA and Tukey or KruskalWallis and Dunns tests. The results revealed that the variation of the vehicle associated to MTA significantly increased its setting time, however did not influence the volumetric change (P>0,05) and the cement's ability to maintain the alkaline medium and ion calcium release. Cements mixed with propylene glycol extracts showed higher flowability (P<0,05). Only propolis extract added to MTA the effect against E. faecalis after 24 and 48 hours (dentin decontamination and direct contact respectively) and against Candida albicans after 10 hours (P<0,05). According to the histological and histomorphometric evaluation of the implants in subcutaneous and alveolar tissue was not observed significant differences between the experimental groups in comparison to the reference group (MTA was mixed with distilled water). The microtomography analysis and expression of TNF-α and IL-10 showed...


Subject(s)
Animals , Male , Rats , Anti-Infective Agents/chemistry , Aluminum Compounds/chemistry , Calcium Compounds/chemistry , Oxides/chemistry , Phytotherapeutic Drugs , Propolis/chemistry , Silicates/chemistry , Anti-Infective Agents/therapeutic use , Biocompatible Materials , Candida albicans , Aluminum Compounds/therapeutic use , Calcium Compounds/therapeutic use , Drug Combinations , Enterococcus faecalis , Materials Testing , Oxides/therapeutic use , Propolis/therapeutic use , Rats, Wistar , Reproducibility of Results , Silicates/therapeutic use , Time Factors
9.
Rio de janeiro; s.n; 2015. 56 p. ilus.
Thesis in Portuguese | LILACS, BBO | ID: biblio-1015204

ABSTRACT

O protocolo atual para o tratamento das reabsorções inflamatórias externas radiculares utiliza o hidróxido de cálcio como agente de desinfecção, como curativo de demora, em várias trocas sucessivas e por longo período de tempo. Além da necessidade de várias consultas para a substituição do hidróxido de cálcio, a sua permanência nos canais por longo período de tempo, provoca o enfraquecimento das estruturas dentárias. Portanto, modificação desta terapia seria aconselhável. Nesta investigação clínica, três pacientes portadores de reabsorção inflamatória externa radicular foram tratados com a terapia de revascularização, usualmente utilizada em dentes com necrose pulpar e ápices abertos. Os dentes foram tratados com o protocolo da terapia de revascularização que consiste na desinfecção do sistema de canais radiculares com pasta tri-antibiótica, com posterior preenchimento do canal com coagulo sanguíneo e selamento do canal com agregado trióxido mineral e resina adesiva. Foi observado durante a proservação a paralização do processo patológico com neoformação tecidual nas áreas radiolúcidas preexistentes. Foi detectada a redução da mobilidade dos elementos dentários tratados. Os três casos foram acompanhados por 30, 18 e 15 meses, respectivamente. Todos os elementos dentários permaneceram assintomáticos, mantidos com função e mobilidade fisiológica. A terapia utilizada no procedimento de revascularização mostrou-se eficiente no tratamento da reabsorção inflamatória externa radicular, reduzindo o número de consultas e aumentando a adesão dos pacientes.


The current external inflammatory root resorption treatment protocol, which uses calcium hydroxide dressing, usually comprises multiple and long-term applications. In addition to the need for multiple appointments for calcium hydroxide replacement, the long-term maintenance of this compound in the root canal weakens dental structures. A modification of this therapy would be advisable. In this clinical investigation, three patients with external inflammatory root resorption were submitted to revascularization therapy protocol usually used in teeth with necrotic pulp and open apices. The teeth were treated with revascularization therapy protocol, which consisted of disinfecting the root canal system with tri-antibiotic paste, filling it with blood clot, and sealing of the root canal with mineral trioxide aggregate and bonded resin restoration. During the follow up, the pathological process was arrested with tissue repair in preexisting radiolucent areas. Reduced mobility was observed in the treated teeth. The three cases were followed up for 30, 18, and 15 months, respectively. All teeth remained asymptomatic and retained function and physiological mobility. The therapy used in the revascularization procedure was efficient in the treatment of external inflammatory root resorption, reducing the number of appointments and increasing patient compliance.


Subject(s)
Humans , Male , Child , Root Resorption/therapy , Tooth Injuries , Drug Combinations , Glass Ionomer Cements/therapeutic use , Anti-Bacterial Agents/therapeutic use , Oxides/therapeutic use , Calcium Hydroxide/therapeutic use , Treatment Outcome , Silicates/therapeutic use , Calcium Compounds/therapeutic use , Aluminum Compounds/therapeutic use
10.
Bauru; s.n; 2015. 183 p. ilus, tab, graf.
Thesis in Portuguese | LILACS, BBO | ID: biblio-867253

ABSTRACT

O objetivo deste estudo foi avaliar as propriedades físico-químicas, antimicrobianas e biocompatibilidade do MTA branco manipulado com extratos aquoso e/ou em propilenoglicol da Arctium lappa L., Casearia sylvestris Sw. e própolis. Dentre os testes físico-químicos foram avaliados o tempo de presa, escoamento, pH, liberação de íons cálcio e alteração volumétrica. Para verificar o efeito antimicrobiano foram aplicadas as metodologias do contato direto (Enterococcus faecalis e a Cândida albicans) e da descontaminação dentinária, empregando a microscopia confocal de varredura laser para verificar a viabilidade de Enterococcus faecalis. Para a avaliação da biocompatibilidade, 162 ratos Wistar foram utilizados, onde cada animal recebeu dois implantes subcutâneos e um alveolar. Após os períodos experimentais de 15, 30 e 60 dias foram realizadas análises microtomográfica, histológica descritiva e histomorfométrica. Adicionalmente amostras do tecido alveolar foram processadas para dosagem das citocinas TNF-α e IL-10 por meio do ensaio imunoenzimático (ELISA). Os dados obtidos foram analisados estatisticamente com os testes ANOVA e Tukey ou Kruskal-Wallis e Dunn. Os resultados revelaram que a variação do veículo associado ao MTA aumentou significativamente o tempo de presa, no entanto, não houve influência na alteração volumétrica (P>0,05) e na capacidade do cimento em manter o meio alcalino e liberar íons cálcio. Os cimentos manipulados com extratos em propilenoglicol apresentaram maior escoamento (P<0,05). Apenas o extrato da própolis agregou ao MTA efeito contra o Enterococcus faecalis após 24 e 48 horas (descontaminação dentinária e contato direto respectivamente) e contra a Cândida albicans após 10 horas (P<0,05). De acordo com as avaliações histológica e histomorfométrica dos implantes em tecidos subcutâneo e alveolar não foi constatada diferença significativa entre os grupos experimentais quando comparados com o grupo no qual o MTA foi manipulado...


The aim of this study was to evaluate the physicochemical, antimicrobial properties and biocompatibility of white MTA mixed with aqueous or propylene glycol extracts of Arctium lappa L., Casearia sylvestris Sw. and propolis. Among physicochemical tests were evaluated the setting time, flowability, pH, ion calcium release and volumetric change. To verify the antimicrobial effects were applied the methods of direct contact (Enterococcus faecalis and Candida albicans) and dentin decontamination by using the confocal laser scanning microscopy to verify the Enterococcus faecalis viability. To evaluate the biocompatibility were used 162 Wistar rats. Each animal received one alveolar and two subcutaneous implants. After the experimental periods of 15, 30 and 60 days were performed the microtomography, histological description and histomorphometric analyses. Additionally alveolar tissue samples were processed for the measurement of TNF-α e IL-10 cytokines by enzyme-linked immunosorbent assay (ELISA). The data were statistically analyzed by the ANOVA and Tukey or KruskalWallis and Dunns tests. The results revealed that the variation of the vehicle associated to MTA significantly increased its setting time, however did not influence the volumetric change (P>0,05) and the cement's ability to maintain the alkaline medium and ion calcium release. Cements mixed with propylene glycol extracts showed higher flowability (P<0,05). Only propolis extract added to MTA the effect against E. faecalis after 24 and 48 hours (dentin decontamination and direct contact respectively) and against Candida albicans after 10 hours (P<0,05). According to the histological and histomorphometric evaluation of the implants in subcutaneous and alveolar tissue was not observed significant differences between the experimental groups in comparison to the reference group (MTA was mixed with distilled water). The microtomography analysis and expression of TNF-α and IL-10 showed...


Subject(s)
Animals , Male , Rats , Anti-Infective Agents/chemistry , Aluminum Compounds/chemistry , Calcium Compounds/chemistry , Oxides/chemistry , Phytotherapeutic Drugs , Propolis/chemistry , Silicates/chemistry , Anti-Infective Agents/therapeutic use , Biocompatible Materials , Candida albicans , Aluminum Compounds/therapeutic use , Calcium Compounds/therapeutic use , Drug Combinations , Enterococcus faecalis , Materials Testing , Oxides/therapeutic use , Propolis/therapeutic use , Rats, Wistar , Reproducibility of Results , Silicates/therapeutic use , Time Factors
11.
J. appl. oral sci ; 21(3): 235-242, May/Jun/2013. graf
Article in English | LILACS | ID: lil-679324

ABSTRACT

Some manufacturers have recently added specific components to improve the ease of handling and insertion material properties of MTA in order to create MTA-based sealers. Objective The aim of this study was to evaluate the healing of periapical lesions in canine teeth after a single session of endodontic treatment with MTA Fillapex® compared with Sealapex® or Endo-CPM-Sealer®. Material and Methods Sixty-two root canals were performed on two 1-year-old male dogs. After coronal access and pulp extirpation, the canals were exposed to the oral cavity for 6 months in order to induce periapical lesions. The root canals were prepared, irrigated with a solution of 2.5% sodium hypochlorite and filled with gutta-percha and different sealers, according to the following groups: 1) Sealapex®; 2) Endo-CPM-Sealer®; and 3) MTA Fillapex®. Some teeth with periapical lesions were left untreated for use as positive controls. Healthy teeth were used as negative controls. After 6 months, the animals were sacrificed and serial sections from the roots were prepared for histomorphologic analysis and stained with hematoxylin and eosin and the Brown and Brenn technique. The lesions were scored according to pre-established histomorphologic parameters and the scores statistically analyzed using the Kruskal-Wallis test. Results All 3 materials produced similar patterns of healing (p>0.05); in particular, persistent inflammation and absence of complete periapical tissue healing were consistently noted. Conclusions Preparation of the infected root canals followed by filling with the materials studied was insufficient to provide complete healing of the periapical tissues. .


Subject(s)
Animals , Dogs , Male , Aluminum Compounds/therapeutic use , Calcium Compounds/therapeutic use , Calcium Hydroxide/therapeutic use , Oxides/therapeutic use , Periapical Tissue/drug effects , Root Canal Filling Materials/therapeutic use , Root Canal Preparation/methods , Salicylates/therapeutic use , Silicates/therapeutic use , Wound Healing/drug effects , Anti-Infective Agents/therapeutic use , Drug Combinations , Dental Pulp Cavity/drug effects , Dental Pulp Cavity/microbiology , Materials Testing , Periapical Tissue/injuries , Periapical Tissue/pathology , Reproducibility of Results , Root Canal Irrigants/therapeutic use , Time Factors
12.
Braz. dent. j ; 24(2): 163-166, Mar-Apr/2013. graf
Article in English | LILACS | ID: lil-675654

ABSTRACT

Two cases are reported in which incomplete placement of 4 mm mineral trioxide aggregate (MTA) plug was performed unintentionally at the apical third of permanent immature teeth with open apex and apical periodontitis. As confirmed radiographically, there were gaps between MTA and dentinal walls along the MTA-dentin interface. After setting of MTA was confirmed, endodontic treatment was completed and access was sealed with composite resin. At 6 to 16 months follow-up examinations, formation of dentin in contact with the MTA surface, as well as apical closure and periapical healing were ideied radiographically for both cases. The results of these cases showed that apical barrier formation and complete periapical healing is possible despite the incomplete apical placement of the MTA plug. This might be due to the biological properties of the MTA. Even so, an incomplete three-dimensional placement of the filling material is not advocated.


Subject(s)
Child , Female , Humans , Male , Aluminum Compounds/therapeutic use , Apexification/methods , Calcium Compounds/therapeutic use , Oxides/therapeutic use , Root Canal Filling Materials/therapeutic use , Silicates/therapeutic use , Tooth Apex/pathology , Aluminum Compounds/administration & dosage , Calcium Compounds/administration & dosage , Calcium Hydroxide/therapeutic use , Drug Combinations , Dental Pulp Necrosis/therapy , Dentin, Secondary/pathology , Dentin/pathology , Epoxy Resins/therapeutic use , Follow-Up Studies , Gutta-Percha/therapeutic use , Incisor/injuries , Oxides/administration & dosage , Periapical Periodontitis/therapy , Root Canal Irrigants/therapeutic use , Root Canal Obturation/methods , Root Canal Preparation/methods , Silicates/administration & dosage , Tooth Avulsion/therapy , Tooth Fractures/therapy
13.
Braz. dent. j ; 24(2): 107-110, Mar-Apr/2013. graf
Article in English | LILACS | ID: lil-675667

ABSTRACT

Despite the excellent properties of mineral trioxide aggregate (MTA), the condensation technique may have some influence in its sealing ability. The purpose of this study was to compare the sealing ability of sonic and ultrasonic setting of MTA. Thirty-four extracted human teeth had their canals prepared and filled with Sealapex sealer and gutta-percha using the active lateral condensation technique. The teeth were rendered waterproof and apicoectomy performed at 3 mm from the apex. Root-end cavities (3.0 mm deep and 1.4 mm diameter) were prepared with diamond ultrasonic tips. The root-end cavities were filled with Pro-Root MTA® with ultrasonic vibration, sonic vibration or no vibration. The positive control group did not receive any material while the negative control group was totally rendered waterproof. After material set, the specimens were immersed in Rodhamine B for 24 h, under vacuum in the first 15 min, then washed, dried and split longitudinally for evaluating the infiltration at the dentin/material interface. Data were analyzed using ANOVA and Tukey's tests at 5% significance level. Sonic vibration promoted the lowest infiltration values (p<0.05). It was concluded that sonic vibration could be considered an efficient aid to improve the sealing ability of MTA when used as root-end filling material.


Resumo O objetivo deste estudo foi avaliar in vitro, a influência da vibração sônica e ultrassônica no selamento marginal proporcionado pelo MTA. Trinta e quatro dentes humanos tiveram seus canais radiculares instrumentados e obturados com cimento Sealapex® pela técnica da condensação lateral ativa. Os dentes foram impermeabilizados e seccionados os 3 mm apicais. Retrocavidades (3 mm de profundidade e 1,4 mm de diâmetro) foram preparadas com pontas ultrassônicas diamantadas. As retrocavidades foram preenchidas com Pro-Root MTA® com auxílio da vibração ultrassônica, com auxílio da vibração sônica e sem vibração alguma. O grupo controle positivo não recebeu material retrobturador, enquanto que o negativo foi totalmente impermeabilizado. Após a presa do material, os espécimes foram mergulhados em Rodamina B por 15 min em vácuo, permanecendo nesta solução por mais 24 h. Em seguida, foram lavados, secados e clivados longitudinalmente para avaliação da infiltração do corante na interface dentina/material retrobturador. Os dados foram analisados utilizando a análise de variância e o teste de Tukey (p<0,05). Observou-se que apenas a vibração sônica foi diferente apresentando os menores índices de infiltração. Pode-se concluir que vibração sônica contribui com a melhora da capacidade de selamento marginal proporcionado pelo MTA quando empregado como material retrobturador. .


Subject(s)
Humans , Aluminum Compounds/therapeutic use , Calcium Compounds/therapeutic use , Dental Bonding , Oxides/therapeutic use , Retrograde Obturation/methods , Root Canal Filling Materials/therapeutic use , Silicates/therapeutic use , Apicoectomy/methods , Calcium Hydroxide/therapeutic use , Drug Combinations , Dentin/ultrastructure , Diamond/chemistry , Fluorescent Dyes , Gutta-Percha/therapeutic use , Rhodamines , Root Canal Preparation/instrumentation , Root Canal Preparation/methods , Sonication , Surface Properties , Salicylates/therapeutic use , Time Factors , Ultrasonics/instrumentation , Vibration
14.
Acta cir. bras ; 27(11): 809-814, Nov. 2012. ilus, tab
Article in English | LILACS | ID: lil-654249

ABSTRACT

PURPOSE: To evaluate the use of Portland cements with additives as furcation perforation repair materials and assess their biocompatibility. METHODS: The four maxillary and mandibular premolars of ten male mongrel dogs (1-1.5 years old, weighing 10-15 kg) received endodontic treatment (n=80 teeth). The furcations were perforated with a round diamond bur (1016 HL). The perforations involved the dentin, cementum, periodontal ligament, and alveolar bone. A calcium sulfate barrier was placed into the perforated bone to prevent extrusion of obturation material into the periradicular space. The obturation materials MTA (control), white, Type II, and Type V Portland cements were randomly allocated to the teeth. Treated teeth were restored with composite resin. After 120 days, the animals were sacrificed and samples containing the teeth were collected and prepared for histological analysis. RESULTS: There were no significant differences in the amount of newly formed bone between teeth treated with the different obturation materials (p=0.879). CONCLUSION: Biomineralization occurred for all obturation materials tested, suggesting that these materials have similar biocompatibility.


OBJETIVO: Avaliar o uso de cimentos Portland aditivados na reparação de perfurações radiculares e a biocompatibilidade destes materiais. MÉTODOS: Oitenta pré-molares, quatro da arcada dentária superior e quatro da arcada inferior de 10 cães machos, sem raça definida, com idade em torno de um a um ano e meio, pesando entre 10 e 15 kg foram submetidos a tratamento endodôntico, sendo realizadas perfurações nas furcas com broca de diamante 1016 HL. A cavidade envolveu dentina e cemento, como também periodonto e o osso alveolar. Na porção óssea da obturação, barreira de sulfato de cálcio foi utilizada evitando extravasamento do cimento para o espaço periodontal. Foi realizada a distribuição randomizada dos cimentos MTA (controle), Portland tipo II, Portland tipo V e Portland branco estrutural nas obturações. Os dentes foram restaurados com resina composta. Após 120 dias realizou-se eutanásia, retirada dos dentes, preparação e análise histológica. RESULTADOS: Entre os cimentos não houve diferença estatística significante quanto à neoformação óssea (p=0,879). CONCLUSÃO: Ocorreu biomineralização com os diferentes cimentos usados no estudo, sugerindo que estes são similares em termos de biocompatibilidade.


Subject(s)
Animals , Dogs , Male , Dental Cements/therapeutic use , Furcation Defects/drug therapy , Root Canal Filling Materials/therapeutic use , Root Canal Obturation/methods , Tooth Root/injuries , Aluminum Compounds/therapeutic use , Bicuspid , Bone Regeneration , Biocompatible Materials/chemistry , Biocompatible Materials/therapeutic use , Calcium Compounds/therapeutic use , Calcium Sulfate/chemistry , Calcium Sulfate/therapeutic use , Drug Combinations , Dental Cements/chemistry , Materials Testing , Oxides/therapeutic use , Root Canal Filling Materials/chemistry , Silicates/therapeutic use , Time Factors
15.
Article in English | IMSEAR | ID: sea-144135

ABSTRACT

Furcal perforations are significant iatrogenic complications of endodontic treatment and could lead to endodontic failure. Mineral trioxide aggregate (MTA) has been regarded as an ideal material for perforation repair, retrograde filling, pulp capping, and apexification. This case report describes a furcal perforation in a maxillary first molar, which was repaired using MTA. The tooth was endodontically treated and coronally restored with resin composite. After 2 years, the absence of periradicular radiolucent lesions, pain, and swelling along with functional tooth stability indicated a successful outcome of sealing the perforation using MTA.


Subject(s)
Aluminum Compounds/therapeutic use , Chlorhexidine/therapeutic use , Dental Pulp Capping/methods , Dental Pulp/injuries , Dental Pulp/surgery , Dental Pulp Cavity/injuries , Dental Pulp Cavity/surgery , Dental Pulp Cavity/therapy , Humans , Lidocaine/therapeutic use , Silicates/therapeutic use , Tooth Injuries/etiology , Tooth Injuries/therapy
16.
Article in English | IMSEAR | ID: sea-140046

ABSTRACT

A 24-year-old female patient reported with a mutilated maxillary left central incisor. The coronal tooth structure remaining was very less, discolored, and brittle. She gave history of trauma about 15 years back when the tooth got fractured. An intraoral periapical radiograph revealed an open apex and a large periapical lesion. The case was managed successfully by conservative means using intracanal calcium hydroxide and mineral trioxide aggregate (MTA) apical barrier followed by a fiber post and a core. The final crown restored back esthetics and function. A 6-month follow-up demonstrated a clinically asymptomatic and adequately functional tooth, with radiological signs of healing.


Subject(s)
Aluminum Compounds/therapeutic use , Apexification/methods , Calcium Compounds/therapeutic use , Calcium Hydroxide/therapeutic use , Crowns , Dental Restoration Failure , Dental Restoration, Permanent/methods , Drug Combinations , Female , Follow-Up Studies , Humans , Incisor/injuries , Incisor/pathology , Maxilla , Oxides/therapeutic use , Periapical Diseases/etiology , Periapical Diseases/therapy , Post and Core Technique , Root Canal Filling Materials/therapeutic use , Root Canal Therapy , Silicates/therapeutic use , Tooth Crown/injuries , Tooth Fractures/complications , Tooth Fractures/therapy , Tooth, Nonvital/therapy , Treatment Outcome , Young Adult
17.
Article in English | IMSEAR | ID: sea-140030

ABSTRACT

Aim: To evaluate and compare mineral trioxide aggregate (MTA) and formocresol as pulpotomy medicaments by clinical and radiographic assessments and to assess the histological features of both pulpotomy medicaments in deciduous teeth. Materials and Methods: This study was performed on 100 mandibular deciduous molar teeth requiring pulpotomy treatment. Children between age four and six years were randomly selected and divided into formocresol or MTA group. The patients were recalled after 3, 6, 9, 12 months respectively and evaluated clinically and radiographically. Histological assessment was done on lower deciduous canine teeth, which were undergoing serial extraction for interceptive orthodontic purpose. Pulpotomy was done on four teeth with formocresol and another four teeth with MTA. The teeth were extracted after six months following pulpotomy procedure and histologically evaluated. Two freshly extracted carious teeth were taken as controls. Results: Clinical and radiographic criteria were laid and Chi analysis revealed significant difference in mobility ( P≤0.05), periodontal ligament widening ( P≤0.01 level) and inter - radicular radiolucency ( P≤0.02 level) between two groups at the end of 12 months. Histologically, in MTA group, a layer of new dentine formation with less dentinal tubules at the pulpotomized site was found. In formocresol group, increased inflammatory cells, a zone of atrophy, were noted in radicular portion of pulp. Conclusion: MTA is superior to formocresol clinically, radiographically. Histological analysis showed better reparative ability with hard tissue barrier formation with MTA compared to formocresol.


Subject(s)
Aluminum Compounds/therapeutic use , Calcium Compounds/therapeutic use , Child , Child, Preschool , Dental Pulp Capping/methods , Dentin, Secondary/drug effects , Tooth, Deciduous , Drug Combinations , Female , Follow-Up Studies , Formocresols/therapeutic use , Humans , Male , Mandible , Molar , Oxides/therapeutic use , Pulp Capping and Pulpectomy Agents/therapeutic use , Pulpotomy/methods , Silicates/therapeutic use , Tooth, Deciduous/surgery , Treatment Outcome
18.
Rev. clín. pesq. odontol. (Impr.) ; 6(2): 129-134, maio-ago. 2010. ilus
Article in English | LILACS, BBO | ID: lil-617375

ABSTRACT

OBJECTIVES: To evaluate the effects of a calcium hydroxide-based intracanal dressing on the initialapical adaptation and leakage of fillings performed with mineral trioxide aggregate (MTA) in teeth withopen apices. STUDY DESIGN: A total of 24 canals were manually prepared and randomly divided intotwo groups (n = 12). In the experimental group, root canals were dressed with calcium hydroxide-basedpaste for 21 days; in the control group, no medication was applied prior to the filling of root canalswith mineral trioxide aggregate. Apical sealing was evaluated on the basis of rhodamine B penetrationand the detection of microscopic apical defects at the filling interface (SEM). The data obtained werecompared by means of t- and Fisher’s Exact tests (á = 0.05). RESULT S: The difference in mean dyeleakage between the experimental (5.03±1.97 mm) and control (4.14±1.13 mm) groups was not statisticallysignificant (ñ < 0.05). The number of microscopic fissures at the experimental group interface (2/12)was significantly lower than that observed for the control group (9/12) (ñ < 0.05). CONCLUSIONS:The use of a calcium hydroxide-based intracanal dressing did not interfere with the initial apical sealingof immature teeth filled with MTA.


OBJETIVOS: Avaliar os efeitos da medicação intracanal à base de hidróxido de cálcio sobre a adaptação apical inicial e selamento de obturações realizadas com agregado de trióxido mineral (MTA) em dentes com ápice aberto. PLANEJAMENTO DO ESTUDO: Um total de 24 canais foram manualmente preparados e aleatoriamente divididosem dois grupos (n = 12). No grupo experimental, canais radiculares foram preenchidos com pasta à base de hidróxido de cálcio por 21 dias; no grupo controle, nenhuma medicação foi aplicada antes da obturação dos canais com agregado de trióxido mineral. O selamento apical foi avaliado com base na penetração de rodamina B e na detecção microscópica de defeitos apicais na interface das obturações (MEV). Os dados obtidos foram comparados por intermédio dos testes “t” e Exato de Fisher (α = 0,05). RESULTADOS: A diferença nos níveis médios de infiltraçãoentre os grupos experimental (5.03±1.97 mm) e controle (4.14±1.13 mm) não se mostrou estatisticamente significante (ρ < 0,05). O número de fendas microscópicas na interface das obturações do grupo experimental (2/12) apresentou-se estatisticamente inferior ao detectado para o grupo controle (9/12) (ρ < 0,05). CONCLUSÕES: O uso de medicação intracanal à base de hidróxido de cálcio não interferiu no selamento apical inicial de dentes imaturos obturados com MTA.


Subject(s)
Humans , Calcium Hydroxide/pharmacology , In Vitro Techniques , Root Canal Irrigants/pharmacology , Tooth Apex/drug effects , Aluminum Compounds/therapeutic use , Calcium Compounds/therapeutic use , Dental Leakage/prevention & control , Microscopy, Electron, Scanning , Oxides/therapeutic use , Silicates/therapeutic use
19.
J. appl. oral sci ; 17(6): 596-599, Nov.-Dec. 2009. ilus, tab
Article in English | LILACS | ID: lil-534426

ABSTRACT

OBJECTIVES: CO2, Er:YAG and Nd:YAG lasers have been used in endodontic surgery. This in vitro study evaluated 1 percent Rhodamine B dye penetration using computer-assisted morphometry (ImageTool Software®) of 108 endodontically treated human permanent canines. MATERIAL AND METHODS: Teeth were divided into 9 groups according to the technique used: A: 90-degree apicoectomy with bur, root-end cavity preparation with ultrasound and filled with MTA; B: 90-degree apicoectomy with bur, root-end cavity prepared with ultrasound and filled with MTA, and treatment of apical surface with CO2 laser (1 W, CW/CW); C: 90-degree apicoectomy with bur, and treatment of apical surface with Nd:YAG laser (150 mJ, 10 Hz); D: 90-degree apicoectomy with bur, and treatment of apical surface with CO2 laser,(1 W, CW/CW); E: apicoectomy with Er:YAG laser (400 mJ, 10 Hz), root-end cavity prepared with ultrasound and filled with MTA; F: apicoectomy with Er:YAG laser (400 mJ, 10 Hz) and treatment of apical surface with Nd:YAG laser (150 mJ, 10Hz); G: apicoectomy with CO2 laser (5W, CW/SP), root-end cavity prepared with ultrasound and filled with MTA; H: irradiation of apical end with CO2 laser (1 W, CW/CW); I: irradiation of apical end with Nd:YAG laser (150 mJ, 10 Hz). RESULTS: Dye penetration was found in all specimens at different rates, the lowest penetration occurring in groups C (16.20 percent), B (17.24 percent) and F (17.84 percent). CONCLUSIONS: Groups B, C and F represent the best technical sequences to perform endodontic surgery.


Subject(s)
Humans , Apicoectomy/methods , Laser Therapy/methods , Lasers, Gas/therapeutic use , Lasers, Solid-State/therapeutic use , Tooth Apex/pathology , Aluminum Compounds/therapeutic use , Apicoectomy/instrumentation , Calcium Compounds/therapeutic use , Cuspid/pathology , Cuspid/surgery , Drug Combinations , Dental Leakage/classification , Dentin/pathology , Fluorescent Dyes , Image Processing, Computer-Assisted , Oxides/therapeutic use , Retrograde Obturation/methods , Rhodamines , Root Canal Filling Materials/therapeutic use , Root Canal Preparation/instrumentation , Root Canal Preparation/methods , Silicates/therapeutic use , Ultrasonic Therapy/methods
20.
Int. j. odontostomatol. (Print) ; 2(2): 203-206, dic. 2008. ilus
Article in Spanish | LILACS | ID: lil-531864

ABSTRACT

El estudio corresponde a la presentación de 2 casos clínicos con fractura radicular horizontal (tercio apical, tercio 1⁄2), tratadas con el agregado del trióxido mineral (MTA). En ambos casos las piezas sufrieron la fractura por trauma y el MTA se utilizo sin acción quirúrgica, vale decir, se coloco intraconducto. El objetivo del estudio es conocer la viabilidad de la terapia en estos casos, recordando que es necesario realizar nuevas investigaciones para demostrar la efectividad del material.


The study corresponds to the presentation of two clinical cases with horizontally root fractures (apical third, 1⁄2 third) treated with mineral trioxide aggregate (MTA). In both cases the pieces suffered fracture for trauma and the MTA was used without surgical action, is worth saying, its place in root canal. The intention of the study is to know the viability of the therapy in these cases, remembering that it is necessary to realize new investigations to demonstrate the efficiency of the material.


Subject(s)
Humans , Aluminum Compounds/therapeutic use , Calcium Compounds/therapeutic use , Tooth Fractures/therapy , Oxides/therapeutic use , Silicates/therapeutic use , Drug Combinations , Treatment Outcome
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