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1.
Int. j. morphol ; 38(3): 611-615, June 2020. tab, graf
Article in Spanish | LILACS (Americas) | ID: biblio-1098295

ABSTRACT

El incremento en las cifras de obesidad se debe esencialmente a factores de carácter ambiental asociados al consumo de alimentos con alto contenido de grasas saturadas. El objetivo del trabajo fue evaluar el efecto de una dieta alta en grasas sobre parámetros alimentarios y tejido adiposo blanco visceral. Se utilizaron ratas macho Sprague Dawley (n=10), divididas en dos grupos experimentales, el grupo control recibió dieta convencional (DC) y el grupo experimental una dieta alta en grasas (HFD), durante 10 semanas. Se determinó peso corporal, ingesta alimentaria, conversión alimenticia y características de tejido adiposo. El análisis de datos se realizó utilizando software IBM SPSS versión 21; tras evaluación de la normalidad de los datos, se aplicaron pruebas paramétricas T para muestras independientes y ANOVA de dos vías para medidas repetidas en uno de los factores, con ajuste Bonferroni. Se observó que el promedio de peso fue mayor en los animales alimentados con HFD, sin diferencia estadística respecto a DC, no obstante, existen diferencias significativas en el peso de las ratas alimentadas con HFD en distintos tiempos del protocolo, específicamente semanas 1, 5 y 10 (p<0,001). La ingesta alimentaria fue mayor en los animales alimentados con DC (p<0,005), sin embargo el consumo de energía fue mayor en aquellos alimentados con HFD (p=0,016), lo que derivó en una mayor conversión alimenticia (p<0,005). El promedio de diámetro teórico calculado de los adipocitos es estadísticamente mayor en grupo HFD (p<0,005), lo que se relaciona a la hipertrofia clásica generada tras un período de alimentación con elevado contenido de grasas. Conclusión: El protocolo permite establecer que efectivamente, dado la mayor densidad energética, HFD induce hipertrofia de los adipocitos, proceso característico de la obesidad.


The continued increase in obesity statistics is the result of environmental factors associated with the consumption of foods high in saturated fat. The objective of the work was to evaluate the effect of a high fat diet on food parameters and visceral white adipose tissue. in Male Sprague Dawley rats (n = 10) were used, divided into two experimental groups, the control group received conventional diet (DC) and the experimental group a high fat diet (HFD), for 10 weeks. Body weight, food intake, food conversion and adipose tissue characteristics were determined. Data analysis was performed using IBM SPSS version 21 software; after evaluating the normality of the data, parametric T tests were applied for independent samples and two-way ANOVA for repeated measurements in one of the factors, with Bonferroni adjustment. It was observed that the average weight was higher in animals fed with HFD, without statistical difference with respect to DC, however, there were significant differences in the weight of rats fed with HFD at different times of the protocol, specifically weeks 1.5 and 10 (p <0.001). Food intake was higher in animals fed DC (p <0.005), however the energy consumption was higher in those fed with HFD (p=0.016), which resulted in a higher feed conversion (p <0.005). The average theoretical diameter calculated for adipocytes is statistically higher in the HFD group (p <0.005), which is related to the classical hypertrophy generated after a period of feeding with high fat content. In conclusion, the protocol allows us to establish that, given the higher energy density, HFD induces adipocyte hypertrophy, a characteristic in the obesity process.


Subject(s)
Animals , Male , Rats , Adipose Tissue/drug effects , Diet, High-Fat/adverse effects , Obesity , Body Weight/drug effects , Analysis of Variance , Rats, Sprague-Dawley , Eating
2.
Rev. bras. ciênc. mov ; 28(1): 78-91, maio 8, 2020. ilus, tab
Article in Portuguese | LILACS (Americas) | ID: biblio-1102548

ABSTRACT

O objetivo do presente estudo foi avaliar o efeito da suplementação de arginina (ARG) sobre marcadores indiretos do dano muscular induzido pelo exercício (DMIE). Participaram do estudo 24 jovens universitários do sexo masculino, com experiência mínima de 1 ano em treinamento de força. Os indivíduos foram alocados em 2 grupos, em seguindo delineamento experimental duplo -cego: suplementado com 7g de arginina (ARG, n=12) ou suplementado com 7g de placebo (PLA, n =12 ). O suplemento foi oferecido 30 min antes da realização do protocolo de 10 séries de 10 repetições máximas (RMs) realizadas no supino. Foram aferidas a circunferência torácica, a dor muscular de in ício tardio (DMIT), por meio da escala visual analógica (EVA), e a carga do teste de uma repetição máxima (1 RM) em repouso, 24h, 48h e 72h após a sessão de treinamento (ST). Os resultados foram analisados utilizando teste de análise de variância ANOVA de dois fatores), seguido pelo teste de Bonferroni. A DMIT apresentou maior magnitude no PLA, em todos momentos avaliados após a ST, em comparação ao grupo ARG (p<0,01). Foi observado maior decréscimo da produção de força no grupo PLA, em 72h após a ST , comparado ao grupo ARG (p<0,05). A suplementação aguda de ARG parece ter atenuado a magnitude da DMIT e acelerado a recuperação da força...(AU)


The purpose of this study was to investigate the effect of arginine (ARG) supplementation o nindirect markers of exercise-induced muscle damage (EIMD). Twenty-four male graduate students, with a minimum of one year of experience in resistance training participated in the study . T he subject s were allocated in 2 groups in a double-blind experimental design: supplemented with 7 g o f argin ine (ARG, n=12) or supplemented with 7g of placebo (PLA, n=12). The dietary supplement was co n sum e d at 3 0 minutes prior to a protocol of 10 sets of 10 maximum repetitions performed in the bench press. Measurements of thoracic circumference, delayed onset muscle soreness (DOMS) using visual an alo gue scale (VAS), and one-repetition maximum (1RM) at rest, 24h, 48h and 72h after the training session (TS). The data were analyzed by ANOVA-two way, followed by the Bonferroni test. DOMS presented a reater magnitude for PLA, in all moments evaluated after TS, compared to the ARG group (p<0.01). There was a greater decrease in the strength for PLA, at 72h after TS, compared to ARG (p<0 .05 ). The acute ARG supplementation seems to attenuate the magnitude of DOMS and accelerate recovery of strength...(AU)


Subject(s)
Humans , Male , Arginine , Exercise , Analysis of Variance , Dietary Supplements , Richter Scale , Muscle Strength , Visual Analog Scale , Muscles , Measurements, Methods and Theories
3.
Int. j. morphol ; 38(2): 444-447, abr. 2020. tab, graf
Article in English | LILACS (Americas) | ID: biblio-1056460

ABSTRACT

This study was undertaken to determine the morphometry of the piriform aperture width and height in Turkish population aged between 18-60 years. It was a retrospective study in which 200 subjects were included 106 males and 94 females, ranging from 18 up to 60 years. Subjects having brain CT in the Radiology Department. Statistical analysis were evaluated with SPSS 21.00 programme. ANOVA Test were used to determine the significance between measurements and age group. The p<0.05 value was considered as significant. The groups were divided into four groups according to age. The overall means and standard deviations of the measurements were: piriform aperture height, 45.19±2.91 mm; piriform aperture width, 24.98±2.85 mm; the golden ratio, 1.84±0.19 in males, respectively whereas, the same measurements were 42.84±2.88; 23.46±2.15 mm; 1.83±0.19 in females, respectively. Also there were an increase in piriform aperture width measurement as the age increased. These anatomical values provides more important knowledge to determine the dimensions of these structures in clinic, surgical processes.


El estudio se realizó para determinar la morfometría del ancho y la altura de la abertura piriforme en la población turca de entre 18 y 60 años. Se llevó a cabo un análisis retrospectivo en el que se incluyeron 200 sujetos 106 hombres y 94 mujeres, entre los 18 y 60 años. Sujetos con TC cerebral en el Departamento de Radiología. El análisis estadístico se evaluó con el programa SPSS 21.00. La prueba ANOVA se utilizó para determinar la importancia entre las mediciones y el grupo de edad. El valor p <0,05 se consideró significativo. La muestra se dividió en cuatro grupos según la edad. Las medias generales y las desviaciones estándar de las mediciones fueron: altura de apertura piriforme, 45,19 ± 2,91 mm; ancho de apertura piriforme, 24,98 ± 2,85 mm; la proporción áurea, 1,84 ± 0,19 en varones, mientras que las mismas medidas fueron 42,84 ± 2,88; 23,46 ± 2,15 mm; 1,83 ± 0,19 en mujeres. También hubo un aumento en la medición del ancho de apertura piriforme a medida que la edad aumentó. Estos valores anatómicos proporcionan un conocimiento más importante para determinar las dimensiones de estas estructuras en procesos clínicos y quirúrgicos.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Young Adult , Nasal Cavity/diagnostic imaging , Turkey , Tomography, X-Ray Computed , Retrospective Studies , Analysis of Variance , Nasal Cavity/anatomy & histology
4.
Int. j. morphol ; 38(2): 322-327, abr. 2020. tab, graf
Article in Spanish | LILACS (Americas) | ID: biblio-1056442

ABSTRACT

La estimación de edad compone un aspecto importante en investigaciones forenses. Diferentes métodos se han descrito en odontología forense basadas en la correlación entre la edad y estructuras dentales. Cameriere et al. proponen un método cuantitativo para estimación de edad en adultos, a partir de la evaluación de la relación del área pulpa/diente, en base a la aposición de dentina secundaria. El objetivo del estudio fue desarrollar modelos de regresión para la estimación de edad dental mediante la relación área pulpa/diente en caninos inferiores en una muestra Chilena. Se analizaron 212 radiografías periapicales digitales (RPD) (86 hombres y 126 mujeres) de caninos mandibulares mediante el programa Image J para establecer el área de la pulpa y el diente. Se registraron los datos de sexo y edad de las RPD seleccionadas en forma ciega. Fueron desarrollados modelos de regresión lineal simples para la estimación de edad. El coeficiente de determinación para R33 fue 27,8 % y de 29,6 % para R44, con un error absoluto medio de 11,02 años y 10,37 años respectivamente. El análisis de ANOVA no mostró diferencias estadísticamente significativas para las relaciones área pulpa/diente de caninos según sexo (p> 0,05). Según los resultados obtenidos, la metodología propuesta por Cameriere et al. es fiable para estimar la edad dental mediante la relación área pulpa/diente en adultos. Sin embargo, en los modelos de regresión desarrollados para la población Chilena, se puede afirmar que el ajuste indicado por los coeficientes de determinación muestran incerteza entre las variables área pulpa/diente y edad cronológica en caninos inferiores, por lo tanto se sugiere considerar otros métodos adicionales para estimar edad en esta población.


Age estimation is an important aspect In forensic investigations. Different methods in forensic odontology based on the correlation between age estimation in adults, from the analysis of the pulp/tooth area, based on the apposition of secondary dentine. The aim of the study was to develop regression models for the dental age estimation by the relation pulp/tooth area, in lower canines in a Chilean sample, using digital peri-apical radiographs (DPR) applying Cameriere's method. We analyzed 212 DPR (86 males and 126 females) mandibular canines through Image J program to measure the pulp/tooth area. Age and sex information was obtained of the DPR's blindly selected. We developed simple linear regression models for age estimation. The coefficient of determination to R33 was R2 age and dental structures have been described. Cameriere et al. proposed a quantitative method for 27.8 % and R2 29.6 % to R44, with a mean absolute error of 11.02 years, to R33 and 10.37 years to R44. ANOVA analysis showed no statistically significant differences for the pulp/tooth relation area of canines according to sex (p> 0.05). According to the results, the Cameriere's et al., method is reliable for dental age estimation according to pulp/tooth ratio in adults. However, in the regression models developed for Chilean population, it can be stated that the adjustment indicated by the coefficients of determination, show uncertainty between the pulp / tooth area and chronological age in lower canines, therefore it is suggested to use additional estimation methods for age in this population.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Young Adult , Tooth/anatomy & histology , Age Determination by Teeth/methods , Radiography, Dental, Digital/methods , Dental Pulp/anatomy & histology , Tooth/diagnostic imaging , Logistic Models , Chile , Analysis of Variance , Dental Pulp/diagnostic imaging , Age and Sex Distribution , Forensic Dentistry
5.
Rev. argent. coloproctología ; 31(1): 8-20, mar. 2020. tab
Article in Spanish | LILACS (Americas) | ID: biblio-1102158

ABSTRACT

Introducción: La región perianal es un área muy rica en terminaciones nerviosas sensitivas, hecho que determina que el erotismo anal sea frecuente, independientemente de la identidad y orientación sexuales. Pese a ello, el impacto del sexo anal receptivo (SAR) en la salud anal ha sido poco estudiado. Algunas personas experimentan dolor durante las relaciones sexuales anorreceptivas. Los objetivos del presente trabajo fueron evaluar su prevalencia en una muestra del colectivo de hombres que tienen sexo con hombres (HSH) residentes en la Argentina, e identificar potenciales factores asociados a su aparición.Diseño: Estudio descriptivo, transversal.Población y método: Se diseñó una encuesta que incluyó variables demográficas y factores relacionados con el SAR. Fue respondida de forma voluntaria y anónima por Internet entre marzo de 2015 y febrero de 2016. Se incluyeron HSH mayores de 18 años residentes en la Argentina, que hubieran practicado SAR durante las últimas cuatro semanas. Se realizaron análisis estadísticos bivariados y multivariados en modelos de regresión logística. Resultados: Respondieron la encuesta 208 HSH. Se seleccionaron para el análisis 135 (64,9%) que acreditaron haber mantenido SAR en las últimas cuatro semanas. El 76,3% pertenecía a la Ciudad Autónoma de Buenos Aires y Provincia de Buenos Aires. El 92,6% tenía estudios superiores. El 88,9% manifestó experimentar algún nivel de dolor durante el SAR, siendo grave en el 5,5% de los casos. En el análisis bivariado se identificaron como variables asociadas al desarrollo de dolor: "edad", "edad de inicio de las relaciones sexuales en general", "miedo a sufrir dolor", "fisting" y "miedo al ensuciamiento". En el modelo multivariado surgieron como potenciales factores de riesgo, "edad de salida del placard", "miedo a sufrir dolor" y "uso de poppers". Como posibles factores protectores, "fisting", "edad al momento del estudio" y "edad de inicio de relaciones con otros hombres". Conclusiones: Este estudio se focalizó en la anodispareunia experimentada específicamente por el colectivo homosexual masculino en Argentina. El 88,8% experimentó algún nivel de dolor, siendo grave en el 5,5%. Como en otros estudios, en éste se identificaron posibles factores predisponentes, algunos modificables y otros no. Un mayor conocimiento de los potenciales factores influyentes permitirá un mejor asesoramiento de los profesionales sanitarios a la población afectada sobre prevención del dolor en particular y sobre el erotismo anal en general. (AU)


Introduction: The perianal region is very rich in sensory nerve endings, which determines that anal erotism is frequent, regardless of sexual identity and sexual orientation. Despite this, the impact of receptive anal sex (RAS) on anal health has been little studied. Some people experience pain during anoreceptive sex. The objectives of this study were to evaluate its prevalence in a sample of men who have sex with men (MSM) resident in Argentina and identify potential factors associated with its appearance.Design: Descriptive, transversal study.Population and method: A voluntary and anonymous survey was designed. It included demographic variables and factors related to RAS. It was answered on the Internet between March 2015 and February 2016. MSM over 18 years of age resident in Argentina, who had practiced RAS during the last four weeks, were included. Bivariate and multivariate statistical analyzes were performed in logistic regression models.Results: Two hundred and eight MSM answered the survey. One hundred and thirty-five (64.9%) who had maintained RAS in the last four weeks were selected for the analysis. 76.3% belonged to the Ciudad Autónoma de Buenos Aires and the Buenos Aires Province. 92.6% had higher education. 88.9% reported that they experienced some level of pain during RAS, being severe in 5.5% of cases. In the bivariate analysis were identified as variables associated with the development of pain: "age", "age of onset of sexual relations in general", "fear of suffering pain", "fisting" and "fear of getting dirty". In the multivariate model, the "age of coming out", the "fear of suffering pain" and the "use of poppers" appeared as possible risk factors. As possible protective factors, "fisting", "outing age", "age" and "age when starting relationships with other men". Conclusions: This study focused on the anodyspareunia experienced specifically by the male homosexual group in Argentina. 88.9% experienced some level of pain, being severe in 5.5%. As in other studies, possible predisposing factors have been identified in this one; some modifiable and others not. A greater knowledge of the potential influential factors will allow a better advice of health professionals to the affected population on pain prevention and on anal erotism in general. (AU)


Subject(s)
Humans , Male , Adolescent , Adult , Middle Aged , Aged , Young Adult , Anus Diseases/epidemiology , Pain Measurement/statistics & numerical data , Homosexuality, Male/statistics & numerical data , Dyspareunia/epidemiology , Argentina , Population , Sexual Behavior/statistics & numerical data , Epidemiology, Descriptive , Prevalence , Analysis of Variance
6.
Int. j. morphol ; 38(1): 17-22, Feb. 2020. tab, graf
Article in English | LILACS (Americas) | ID: biblio-1056390

ABSTRACT

Thorough knowledge of splenic artery course and morphology may help clinician to provide better practice. This Study aims at finding out if there was a relationship between splenic artery tortuosity index and age, sex, Body Mass Index (BMI) and abdominal cavity diameters. Routine abdominal Computerized Tomography (CT) scan images were retrospectively analyzed for 219 patients. Splenic artery tortuosity index was calculated. Abdominal cavity diameters were measured. Age, sex, and BMI were recorded. Splenic artery straight length (x) mean was 9.41 cm (SD 1.33). Splenic artery tortuous length mean was 15.15 cm (SD 3.31). Splenic artery tortuosity index mean was 1.63 (SD 0.36). Pearson correlation coefficient for Splenic artery tortuosity index vs. age was: 0.02 (P value 0.80). Splenic artery tortuosity index for females vs. males were 1.70 vs. 1.57 (P value 0.01). Pearson correlation coefficient for Splenic artery tortuosity index vs. BMI was 0.02 (P value 0.75). Pearson correlation coefficient for Splenic artery tortuosity index vs. abdominal cavity diameters were: Anterior-Posterior (AP) diameter -0.01 (P value 0.88) and transverse diameter 0.00 (P value 0.98). There may be a relationship between splenic artery tortuosity and female sex, but not with age, BMI and abdominal cavity diameters (AP and Transverse).


El conocimiento del curso y la morfología de la arteria esplénica puede ayudar al médico a proporcionar un diagnóstico y tratamiento oportuno al paciente. Este estudio tuvo como objetivo determinar si existe una relación entre el índice de tortuosidad de la arteria esplénica y la edad, el sexo, el índice de masa corporal (IMC) y los diámetros de la cavidad abdominal. Se tomaron imágenes retrospectivas, de rutina, de 219 pacientes de tomografía computarizada (TC) abdominal. Se calculó el índice de tortuosidad de la arteria esplénica. Se midieron los diámetros de la cavidad abdominal y se registró la edad, sexo y el IMC. La media de la longitud recta de la arteria esplénica (x) fue de 9,41 cm (DE 1,33). La longitud tortuosa de la arteria esplénica fue de 15,15 cm (DE 3,31). La media del índice de tortuosidad de la arteria esplénica fue de 1,63 (DE 0,36). El coeficiente de correlación de Pearson para el índice de tortuosidad de la arteria esplénica vs. edad fue: 0,02 (valor de P 0,80). El índice de tortuosidad de la arteria esplénica para las mujeres frente a los hombres fue de 1,70 frente a 1,57 (valor de P 0,01). El coeficiente de correlación de Pearson para el índice de tortuosidad de la arteria esplénica versus el IMC fue de 0,02 (valor de P 0,75). El coeficiente de correlación de Pearson para el índice de tortuosidad de la arteria esplénica frente a los diámetros de la cavidad abdominal fue: diámetro anterior-posterior (AP) -0,01 (valor P 0,88) y diámetro transversal 0,00 (valor P 0,98). Puede existir una relación entre la tortuosidad de la arteria esplénica y el sexo femenino, sin embargo no se encontró relación con la edad, el IMC y los diámetros de la cavidad abdominal (AP y transversal).


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Splenic Artery/anatomy & histology , Tomography, X-Ray Computed , Abdomen/diagnostic imaging , Splenic Artery/abnormalities , Splenic Artery/diagnostic imaging , Body Mass Index , Sex Factors , Analysis of Variance , Age Factors , Correlation of Data , Abdomen/anatomy & histology
7.
Int. j. morphol ; 38(1): 153-158, Feb. 2020. tab, graf
Article in English | LILACS (Americas) | ID: biblio-1056414

ABSTRACT

The aim of this research was to determine the differences among the football players of three the most successful football clubs in Kosovo, FC Trepca ´89, FC Prishtina and FC Besa Peje in a terms of morphological characteristics and body composition. A sample of 53 subjects was divided into three sub-samples. Fifteen (15) players of FC Trepca ´89 of the average age 21.80±3.57, the champions of Kosovo, twenty (20) players of FC Prishtina of the average age of 24.30±4.99, the vice champions of the Kosovo Championship, and eighteen (18) players of FC Besa Peje of the average age 21.83±3.17, the champions of the Cup of Kosovo. Football players were tested immediately after the end of the competition season. Morphological characteristics in the body composition were evaluated by a battery of 10 variables: body height, body weight, waist circumference, triceps skinfold, biceps skinfold, skinfold of the back, abdominal skinfold, body mass index, fat percentage and muscle mass. The significance of the differences between the players of the three the most successful football clubs in the morphological characteristics and variables for assessing body composition were determined by ANOVA and LSD post hoc test. ANOVA test found that the football players of the three mentioned clubs have statistically significant differences in one variable that estimate the waist circumference. The LSD Post Hoc test showed that football players of FC Besa Peje had significantly less value of waist circumference compared to the football players of FC Prishtina and FC Trepca ´89. The values of the waist circumference of all football players show that they belong to professional trained players, although their differences in this variable are statistically significant.


El objetivo de esta investigación fue determinar las diferencias entre los jugadores de fútbol de los tres clubes de mayor éxito en Kosovo, FC Trepca ´89, FC Prishtina y FC Besa Peje, en términos de características morfológicas y composición corporal. En el estudio se dividieron los 53 sujetos en tres grupos, quince (15) jugadores del FC Trepca ´89 con una edad promedio de 21,80 ± 3,57, los campeones de Kosovo, veinte (20) jugadores del FC Prishtina con una edad promedio de 24,30 ± 4,99, los vicecampeones del Campeonato de Kosovo, y dieciocho (18) jugadores del FC Besa Peje con una edad promedio de 21,83 ± 3,17, los campeones de la Copa de Kosovo. Los jugadores de fútbol fueron evaluados inmediatamente después del final de la temporada de competencias. Las características morfológicas en la composición corporal se evaluaron mediante una batería de 10 variables: altura corporal, peso corporal, circunferencia de la cintura, pliegue de tríceps, pliegue de bíceps, pliegue de la espalda, pliegue abdominal, índice de masa corporal, porcentaje de grasa y masa muscular. El ANOVA y el LSD post hoc determinaron la importancia de las diferencias entre los jugadores de los tres clubes de fútbol más exitosos en las características morfológicas y las variables para evaluar la composición corporal. La prueba de ANOVA encontró que los jugadores de fútbol de los tres clubes mencionados tienen diferencias estadísticamente significativas en una variable que estima la circunferencia de la cintura. La prueba LSD post hoc indicó que los jugadores de fútbol del FC Besa Peje tenían un valor significativamente menor de la circunferencia de la cintura en comparación con los jugadores de fútbol del FC Prishtina y el FC Trepca ´89. Los valores de circunferencia de la cintura de todos los jugadores de fútbol muestran que pertenecen a jugadores entrenados profesionalmente; las diferencias en esta variable son estadísticamente significativas.


Subject(s)
Humans , Male , Adolescent , Adult , Young Adult , Soccer , Body Composition , Analysis of Variance , Kosovo
8.
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 42(1): 54-62, Jan.-Feb. 2020. tab, graf
Article in English | LILACS (Americas) | ID: biblio-1055351

ABSTRACT

Objective: Although studies have shown an association between poor sleep and chronotype with psychiatric problems in young adults, few have focused on identifying multiple concomitant risk factors. Methods: We assessed depressive symptoms (Beck Depression Inventory [BDI]), circadian typology (Morningness-Eveningness Questionnaire [MEQ]), sleep quality (Pittsburgh Sleep Quality Index [PSQI]), perceived stress (Perceived Stress Scale [PSS]), social rhythm (Social Rhythm Metrics [SRM]), and salivary cortisol (morning, evening and night, n=37) in 236 men (all 18 years old). Separate analyses were conducted to understand how each PSQI domain was associated with depressive symptoms. Results: Depressive symptoms were more prevalent in individuals with higher perceived stress (prevalence ratio [PR] = 6.429, p < 0.001), evening types (PR = 2.58, p < 0.001) and poor sleepers (PR = 1.808, p = 0.046). Multivariate modeling showed that these three variables were independently associated with depressive symptoms (all p < 0.05). The PSQI items subjective sleep quality and sleep disturbances were significantly more prevalent in individuals with depressive symptoms (PR = 2.210, p = 0.009 and PR = 2.198, p = 0.008). Lower levels of morning cortisol were significantly associated with higher depressive scores (r = -0.335; p = 0.043). Conclusion: It is important to evaluate multiple factors related to sleep and chronotype in youth depression studies, since this can provide important tools for comprehending and managing mental health problems.


Subject(s)
Humans , Male , Adolescent , Sleep Wake Disorders/psychology , Stress, Psychological/psychology , Hydrocortisone/analysis , Chronobiology Disorders/psychology , Depression/etiology , Military Personnel/psychology , Psychiatric Status Rating Scales , Reference Values , Saliva/metabolism , Sleep/physiology , Time Factors , Multivariate Analysis , Risk Factors , Analysis of Variance , Statistics, Nonparametric , Depression/metabolism , Self Report
9.
Arch. argent. pediatr ; 118(1): 18-24, 2020-02-00. tab, graf
Article in English, Spanish | LILACS (Americas), BINACIS | ID: biblio-1095334

ABSTRACT

Introducción. El cortisol salival es una herramienta útil como biomarcador de estrés en pediatría, ya que la obtención de muestras no es invasiva. Hay escasa información sobre su uso en niños, y no se reportaron valores de referencia en lactantes sanos en la Argentina. Es importante establecerlos en cada centro como base para realizar estudios posteriores en lactantes, en quienes parece ser la herramienta objetiva más relevante en la actualidad para evaluar estrés. Objetivo. Determinar los valores de referencia de cortisol salival en lactantes sanos de 0 a 12 meses de edad. Métodos. Estudio descriptivo, de corte transversal, que evaluó cortisol salival matutino de niños sanos de ambos sexos de 0 a 12 meses que concurrieron a control de salud en el Hospital Pirovano entre marzo de 2017 y marzo de 2018. Se tomaron muestras de saliva de 8 a 9 a. m. en ayunas y se procesaron con electroquimioluminiscencia. Los resultados se informaron como media y desvío estándar. Resultados. Se incluyeron 140 niños, y se obtuvieron 96 muestras. La media de cortisol salival matutino fue 5,46 nmol/l (intervalo de confianza del 95 %: 4,66-6,38), desvío estándar 2,15. No se observó correlación con la variable edad, por lo cual el intervalo de referencia no requirió el fraccionamiento por grupo etario. No se observaron diferencias significativas respecto a sexo, edad gestacional, peso al nacer, tipo de parto o tipo de alimentación. Conclusión. Se informó el intervalo de referencia de cortisol salival matutino en lactantes sanos de 0 a 12 meses.


Introduction. Salivary cortisol is a useful tool as a biomarker of stress in pediatrics because it allows for non-invasive sampling. There is little information about its use in children, and no reference values for healthy infants have been reported in Argentina. Reference values should be established at each site as the basis for subsequent tests in infants, for whom salivary cortisol appears to be the most relevant objective tool to assess stress at present. Objective. To determine reference values for salivary cortisol in healthy infants aged 0-12 months. Methods. Descriptive, cross-sectional study that assessed morning salivary cortisol levels in healthy male and female infants aged 0-12 months that attended Hospital Pirovano for a health checkup between March 2017 and March 2018. Fasting saliva samples were collected between 8 and 9 a.m. and were processed using electrochemiluminescence. Results were reported as mean and standard deviation. Results. A total of 140 infants were included, and 96 samples were collected. Mean morning salivary cortisol levels were 5.46 nmol/L (95 % confidence interval: 4.66-6.38), standard deviation: 2.15. No correlation to age was observed, so it was not necessary to divide the reference range into age groups. No significant differences were observed in terms of sex, gestational age, birth weight, type of delivery or type of feeding. Conclusion. The reference range of morning salivary cortisol levels in healthy infants aged 0-12 months was reported.


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Saliva/chemistry , Stress, Psychological/metabolism , Hydrocortisone/metabolism , Reference Values , Hydrocortisone/analysis , Epidemiology, Descriptive , Cross-Sectional Studies , Analysis of Variance , Luminescent Measurements
10.
Braz. dent. sci ; 23(1): 1-7, 2020. tab
Article in English | LILACS (Americas), BBO | ID: biblio-1049603

ABSTRACT

Objective: Evaluate the microtensile bond strength (µTBS) in different dentin thicknesses, under simulated pulpal pressure (SPP), submitted to an adhesive technique using laser irradiation. Material and methods: Forty sound human molars were sectioned and randomly divided into two groups (n=20): Group 1 ­ 1 mm of dentin thickness; Group 2 ­ 2 mm of dentin thickness. Each group was divided into two subgroups (n=10): Subgroup A ­ Absence of SPP; Subgroup P ­ Presence of SPP (15 cm H2 O). The samples were sequentially treated with: 37% phosphoric acid, adhesive system (Adper Single Bond 2), Nd:YAG laser irradiation (60 s, 1064 nm, 10 Hz) using 60 and 100 mJ/pulse energy parameters and photopolymerization (10 s). A composite resin block (Filtek Z350) was built up onto the irradiated area. After 30 days stored in water, the samples were sectioned and submitted to microtensile test (10 kgf load cell, 0.5mm/min). Data were analyzed by twoway ANOVA and Tukey tests. Results: Two-way ANOVA revealed no significant differences for SPP on bond strength. The laser energy parameters indicated that 100 mJ showed greater µTBS means compared to the group irradiated with 60 mJ. The presence of SPP reduced the mean µTBS values. Conclusions: Simulated pulpal pressure did not affect the µTBS using 60 mJ of laser energy parameter. At 100 mJ, the presence of SPP negatively influenced the bond strength, regardless of dentin thickness (AU)


Objetivo: O objetivo deste estudo foi avaliar a resistência adesiva (RA) em diferentes espessuras de dentina, associada à pressão pulpar simulada (PPS), quando submetidos à técnica adesiva por irradiação laser. Material e Métodos: Quarenta molares humanos hígidos foram seccionados e divididos aleatoriamente em dois grupos (n=20): Grupo 1 ­ 1 mm de espessura de dentina; Grupo 2 ­ 2 mm de espessura de dentina. As amostras foram divididas em 2 subgrupos (n=10): Subgrupo A ­ ausência de PPS; Subgrupo P ­ presença de PPS (15 cm de H2 O). As amostras foram tratadas seqüencialmente com: ácido fosfórico 37%, sistema adesivo (Adper Single Bond 2), irradiação com Nd:YAG laser (60 s, 1064 nm, 10 Hz) nos parâmetros de energia de 60 e 100 mJ/pulso e fotopolimerização (10 s). Um bloco de resina composta (Filtek Z350, 3M ESPE) foi confeccionado sobre a área irradiada. Após 30 dias armazenados em água, os espécimes foram seccionados e submetidos ao teste de microtração (carga de 10 kgf, 0.5mm/min). Os dados foram analisados pelos testes ANOVA sob 2 fatores e Tukey (p<0.05). Resultados: ANOVA mostrou que não houve diferenças significativas para PPS na RA. Para os parâmetros de energia do laser, 100 mJ apresentou maiores médias de RA quando comparado ao grupo irradiado à 60 mJ. A presença da PPS reduziu as médias de RA. Conclusão: Pressão pulpar simulada não afetou os valores de resistência adesiva para o grupo irradiado com 60 mJ. Para 100 mJ, a presença da pressão pulpar influenciou negativamente na resistência adesiva, independente das espessuras de dentina.(AU)


Subject(s)
Humans , Dental Cements , Dental Pulp , Dentin , Lasers, Solid-State , Hydrostatic Pressure , Random Allocation , Analysis of Variance , Composite Resins , Dentin/radiation effects , Molar
11.
Int. j. morphol ; 37(4): 1286-1293, Dec. 2019. tab, graf
Article in English | LILACS (Americas) | ID: biblio-1040126

ABSTRACT

Profile and standards for the diagnostics of percent of body fat and muscles were defined on a sample of 1924 women from the Republic of Serbia, aged 18.0 to 69.9, where the body structure of subjects was measured by applying multichannel segmental bioimpedance. Total sample was divided into six age groups, for the purpose of the definition of standard with regards to age. When it comes to body fat percentage results have shown that the average value of the total sample was 28.51±9.26 %, and between the range of 23.81 and 39.94 % for age groups 18.0-19.9 yr and 60.0-69.9 yr, respectively. Regression analysis results have shown that the constant of body fat percentage increase by trend of 3.417 % per decade, and that 25.1 % of mutual variance trend was explained by the model, with prediction error of 4.55 %. With regards to the percentage of skeletal muscles in the body, the results have shown that the average value of the total sample was 39.30±5.25 %, and within the range of 42.25 to 32.58 % for age groups 18.0-19.9 yr and 60.0-69.9 yr, respectively. Regression analysis results have shown that the constant of the skeletal muscles decrease by tend of -2.016 % per decade and that the model explained 23.8 % of mutual variance trend with prediction error of 8.08 %.


El perfil y estándares para el diagnóstico del porcentaje de grasa corporal y masa muscular fueron definidos en una muestra de 1924 mujeres de la República de Serbia, con edades comprendidas entre 18,0 y 69,9 años, donde la composición corporal de los sujetos fue medida por bioimpedancia segmentaria multicanal. La muestra fue dividida en seis grupos, con el propósito de definir los estándares respecto a la edad. Respecto al porcentaje de grasa corporal los resultados han mostrado que el valor promedio de la muestra fue de 28,51±9,26 %, y entre los rangos de 23,81 y 39,94 para los grupos de edad de 18,0-19,9 años y 60,069,9 años, respectivamente. Los resultados del análisis de regresión mostraron que la constante del porcentaje de grasa corporal aumentó 3,417 % por década, y que un 25,1 % de la varianza fue explicada por el modelo, con un error de predicción de 4,55 %. Con respecto al porcentaje de masa muscular, los resultados han mostrado que el valor promedio de la muestra fue de 39,30±5,25 %, y entre los rangos de 42,24 y 32,58 para los grupos de edad de 18,0-19,9 años y 60,0-69,9 años, respectivamente. Los resultados del análisis de regresión han mostrado que la constante de masa muscular decreció -2,016 % por década y que el modelo explicó 23,8 % de la varianza con un error de predicción de 8,08 %.


Subject(s)
Humans , Female , Adolescent , Adult , Middle Aged , Aged , Young Adult , Body Composition , Adipose Tissue/anatomy & histology , Muscle, Skeletal/anatomy & histology , Reference Values , Cross-Sectional Studies , Surveys and Questionnaires , Regression Analysis , Analysis of Variance , Electric Impedance , Age Distribution , Serbia
12.
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 41(6): 479-484, Nov.-Dec. 2019. tab, graf
Article in English | LILACS (Americas) | ID: biblio-1055343

ABSTRACT

Objective: The relationship between biomarkers of amyloid-beta aggregation (Aβ1-42) and/or neurodegeneration (Tau protein) in cerebrospinal fluid (CSF) and cognitive decline is still unclear. We aimed to ascertain whether CSF biomarkers correlate with cognitive performance in healthy and cognitively impaired subjects, starting from clinical diagnoses. Methods: We tested for correlation between CSF biomarkers and Mini-Mental State Examination (MMSE) scores in 208 subjects: 54 healthy controls, 82 with mild cognitive impairment (MCI), 46 with Alzheimer's disease (AD), and 26 with other dementias (OD). Results: MMSE correlated weakly with all CSF biomarkers in the overall sample (r = 0.242, p < 0.0006). Aβ1-42 and MMSE correlated weakly in MCI (r = 0.247, p = 0.030), and moderately in OD (r = 0.440, p = 0.027). t-Tau showed a weak inverse correlation with MMSE in controls (r = -0.284, p = 0.043) and MCI (r = -0.241, p = 0.036), and a moderate/strong correlation in OD (r = 0.665), p = 0.0003). p-Tau correlated weakly with MMSE in AD (r = -0.343, p = 0.026) and moderately in OD (r = -0.540, p = 0.0005). The Aβ1-42/p-Tau ratio had a moderate/strong correlation with MMSE in OD (r = 0.597, p = 0.001). Conclusion: CSF biomarkers correlated best with cognitive performance in OD. t-Tau correlated weakly with cognition in controls and patients with MCI. In AD, only p-Tau levels correlated with cognitive performance. This pattern, which has been reported previously, seems to indicate that CSF biomarkers might not be reliable as indicators of disease severity.


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Peptide Fragments/cerebrospinal fluid , Amyloid beta-Peptides/cerebrospinal fluid , tau Proteins/cerebrospinal fluid , Alzheimer Disease/cerebrospinal fluid , Cognitive Dysfunction/cerebrospinal fluid , Reference Values , Biomarkers/cerebrospinal fluid , Case-Control Studies , Analysis of Variance , Cohort Studies , Statistics, Nonparametric , Alzheimer Disease/psychology , Mental Status and Dementia Tests , Middle Aged
13.
An. bras. dermatol ; 94(6): 704-709, Nov.-Dec. 2019. tab
Article in English | LILACS (Americas) | ID: biblio-1054884

ABSTRACT

Abstract Background: Rosacea may result in emotional distress and anxiety. However, data on the presence of generalized anxiety disorder in rosacea patients are scarce. Objective: The aim of the study was to detect the frequency and level of anxiety and depression in patients with rosacea. Methods: A total of 194 consecutive rosacea patients and 194 age- and sex-matched controls were enrolled. Severity of rosacea was assessed in patients according to the criteria of the National Rosacea Society Ethics Committee. Both patients and controls were evaluated by the Generalized Anxiety Disorder 7-item scale, and severity was measured by the Generalized Anxiety Disorder-Adult. Results: Individuals who were diagnosed with an anxiety and/or depressive disorder were more common in patient group (24.7% vs. 7.2%, p < 0,01). Female patients were particularly at risk for having generalized anxiety disorder (OR = 2.8; 95% CI 1.15-7.37; p = 0.02). Study limitations: Single center study and limited sample size. Conclusions: Rosacea patients show greater risk of having anxiety disorders, including generalized anxiety disorder. Female patients, those with lower educational levels, those with phymatous subtype, untreated patients, and patients with prior psychiatric morbidity may be at particular risk for anxiety. It is essential to consider the psychological characteristics of patients to improve their well-being.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Anxiety Disorders/etiology , Anxiety Disorders/epidemiology , Rosacea/complications , Rosacea/epidemiology , Depressive Disorder/etiology , Depressive Disorder/epidemiology , Psychiatric Status Rating Scales , Quality of Life , Case-Control Studies , Logistic Models , Prevalence , Cross-Sectional Studies , Analysis of Variance , Educational Status
14.
Prensa méd. argent ; 105(10): 710-719, oct 2019. tab
Article in English | LILACS (Americas), BINACIS | ID: biblio-1026043

ABSTRACT

This study aimed to investigate the effectiveness of group life sills training on the life expectancy and psychological well-being of female students under the auspices of Shahid Chamran University of Ahvaz. The population of the present study consisted of all female students under the auspices of Shahid Chamran University of Ahvaz in 2016-17. The sample included 50 students who obtained the lowest scores in the Snyder's Life Expectancy Scale and Ryff's Psychological Well-being Scale. They were randomly assigned to experimental group and control group. This semi-experimental design consisted of a pre-test, post-test and follow-up. Firstly, both groups responded to the research tools, and then the experimental group received 13 sessions life skills training, each session 90 minutes (one session per week), while the control group did not receive any intervention. Once the intervention was over, both groups responded to the research tools and the follow-up test was performed one month after the post-test on both groups. The findings were analyzed using MANCOVA. The results showed that life skills training increased life expectancy and psychological well-being in experimental group compared to control group. According to the results, life skills training could be used to increase the life expectancy and psychological well-being of girls


Subject(s)
Humans , Female , Social Welfare/psychology , Effectiveness , Control Groups , Epidemiology, Experimental , Multivariate Analysis , Analysis of Variance , Follow-Up Studies , Life Expectancy/trends , Mentoring
15.
Prensa méd. argent ; 105(10): 736-744, oct 2019. tab
Article in English | LILACS (Americas), BINACIS | ID: biblio-1026066

ABSTRACT

Background and objective: Occupational exposure makes healthcare provider at risk of a variety of infections such as AIDS, Hepatitis B, and Hepatitis C. This study investigated the effect of educational intervention on standardized precautionary behaviors in healthcare provider based on health belief model, in Jam city, Iran during 2016. Methods: This experimental study was carried out on Tohid hospital staff and health care provider of Jam`s health center. Random stratified sampling based on different occupation designated into two groups, intervention (n=50) and control (n=50). After confirming the validity and reliability of the data collection tool, the educational intervention was examined before and after the intervention. Data were analyzed using descriptive statistical methods, independent t-test and one-way ANOVA (SPSS 20). Results: The results revealed that the healthcare provider did not have any previous educational background on standardized precautionary (34.3%). Furthermore, the history of needle stick injuries (42.5%) and contact with patients' body fluids (17.5%) were reported. Educational intervention regarding to standardized precautions in the intervention group was significantly increased the mean score of knowledge constructs, perceived sensitivity, perceived severity, perceived benefits, perceived barriers and behaviors. However, no significant changes were observed in increasing the self-efficacy the score. Conclusion: The results indicate the effectiveness of educational intervention on standard precautionsamong healthcare provider based on health belief model. Educational program based on promotion behavioral pattern in relation to standard precautionsis recommended to the healthcare provider


Subject(s)
Humans , Male , Female , Effectiveness , Stratified Sampling , Epidemiology, Experimental , Data Collection/classification , Analysis of Variance , Health Personnel , Models, Educational , Communication , Precaution
16.
Int. j. cardiovasc. sci. (Impr.) ; 32(5): 483-489, Sept-Oct. 2019. tab, graf
Article in English | LILACS (Americas) | ID: biblio-1040100

ABSTRACT

Neuromuscular electrical stimulation seems to be a promising option to intensify the rehabilitation and improve the exercise capacity of patients in the immediate postoperative period of cardiac surgery. Objective: This study aimed to evaluate the hemodynamic (heart rate, systolic blood pressure, diastolic blood pressure, and mean blood pressure) and respiratory (respiratory rate and oxygen saturation) responses to neuromuscular electrical stimulation in the immediate postoperative period in patients submitted to cardiac surgery and to verify its feasibility and safety. Methods: This is a pilot randomized controlled trial, wherein critical patients in the immediate postoperative period of cardiac surgery were randomly assigned to a control group, using sham neuromuscular electrical stimulation, or an experimental group, submitted to neuromuscular electrical stimulation sessions (FES), for 60 min, with a 50-Hz frequency, 200-µs pulse duration, time on: 3 s, and time off: 9 s. Data distribution was evaluated by the Shapiro-Wilk test. The analysis of variance was used and a p-value < 0.05 was considered significant. Results: Thirty patients were included in the study. The neuromuscular electrical stimulation was applied within the first 23.13 ± 5.24 h after cardiac surgery, and no changes were found regarding the hemodynamic and respiratory variables between the patients who underwent neuromuscular electrical stimulation, and those in the control group. Conclusions: In the present study, neuromuscular electrical stimulation did not promote changes in hemodynamic and respiratory responses of patients in the immediate postoperative period of cardiac surgery


Subject(s)
Humans , Male , Female , Postoperative Period , Thoracic Surgery , Electric Stimulation Therapy/methods , Cardiac Rehabilitation , Blood Pressure , Exercise , Oxygen Level/methods , Diagnosis of Health Situation , Statistical Analysis , Analysis of Variance , Randomized Controlled Trial , Outcome Assessment, Health Care/methods , Arterial Pressure , Heart Rate
18.
Neumol. pediátr. (En línea) ; 14(3): 122-125, sept. 2019. tab
Article in Spanish | LILACS (Americas) | ID: biblio-1087519

ABSTRACT

When formulating a quantitative research question, implicitly the terms or variables included in it are being considered. The definition of the variables is necessary for the people who review or read the research to understand what the researcher is referring to when he/she mentions them, to make sure that they can be observed or measured, to be able to compare with similar investigations, and to analyze and adequately communicate the results. This article aims to highlight the importance of defining the variables in the process of an investigation.


Al formular una pregunta de investigación cuantitativa, de manera implícita se están planteando los términos o variables incluidas en ésta. La definición de las variables es necesaria para que las personas que revisen o lean la investigación entiendan a que se está refiriendo el investigador cuando las menciona, para asegurarse de que éstas puedan ser observadas o medidas, para poder comparar con investigaciones similares, y para analizar y comunicar adecuadamente los resultados. Este artículo tiene por objetivo destacar la importancia de la definición de las variables en el proceso de una investigación.


Subject(s)
Epidemiologic Factors , Analysis of Variance , Biomedical Research , Scientific and Technical Publications
19.
Estud. psicol. (Natal) ; 24(3): 258-268, Jul.-Sept. 2019. tab
Article in Portuguese | LILACS (Americas), INDEXPSI | ID: biblio-1098238

ABSTRACT

O presente artigo pretendeu conhecer os níveis de stresse e engagement laboral que os assistentes sociais, em Portugal, estavam expostos. Para tal, aplicou-se um inquérito por questionário, composto pela Perceived Stress Scale e a Utrecht Work Engagement Scale, a 1369 profissionais. Os resultados identificaram um nível mediano de stresse e engagement, o que pode ser indicativo de níveis de bem-estar laboral satisfatórios. Observou-se, ainda, que à medida que o stresse percecionado aumentava, diminuía o engagement destes profissionais. Foram, também, encontradas conexões significativas entre estas variáveis e o vencimento auferido.


This article intended to know stress and engagement work levels that social workers in Portugal were exposed to. A survey was answered by 1369 professionals. Perceived Stress Scale and Utrecht Work Engagement Scale were used in the construction of the questionnaire. The results point to a median level of work stress and engagement, which may be a sign of satisfactory levels of well-being. We also found that as perceived stress increases the engagement of these professionals decrease. Significant connections between these variables and the earned salary emerged.


El presente artículo pretendió conocer los niveles de estrés y engagement que los trabajadores sociales em Portugal fueran expuestos. Para ello, se aplicó una encuesta por cuestionario, compuesto por la Perceived Stress Scale y la Utrecht Work Engagement Scale, a 1369 profesionales. Los resultados identificaron un nivel mediano de estrés y engagement, lo que puede ser indicativo de niveles de bienestar laboral satisfactorios. Se observo, además, que a medida que el estrés percibido aumentaba, disminuía el engagement de estos profesionales. También se encontraron conexiones significativas entre estas variables y el vencimiento obtenido.


Subject(s)
Humans , Male , Female , Adult , Aged , Portugal , Work , Social Workers , Occupational Stress , Work Engagement , Quality of Life , Surveys and Questionnaires , Analysis of Variance
20.
J. pediatr. (Rio J.) ; 95(5): 567-574, Sept.-Oct. 2019. tab
Article in English | LILACS (Americas) | ID: biblio-1040356

ABSTRACT

Abstract Objective: The objective of this study was to evaluate the effects of two low-dose combined oral contraceptives on bone metabolism in adolescents for one year. Methods: This was a quasi-experimental study. The adolescents were divided into three groups: oral contraceptives 1 (n = 42) (20 µg EE/150 µg desogestrel), oral contraceptives 2 (n = 66) (30 µg EE/3 mg drospirenone), and a control group (n = 70). Adolescents underwent anthropometric assessment and densitometry (dual-energy X-ray). Bone age and bone formation markers (osteocalcin and bone alkaline phosphatase) were evaluated. The oral contraceptives users were evaluated again after 12 months. Linear regression analysis was used to indirectly study the effect of each additional year of chronological age on anthropometric and densitometric variables as well as on bone markers in the control group. Results: At study entry, no significant differences were observed between the oral contraceptives 1, oral contraceptives 2, and controls in the analyzed variables. Linear regression analysis showed an increase in bone mineral density and bone mineral content for each additional year. There was a significant reduction in bone alkaline phosphatase levels; no significant difference was observed for osteocalcin in control individuals. Comparison of dual-energy X-ray variables at baseline and after one year showed no significant differences in the oral contraceptives 1 or oral contraceptives 2 groups. A significant reduction in bone alkaline phosphatase and osteocalcin levels was observed in both the oral contraceptives 1 and oral contraceptives 2 groups. Conclusion: Adolescent women gain peak bone mass during this phase of life. Two low-dose combined oral hormonal contraceptives were associated with lower bone gain and lower bone formation markers than in untreated controls.


Resumo: Objetivo: O objetivo deste estudo foi avaliar os efeitos de dois contraceptivos orais combinados de baixa dosagem por um ano sobre o metabolismo ósseo em adolescentes. Métodos: Este foi um estudo quase experimental. As adolescentes foram divididas em três grupos: contraceptivos orais 1 (n = 42) (20 µg de EE/150 µg de desogestrel), contraceptivos orais 2 (n = 66) (30 µg EE/3 mg de drospirenona) e grupo controle (n = 70). As adolescentes foram submetidas à avaliação antropométrica e densitometria (raio-X de dupla energia). Foram avaliados a idade óssea e os marcadores de formação óssea (osteocalcina e fosfatase alcalina óssea). As usuárias de contraceptivos orais foram novamente avaliadas após 12 meses. A análise de regressão linear foi utilizada para estudar, indiretamente, o efeito de cada ano adicional da idade cronológica sobre as variáveis antropométricas e densitométricas e sobre os marcadores ósseos no grupo de controle. Resultados: No início do estudo, não foram observadas diferenças significativas nas variáveis analisadas entre as usuárias de contraceptivos orais 1, contraceptivos orais 2 e o grupo controle. A análise de regressão linear mostrou um aumento na densidade mineral óssea e no conteúdo mineral ósseo para cada ano adicional. Houve uma redução significativa nos níveis de fosfatase alcalina óssea e não foi observada diferença significativa para osteocalcina nos indivíduos controles. A comparação das variáveis do raio-X de dupla energia no início e após um ano não mostrou diferença significativa no grupo de contraceptivos orais 1 ou contraceptivos orais 2. Foi observada uma redução significativa nos níveis de fosfatase alcalina óssea e osteocalcina nos dois grupos contraceptivos orais 1 e contraceptivos orais 2. Conclusão: As adolescentes atingiram o pico de massa óssea durante essa fase da vida. Duas formulações de contraceptivos hormonais orais de baixa dosagem, após um ano de uso, se associaram a menor incremento na densidade mineral óssea e menor concentração de marcadores de formação óssea quando confrontados com resultados de adolescentes não usuárias de contraceptivos.


Subject(s)
Humans , Female , Child , Adolescent , Young Adult , Osteogenesis/drug effects , Bone Density/drug effects , Desogestrel/administration & dosage , Contraceptives, Oral, Hormonal/administration & dosage , Ethinyl Estradiol/administration & dosage , Androstenes/administration & dosage , Osteogenesis/physiology , Reference Values , Time Factors , Bone Density/physiology , Linear Models , Osteocalcin/analysis , Anthropometry , Analysis of Variance , Statistics, Nonparametric , Alkaline Phosphatase/analysis , Non-Randomized Controlled Trials as Topic
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