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Autops. Case Rep ; 11: e2021308, 2021. tab, graf
Article in English | LILACS | ID: biblio-1285420


Angiomyolipoma with epithelial cysts (AMLEC) is a recently described entity and is an uncommon subtype of kidney angiomyolipomas. AMLEC is a benign entity but usually masquerades a renal cell carcinoma on imaging examination. AMLEC has a distinct histological and immunohistochemical staining pattern, which helps in the pathological diagnosis. We present a rare case of AMLEC in a 26-year-old female, which was provisionally diagnosed as renal cell carcinoma on radiology. We also summarize the differential diagnosis of this rare variant, its characteristic features, and a review of the literature.

Humans , Female , Adult , Carcinoma, Renal Cell/diagnosis , Angiomyolipoma/pathology , Kidney Neoplasms/diagnosis , Diagnosis, Differential , Nephrectomy
Autops. Case Rep ; 10(3): e2020173, 2020. graf
Article in English | LILACS | ID: biblio-1131839


Angiomyolipoma is a benign mesenchymal neoplasm of the renal parenchyma, accounting for 1% of all renal parenchymal tumors. However, this entity may rarely occur in extrarenal sites. Extrarenal angiomyolipoma has been documented in various sites of the body, but angiomyolipoma of the broad ligament was reported in only two cases. We report the reputed third case of angiomyolipoma of the broad ligament in a 33-year-old female, who presented clinically with abdominal distension. With a working diagnosis of low-grade neoplasm, an en-bloc excision of the left broad ligament mass was performed. Based on histopathology and immunohistochemistry, a diagnosis of the classical variant of angiomyolipoma of the left broad ligament was made. The post-operative period was uneventful with no recurrence after 6 months of follow-up.

Humans , Female , Adult , Broad Ligament/abnormalities , Angiomyolipoma/pathology , Immunohistochemistry , Adipose Tissue
Autops. Case Rep ; 10(4): e2020190, 2020. graf
Article in English | LILACS | ID: biblio-1131850


Epithelioid angiomyolipoma is an uncommon subtype of renal angiomyolipoma associated with potentially malignant behavior and is considered a distinct entity by the World Health Organization classification of renal tumors. We present a case of an epithelioid variant of angiomyolipoma with extension into the renal vein, inferior vena cava reaching up to the right atrium. Pre-operatively, a diagnosis of renal cell carcinoma was considered based on imaging findings. Intra-operatively due to extensive adhesions, surgical resection was not performed and only tissue sampling was performed for histopathology. Microscopic examination revealed short fascicles of spindle cells and perivascular epithelioid cells. A differential diagnosis of renal cell carcinoma with sarcomatoid differentiation was considered. The immunohistochemical profile showed tumor cells that express Melan-A and smooth muscle actin, while they were negative for pan-cytokeratin, PAX8, CK7, CD117 and CD34. Therefore a diagnosis of epithelioid angiomyolipoma was rendered. The presence of intravascular thrombi on radiological investigation and carcinoma-like growth pattern on light microscopy may compound an erroneous diagnosis of renal cell carcinoma. Hence, it is prudent for the urologist to consider differential diagnosis other than renal cell carcinoma when confronted with a renal neoplasm presenting with intravascular thrombi. In these cases, a core biopsy should be planned pre-operatively and diagnosis should be made with aid of appropriate immunohistochemical markers.

Humans , Female , Adult , Epithelioid Cells/pathology , Angiomyolipoma/pathology , Kidney Neoplasms/pathology , Carcinoma, Renal Cell , Diagnosis, Differential
Rev. Assoc. Med. Bras. (1992) ; 65(7): 977-981, July 2019. tab, graf
Article in English | LILACS | ID: biblio-1013013


SUMMARY INTRODUCTION Angiomyolipoma is one of the most common benign solid renal tumors. We investigated the characteristics of renal angiomyolipomas and the clinical outcomes of patients in the last thirteen years. METHODS The medical records of the patients who underwent nephrectomy were reviewed retrospectively from July 2005 to May 2018. The laboratory data, radiology, and pathology reports were recorded. Patients diagnosed with angiomyolipoma were included in the study. RESULTS A total of 28 patients were included in the study, eight of them male. The mean age of the patients was 55.89+14.49 years. The patients were treated with open and laparoscopic techniques. Partial nephrectomy was performed in 12 patients(42.85%). After pathological examination, 23 patients were diagnosed as fat rich, four patients as fat poor, and one as epithelioid angiomyolipoma. There were no recurrences in the follow-up 91.21+48.31 months. CONCLUSION Angiomyolipoma is a rare renal tumor in daily urology practice. Clinicians must be aware of its complications and manage patients well.

RESUMO OBJETIVO O angiomiolipoma é um dos tumores renais benignos sólidos mais comuns. Investigamos as características dos angiomiolipomas renais e os desfechos clínicos dos pacientes nos últimos treze anos. MÉTODOS Os prontuários dos pacientes, para os quais a nefrectomia foi realizada, foram revisados retrospectivamente de 2008 a 2018. Os dados laboratoriais, relatórios de radiologia e patologia foram registrados. Os pacientes diagnosticados como angiomiolipoma foram incluídos no estudo. RESULTADOS Vinte e oito pacientes foram incluídos no estudo, oito deles do sexo masculino. A média de idade dos pacientes foi de 55,89 + 14,49 anos. Os pacientes foram tratados com técnicas abertas e laparoscópicas. Nefrectomia parcial foi realizada em 12 pacientes (42,85%). Depois de exame patológico, 23 pacientes foram diagnosticados como ricos em gordura, quatro pacientes como gordurosos e um paciente como angiomiolipoma epitelioide. Nenhum paciente teve recorrências no seguimento. CONCLUSÕES O angiomiolipoma é um tumor renal raro na prática urológica diária. Os médicos devem estar cientes das complicações e gerenciar bem os pacientes.

Humans , Male , Female , Adult , Aged , Angiomyolipoma/pathology , Kidney Neoplasms/pathology , Immunohistochemistry , Magnetic Resonance Imaging/methods , Retrospective Studies , Angiomyolipoma/surgery , Tumor Burden , Kidney Neoplasms/surgery , Middle Aged , Nephrectomy/methods
Rev. méd. Chile ; 147(6): 703-708, jun. 2019. tab
Article in Spanish | LILACS | ID: biblio-1020718


Background: Small renal masses (SRM) are defined as complex organ-confined solid or cystic lesions < 4 cm. Up to 20% of these can be benign. A conservative management with active surveillance can be done in some patients. However, it is difficult to identify patients with a higher risk of malignancy. Aim: To characterize the clinical, radiological and histopathological aspects of patients with SRM, analyzing predictive factors for tumor aggressiveness. Material and Methods: Retrospective analysis of a cohort of patients undergoing partial or total nephrectomy for renal tumors between 2006 and 2016. All tumors of 4 cm or less were included. Four histological groups were defined: benign, favorable, intermediate and unfavorable. Two categories of risk were also defined: low and high. Preoperative clinical and radiological variables of these patients were analyzed. Results: Data of 152 patients were analyzed. Six percent had a benign histology, and the majority was of intermediate risk (74%). According to histological type, clear cell carcinoma was the most common type (74%). Three percent were benign angiomyolipomas. No malignancy predictive variable was identified. Conclusions: In these patients, the percentage of benign SRM was low. No variable that could predict the presence of a benign or malignant lesion in the definitive biopsy was identified.

Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Carcinoma, Renal Cell/pathology , Angiomyolipoma/pathology , Kidney Neoplasms/pathology , Biopsy , Carcinoma, Renal Cell/surgery , Carcinoma, Renal Cell/epidemiology , Logistic Models , Chile/epidemiology , Multivariate Analysis , Retrospective Studies , Risk Factors , Angiomyolipoma/surgery , Angiomyolipoma/epidemiology , Risk Assessment , Kidney Neoplasms/surgery , Kidney Neoplasms/epidemiology , Nephrectomy
Rev. bras. ginecol. obstet ; 41(3): 199-202, Mar. 2019. graf
Article in English | LILACS | ID: biblio-1003539


Abstract Angiomyolipomas (AMLs) are rare benign tumors derived from mesenchymal tissue and composed of varying degrees of adipose tissue, muscle and blood vessels. Renal AMLs (RAMLs) are the result of a sporadic event, and, in most of cases, the diagnosis is usually incidental, but hemorrhage and shock may be present. During pregnancy, the size of AMLs may increase and they may rupture, probably due to the high expression of hormone receptors, and the increase in maternal circulation and abdominal pressure. The authors present a case of a woman with ruptured RAML submitted to urgent endovascular treatment four days after giving birth by cesarean section.

Resumo Angiomiolipomas (AMLs) são tumores benignos raros derivados do tecido mesenquimal, compostos em graus variados de tecido adiposo, muscular e de vasos sanguíneos. Os AMLs renais (AMLRs) resultam de um evento esporádico e, na maioria dos casos, o diagnóstico costuma ser fortuito, mas quadros de hemorragia e choque podem estar presentes. Durante a gestação, os AMLs podem aumentar de tamanho e romper, provavelmente pela altaexpressãodereceptoreshormonais,epeloaumentodacirculaçãomaternaedapressão abdominal. Os autores apresentam um caso de uma paciente com AMLR roto submetida a tratamento endovascular de urgência no quarto dia pós-operatório de uma cesariana.

Humans , Female , Pregnancy , Adult , Pregnancy Complications, Neoplastic/therapy , Cesarean Section , Angiomyolipoma/therapy , Embolization, Therapeutic , Kidney Neoplasms/therapy , Rupture, Spontaneous/therapy , Postoperative Hemorrhage/etiology , Postoperative Hemorrhage/therapy , Postpartum Hemorrhage/etiology , Postpartum Hemorrhage/therapy
Rev. colomb. radiol ; 29(2): 4929-4923, 2018. ilus
Article in Spanish | LILACS, COLNAL | ID: biblio-986310


El complejo linfangioleiomiomatosis (LAM)-esclerosis tuberosa (ET) es una enfermedad rara, con compromiso multisistémico que afecta principalmente pulmón y cerebro. Se presenta el caso de una paciente de 25 años con LAM pulmonar que ingresa a la institución para protocolo de trasplante pulmonar. Durante los estudios de extensión se documenta compromiso extrapulmonar sistémico del complejo LAM-ET. A partir de este caso, se realizó una revisión de la literatura de las manifestaciones radiológicas sistémicas de la enfermedad y las recomendaciones de diagnóstico y manejo de estos pacientes; en especial, las indicaciones y contraindicaciones del trasplante pulmonar.

The lymphangioleiomyomatosis (LAM) - Tuberous Sclerosis (TS) Complex is a rare disease with multisystem involvement affecting mainly lung and brain. We present the case of a 25-year-old female patient with pulmonary LAM. During the work-up studies for the lung transplantation protocol, the systemic extrapulmonary involvement of the LAM-TS complex is documented. From this case, a literature review of the systemic radiological manifestations of the disease and of the diagnosis and management recommendations of these patients was made. Special focus was made on the indications and contraindications of lung transplantation.

Humans , Tuberous Sclerosis , Transplantation , Lymphangioleiomyomatosis , Angiomyolipoma
Article in English | WPRIM | ID: wpr-742113


Angiomyolipoma (AML) is a rare benign mesenchymal tumor in the liver, which is composed of blood vessels, smooth muscle, and adipose cells. The proportion of each component varies, making a diagnosis difficult. This paper reports a case of AML in the liver without adipose tissue, mimicking a hepatocellular carcinoma (HCC), which was diagnosed by a surgical tissue biopsy. A 65-year-old woman was admitted for an evaluation of a hepatic mass that had been detected by ultrasonography. The serologic markers of viral hepatitis B and C were negative. The liver function tests and alpha fetoprotein level were within the normal limits. Magnetic resonance imaging revealed a 1.9 cm sized mass in segment 6 of the liver with early arterial enhancement and washout on the delayed phase accompanied by a rim-like enhancement, which is similar to the imaging findings of HCC. A frozen section examination during surgery indicated a hepatocellular neoplasm and suggested the possibility of HCC. On the other hand, the final pathologic diagnosis was epithelioid myoid type of AML with no adipose tissue component. The tumor cells were positive for human melanocyte B-45 and negative for cytokeratin and hepatocyte paraffin 1. This paper reports a very rare case of AML without adipose tissue in the liver mimicking HCC that was diagnosed by a surgical tissue biopsy.

Adipose Tissue , Aged , alpha-Fetoproteins , Angiomyolipoma , Biopsy , Blood Vessels , Carcinoma, Hepatocellular , Diagnosis , Female , Frozen Sections , Hand , Hepatitis B , Hepatocytes , Humans , Keratins , Liver Function Tests , Liver , Magnetic Resonance Imaging , Melanocytes , Muscle, Smooth , Paraffin , Ultrasonography
Rev. chil. cir ; 69(6): 483-488, dic. 2017. ilus
Article in Spanish | LILACS | ID: biblio-899641


Resumen Introducción: Los tumores de células epitelioides perivasculares (PEComas) son neoplasias poco frecuentes de origen mesenquimal. Estos incluyen el angiomiolipoma epitelioide (EAML), una neoplasia con potencial maligno y cuya presentación simultánea con cáncer de tiroides es bastante rara. Presentación del caso: Hombre de 40 años con masa de crecimiento rápido en relación con polo inferior derecho de tiroides e infiltración de tráquea. La TAC abdominopélvica contrastada muestra múltiples masas renales con masa dominante en polo superior izquierdo. El estudio histopatológico de tiroides evidenció una lesión en lóbulo derecho correspondiente a cáncer papilar de tiroides (PTC) de variante de células altas y una segunda neoplasia en el lóbulo contralateral correspondiente a PTC moderadamente diferenciado de variante clásica. En riñón se encontró una lesión correspondiente a EAML, con células de aspecto epitelioide equivalentes al 40%. Discusión: El presente artículo corresponde al primero en la literatura en describir la presentación simultánea de EAML con PTC bilateral sincrónico (SBiPTC). Se describe una vía molecular común, que corresponde a la vía TSC/mTOR, la prevalencia de SBiPTC y los marcadores inmunohistoquímicos para diagnóstico de EAML.

Abstract Introduction: Perivascular Epithelioid Cell Neoplasms (PEComas) are uncommon tumors of mesenchymal origin. These ones include the epithelioid angiomyolipoma (EAML), a tumor with malignant potential and whose simultaneous presentation with thyroid cancer is quite rare. Presentation of case: Forty years old man with fast-growing mass in relation to lower right thyroid pole and tracheal infiltration. Abdominopelvic contrast-enhanced CT shows multiple renal masses with dominant mass in the left upper pole. Thyroid histopathology showed a lesion in right lobe corresponding to tall cell variant of papillary thyroid cancer (PTC) and a second neoplasm in the contralateral lobe corresponding to classical variant of moderately differentiated PTC. In the kidney was found a tumor corresponding to EAML with epithelioid aspect cells equivalent to 40%. Discussion: This article corresponds to the first in the literature to describe the simultaneous presentation of EAML with synchronous bilateral PTC (SBiPTC) and its possible association. A common molecular pathway corresponding to the TSC/mTOR pathway is described, as well as SBiPTC prevalence and immunohistochemical markers for EAML diagnosis.

Humans , Male , Adult , Thyroid Neoplasms/pathology , Angiomyolipoma/pathology , Perivascular Epithelioid Cell Neoplasms/pathology , Neoplasms, Multiple Primary/pathology , Thyroidectomy , Thyroid Neoplasms/surgery , Immunohistochemistry , Biomarkers, Tumor , Angiomyolipoma/surgery , Perivascular Epithelioid Cell Neoplasms/surgery , Neoplasms, Multiple Primary/surgery
Rev. Asoc. Méd. Argent ; 130(1): 30-33, mar. 2017. ilus
Article in Spanish | LILACS | ID: biblio-973067


Los angiomiolipomas renales son formaciones renales que se presentan de forma aislada o asociadas con otras patologías como esclerosis tuberosa o enfermedad de Von Hippel Lindau. Los angiomiolipomas renales se pueden presentar clínicamente con un shock hipovolémico por lesión de uno de sus vasos o con dolor abdominal por efecto masa debido a su tamaño. La resolución de los angiomiolipomas puede ser de manera programada o de urgencia, siendo las vías elegidas la nefrectomía parcial o la embolización arterial selectiva, dependiendo siempre de los recursos que se tengan y la experiencia del equipo quirúrgico.

Renal angiomyolipomas are kidney formations presented in isolation or associated with other diseases such as tuberous sclerosis or Von Hippel Lindau disease. Renal angiomyolipoma may present clinically with hypovolemic shock due to injury of one of its vessels or with abdominal pain due to mass effect because of its size. Angiomyolipomas can be resolved on scheduled basis or emergency, where the chosen ways are partial nephrectomy or selective arterial embolization, always depending on the resources you count on and the experience of the surgical team.

Female , Humans , Young Adult , Kidney/surgery , Tuberous Sclerosis/complications , Tuberous Sclerosis/surgery , Angiomyolipoma/diagnosis , Angiomyolipoma/surgery , Urogenital Abnormalities/surgery , Organ Sparing Treatments , Emergencies , Sex Distribution , Hypovolemia , Sepsis
Med. interna (Caracas) ; 33(2): 110-116, 2017. ilus
Article in Spanish | LILACS, LIVECS | ID: biblio-1009210


El angiomiolipoma renal es un tumor benigno poco frecuente y constituye menos del 2% de todos los tumores renales, teniendo una incidencia de 0.3-3% aproximadamente a nivel mundial. En Venezuela solo existe un reporte de angiomiolipoma, publicado en el 2015. Aunque estos tumores se asocian en un 20% con el complejo de esclerosis tuberosa y la linfangioleiomiomatosis esporádica, pueden presentarse aisladamente con una relación mujer-hombre de 2:1 y más en la 4ª y 5a década de la vida. Presentamos el caso de una mujer de 32 años de edad, quien consultó en 2006 por hematuria macroscópica, dolor en hipogastrio, sin relación con la menstruación; concomitante polaquiuria, astenia y palpitaciones; tuvo episodios recurrentes 3-4 veces/año con transfusión de hemoderivados por anemia severa. En el año 2015 la tomografía mostró "síndrome de cascanueces". La uretrocistoscopia mostró hemorragia activa por uréter derecho, y se realizó nefrectomía parcial derecha cuya biopsia reportó angiomiolipoma renal, con buena evolución y egreso a las 72 horas(AU)

Renal angiomyolipoma is a benign, rare tumor present in less than 2% of all renal tumors; it´s world incidence is 0.3-3%. In Venezuela only one case was reported in 2015. Although these tumors are associated with 20% of the Tuberous Sclerosis, they can present with a gender proportion of 2:1, more often in the 4th and 5th decade. We present here the case of a 32 year- old woman who in 2006 had consulted for hematuria, pelvic pain, weakness and palpitations not related with her menses. These episodes recurred several times per year and she received red blood cell transfusions. In the year 2015 a computerized tomography showed Nutcracker Syndrome and the urethrocystoscopy showed an active bleeding originating in the right urether. A right partial nephrectomy was done and the biopsy was reported as Renal angiomyolipoma. She was discharged 72 hours after her operation(AU)

Humans , Female , Adult , Angiomyolipoma/pathology , Kidney Neoplasms/pathology , Nephrectomy , Urologic Diseases , Internal Medicine
Article in English | WPRIM | ID: wpr-193555


The diagnosis of hepatocellular carcinoma (HCC) is based on imaging studies particularly in high-risk patients without histologic confirmation. This study evaluated the prevalence and characteristics of false-positively diagnosed HCC in a liver resection cohort for HCC. A retrospective review was performed of 837 liver resection cases for clinically diagnosed HCC between 2005 and 2010 at our institute. High-risk patients with tumors > 1 cm with one or two image findings consistent with HCC and tumors 0.05) compared to non-HCC patients except for higher rate of history of alcoholism (P < 0.05) observed in non-HCC patients. Four of 18 non-HCC patients (22.2%) showed diagnostic discordance on the dynamic imaging study. Despite the recent progression in diagnostic imaging techniques, 2.2% of cases were false-positively diagnosed as HCC in a liver resection patient cohort; and the final diagnosis was benign disease in 0.8% of liver resection patients clinically diagnosed with HCC.

Adenoma , Adenoma, Bile Duct , Alcoholism , alpha-Fetoproteins , Angiomyolipoma , Carcinoma, Hepatocellular , Cohort Studies , Cystadenocarcinoma , Diagnosis , Diagnostic Imaging , Hemangioma , Hepatitis , Hepatoblastoma , Humans , Inflammation , Liver , Nasopharynx , Prevalence , Reference Values , Retrospective Studies
Article in English | WPRIM | ID: wpr-165803


Epithelioid angiomyolipoma (EAML) of liver is a rare neoplasm. Hepatic EAML is often misdiagnosed as other neoplasms such as hepatocellular carcinoma due to non-specific clinical and radiologic features. The morphologic features under microscope and immunohistochemistry staining profile are important in the diagnosis EAML. Here, we report a case of 52-year-old man who found 1.2 cm mass in liver by routine checkup. On the impression of hepatocellular carcinoma, lateral sectionectomy of the liver was done. Microscopically, the tumor is composed of predominant epithelioid cells with vascular component and foamy cells. These cells were positive for HMB45, MelanA, and smooth muscle actin and negative for epithelial membrane antigen. The final diagnosis was hepatic EAML.

Actins , Angiomyolipoma , Carcinoma, Hepatocellular , Diagnosis , Epithelioid Cells , Humans , Immunohistochemistry , Liver , MART-1 Antigen , Middle Aged , Mucin-1 , Muscle, Smooth , Perivascular Epithelioid Cell Neoplasms
Article in English | WPRIM | ID: wpr-160329


Angiomyolipomas are hamartomatous lesions consisting of smooth muscle bundles, thick-walled blood vessels, and mature adipocytes. They are usually found in the kidneys of tuberous sclerosis patients and more rarely in other organs, such as the liver, the oral cavity, the sinonasal tract, the heart, the large intestines, the lungs, and the skin. Cutaneous angiomyolipoma has shown to be very rare and generally occurs at the ends of the digits, the elbows, the ears, and the nose. Herein, we report the first documented case of angiomyolipoma of the glabellar region.

Adipocytes , Angiomyolipoma , Blood Vessels , Ear , Elbow , Heart , Humans , Intestines , Kidney , Liver , Lung , Mouth , Muscle, Smooth , Nose , Perivascular Epithelioid Cell Neoplasms , Skin , Tuberous Sclerosis
Article in English | WPRIM | ID: wpr-10606


A 31-year-old male visited a local hospital due to sudden-onset severe abdominal pain. Abdominal computed tomography revealed a solid cystic mass with a size of approximately 12 cm and exhibiting both hemorrhage and fluid collection in the pelvic cavity. Emergency angiography and embolization were performed, and a large hepatic tumor was subsequently surgically resected. The tumor cells stained positive for human melanoma black-45 and smooth-muscle actin, and the pathologic diagnosis was hepatic angiomyolipoma. This case report also discusses the spontaneous rupture of a hepatic angiomyolipoma.

Abdominal Pain , Actins , Adult , Angiography , Angiomyolipoma , Diagnosis , Emergencies , Hemorrhage , Humans , Liver , Male , Melanoma , Rupture, Spontaneous
Rev. argent. radiol ; 80(2): 99-111, jun. 2016. ilus, graf, tab
Article in Spanish | LILACS | ID: biblio-843221


Objetivo: Diferenciar el angiomiolipoma atípico del carcinoma de células renales del mismo tamaño mediante hallazgos tomográficos. Materiales y métodos: Se realizó un estudio retrospectivo con 68 pacientes (17 con angio-miolipomas atípicos y 51 con carcinoma de células renales) nefrectomizados por diagnóstico presuntivo preoperatorio, mediante tomografía computada trifásica (fases sin contraste, corticomedular y excretora temprana), de carcinoma de células renales menor de 45mm. Dos radiólogos que desconocían el diagnóstico definitivo evaluaron retrospectivamente las características generales del tumor, su atenuación en fase sin contraste y las características de su realce. Se realizó un análisis estadístico con software R, aplicándose el modelo logit para diferenciar el angiomiolipoma atípico del carcinoma de células renales a partir de los hallazgos tomográficos de masa renal, incluidos en el modelo final el contorno, la atenuación en fase sin contraste y el patrón de realce con el tiempo. Resultados: Los hallazgos de angiomiolipoma atípico que resultaron significativos fueron atenuación tumoral en fase sin contraste hiperdensa y patrón de realce con tiempo prolongado con chance de ocurrencia de 10,49 (p=0,0381) y 36,71 (p=0,0009), respectivamente. En los pacientes, según el valor de cada hallazgo incluido en el modelo, se calculó probabilidad, sensibilidad (0,2941) y especificidad (0,9804). La curva característica operativa del receptor (ROC) determinó un punto de corte óptimo (0,9694) para discriminar el angiomiolipoma atípico, por lo que se confirmó su presencia. Conclusión: La tomografía computada helicoidal trifásica es útil para diferenciar el angiomiolipoma atípico del carcinoma de células renales, siendo la atenuación hiperdensa sin contraste del tumor y su patrón de realce prolongado los hallazgos tomográficos más valiosos.

Objective: To compare various computed tomographic features of atypical angiomyolipoma with those of size-matched renal cell carcinoma. Materials and methods: Sixty-eight patients (17 with atypical angiomyolipomas and 51 with carcinoma renal cells) who had undergone nephrectomy by presumptive diagnosis of carcinoma renal cell<45mm on diameter by preoperative triphasic computed tomography (CT) (with unenhanced, corticomedullary, and early excretory phase scanning) were evaluated in a retrospective study. Two reviewers who were unaware of the diagnosis retrospectively recorded tumor attenuation on unenhanced scans, enhancement characteristics and general characteristics of the tumor. Statistical analysis was performed with R software, applying logit model to differentiate atypical angiomyolipoma from renal cell carcinoma from CT findings of renal mass, included in the final model the tumor margin, its attenuation on unenhanced scans and the enhancement pattern over time. Results: For atypical angiomyolipomas the most valuable CT findings were hyperdense attenuation tumour in unenhaced phase scan and prolonged enhancement pattern, with chance of occurrence of 10.49 (p=0.0381) and 36.71 (p=0.0009), respectively. In the patients, as each finding value in the model, probability, sensitivity (0.2941) and specificity (0.9804) was calculated ROC curve was constructed that determined optimal cutoff (0.9694) to discriminate atypical angiomyolipoma, confirming their presence. Conclusion: Triphasic helical CT may be useful in differentiating atypical angiomyolipoma from renal cell carcinoma, with hyperdense tumor attenuation on unenhanced scans and prolonged enhancement pattern being the most valuable CT findings.

Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Carcinoma, Renal Cell/diagnostic imaging , Angiomyolipoma/diagnostic imaging , Kidney Neoplasms/diagnostic imaging , Retrospective Studies , ROC Curve , Tomography, Spiral Computed
Rev. colomb. obstet. ginecol ; 67(2): 153-158, apr.-jun. 2016. ilus, tab
Article in Spanish | LILACS | ID: lil-791323


Objetivo: presentar el caso de una paciente con angiolipoleiomioma uterino confirmado histopatológicamente y diagnosticado prequirúrgicamente como un teratoma anexial, y realizar una revisión de la literatura respecto al diagnóstico clínico, imagenológico e histopatológico de la entidad. Materiales y métodos: se presenta el caso de una mujer de 61 años, a quien se le practicó laparotomía por sospecha de un teratoma anexial. En la cirugía se hace diagnóstico de miomatosis uterina y se practica histerectomía abdominal total y salpingooforectomía bilateral. En el estudio histopatológico se encuentran hallazgos compatibles con angiolipoleiomioma uterino. Se realizó una búsqueda en las bases de datos Medline vía PubMed, OVID y en Lilacs, con los términos "angiolipoleiomyoma", "angiolipoleiomyoma uterus", "uterine angiolipoleiomyoma","uterine angiolipoleiomyomas" y "angiomyolipoma uterus", se buscaron artículos de revisión, reportes y series de casos en inglés y español publicados desde 1966 hasta mayo de 2016. Resultados: se encontraron siete artículos, que corresponden a reportes de casos y revisión de la literatura, los cuales describen las principales características en cuanto a presentación clínica, diagnóstico clínico y paraclínicos basándose en pruebas de imagenología y estudios de histopatología. Conclusión: el angiolipoleiomioma uterino es una entidad benigna muy rara, cuyo diagnóstico diferencial clínico es complejo, ya que simula otras patologías ginecológicas. Es de suma importancia la sospecha clínica prequirúrgica de esta entidad y la posterior confirmación histopatológica.

Objectives: To present the case of a patient with a uterine angiolipoleiomyoma confirmed by histopathology, diagnosed as adnexal teratoma before surger y, and to conduct a review of the literature regarding clinical, imaging and histopathological diagnosis of this condition. Materials and methods: A 61-year old patient taken to laparotomy due a suspected adnexal teratoma. During surgery, uterine myomatosis was diagnosed and total abdominal hysterectomy and bilateral oophorectomy are performed. Findings on histopatholog y were consistent with uterine angiolipoleiomyoma. A search was conducted in the Medline databases via PubMed, Ovid and in LILACS using the terms "angiolipoleiomyoma", "angiolipoleiomyoma uterus", "uterine angiolipoleiomyoma", "uterine angiolipoleiomyomas" and "angiomyolipoma uterus". The search included review articles and case series and reports published in English and Spanish from 1966 to May 2016. Results: Seven study articles were found, including case reports and literature reviews describing the main characteristics in terms of clinical presentation, clinical diagnosis and paraclinical tests, based on imaging studies and histopathology. Conclusion: Uterine angiolipoleiomyoma is an extremely rare benign condition that mimics other gynaecological pathologies, making it a difficult clinical differential diagnosis. Preoperative clinical suspicion and postoperative histopathological confirmation are of the utmost importance.

Angiomyolipoma , Leiomyoma , Teratoma