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1.
Article in Portuguese | LILACS | ID: biblio-1353115

ABSTRACT

A intoxicação por vitamina D era pouco frequente no Brasil até seu crescente uso na última década. Neste artigo relatamos um caso de intoxicação por vitamina D em que houve a prescrição intencional de dose muito superior ao recomendado pela literatura, com a finalidade de prevenir doenças via "modulação hormonal". A paciente em questão, idosa, previamente hígida, foi submetida a um tratamento não regulamentado e sem respaldo científico, que culminou em sintomas como náuseas e vômitos, além de perda de peso, inapetência, poliúria e astenia ao longo dos meses. Através da história e exames laboratoriais foi diagnosticada intoxicação por vitamina D e lesão renal aguda. Após o tratamento houve remissão completa dos sintomas. A "modulação hormonal" é uma prática condenada pelos Conselhos Federais de Medicina e Odontologia e pela Sociedade Brasileira de Endocrinologia e Metabologia. O ato de prescrever é de grande responsabilidade ética e técnica e deve ser embasado em evidências científicas, oferecendo o melhor tratamento possível aos pacientes, seja ele preventivo ou curativo, minimizando riscos e danos, respeitando as recomendações das autoridades competentes. (AU)


Vitamin D poisoning was not frequent in Brazil until its increasing use in the last decade. In this article, we report a case of intoxication by intentional prescription of vitamin D in a much higher dose than the literature recommends, in order to prevent diseases via "hormonal modulation". The case described in this report was an elderly woman, previously healthy patient that was submitted to an unregulated treatment without scientific support, leading to symptoms such as nausea and vomiting, in addition to weight loss, lack of appetite, polyuria and asthenia over the months. Through the history and laboratory testing, vitamin D intoxication and acute kidney injury were diagnosed. After treatment, there was a complete remission of the symptoms. "Hormonal modulation" is a practice condemned by the Federal Councils of Medicine and Dentistry and by the Brazilian Society of Endocrinology and Metabology. The act of prescribing is of great ethical and technical responsibility and it must be based on scientific evidence. Thus, the patient can receive the best possible treatment, for either preventive or curative nature, by respecting the recommendations of the competent authorities and, therefore, minimizing risks and damages to patients. (AU)


Subject(s)
Humans , Female , Aged , Polyuria , Asthenia , Vitamin D/toxicity , Weight Loss , Anorexia , Ethics, Professional , Acute Kidney Injury
2.
Ciênc. Saúde Colet ; 26(supl.3): 5293-5301, Oct. 2021.
Article in English, Portuguese | LILACS | ID: biblio-1345747

ABSTRACT

Resumo O presente artigo procurou compreender como jovens anoréxicas utilizam ambientes virtuais como espaços de sociabilidade para a construção de uma narrativa sobre a anorexia, para ancorar suas experiências pela mutualidade emocional e para validar discursos. Realizou-se análise de conteúdo da sessão de comentários e posts de blogs pró-anorexia sendo identificadas três categorias temáticas: corpo, identidade pessoal e sociabilidade na rede. Observou-se que os blogs são espaços virtuais de sociabilidade e de construção de coletivos identitários. As representações e as vivências pela materialidade corporal alimentam o cyber espaço e são o ponto de partida para compreensão de um fenômeno particular à contemporaneidade, que são as trocas virtuais. Nos blogs localizam-se narrativas corporais que procuram dar coerência ao indivíduo e à sua existência bem como ancorar e legitimar experiências pessoais e validar atitudes pró-anorexia. São reforçados os laços sociais dentro do grupo que se transforma em uma comunidade emocional. Os sentidos dos discursos circulantes permitem inferir que nestes grupos, a materialidade dos corpos anoréxicos se emancipa dos estigmas sociais de doença.


Abstract The study presented in this paper aimed at understanding how anorexic young women use virtual environments as spaces of sociability in order to construct a narrative about anorexia, anchor their experiences through emotional mutuality and validate discourses. To do so, an analysis of the content found in the commenting and posting sections of pro-anorexia blogs was carried out. Three thematic categories were identified: body, personal identity and sociability on the web. It was observed that blogs are virtual spaces of sociability and construction of identity groups. The representations and the experiences lived by the corporal materiality feed cyberspace and are the starting point for understanding a phenomenon particular to the contemporaneity, that is the virtual exchanges. In blogs, one can find body narratives that seek to give coherence to an individual and to his or her existence as well as narratives that aim at anchoring and legitimizing personal experiences and validating pro-anorexia attitudes. Social ties are strengthened within the group, which becomes an emotional community. The meanings of the spreading discourses allow us to infer that in these groups, the materiality of anorexic bodies emancipates itself from the social stigmas of a disease.


Subject(s)
Humans , Male , Female , Ethers , Ether , Anorexia , Internet , Emotions , Blogging
3.
Rev. cuba. pediatr ; 93(2): e1330,
Article in Spanish | LILACS, CUMED | ID: biblio-1280369

ABSTRACT

Introducción: Los síntomas gastrointestinales asociados a la COVID-19 puede afectar entre el 3 y 39 por ciento de los enfermos. Objetivo: Examinar la relación entre la infección por el virus, la microbiota intestinal y la presencia de síntomas digestivos. Métodos: Búsqueda bibliográfica en Medline, Pubmed, Scielo, LILACS y Cochrane en los últimos 6 meses de 2020 en idioma inglés y español, sobre la presencia de síntomas digestivos en enfermos de COVID-19. Resultados: El eje pulmón-intestino está conectado bidireccionalmente, por lo que los metabolitos y microbios del pulmón pueden afectar la microbiota intestinal y se justifica así, la posibilidad de que SARS-CoV-2 tenga impacto en ese ecosistema. Se ha confirmado la detección de ARN del SARS-CoV-2 en muestras de heces incluso después que los resultados de muestras respiratorias han sido negativas, lo que supone que el mecanismo fecal-oral es una posible ruta de transmisión de la enfermedad. Los síntomas gastrointestinales que se asocian a la infección por SARS-CoV-2 son: anorexia, náuseas, dolor abdominal y vómitos, este último es el síntoma más frecuente en la población pediátrica. Los pacientes que presentaron diarrea se relacionaron con una evolución desfavorable de la enfermedad, aunque aún no se confirman las hipótesis planteadas al respecto. Consideraciones finales: Se necesitan más investigaciones sobre las alteraciones de la microbiota intestinal, la potencial transmisión fecal-oral del SARS-CoV-2 y la caracterización de las manifestaciones digestivas en los enfermos de COVID-19. Son importantes las medidas de bioseguridad para la manipulación de los deshechos biológicos de los enfermos(AU)


ABSTRACT Introduction: Gastrointestinal symptoms associated with COVID-19 can affect between 3 and 39 percent of patients. Objective: Examine the relationship between infection with the virus, the gut microbiota and the presence of digestive symptoms. Methods: Bibliographic search in Medline, Pubmed, Scielo, LILACS and Cochrane in the last 6 months of 2020 in English and Spanish languages on the presence of digestive symptoms in COVID-19 patients. Results: The lung-intestinal axis is bidirectionally connected, so the metabolites and microbes of the lung can affect the gut microbiota and thus justify the possibility that SARS-CoV-2 will have an impact on that ecosystem. SARS-CoV-2 RNA detection has been confirmed in stool samples even after respiratory sample results have been negative, implying that the fecal-oral mechanism is a possible route of transmission of the disease. Gastrointestinal symptoms associated with SARS-CoV-2 infection are: anorexia, nausea, abdominal pain and vomiting, the latter is the most common symptom in the pediatric population. Patients who had diarrhea were associated with an unfavorable evolution of the disease, although the hypotheses raised in this regard are not yet confirmed. Final considerations: More research is needed on alterations of the gut microbiota, the potential fecal-oral transmission of SARS-CoV-2 and the characterization of digestive manifestations in COVID-19 patients. Biosecurity measures are important for the handling of biological waste of the patients(AU)


Subject(s)
Humans , Signs and Symptoms , Anorexia , Containment of Biohazards , Betacoronavirus
4.
Article in Chinese | WPRIM | ID: wpr-879190

ABSTRACT

Child Compound Endothelium Corneum(CCEC)has the effects in invigorating the spleen and appetizing the appetite, and dissolving the accumulation of food. The recent studies have proved that it could improve gastrointestinal motility, restore physiological gastrointestinal peristalsis, increase gastrointestinal digestive motility, and enhance appetite. This trial aimed to evaluate its clinical efficacy and safety in the treatment of children's anorexia(spleen-stomach disharmony). A total of 240 children with anorexia in line with the inclusion and exclusion criteria were selected and randomly divided into experimental group and control group, with 120 in each group. Patients in the experimental group took CCEC and Erpixing Granules simulant. Patients in the control group took Erpi-xing Granules and CCEC simulant. After 21 days of treatment, there was no statistical difference in the recovery rate of anorexia, reduced food intake, eating time, weight change, traditional Chinese medicine syndrome effect, single symptom effect, and trace element Zn recovery rate between the two groups. Based on the non-inferiority test, the experimental group was not inferior to the control group in efficacy. How-ever, the effect of CCEC in reducing appetite in children with anorexia was better than that of control drugs(P<0.05). There was no statistical difference in the incidence of adverse events and adverse reactions between the two groups during the trial. This experiment confirmed the efficacy and safety of CCEC in the treatment of children's anorexia(spleen-stomach disharmony), with a safety and re-liability in clinical application. In addition, it was a better choice for children with anorexia who were mainly manifested by reduced appetite. Meanwhile, compared with granule, chewable tablets were more convenient to take in clinic. Therefore, the efficacy and safety of CCEC for the treatment of children's anorexia(spleen-stomach disharmony) were not inferior to those of Erpixing Granules, with a safety and reliability in clnic. However, due to the small sample size of this trial, the efficacy results only show a trend. It is suggested to further carry out a large-sample-size clinical study to define the clinical advantages of CCEC.


Subject(s)
Anorexia/drug therapy , Child , Double-Blind Method , Endothelium , Humans , Reproducibility of Results , Spleen , Stomach , Treatment Outcome
5.
Article in English, Portuguese | LILACS | ID: biblio-1363580

ABSTRACT

Introdução: O câncer é uma das principais causas de morte no mundo, podendo ser motivado tanto por fatores externos como internos. A recusa alimentar está frequentemente associada à desnutrição em pacientes oncológicos e, muitas vezes, à caquexia, levando ao aumento da mortalidade. Objetivo: Apresentar evidências científicas, com base em uma revisão integrativa, para avaliar o impacto da recusa alimentar em pacientes oncológicos. Método: Para a seleção dos estudos, foi utilizada uma combinação de termos indexados no Medical Subject Heading Terms (MeSH). Foram utilizadas as bases de dados MEDLINE (PubMed), LILACS, SciELO, Scopus, Web of Science, Microsoft Academic Search, Cochrane, RCAAP e BIREME para a seleção de manuscritos, sem restrição de idioma, período de publicação e localização geográfica. A escala utilizada para avaliar os estudos foi o protocolo para pontuação qualitativa. Resultados: Foram recuperados dez artigos com potencial de inclusão, sendo que três responderam à pergunta norteadora que consistiu em verificar o impacto da recusa alimentar em indivíduos com câncer. Os estudos selecionados obtiveram pontuação maior do que seis no protocolo para avaliação da sua qualidade. Conclusão: Os estudos relataram indicadores frequentes de recusa alimentar em pacientes oncológicos associada à desnutrição, ao medo de se alimentar e ao apetite limitado


Introduction: Cancer is one of the leading causes of death in the world and can be provoked by both external and internal factors. Food refusal is often associated with malnutrition in cancer patients and is often associated with cachexia, which can lead to increased mortality. Objective: To present scientific evidence, based on an integrative review, to assess the impact of food refusal on cancer patients. Method: For the selection of studies, a combination of terms indexed in the Medical Subject Heading Terms (MeSH) was used. The databases MEDLINE (PubMed), LILACS, SciELO, Scopus, Web of Science, Microsoft Academic Search, Cochrane, RCAAP and BIREME were utilized for the selection of manuscripts, without restriction of language, period of publication and geographical location. The scale that was used to evaluate the studies was the protocol of qualitative score. Results: 10 articles with potential for inclusion were retrieved, and 3 articles responded the guiding question that consisted in verifying the impact of food refusal in individuals with cancer. The selected studies scored higher than six in the protocol for assessing their quality. Conclusion: Studies have reported frequent indicators of food refusal in cancer patients, associated with malnutrition, fear of eating and limited appetite


Introducción: El cáncer es una de las principales causas de muerte en el mundo y puede ser causado tanto por factores externos como internos. El rechazo de alimentos a menudo está relacionado con la desnutrición en pacientes con cáncer y, a menudo, también se asocia con la caquexia, que puede conducir a un aumento de la mortalidad. Objetivo: Presentar evidencia científica, basada en una revisión integradora, para evaluar el impacto del rechazo de alimentos en pacientes con cáncer. Método: Para la selección de estudios se utilizó una combinación de términos indexados en Medical Subject Heading Terms (MeSH). Para la selección de manuscritos se utilizaron las bases de datos MEDLINE (PubMed), LILACS, SciELO, Scopus, Web of Science, Microsoft Academic Search, Cochrane, RCAAP y BIREME, sin restricción de idioma, período de publicación y ubicación geográfica. La escala que se utilizó para evaluar los estudios fue el protocolo de puntuación cualitativa. Resultados: Se recuperaron diez artículos con potencial de inclusión y tres artículos respondieron a la pregunta orientadora que consistía en verificar el impacto del rechazo de alimentos en individuos con cáncer. Los estudios seleccionados obtuvieron una puntuación superior a seis en el protocolo para evaluar su calidad. Conclusión: Los estudios han reportado indicadores frecuentes de rechazo de alimentos en pacientes con cáncer, asociados con desnutrición, miedo a comer y apetito limitado.


Subject(s)
Humans , Male , Female , Cachexia , Anorexia , Malnutrition , Diet , Neoplasms
6.
Esc. Anna Nery Rev. Enferm ; 25(4): e20200520, 2021. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1279021

ABSTRACT

Resumo Objetivo identificar os principais sinais e sintomas manifestados por pacientes em cuidados paliativos oncológicos na assistência domiciliar. Método revisão integrativa nas bases LILACS, MEDLINE e CINAHL em janeiro de 2020. Perguntou-se: "Quais os principais sinais e sintomas manifestados por pacientes em cuidados paliativos oncológicos destacados nos estudos abrangendo o contexto do domicílio?". Foram descritores/termos: Sinais e Sintomas/Signs and Symptoms; Assistência Domiciliar/Home Care Services; Cuidados Paliativos/Palliative Care e Neoplasias/Neoplasms. Elencaram-se como critérios de elegibilidade: texto completo; entre 2015 e 2019; em inglês, português ou espanhol e idade adulta. Para o mapeamento dos dados, consideraram-se: título; país; ano; objetivo; método; sinais e sintomas. Os resultados foram categorizados em subgrupos, considerando a classificação conceitual predeterminada (sinal e sintoma). O elemento contagem facilitou a análise e a comparação de dados. Resultados foram selecionados 35 artigos, sendo identificados 25 sinais e 23 sintomas. Os mais frequentes foram: dor, náusea/vômito, dispneia, fadiga, depressão, ansiedade, constipação, perda de apetite, sonolência, bem-estar e insônia. A maioria (39) relacionou-se ao domínio físico. Conclusão a identificação dos principais sinais e sintomas, neste contexto, direciona a prática dos profissionais de saúde para as intervenções mais adequadas e o mais precocemente possível, contribuindo para viabilizar a assistência domiciliar, e alerta para a necessidade de educação permanente sobre este tema.


Resumen Objetivo identificar los principales signos y síntomas que manifiestan los pacientes en cuidados oncológicos paliativos en la atención domiciliaria. Método revisión integradora basada en LILACS, MEDLINE y CINAHL en enero de 2020. Se preguntó: "¿Cuáles son los principales signos y síntomas que manifiestan los pacientes en cuidados paliativos oncológicos destacados en estudios que abarcan el contexto del hogar?". Los descriptores / términos fueron: signos y síntomas / /Signs and Symptoms; Asistencia domiciliaria / Home Care Services; Cuidados paliativos / Palliative Care / y Neoplasias/ Neoplasms. Se enumeraron los siguientes criterios de elegibilidad: texto completo; entre 2015 y 2019; en inglés, portugués o español y edad adulta. Para el mapeo de datos, se consideraron los siguientes: título; padres; año; objetivo; método; signos y síntomas. Los resultados se categorizaron en subgrupos, considerando la clasificación conceptual predeterminada (signo y síntoma). El elemento de conteo facilitó el análisis y la comparación de datos. Resultados Se seleccionaron 35 artículos, se identificaron 25 signos y 23 síntomas. Los más frecuentes fueron: dolor, náuseas / vómitos, disnea, fatiga, depresión, ansiedad, estreñimiento, pérdida de apetito, somnolencia, bienestar e insomnio. La mayoría (39) estaban relacionados con el dominio físico. Conclusión la identificación de los principales signos y síntomas, en este contexto, orienta la práctica de los profesionales de la salud hacia las intervenciones más adecuadas y lo más temprano posible, contribuyendo a hacer factible la atención domiciliaria, y alerta sobre la necesidad de una educación permanente sobre este tema.


Abstract Objective to identify the main signs and symptoms manifested by palliative care oncology patients in home care. Method integrative review in LILACS, MEDLINE and CINAHL databases in January 2020. The question was asked: "What are the main signs and symptoms manifested by patients in palliative oncology care highlighted in studies covering the context of the home?" Descriptors/terms were: Signs and Symptoms/Signs and Symptoms; Home Care/Home Care Services; Palliative Care/Palliative Care and Neoplasms/Neoplasms. Eligibility criteria were listed as follows: full text; between 2015 and 2019; in English, Portuguese or Spanish and adult age. For data mapping, the following were considered: title; country; year; objective; method; signs and symptoms. The results were categorized into subgroups, considering the predetermined conceptual classification (sign and symptom). The counting element facilitated the analysis and comparison of data. Results a total of 35 articles were selected, and 25 signs and 23 symptoms were identified. The most frequent were: pain, nausea/vomiting, dyspnea, fatigue, depression, anxiety, constipation, loss of appetite, sleepiness, well-being, and insomnia. Most (39) were related to the physical domain. Conclusion the identification of the main signs and symptoms, in this context, directs the practice of health professionals to the most appropriate interventions as early as possible, contributing to the feasibility of home care, and alerts to the need for continuing education on this topic.


Subject(s)
Humans , Adult , Palliative Care , Death , Home Nursing , Neoplasms , Anxiety , Quality of Life , Anorexia , Constipation , Depression , Dyspnea , Fatigue , Cancer Pain , Sleepiness , Sleep Initiation and Maintenance Disorders , Nausea
7.
An. Fac. Cienc. Méd. (Asunción) ; 54(2): 151-156, 2021.
Article in Spanish | LILACS | ID: biblio-1281113

ABSTRACT

La Colitis Ulcerativa (CU) es una enfermedad crónica multifactorial de etiología desconocida caracterizada por la presencia de inflamación difusa en la mucosa colónica en presencia de diarrea sanguinolenta asociada con urgencia y tenesmo rectal. Una mujer de 51 años, acudió al Servicio de Urgencias por rectorragia con molestias en hipogastrio y tenesmo, además un mes y medio de deposiciones liquidas, sensación febril intermitente, anorexia, nauseas sin vómitos y pérdida de peso de aprox. 10 kilos en 1 mes, con un abdomen distendido, levemente depresible, doloroso en hipogastrio. La colonoscopía y anatomía patológica informan una Rectocolitis Ulcerativa Pancolónica. La paciente continua con mala evolución a pesar de tratamiento médico, por lo que se decide el manejo quirúrgico con una colectomía subtotal con confección de ileostomía y fístula mucosa de sigmoides por colitis aguda grave refractaria al tratamiento. El manejo médico previo al manejo quirúrgico en este caso se vio limitado por la disponibilidad de fármacos. Esto resalta la necesidad del conocimiento del manejo multidisciplinario de las patologías colorectales.


Ulcerative Colitis (UC) is a multifactorial chronic disease of unknown etiology characterized by the presence of diffuse inflammation in the colonic mucosa and often the presence of bloody diarrhea associated with rectal urgency. A 51-year-old woman came to the emergency room due to rectal bleeding with hypogastric pain and tenesmus, in addition to a month and a half of diarrhea, intermittent fever, anorexia, nausea without vomiting and weight loss of approx. 10 kilos in 1 month, with a distended abdomen, slightly depressible, painful in the hypogastrium. Colonoscopy and pathological anatomy report a Pancolonic Ulcerative Rectocolitis. The patient continues with poor evolution despite medical treatment, so a surgical approach is decided with a subtotal colectomy, terminal ileostomy and sigmoid fistula due to severe acute colitis refractory to treatment. Medical treatment prior to a surgical approach in this case was limited by the availability of drugs. This highlights the need for a multidisciplinary management of colorectal pathologies.


Subject(s)
Anorexia , Colitis, Ulcerative , Chronic Disease , Colectomy , Diarrhea , Colon, Sigmoid , Abdomen
8.
Rev. gaúch. enferm ; 42(spe): e20200205, 2021. tab, graf
Article in English | LILACS, BDENF | ID: biblio-1251789

ABSTRACT

ABSTRACT Objective To identify symptoms of COVID-19 in adults in the scientific literature. Method Systematic review of studies published from December 1, 2019 to April 21, 2020 from the Scopus, Web of Science and PubMed databases, in order to answer the following research question: "What are the symptoms caused by COVID-19 in adults?" using the keywords "Symptoms", "Clinical Manifestations", "Coronavirus", "COVID-19". Results Of the total 105 references, 13 references that addressed the symptoms of COVID-19 were selected. Fever and normal or dry cough were symptoms present in all studies. Conclusion The symptoms identified in adult patients were fever, normal or dry cough, headache, pharyngalgia, dyspnea, diarrhea, myalgia, vomiting, sputum or expectoration, anxiety or chest pain, fatigue, nausea, anorexia, abdominal pain, rhinorrhea, runny nose or nasal congestion, dizziness, chills, systemic pain, mental confusion, hemoptysis, asthma, taste disorder, smell disorder, belching and tachycardia.


RESUMEN Objetivo Verificar en la literatura científica las manifestaciones sintomáticas de COVID-19 en adultos. Método Una revisión sistemática realizada en las bases de datos Scopus, Web of Science y PubMed con estudios publicados del 1 de diciembre de 2019 al 21 de abril de 2020, con el fin de responder a la pregunta orientadora: "¿Cuáles son las manifestaciones sintomáticas causada por COVID-19 en adultos?" utilizando las palabras clave: "Síntomas", "Manifestaciones clínicas", "Coronavirus", "COVID-19". Resultados Del total de 105 referencias, se seleccionaron 13 que abordaron las manifestaciones sintomáticas de COVID-19, con fiebre y tos normal o seca presente en todos los estudios. Conclusión Las manifestaciones sintomáticas identificadas en pacientes adultos fueron: fiebre, tos normal o seca, dolor de cabeza, faringalgia, disnea, diarrea, mialgia, vómitos, esputo o expectoración, angustia o dolor en el pecho, fatiga, náuseas, anorexia, dolor abdominal, rinorrea, secreción nasal o congestión nasal, mareos, escalofríos, dolor sistémico, confusión mental, hemoptisis, asma, alteración del gusto, alteración del olfato, eructos y taquicardia.


RESUMO Objetivo Verificar na literatura científica as manifestações sintomáticas da COVID-19 em pessoas adultas. Método Revisão sistemática utilizando as bases Scopus, Web of Science e PubMed com estudos publicados de 1 de dezembro de 2019 a 21 de abril de 2020, a fim de responder à questão norteadora: "Quais as manifestações sintomáticas causada pela COVID-19 em pessoas adultas?" utilizando-se as palavras-chave: "Symptoms", "Clinical Manifestations", "Coronavirus", "COVID-19". Resultados Do total de 105 referências, foram selecionadas 13 que abordaram as manifestações sintomáticas da COVID-19, estando a febre e a tosse normal ou seca presente em todos os estudos. Conclusão As manifestações sintomáticas identificadas nos pacientes adultos foram: febre, tosse normal ou seca, cefaleia, faringalgia, dispneia, diarreia, mialgia, vômito, escarro ou expectoração, angústia ou dor no peito, fadiga, náusea, anorexia, dor abdominal, rinorreia, coriza ou congestão nasal, tontura, calafrios, dor sistêmica, confusão mental, hemoptise, asma, comprometimento do paladar, comprometimento do olfato, arroto e taquicardia.


Subject(s)
Humans , Male , Female , Adult , General Symptoms , SARS-CoV-2 , COVID-19 , Asthma , Vomiting , Anorexia , Databases, Bibliographic , Cough , Ageusia , Diarrhea , Dizziness , Fatigue , Fever , Olfaction Disorders
9.
Psicol. ciênc. prof ; 40: 1-15, jan.-maio 2020. ilus
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1151008

ABSTRACT

Este artigo tem como objeto a pesquisa etiológica sobre a anorexia. Nesse sentido, expõe os resultados da pesquisa teórica em psicanálise conduzida em 2016, com recursos públicos para implementação de bolsa de iniciação científica. Por meio da análise e organização do levantamento conceitual sobre o tema no campo da psicopatologia clássica e da psicanálise, foi possível problematizar a validade da classe de transtorno alimentar, definida na quinta edição do Manual Diagnóstico e Estatístico de Transtornos Mentais (DSM-5) para elucidar o quadro sintomático da anorexia, e conduzir uma pesquisa etiológica, em psicanálise, sobre os determinantes psíquicos do desencadeamento da anorexia. A pesquisa interrogou a consistência do diagnóstico psicanalítico de psicose para alguns casos em que vigorariam características clínicas que, no DSM-5, induziriam ao diagnóstico de anorexia e formulou a hipótese de que o diagnóstico de psicose, tal como definido pela psicanálise, elucida a etiologia de determinados casos de anorexia em que vigora a recusa do alimento a serviço da cadaverização, da desvitalização e da rigidez identificatória à denominação sou anoréxica. A retomada do caso de Ellen West, paciente do psiquiatra suíço Ludwig Binswanger, cumpre neste artigo exatamente o papel de verificar a hipótese da pesquisa de que a recusa do alimento, a serviço da cadaverização e da desvitalização, pode ser tributária da psicose....(AU)


This paper is an etiological research on anorexia exposing the results of a psychoanalysis study conducted in 2016 with help of a scientific initiation scholarship. Analysis and organization of the conceptual survey on the subject allowed to question the validity of the class of Eating Disorder defined in the fifth edition of DSM-5 and to elucidate anorexia symptoms. We evaluated the psychic determinants that trigger anorexia and verified the consistency of diagnoses of psychosis for cases in which there would be clinical characteristics that, as per the DSM-5, would induce a diagnosis of anorexia. Psychosis was hypothesized to cause certain cases of anorexia where food refusal in favor of cadaverization, devitalisation and rigidity. The Ellen West case involving a patient of the Swiss psychiatrist Ludwig Binswanger served to confirm the hypothesis of this study....(AU)


El presente artículo tiene como objeto la investigación etiológica sobre la anorexia. Para ello, expone los resultados de la investigación teórica en psicoanálisis conducida en 2016 con recursos públicos para la implementación de una beca de iniciación científica. Por medio del análisis y organización del levantamiento conceptual sobre el tema en el campo de la psicopatología clásica y del psicoanálisis, fue posible problematizar la validez de la clase de trastorno alimenticio, definida en la quinta edición del Manual Diagnóstico y Estadístico de los Trastornos Mentales (DSM-5) para la elucidación del cuadro sintomático de la anorexia, y conducir una investigación etiológica en psicoanálisis sobre los determinantes psíquicos del desencadenamiento de la anorexia. La investigación interrogó la consistencia del diagnóstico psicoanalítico de psicosis para algunos casos en que pudieran aplicarse características clínicas que, en el DSM-5, inducirán al diagnóstico de anorexia, y formuló la hipótesis de que el diagnóstico de psicosis, tal como es definido por el psicoanálisis, elucida la etiología de determinados casos de anorexia en los cuales se rige el rechazo del alimento al servicio de la cadaverización, de la desvitalización y de la rigidez identificatoria a la denominación soy anoréxica. Este artículo reanuda el caso de Ellen West, paciente del psiquiatra suizo Ludwig Binswanger, para verificar exactamente la hipótesis de que la negativa del alimento, al servicio de la cadaverización y de la desvitalización, puede ser tributaria de la psicosis....(AU)


Subject(s)
Patients , Psychoanalysis , Psychotic Disorders , Anorexia , Feeding and Eating Disorders , Diagnostic and Statistical Manual of Mental Disorders , Diagnosis , Fellowships and Scholarships , Food , Psychopathology
10.
Arq. bras. med. vet. zootec. (Online) ; 72(2): 312-316, Mar./Apr. 2020. ilus
Article in English | LILACS, VETINDEX | ID: biblio-1128168

ABSTRACT

Cercopithifilaria bainae is a nematode belonging to the family Onchocercidae that parasitizes the subcutaneous tissue of dogs. Its transmission occurs through the tick Rhipicephalus sanguineus and its geographical distribution overlaps that of this vector. The present study reports the detection of microfilaremia by C. bainae in an eight-year-old male dog that presented anorexia, hyperthermia, motor incoordination, mydriasis, a nodule in the left testicle and concomitant infection by Ehrlichia sp. Blood samples were analyzed using microscopy, PCR and DNA sequencing. Microfilariae measuring 150±5.5µm in length and 7±1.8µm in width were retrieved. The DNA sequence exhibited 98% identity with C. bainae sequences available in Genbank. This is the first report of microfilaremia by C. bainae in a dog in the central western region of Brazil.(AU)


Cercopithifilaria bainae é um nematoide pertencente à família Onchocercidae, que parasita o tecido subcutâneo de cães. Sua transmissão ocorre pelo carrapato Rhipicephalus sanguineus, e sua distribuição geográfica se sobrepõe ao espalhamento desse vetor. O presente estudo relata a detecção de microfilaremia por C. bainae em um cão macho de oito anos que apresentava anorexia, hipertermia, incoordenação motora, midríase e nódulo no testículo esquerdo e infecção concomitante por Ehrlichia sp. A coleta de sangue foi realizada, e o material analisado por meio dos exames de microscopia, PCR e sequenciamento de DNA. Microfilárias medindo 150±5,5µm de comprimento e 7±1,8µm de largura foram recuperadas. A sequência de DNA obtida mostrou 98% de identidade com sequências de C. bainae disponíveis no Genbank. Este é o primeiro relato de microfilaremia de C. bainae em um cão na região Centro-Oeste do Brasil.(AU)


Subject(s)
Animals , Male , Dogs , Onchocerca , Subcutaneous Tissue/parasitology , Microfilariae , Nematoda , Brazil , Base Sequence , Anorexia , Polymerase Chain Reaction , Sequence Analysis, DNA , Disease Transmission, Infectious
11.
Rev. chil. neuro-psiquiatr ; 58(1): 16-28, mar. 2020. tab, ilus
Article in Spanish | LILACS | ID: biblio-1115467

ABSTRACT

Resumen Introducción: los trastornos alimentarios (anorexia y bulimia) han aumentado en todo el mundo y en todo el país. Antes del desarrollo de este trastorno, la actual insatisfacción corporal de los adolescentes, cuyo estudio a través del "Modelo de influencia tripartita" nos da tres presiones principales: la presión de los padres, los medios y los compañeros. Factores que se estudian a través de SATAQ-4. Realizamos un estudio para validar la versión peruana de SATAQ-4 "Actitudes socioculturales hacia el cuestionario de apariencia-4". Métodos: se realizó un estudio transversal en 2015. Se comenzó adaptando culturalmente la prueba. Posteriormente, la validez se determinó a través de la validez del constructo y la confiabilidad a través de la evaluación de consistencia interna y la confiabilidad intraobservador (prueba- volver a probar). Resultados: Obtuvimos un instrumento adaptado culturalmente que presentó una media mayor que 3 en el método Delphi, una correlación intraclase igual a 0,83 y una consistencia interna (alfa de Cronbach) de 0,90. El análisis factorial confirmatorio apoyó la estructura original de cinco factores y el análisis de validez convergente (r Pearson) cuando se comparó con BSQ una correlación de 0,70. Conclusiones: El instrumento mide adecuadamente el constructo para el cual fue creado y puede aplicarse en el entorno universitario peruano.


Introduction: Eating disorders (anorexia and bulimia) have been increasing worldwide and nationally. Prior to the development of this disorder, adolescents' present body dissatisfaction, whose study through the "Tripartite Influence Model" gives us three main pressures: Pressure from parents, media and peers. Factors that are studied through SATAQ-4. We conduct a study to validate the Peruvian version of SATAQ-4 "Sociocultural Attitudes Toward Appearance Questionnaire-4". Methods: A cross-sectional study was carried out in 2015. It was started by culturally adapting the test. Subsequently, validity was determined through the validity of the construct, and reliability through internal consistency assessment and intra-observer reliability (test-retest). Results: We obtained a culturally adapted instrument which presented a mean greater than 3 in the Delphi method, an intraclass correlation equal to 0.83 and an internal consistency (Cronbach alpha) of 0.90. The confirmatory factor analysis supported the original five-factor structure and the convergent validity analysis (r Pearson) when compared with BSQ a correlation of 0.70. Conclusions: The instrument adequately measures the construct for which it was created and can be applied in the Peruvian university environment.


Subject(s)
Humans , Male , Female , Weights and Measures , Attitude , Anorexia , Bulimia , Feeding and Eating Disorders , Surveys and Questionnaires , Peru , Universities , Cross-Sectional Studies
12.
J. bras. pneumol ; 46(4): e20190420, 2020. tab, graf
Article in English | LILACS | ID: biblio-1134882

ABSTRACT

ABSTRACT Objective: To evaluate the prevalence of anorexia and weight loss at diagnosis (pre-treatment), to identify the factors associated with pre-treatment weight loss, and to determine the prognostic role of anorexia and weight loss in the overall survival of patients with stage IV lung cancer. Methods: This was a retrospective observational cohort study. The patients were stratified by the presence/absence of anorexia and of pre-treatment weight loss, which generated a measure composed of four categories, which were the independent variables. Results: Among the 552 patients included in the study, anorexia and pre-treatment weight loss were present in 39.1% and 70.1%, respectively. After adjusting for age, male gender, and Karnofsky performance status, we found that anorexia and tumor size were significantly associated with pre-treatment weight loss. In a Cox multivariate analysis, adjusted for age, male gender and low Karnofsky performance status were found to be independent predictors of worse survival, as was concomitance of anorexia and weight loss. Conclusions: Anorexia and pre-treatment weight loss appear to be relevant problems in the follow-up of patients with advanced (stage IV) lung cancer Specific interventions are of crucial importance in individualized treatment plans, even within the context of palliative care.


RESUMO Objetivo: Avaliar a prevalência de anorexia e perda de peso ao diagnóstico (pré-tratamento), os fatores associados à perda de peso pré-tratamento e o papel prognóstico da anorexia e da perda de peso na sobrevida global de pacientes com câncer de pulmão em estádio IV. Métodos: Estudo de coorte retrospectivo observacional. Os pacientes foram estratificados, dependendo da presença/ausência de anorexia e da presença/ausência de perda de peso pré-tratamento, o que gerou uma medida composta de anorexia e perda de peso de quatro níveis, que foi a variável independente. Resultados: Entre os 552 pacientes incluídos no estudo, as prevalências de anorexia e de perda de peso pré-tratamento foram de 39,1% e 70,1%, respectivamente. Após ajustar para idade, sexo masculino e índice de Karnofsky, a presença de anorexia e o tamanho do tumor foram significativamente associados à perda de peso pré-tratamento. Na análise multivariada de Cox, após ajustar para a idade, as variáveis sexo masculino, presença concomitante de anorexia e perda de peso e índice de Karnofsky reduzido foram preditores independentes de pior probabilidade de sobrevida. Conclusões: O presente estudo demonstrou que a presença de anorexia e de perda de peso pré-tratamento são problemas relevantes no seguimento de pacientes com câncer de pulmão avançado (estádio IV). Intervenções específicas são de crucial importância no plano de assistência individualizada, mesmo dentro da proposta de cuidados paliativos.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Weight Loss , Anorexia/epidemiology , Lung Neoplasms/mortality , Prognosis , Cachexia/diagnosis , Cachexia/etiology , Cachexia/mortality , Anorexia/etiology , Prevalence , Survival Rate , Retrospective Studies , Cohort Studies , Karnofsky Performance Status , Lung Neoplasms
13.
Rev. cienc. cuidad ; 17(2): 102-115, 2020.
Article in Spanish | LILACS, BDENF, COLNAL | ID: biblio-1122404

ABSTRACT

Introducción: La anorexia nerviosa es un trastorno de la conducta alimentaria que afecta al individuo fisiológica y psicológicamente. El profesional de enfermería y equipo multidisciplinar debe promocionar, prevenir y rehabilitar para modificar estas conductas y reducir su progresión. Metodología: Revisión integrativa de la literatura. Palabras clave utilizadas Atención de Enfermería, Jóvenes, Anorexia, Conducta alimentaria trastorno de la Ingesta Alimentaria Evitativa/Restrictiva, Tratamiento multimodal y Habilidades de afrontamiento. Se incluyeron artículos en español, inglés y portugués de cualquier nacionalidad y diseño metodológico publicados entre 2014 y 2019 indexados en bases de datos ClinicalKey, Scielo, CINAHL y metabuscador Google académico. Se filtraron por lectura de título, resumen y texto completo, se clasificaron según el nivel de evidencia y grado de recomendación; finalmente se ejecutó lectura crítica mediante las escalas Amstar, Consort y Strobe.. Resultados: Se incluyeron 34 artículos y se construyeron cuatro temáticas: cuidados de enfermería que modifican la conducta alimentaria, factores que influyen en el cambio de la conducta alimentaria, impacto de los cuidados de enfermería y consecuencias de la no aplicación de los cuidados de enfermería. Conclusión: Las intervenciones de enfermería son fundamentales para la recuperación de los adolescentes en etapa inicial de anorexia ya que reducen la progresión de la enfermedad y favorece la expresión de sentimientos.


Introduction: Anorexia nervosa is an eating disorder that affects the individual physiologically and psychologically. The nursing professional, along with a multidisciplinary team must promote, prevent and rehabilitate the individual, to modify these behaviors and reduce its progression. Methodology: Integrative review of the literature. Keywords used: nursing care, young people, anorexia, eating behavior, avoidant/restrictive food intake disorders, multimodal treatment and methodological design. Articles in English, Spanish and Portuguese were included, from any nationality and methodological design. The articles selected were published between 2014 and 2019 and were indexed to the databases ClinicalKey, Scielo, CINAHL, and Google Scholar. These were filtered by reading the title, abstract and complete text; and were classified according to their level of evidence and grades of recommendation. Finally, a critical reading was made using the tools, AMSTAR, CONSORT and STROBE. Results: 34 articles were included, and four themes were built: nursing care to modify eating habits, factors that include change in eating behaviors, nursing care impact and consequences of not applying nursing care. Conclusion: The nursing interventions are fundamental for the recovery of adolescents in the first stage of anorexia since these reduce the progression of the disease and support expressing their feelings.


Introdução: A anorexia nervosa é um transtorno do comportamento alimentar que afeta ao sujeito fisiologica e psicologicamente. O profissional de enfermagem junto com a equipe multiprofissional deve promover, prever e reabilitar para mudar essas condutas e reduzir o progresso. Métodos: Revisão integrativa da literatura. Palavras-chave empregadas: cuidados de enfermagem, adolescente, anorexia, comportamento alimentar, transtorno da evitação ou restrição da ingestão de alimentos, terapia combinada, adaptação psicológica. Incluíram-se artigos publicados em espanhol, inglês e português com qualquer nacionalidade ou metodologia. Foram selecionadas as publicações entre 2014-2019 disponíveis na ClinicalKey, Scielo, CINAHL e no Google Scholar. Foram filtrados pela leitura do título, o resumo e o texto completo; classificaram-se segundo o nível de evidência e o grau de recomendação. Finalmente, efetivou-se uma leitura crítica empregando as escalas Amstar, Consort e Strobe. Resultados: Incluíram-se 34 artigos e construíram-se quatro temas: cuidados de enfermagem que mudam os comportamentos alimentares; fatores que influenciam a mudança de comportamento alimentar; impacto nos cuidados de enfermagem; e, consequências da ausência de cuidados de enfermagem. Conclusão: As intervenções de enfermagem são fundamentais para a recuperação dos adolescentes na etapa inicial da anorexia, devido à redução do progresso do transtorno, além de favorecer a expressão dos seus sentimentos.


Subject(s)
Feeding Behavior , Avoidant Restrictive Food Intake Disorder , Anorexia , Adolescent , Nursing Care
14.
Rev. Pesqui. (Univ. Fed. Estado Rio J., Online) ; 12: 737-743, jan.-dez. 2020. ilus
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1102738

ABSTRACT

Objetivo: Identificar as evidências científicas acerca das condutas para o manejo da anorexia em cuidados paliativos. Métodos: Trata-se de uma revisão integrativa, cujo levantamento bibliográfico dos dados deu-se através da pesquisa em quatro bases de dados/bibliotecas virtuais. Incluíram-se artigos em português, inglês e espanhol, publicados nos últimos dez anos e com o texto completo disponível. Resultados: Foram elegíveis 25 artigos, e foram atribuídos dois eixos temáticos para melhor ilustrar os dados encontrados: o manejo farmacológico e o não-farmacológico. Corticosteroides, progestinas, anamorelina e dronabinol foram os fármacos mais pesquisados para o controle da anorexia, com maiores evidências de eficácia nos 3 primeiros. No contexto não-farmacológico, o aconselhamento nutricional foi a medida mais indicada, incluindo a fortificação de alimentos e uso de suplementos e a nutrição artificial mais controversa. Conclusão: Os achados desta revisão podem colaborar para a elaboração de protocolos para o manejo da anorexia em cuidados paliativos


Objective: The study's main goal has been to identify scientific evidence on the management of anorexia in palliative care. Methods: This is an integrative review, whose data collection occurred by researching four databases/virtual libraries. Articles in Portuguese, English, and Spanish, published over the last ten years and with the full text available, were included. Results: 25 articles were selected, and two thematic axes were assigned to better illustrate the data found: pharmacological and non-pharmacological management. Corticosteroids, progestins, anamorelin, and dronabinol were the most-researched drugs for the control of anorexia, with greater evidence of effectiveness for the first three. In the non-pharmacological treatment, nutritional counseling was the most recommended measure, including the fortification of foods and the use of supplements and the more-controversial artificial nutrition. Conclusion: The findings of this review may aid in the development of protocols for the treatment of anorexia in palliative care


Objetivo: El propósito principal del estudio ha sido identificar evidencia científica sobre el manejo de la anorexia en los cuidados paliativos. Métodos: Esta es una revisión integradora, cuya investigación bibliográfica de datos ocurrió mediante búsqueda en cuatro bases de datos/bibliotecas virtuales. Se incluyeron artículos en portugués, inglés y español, publicados en los últimos diez años y con texto completo disponible. Resultados: Fueron elegibles 25 artículos, siendo atribuidos dos ejes temáticos para ilustrar mejor los datos encontrados: el manejo farmacológico y el no farmacológico. Corticosteroides, progestinas, anamorelina y dronabinol han sido los fármacos más buscados para el control de la anorexia, con mayores evidencias de eficacia en los 3 primeros. En el contexto no farmacológico, el asesoramiento nutricional fue la medida más indicada, incluyendo la fortificación de alimentos y uso de suplementos y la nutrición artificial más controversia. Conclusión: Los hallados de esta revisión pueden colaborar para la elaboración de protocolos para el manejo de la anorexia en cuidados paliativos


Subject(s)
Humans , Male , Female , Palliative Care , Anorexia/drug therapy , Diet Therapy
15.
Rev. colomb. gastroenterol ; 34(4): 445-449, oct.-dic. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1092975

ABSTRACT

Resumen El síndrome de Bouveret (SB) es una patología poco frecuente, la cual se caracteriza por la presencia de obstrucción gástrica o duodenal secundaria a un cálculo enclavado en la luz duodenal, el cual migra a través de una fístula colecistoduodenal. Su incidencia es de alrededor 1% al 3% de todos los casos de íleo biliar. Los principales síntomas consisten en vómito, dolor abdominal, hematemesis, pérdida de peso y anorexia. En el 91% de los casos se requiere manejo quirúrgico. En este artículo se presenta un caso de un paciente de 50 años, con cuadro clínico de 2 meses de evolución de dolor abdominal en epigastrio y mesogastrio, distensión abdominal y múltiples episodios de emesis. Al examen físico con clínica de obstrucción intestinal se realizó tomografía abdominal, donde se evidenció obstrucción intestinal por imagen intraluminal en primera porción duodenal asociada con tríada de Rigler, con diagnóstico de síndrome de Bouveret.


Abstract Bouveret syndrome is a rare pathology which is characterized by gastric or duodenal obstruction secondary to a gallstone embedded in the lumen after migrating through a cholecystoduodenal fistula. Its incidence is approximately 1% to 3% of all cases of biliary ileus. The main symptoms consist of vomiting, abdominal pain, hematemesis, weight loss and anorexia. Surgery is required in 91% of cases. This article presents the case of a 50-year-old patient who had suffered from abdominal pain in the epigastrium and mesogastrium, abdominal distension and multiple episodes of emesis for two months. Physical examination indicated obstruction of the intestine. An abdominal CT scan showed that the obstruction was in the first duodenal portion and that Rigler's triad was present. It was diagnosed as Bouveret Syndrome.


Subject(s)
Humans , Female , Middle Aged , Syndrome , Duodenal Obstruction , Intestinal Obstruction , Vomiting , Weight Loss , Anorexia , Abdominal Pain , Intestinal Fistula , Fistula
16.
Natural Product Sciences ; : 255-260, 2019.
Article in English | WPRIM | ID: wpr-760563

ABSTRACT

Piper nigrum L. (Piperaceae), which is a well-known food seasoning, has been used as a traditional medicine for the treatment of vomiting, abdominal pain, diarrhea and anorexia in Korea, China and Japan. Methanol extract from the fruit of P. nigrum was successively partitioned as n-hexane, methylene chloride, ethyl acetate, n-butanol and H₂O soluble fractions. Among those fractions the ethyl acetate soluble fraction showed the most potent DPPH radical scavenging activity, and piperine was isolated from the ethyl acetate fraction. To know the antioxidant activity of piperine, we tested the activities of superoxide dismutase (SOD) and catalase together with oxidative stress tolerance and intracellular ROS level in Caenorhabditis elegans. To investigate whether piperine-mediated increased stress tolerance was due to regulation of stress-response gene, we quantified SOD-3 expression using transgenic strain including CF1553. Consequently, piperine enhanced SOD and catalase activities of C. elegans, and reduced intracellular ROS accumulation in a dose–dependent manner. Moreover, piperine-treated CF1553 worms exhibited significantly higher SOD-3::GFP intensity.


Subject(s)
1-Butanol , Abdominal Pain , Anorexia , Caenorhabditis elegans , Caenorhabditis , Catalase , China , Diarrhea , Fruit , Japan , Korea , Medicine, Traditional , Methanol , Methylene Chloride , Oxidative Stress , Piper nigrum , Piper , Seasons , Superoxide Dismutase , Vomiting
17.
Article in English | WPRIM | ID: wpr-760233

ABSTRACT

BACKGROUND: Attention deficit-hyperactivity disorder (ADHD) is one of the most common chronic behavioral disorders in school-aged children. PURPOSE: This study aimed to evaluate the effect of omega-3 supplementation as an alternative therapy for ADHD, which can be caused by vitamin and mineral deficiencies. METHODS: This was a double-blinded clinical trial study. Sixty-six children with ADHD (aged 6–12 years) referred to our child and adolescent psychiatric educational and therapeutic clinic were selected based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. Instruments including the Parent ADHD Rating Scale were used to assess ADHD at 0, 2, 4, and 8 weeks during the study. RESULTS: The results showed no statistically significant difference between the methylphenidate with omega-3 group and methylphenidate with placebo group based on the Parents ADHD Rating Scale between week 0 (P≥0.96) and week 8 (P≥0.75). There were no significant intergroup differences between the Inattention (P≥0.48) and hyperactivity/impulsivity (P≥0.80) subscale scores on the Parents ADHD Rating Scale. The most common drug complications in the methylphenidate with placebo and methylphenidate with omega-3 groups were anorexia (27 [54%] vs. 41 [60.29%], respectively) and diarrhea (10 [20%] vs. 8 [11.76%], respectively), but the differences were not statistically significant (P>0.05). CONCLUSION: Our results demonstrate that a specific dose of omega-3 for 8 weeks had no effect on ADHD.


Subject(s)
Adolescent , Anorexia , Attention Deficit Disorder with Hyperactivity , Child , Diagnostic and Statistical Manual of Mental Disorders , Diarrhea , Humans , Methylphenidate , Miners , Parents , Vitamins
18.
Journal of Bone Metabolism ; : 133-143, 2019.
Article in English | WPRIM | ID: wpr-764257

ABSTRACT

Anorexia nervosa (AN) affects 2.9 million people, many of whom experience bone loss and increased fracture risk. In this article, we review data on the underlying pathophysiology of AN-related osteoporosis and possible approaches to disease management. Available research suggests that low body weight and decreased gonadal function are the strongest predictors of bone loss and fractures in patients with AN. Additionally, other metabolic disturbances have been linked to bone loss, including growth hormone resistance, low leptin concentrations, and hypercortisolemia, but those correlations are less consistent and lack evidence of causality. In terms of treatment of AN-related bone disease, weight gain has the most robust impact on bone mineral density (BMD). Restoration of gonadal function seems to augment this effect and may independently improve BMD. Bisphosphonates, insulin-like growth factor 1 supplementation, and teriparatide may also be reasonable considerations, however need long-term efficacy and safety data.


Subject(s)
Anorexia Nervosa , Anorexia , Body Weight , Bone Density , Bone Diseases , Diphosphonates , Disease Management , Feeding and Eating Disorders , Gonads , Growth Hormone , Humans , Leptin , Osteoporosis , Teriparatide , Weight Gain
19.
Article in English | WPRIM | ID: wpr-763115

ABSTRACT

PURPOSE: Dose-dense chemotherapy (DD-CT) is a preferred (neo)adjuvant regimen in early breast cancer (BC). Although the results of reported randomized trials are conflicting, a recent meta-analysis showed improved overall and disease-free survival with DD-CT compared to conventional schedules. However, no DD-CT safety data for Korean BC patients are available. This phase II study was conducted to evaluate the safety and efficacy of pegteograstim in Korean BC patients receiving DD-CT. MATERIALS AND METHODS: Patients with operable (stage I-III), histologically confirmed BC received four cycles of intravenous doxorubicin (60 mg/m2) and cyclophosphamide (600 mg/m2) on day 1 every 2 weeks as neoadjuvant or adjuvant therapy. Pegteograstim (6.0 mg) was administered subcutaneously on day 2 of each cycle. The primary endpoint was the incidence of febrile neutropenia (FN). The secondary endpoints were safety and tolerability. RESULTS: Of 63 patients, one (1.6%) developed FN during all cycles of DD-CT. Dose delay was observed in four patients (6.3%) and dose reduction in two (3.2%) during DD-CT. Frequent adverse events (AEs) were nausea, alopecia, generalized muscle weakness, myalgia, mucositis, anorexia, dyspepsia, and diarrhea; most AEs were related to chemotherapy. Grade 3-4 AEs were reported in five of 63 patients (7.9%), and all grade 3 and 4 AEs were related to chemotherapy. Adverse drug reactions possibly linked to pegteograstim were abdominal pain, bone pain, myalgia, generalized muscle weakness, and headache in five of 63 patients (7.9%). CONCLUSION: Dose-dense AC (doxorubicin/cyclophosphamide) chemotherapywith pegteograstim support is a tolerable and safe regimen in Korean early BC patients.


Subject(s)
Abdominal Pain , Alopecia , Anorexia , Appointments and Schedules , Breast Neoplasms , Breast , Cyclophosphamide , Diarrhea , Disease-Free Survival , Doxorubicin , Drug Therapy , Drug-Related Side Effects and Adverse Reactions , Dyspepsia , Febrile Neutropenia , Headache , Humans , Incidence , Mucositis , Muscle Weakness , Myalgia , Nausea
20.
Article in English | WPRIM | ID: wpr-761738

ABSTRACT

A clonorchiasis case in a captive leopard cat, Prionailurus bengalensis euptilurus, was confirmed by ultrasonographic findings and egg morphologies found in the bile juice sample in the Korea. The leopard cat was introduced from the wild habitat of Gyeongsangnam-do, to Cheongju Zoo in Cheongju-si, Chungcheongbuk-do, Korea in August 2014. Physical examinations were basically performed for quarantine and check-up health. The cat was comparatively good in health except anorexia. The cyst-like bile duct dilation and the increased echogenicity of gall bladder wall and hepatic parenchyma were observed by ultrasonography. Ultrasound-guided needle biopsy was conducted for collecting bile juice and the specimens were observed under light microscope. The numerous small trematode eggs were detected in the bile juice sample of the light microscopy. The eggs were 25–33 (28±3) μm by 18–22 (20±1) μm in size and showed typical characteristics of Clonorchis sinensis egg, i.e., a dominantly developed operculum, shoulder rim and dust-like wrinkles in surface. To treat the liver fluke infection, 20 mg/kg of praziquantel was orally administered only once to the case. Follow-up studies including fecal examinations were conducted during 2 years after treatment. But no more eggs were detected from the case. In the present study, we described the first clonorchiasis case of leopard cat, which was confirmed by ultrasonographic findings and egg morphologies from the bile juice sample in Korea.


Subject(s)
Animals , Anorexia , Bile , Bile Ducts , Biopsy, Needle , Cats , Clonorchiasis , Clonorchis sinensis , Ecosystem , Eggs , Fasciola hepatica , Follow-Up Studies , Korea , Microscopy , Ovum , Panthera , Physical Examination , Praziquantel , Quarantine , Republic of Korea , Shoulder , Ultrasonography , Urinary Bladder
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