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1.
Rev. bras. med. esporte ; 27(4): 414-418, Aug. 2021. tab, graf
Article in English | LILACS | ID: biblio-1288594

ABSTRACT

ABSTRACT Introduction: The Functional Movement Test (FMS) is an evaluation method for the basic movement patterns of the human body that is designed by Gray Cook. Objective: This paper explores the application value of functional action test (FMS) biological image data in the risk assessment of sports injuries of Chinese rugby players. Methods: Taking the active national football team and provincial football players as the object, the standard FMS test is used to collect the data to determine the best deadline for the total FMS score. Results: The area under the ROC curve (AUC) of the overall athletes, men and women was significantly different from the assumption of AUC=0.5, which were 0.780 (P=0.000), 0.877 (P=0.001), 0.7130 (P=0.013); The best cutoff points corresponding to the total score of FMS are 13.5 points, 15.5 points, and 13.5 points, respectively. The chi-square test showed that the prevalence of the positive group (the total FMS score was less than the corresponding cutoff point) was significantly higher than the negative group (the total FMS score was greater than the corresponding cutoff point) (P<0.01). The OR values of the total athlete, male and female FMS total score positive groups were 25.85 (95%CI: 3.34∼200.23), 25.00 (95%CI: 2.36∼264.80), 14.22 (95%CI: 1.76∼114.92). Conclusions: Among Chinese rugby players, the total score of FMS has a strong correlation with non-contact sports injuries. The score is 13.5 for women and 15.5 for men. Level of evidence II; Therapeutic studies - investigation of treatment results.


RESUMO Introdução: O Teste de Movimento Funcional (FMS) é um método de avaliação dos padrões básicos de movimento do corpo humano, projetado por Gray Cook. Objetivo: Este artigo explora o valor da aplicação de dados de imagem biológica do teste de ação funcional (FMS) na avaliação do risco de lesões esportivas em jogadores de rúgbi chineses. Métodos: visando a seleção nacional de futebol e jogadores de futebol da província, o teste FMS padrão foi usado para coletar os dados e determinar o melhor limite para o escore total do FMS. Resultados: A área sob a curva ROC (AUC) dos atletas em geral, homens e mulheres, foi significativamente diferente da suposição de AUC = 0,5, que foi 0,780 (P = 0,000), 0,877 (P = 0,001), 0,7130 (P = 0,013); Os melhores pontos de corte para o escore total da FMS são 13,5 pontos, 15,5 pontos e 13,5 pontos, respectivamente. O teste do qui-quadrado mostrou que a prevalência do grupo positivo (a pontuação total da FMS foi menor do que o ponto de corte correspondente) foi significativamente maior do que a do grupo negativo (a pontuação total da FMS foi maior do que o ponto de corte correspondente) (P <0,01). Os valores de OR do total de atletas, homens e mulheres, grupos positivos de pontuação total de FMS foram 25,85 (IC 95%: 3,34 ∼ 200,23), 25,00 (IC 95%: 2,36 ∼ 264,80), 14,22 (IC 95%: 1,76 ∼ 114,92). Conclusões: Entre os jogadores de rúgbi chineses, a pontuação total da FMS tem uma forte correlação com lesões esportivas sem contato. A pontuação é de 13,5 para mulheres e 15,5 para homens. Nível de evidência II; Estudos terapêuticos- investigação dos resultados do tratamento.


RESUMEN Introducción: La prueba de movimiento funcional (FMS) es un método de evaluación de los patrones de movimiento básicos del cuerpo humano diseñado por Gray Cook. Objetivo: Este artículo explora el valor de la aplicación de los datos de imágenes biológicas de la prueba de acción funcional (FMS) en la evaluación del riesgo de lesiones deportivas de los jugadores de rugby chinos. Métodos: Tomando como objeto el equipo nacional de fútbol y los jugadores de fútbol provinciales, se utilizó la prueba estándar de FMS para recopilar los datos y determinar el mejor límite para la puntuación total de FMS. Resultados: El área bajo la curva ROC (AUC) de los atletas en general, hombres y mujeres fue significativamente diferente del supuesto de AUC = 0.5, que fue 0.780 (P = 0.000), 0.877 (P = 0.001), 0.7130 (P = 0,013); Los mejores puntos de corte correspondientes a la puntuación total de FMS son 13,5 puntos, 15,5 puntos y 13,5 puntos, respectivamente. La prueba de chi-cuadrado mostró que la prevalencia del grupo positivo (la puntuación total de FMS fue menor que el punto de corte correspondiente) fue significativamente más alta que la del grupo negativo (la puntuación total de FMS fue mayor que el punto de corte correspondiente) (P <0.01). Los valores de OR del total de atletas, hombres y mujeres, grupos positivos de puntuación total de FMS fueron 25,85 (95% CI: 3,34 ∼ 200,23), 25,00 (95% CI: 2,36 ∼ 264,80), 14,22 (95% CI: 1,76 ∼ 114,92). Conclusiones: Entre los jugadores de rugby chinos, la puntuación total de FMS tiene una fuerte correlación con las lesiones de deportes sin contacto. La puntuación es de 13,5 para las mujeres y 15,5 para los hombres. Nivel de evidencia II; Estudios terapéuticos-investigación de los resultados del tratamiento.


Subject(s)
Humans , Male , Female , Athletic Injuries/prevention & control , Athletic Injuries/diagnostic imaging , Football , ROC Curve , Risk Assessment , Asian Continental Ancestry Group , Exercise Test , Models, Theoretical , Movement
2.
Article in Chinese | WPRIM | ID: wpr-880830

ABSTRACT

OBJECTIVE@#To explore the association between rare HSPB1 variants and amyotrophic lateral sclerosis (ALS).@*METHODS@#We performed next-generation sequencing for 166 Chinese ALS patients to screen for possible pathogenic rare variants of HSPB1. The control individuals were obtained from 1000 Genome Project and an in-house whole-exome sequencing database. The Sequence Kernel Association Test (SKAT) and the SKAT-optimal test (SKAT-O) were used to identify the association between rare HSPB1 variants and ALS.@*RESULTS@#We identified 3 possible pathogenic rare variants of HSPB1 (all were missenses), including c.379C>T (p.R127W), c.446A>C (p.D149A) and c.451A>C (p.T151P). Compared with 1000 Genome Project, SKAT p=3.61×10@*CONCLUSIONS@#Rare variants of HSPB1 are probably associated with the pathogenesis of ALS.


Subject(s)
Amyotrophic Lateral Sclerosis/genetics , Asian Continental Ancestry Group , Heat-Shock Proteins , Heterozygote , High-Throughput Nucleotide Sequencing , Humans , Molecular Chaperones , Phenotype
3.
Article in English | WPRIM | ID: wpr-880666

ABSTRACT

OBJECTIVES@#Due to the genetic feature of high diversity than other DNA markers, short tandem repeat (STR) plays key roles in forensic, anthropology, and population genetics. Newly introduced multiple STR kit is more valuable because of the greatly improved discriminatory power with the increase in the number of STR loci. The genetic polymorphic data are essential for the application and research in specific population. This study aims to investigate the genetic polymorphism of Han population residing in Yuncheng district, Shanxi Province, to evaluate the application of 23 STR loci in forensic personal identification and paternity test, and to explore the genetic relationship of Han population between Yuncheng and other populations.@*METHODS@#A total of 23 STR loci were amplified from 525 healthy unrelated individuals from the Han nationality in Yuncheng, Shanxi Province using the AGCU EX25 amplification kit. The products were detected and separated by ABI 3500 Genetic Analyzer. Alleles were genotyped by GeneMapper ID (Version 3.2) software, and corresponding frequencies and forensic parameters were calculated. We calculated the genetic distance and plotted the neighboring-joining tree with other 13 population.@*RESULTS@#The allele frequency of the 23 STRs ranged from 0.0010 to 0.5090. No deviation from Hardy-Weinberg equilibrium (@*CONCLUSIONS@#These 23 STRs are highly genetic polymorphic and informative in the Han population of Yuncheng, Shanxi Province, which can provide basic data for forensic personal identification, paternity testing, and population genetic research.


Subject(s)
Asian Continental Ancestry Group/genetics , China , Ethnic Groups/genetics , Gene Frequency , Genetic Loci , Genetics, Population , Humans , Microsatellite Repeats/genetics , Polymorphism, Genetic
4.
Article in Chinese | WPRIM | ID: wpr-879614

ABSTRACT

OBJECTIVE@#To investigate the genetic polymorphisms of 21 non-combined DNA index system short tandem repeat (STR) loci in Hainan Li population.@*METHODS@#DNA samples from 339 unrelated healthy individuals of Li population from Hainan Province were extracted and amplified with fluorescence labeled multiplex PCR system. PCR products were electrophoresed on an ABI3130 Genetic Analyzer following the manufacturer's instructions. Allele designation was performed with a GeneMapper ID-X by comparison with the allele ladder provided by the corresponding kit.@*RESULTS@#A total of 173 alleles and 489 genotypes were observed for the 21 STR loci, respectively. The frequencies of alleles and genotypes were 0.0010-0.5434 and 0.0020-0.3274, respectively. The heterozygosity varied from 0.639 to 0.833. Discrimination power (DP) was 0.803-0.948, power of exclusion for trio-paternity was 0.416-0.584, power of exclusion for duo-paternity was 0.140-0.238, the polymorphism information content(PIC) was 0.57-0.81, respectively. The total discrimination power (TDP), cumulative probability of exclusion for trio-paternity testing(CPE-trio) and cumulative probability of exclusion for duo-paternity testing (CPE-duo) were 0.999 999 999 999 99, 0.999 999 883 211 752, and 0.987 266, respectively.@*CONCLUSION@#The 21 STR loci are highly polymorphic and informative in the studied population and can be employed as supplementary loci in duo-paternity testing or cases with variant circumstances.


Subject(s)
Asian Continental Ancestry Group/genetics , China , DNA , Gene Frequency , Genetics, Population , Humans , Microsatellite Repeats/genetics , Polymorphism, Genetic
5.
Article in Chinese | WPRIM | ID: wpr-879560

ABSTRACT

OBJECTIVE@#To explore the clinical characteristics and genetic basis for a pair of twins affected with hyaline fibromatosis syndrome (HFS).@*METHODS@#Clinical data of the twins were retrospectively analyzed. High-throughput sequencing was carried out to detect potential pathogenic variants. CLUSTALX was employed to analyze cross-species conservation of the mutant amino acids. Impact of the mutations was predicted by using software including PolyPhen-2 and Mutation taster.@*RESULTS@#The pair of twins have featured growth and intelligence retardation, and were found to carry compound heterozygous variants of the ANTXR2 gene including c.1214G>A and c.1074delT, among which c.1214G>A was unreported previously. Both variants were predicted to be pathogenic. In addition to growth and mental delay, the pair of twins also featured hyperplasia of the gum and soft tissue-like masses of the auricle. The younger brother had rupture of the auricle mass during follow-up.@*CONCLUSION@#The patients' condition can probably be attributed to the compound heterozygous variants of the ANTXR2 gene. Above finding has facilitated molecular diagnosis of the patients.


Subject(s)
Asian Continental Ancestry Group/genetics , China , Humans , Hyalinosis, Systemic/genetics , Male , Mutation , Pedigree , Receptors, Peptide/genetics , Retrospective Studies
6.
Article in English | WPRIM | ID: wpr-878316

ABSTRACT

Objective@#The relationship between serum uric acid (SUA) levels and glycemic indices, including plasma glucose (FPG), 2-hour postload glucose (2h-PG), and glycated hemoglobin (HbA1c), remains inconclusive. We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.@*Methods@#The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study. A total of 105,922 community-dwelling adults aged ≥ 40 years underwent the oral glucose tolerance test and uric acid assessment. The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.@*Results@#A total of 30,941 men and 62,361 women were eligible for the current analysis. Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels, but with different inflection points in men and women. The thresholds for FPG, 2h-PG, and HbA1c for men and women were 6.5/8.0 mmol/L, 11.0/14.0 mmol/L, and 6.1/6.5, respectively (SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).@*Conclusion@#An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes, while the inflection points were reached earlier in men than in women.


Subject(s)
Aged , Asian Continental Ancestry Group , Blood Glucose/analysis , China/epidemiology , Cohort Studies , Diabetes Mellitus/blood , Female , Glucose Tolerance Test , Glycated Hemoglobin A/analysis , Glycemic Index , Humans , Male , Middle Aged , Uric Acid/blood
7.
Chinese Medical Journal ; (24): 1138-1145, 2021.
Article in English | WPRIM | ID: wpr-878167

ABSTRACT

BACKGROUND@#Single-nucleotide polymorphisms (SNPs)-associated genes and long non-coding RNAs (lncRNAs) can contribute to human disease. To comprehensively investigate the contribution of lncRNAs to breast cancer, we performed the first genome-wide lncRNA association study on Han Chinese women.@*METHODS@#We designed an lncRNA array containing >800,000 SNPs, which was incorporated into a 96-array plate by Affymetrix (CapitalBio Technology, China). Subsequently, we performed a two-stage genome-wide lncRNA association study on Han Chinese women covering 11,942 individuals (5634 breast cancer patients and 6308 healthy controls). Additionally, in vitro gain or loss of function strategies were performed to clarify the function of a novel SNP-associated gene.@*RESULTS@#We identified a novel breast cancer-associated susceptibility SNP, rs11066150 (Pmeta = 2.34 × 10-8), and a previously reported SNP, rs9397435 (Pmeta = 4.32 × 10-38), in Han Chinese women. rs11066150 is located in NONHSAT164009.1 (lncHSAT164), which is highly expressed in breast cancer tissues and cell lines. lncHSAT164 overexpression promoted colony formation, whereas lncHSAT164 knockdown promoted cell apoptosis and reduced colony formation by regulating the cell cycle.@*CONCLUSIONS@#Based on our lncRNA array, we identified a novel breast cancer-associated lncRNA and found that lncHSAT164 may contribute to breast cancer by regulating the cell cycle. These findings suggest a potential therapeutic target in breast cancer.


Subject(s)
Asian Continental Ancestry Group/genetics , Breast Neoplasms/genetics , Case-Control Studies , China , Female , Genetic Predisposition to Disease/genetics , Genome-Wide Association Study , Humans , Polymorphism, Single Nucleotide/genetics , RNA, Long Noncoding/genetics
8.
Chinese Medical Journal ; (24): 920-926, 2021.
Article in English | WPRIM | ID: wpr-878086

ABSTRACT

BACKGROUND@#Cumulative blood pressure (BP), a measure incorporating the level and duration of BP exposure, is associated with the risk of cardiovascular disease (CVD). However, the level at which cumulative BP could significantly increase the risk remains unclear. This study aimed to investigate the association of 15-year cumulative BP levels with the long-term risk of CVD, and to examine whether the association is independent of BP levels at one examination.@*METHODS@#Data from a 26-year follow-up of the Chinese Multi-provincial Cohort Study-Beijing Project were analyzed. Cumulative BP levels between 1992 and 2007 were calculated among 2429 participants free of CVD in 2007. Cardiovascular events (including coronary heart disease and stroke) occurring from 2007 to 2018 were registered. Adjusted hazard ratios (HRs) for CVD incidence associated with quartiles of cumulative systolic blood pressure (SBP) and diastolic blood pressure (DBP) were calculated.@*RESULTS@#Of the 2429 participants, 42.9% (1042) were men, and the mean age in 2007 was 62.1 ± 7.9 years. Totally, 207 CVD events occurred during the follow-up from 2007 to 2018. Participants with higher levels of cumulative SBP or DBP exhibited a higher incidence rate of CVD (P < 0.001). Compared with the lowest quartile of cumulative SBP, the HR for CVD was 1.03 (95% confidence interval [CI]: 0.59-1.81), 1.69 (95% CI: 0.99-2.87), and 2.20 (95% CI: 1.21-3.98) for the second to the fourth quartile of cumulative SBP, and 1.46 (95% CI: 0.86-2.48), 1.99 (95% CI: 1.18-3.35), and 2.08 (95% CI: 1.17-3.71) for the second to the fourth quartile of cumulative DBP, respectively. In further cross-combined group analyses with BP measurements in 2007, 15-year cumulative BP levels higher than the median, that is, 1970.8/1239.9 mmHg·year for cumulative SBP/DBP, which were equivalent to maintaining SBP/DBP levels of 131/83 mmHg or above on average in 15 years, were associated with higher risk of CVD in subsequent years independent of BP measurements at one-time point.@*CONCLUSION@#Cumulative exposure to moderate elevation of BP is independently associated with increased future cardiovascular risk.


Subject(s)
Aged , Asian Continental Ancestry Group , Blood Pressure/physiology , Cardiovascular Diseases/etiology , China/epidemiology , Cohort Studies , Humans , Hypertension/epidemiology , Incidence , Male , Middle Aged , Risk Factors
9.
Article in Chinese | WPRIM | ID: wpr-877516

ABSTRACT

Hypertension is a major problem of public health that endangers the health of the oldest old. However, the current guidelines for hypertension management do not uniformly diagnose hypertension among the oldest old, nor recommend a normal blood pressure range, which is not convictive enough to support the decision making to the prevention of blood pressure-related adverse events. This guideline gives guiding opinions on optimal blood pressure range for the Chinese oldest old, which applies to the staff of medical and health institutions at all levels nationwide to evaluate the blood pressure levels of the oldest old. It includes the sections of general principles, methods and standards of blood pressure evaluation, measurement conditions, specifications of blood pressure measurement, implementation approaches, etc. The guideline has important directive significance for improving the blood pressure management and decision-making level of the Chinese oldest old.


Subject(s)
Aged, 80 and over , Asian Continental Ancestry Group , Blood Pressure , Blood Pressure Determination , China , Humans , Hypertension/prevention & control
10.
Rev. méd. Minas Gerais ; 31: 31411, 2021.
Article in Portuguese | LILACS | ID: biblio-1291393

ABSTRACT

A paralisia periódica hipocalêmica tireotóxica é uma complicação rara do hipertireoidismo. Caracteriza-se por episódios de fraqueza muscular recorrente, associado à tireotoxicose e hipocalemia. Ocorre frequentemente em pacientes do sexo masculino e de origem asiática. Nesse contexto, o objetivo deste estudo é descrever o relato de caso de um paciente acometido por paralisia periódica hipocalêmica tireotóxica com redução acentuada da qualidade de vida e internações recorrentes devido a quadro agudo de tetraparesia flácida ascendente associado a hipocalemia grave por não adesão ao tratamento do hipertireoidismo. A paralisia periódica hipocalêmica tireotóxica apresenta evolução favorável quando reconhecida e tratada com controle inicial dos sintomas para normalização sérica do potássio e posterior resolução do quadro tireotóxico.


Thyrotoxic hypokalemic periodic paralysis is a rare complication of hyperthyroidism. The issue has been characterized by episodes of recurrent muscle weakness associated with thyrotoxicosis and hypokalemia. It occurs most often in male patients of Asian origin. This study aims on describing the case report of a patient affected by thyrotoxic hypokalemic periodic paralysis with intense reduction in life quality and recurrent hospitalizations due to ascending acute flaccid tetraparesis associated with severe hypokalemia due to non-adherence to treatment of hyperthyroidism. Thyrotoxic hypokalemic periodic paralysis presents a favorable evolution when identified and treated with initial symptom control for serum potassium normalization and subsequent resolution of the thyroid toxicity.


Subject(s)
Humans , Male , Adult , Thyrotoxicosis , Hypokalemic Periodic Paralysis , Potassium , Thyroid Gland , Muscle Weakness , Asian Continental Ancestry Group , Hyperthyroidism , Hypokalemia
11.
Braz. j. med. biol. res ; 54(2): e10099, 2021. tab
Article in English | LILACS, ColecionaSUS | ID: biblio-1142582

ABSTRACT

The objective of this study was to analyze the infection rate and drug resistance of Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) in the genitourinary tract of Chinese patients. From December 2018 to June 2019, vaginal secretion or urinary secretion of outpatients in our hospital were selected for culture and drug sensitivity analysis of Ureaplasma urealyticum and Mycoplasma hominis. In 4082 Chinese samples, 1567 Mycoplasma were detected, a detection rate of 38.39%, among which 1366 cases were UU single positive, accounting for 33.47%, 15 cases were MH single positive, accounting for 0.36%, 186 cases were UU and MH mixed positive, accounting for 4.56%. The most affected age groups were 21-30 years and 31-40 years, accounting for 19.09 and 15.05%, respectively. The results of drug sensitivity showed that doxycycline, minocycline, josamycin, clarithromycin, and roxithromycin were more sensitive to mycoplasma infection. The distribution of Ureaplasma urealyticum and Mycoplasma hominis in the human genitourinary system and their sensitivity to antibiotics is different for sex and age groups.


Subject(s)
Humans , Male , Female , Adult , Young Adult , Ureaplasma urealyticum/drug effects , Ureaplasma Infections/microbiology , Mycoplasma hominis/drug effects , Microbial Sensitivity Tests , China , Ureaplasma urealyticum/isolation & purification , Mycoplasma hominis/isolation & purification , Asian Continental Ancestry Group , Anti-Bacterial Agents/pharmacology
12.
Chinese Journal of Stomatology ; (12): 318-323, 2021.
Article in Chinese | WPRIM | ID: wpr-879317

ABSTRACT

Tooth preparation is the primary and core operation technique for prosthodontics. Microscopic tooth preparation can improve the accuracy and efficiency of the operation. Experts from Society of Prosthodontics, Chinese Stomatological Association formulated the standard operating procedure for microscopic tooth preparation, so as to standardize its design points and operating procedures, highlight the difference between this novel technique and the traditional naked eye tooth preparation and promote the application of microscopic tooth preparation.


Subject(s)
Asian Continental Ancestry Group , Humans , Oral Medicine , Prosthodontics , Reference Standards , Tooth Preparation
13.
Article in Chinese | WPRIM | ID: wpr-878997

ABSTRACT

On the basis of literatures and standards relating to Tibetan medicine, the varieties, origin, standards and efficacy of Saxifragaceae plant used in Tibetan medicine were summarized. According to the findings, 75 species(including varieties) in 8 genera of Saxifragaceae plants, involving 21 varieties, are used in Tibetan medicine. Among them, 9 commonly used varieties, namely Songdi, Sedi, Yajima, Aoledansaierbao, Jiansidawu, Saiguo, Katuer, Sangdi, Maoqinghong, are recorded in Chinese Pharmacopoeia, Ministry Standards for Tibetan Medicine, Tibetan Medicine Standards and other local standards, accounting for 42.9% of the total number of varieties. Tibetan names, Tibetan translation of Chinese names, as well as original plant of Tibetan medicine varieties are quite different in relevant Tibetan medicine standards and literatures, which resulted in common phenomena of synonym and homonym. The standards of most varieties only involve characters, and microscopic, physical and chemical identification, with low quality standards. Based on the results of the analysis, this paper suggests strengthening surveys on herbal textual research, resources and current utilization of Saxifragaceae plants used in Tibetan medicine, summarizing the varieties, establishing improved quality standards, and perfor-ming a comparative study on therapeutic material basis and biological activity of different original plants, in order to promote rational use of these medicinal plant resources, and ensuring the accuracy, safety, and effectiveness of clinical medication.


Subject(s)
Asian Continental Ancestry Group , Drugs, Chinese Herbal , Humans , Medicine, Tibetan Traditional , Plants, Medicinal , Reference Standards , Saxifragaceae
14.
Rev. cuba. angiol. cir. vasc ; 21(3): e217, sept.-dic. 2020. fig
Article in Spanish | LILACS, CUMED | ID: biblio-1156384

ABSTRACT

En diciembre de 2019 en la ciudad china de Wuham se reportaron los primeros casos de una nueva enfermedad asociada al SARS-Cov2, denominada COVID-19 y declarada como pandemia por la OMS, con alta letalidad en pacientes mayores de 60 años, que reportaban, en algunos casos, una predisposición a desarrollar microtrombosis y/o trombosis en el sistema arterial y venoso. Cuba presentó su primer caso en abril de 2020, con un comportamiento similar, por lo que nuestro sistema de salud aplicó medidas efectivas, así como puso en práctica el conocimiento acumulado por la comunidad científica. En este sentido, se presenta un caso de gangrena isquémica de miembro inferior en paciente con COVID-19, de interés científico. A la paciente de 42 años se le diagnosticaron COVID-19 y otras comorbilidades, así como un cuadro respiratorio agudo severo, asociado con un proceso de microtrombosis y lesiones de gangrena isquémica distal de los dedos del miembro inferior izquierdo, por la producción de microtrombosis relacionadas con excesiva inflamación, activación plaquetaria, disfunción endotelial y estasis. Según protocolos aplicados en Cuba, la paciente logró sobrevivir a dichas complicaciones. Este caso da a conocer una complicación no relatada en toda su magnitud hasta el momento, lo cual debe ser reportado y conocido como interés científico teórico-práctico de nuestros profesionales de la salud(AU)


In December, 2019 in the Chinese city of Wuhan were reported the first cases of a new disease associated to SARS-CoV-2, called COVID-19 and it was declared as a pandemic by WHO. This disease had high lethality in patients older than 60 years whom in some cases reported predisposition to develop microthrombosis and/or thrombosis in the arterial and venous system. Cuba presented its first case in April, 2020 with a similar behaviour, then our health system implemented effective measures and put into practice all the knowledge accumulated by the scientific community. In this sense, it is presented a scientific interest case of ischemic gangrene of low limb in a patient with COVID-19. The 42 years old female patient was diagnosed with COVID-19 and other comorbidities, as well as with a severe acute respiratory condition, associated to a microthrombosis process and lesions of distal ischemic grangrene of left low limb´s toes, due to the microthrombosis related with excesive inflammation, platelets activation, endothelial dysfunction and stasis. Thanks to the protocols applied in Cuba, the patient survived to those complications. This case shows a complication that is not fully described to the moment, something which must be reported and known as theoric-practical scientific interest of our health professionals(AU)


Subject(s)
Humans , Male , Female , Mortality , Severe Acute Respiratory Syndrome , Asian Continental Ancestry Group , Gangrene , World Health Organization , Pandemics
15.
Rev. bras. ortop ; 55(1): 8-16, Jan.-Feb. 2020. tab, graf
Article in English | LILACS | ID: biblio-1092686

ABSTRACT

Abstract Several association studies of genes polymorphisms on estrogen receptors-α and β with respect to adolescent idiopathic scoliosis (AIS) have been published in the past two decades. However, the association with AIS, especially among different ethnic subgroups, still remains controversial. Thus, we investigated these inconclusive data by performing a meta-analysis to systematically evaluate the association. A literature search was conducted in the PubMed, ISI Web of Science, EMBASE, SCOPUS, EBSCO, Cochrane Library, China National Knowledge Infrastructure (CNKI) and Wanfang databases until January 20, 2018. The strength of relationship was assessed using odds ratios (ORs) and 95% confidence intervals (95%CIs). A total of 12 case-control studies with 4,304 cases of AIS and 3,123 controls met our criteria. The pooled ORs indicated that the ESRα XbaI A > G, ESRα PvuII T > C and ESRβ AlwNI T > C polymorphisms were not significantly associated with the risk of developing AIS in the overall analysis. However, we found a significant association between the ESRα XbaI A > G polymorphism and AIS under the homozygote model (GG versus AA; OR = 1.448, 95%CI: 1.052-1.993; p = 0.023). The present meta-analysis suggests that the ESRα XbaI A > G, ESRα PvuII T > C and ESRβ AlwNI T > C polymorphisms may not be associated with the risk of developing AIS in the overall analysis. However, ESRα XbaI A > G might have an influence on the susceptibility to develop AIS among Asians. Considering the limited sample size and ethnicity, further larger studies are needed to provide a more precise estimation of the associations.


Resumo Vários estudos de associação entre os polimorfismos genéticos nos receptores α e β de estrogênio e a escoliose idiopática da adolescência (EIA) foram publicados nas últimas duas décadas. No entanto, a associação com a EIA, especialmente em diferentes subgrupos étnicos, continua a ser controversa. Assim, o presente estudo investigou esses dados inconclusivos por meio de uma metanálise para avaliar sistematicamente essa associação. Uma pesquisa bibliográfica foi realizada nas bases de dados PubMed, ISI Web of Science, EMBASE, SCOPUS, EBSCO, Cochrane Library, China National Knowledge Infrastructure (CNKI) e Wanfang até 20 de janeiro de 2018. A força de associação foi avaliada por meio de razões de probabilidades (RPs) e intervalos de confiança de 95% (ICs95%). Um total de 12 estudos de caso-controle, com 4.304 casos de EIA e 3.123 controles, atenderam aos critérios de inclusão do presente estudo. As RPs combinadas indicaram que os polimorfismos ESRα XbaI A > G, ESRα PvuII T > C e ESRβ AlwNI T > C podem não estar significativamente associados ao risco geral de desenvolvimento de EIA. No entanto, observou-se uma associação significativa entre o polimorfismo ESRα XbaI A > G e a EIA sob o modelo homozigótico (GG versus AA; RP = 1,448; IC95%: 1,052-1,993; p = 0,023). Esta metanálise sugere que os polimorfismos ESRα XbaI A > G, ESRα PvuII T > C e ESRβ AlwNI T > C podem não estar associados ao risco geral de desenvolvimento de EIA. No entanto, ESRα XbaI A > G pode influenciar a suscetibilidade de desenvolver EIA entre indivíduos asiáticos. Considerando o tamanho e a variação étnica limitada da amostra, outros estudos de maior escala são necessários para obter uma estimativa mais precisa das associações.


Subject(s)
Polymorphism, Genetic , Scoliosis , Ethnic Groups , Interleukin-6 , Meta-Analysis , Asian Continental Ancestry Group , Genes
16.
Arch. endocrinol. metab. (Online) ; 64(1): 52-58, Jan.-Feb. 2020. tab, graf
Article in English | LILACS | ID: biblio-1088768

ABSTRACT

ABSTRACT Objective This study aimed to present the impact of age and gender on thyroid hormone levels in a large Chinese population with sufficient iodine intake. Subjects and methods A total of 83643 individuals were included and were stratified by age and gender. The median, 2.5th and 97.5th of thyrotropin (TSH), free triiodothyronine (FT3), free thyroxine (FT4) and FT3/FT4 ratio were calculated for both genders for every decade from 18 to over 80 years. TSH, FT3, FT4, FT3/FT4 distribution in each age group was evaluated for females and males using smoothing splines in the generalized additive models (GAM). TSH concentrations were compared in the different age groups in gender. Results In the over 80s age group, the TSH level (median: 2.57 mIU/L, 2.5th-97.5th: 0.86-7.56 mIU/L) was significantly higher than other age groups, irrespective to gender (P<0.001). Females had a higher TSH value than males in all age groups (P<0.001). Results of the smoothing curves showed that TSH increased with age, FT3 concentration was higher in males than in females and the tendency of the FT3/FT4 ratio was basically similar to that of FT3. TSH concentration in the 50s age group (median 2.48 mIU/L for females versus 2.00 mIU/L for males) was significantly higher than that in the 30s age group (median 2.18 mIU/L for females versus median 1.85 mIU/L for males). Conclusions In accord with increasing TSH values during aging, females and older adults have lower FT3 values and lower FT3/FT4 ratios, while the FT4 values remain stable.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Thyroxine/blood , Triiodothyronine/blood , Thyrotropin/blood , Sex Factors , Age Factors , Reference Values , Thyroid Function Tests , Retrospective Studies , Asian Continental Ancestry Group
17.
Article in Chinese | WPRIM | ID: wpr-828911

ABSTRACT

To study the cultural beliefs of medical students and its relationship with depression.A questionnaire survey was conducted among 977 medical students using the Chinese Traditional Culture Belief Scale (CTCBS) and Nine Item-Patient Health Questionnaire (PHQ-9).The total score of medical students' cultural belief was 48.34± 7.31, and 54.4% of them had clear cultural belief. Cultural belief did not differ significantly among the medical students with different genders, places of residence or economic status, but those with ideals and beliefs had significantly higher cultural belief than those without (48.87±7.40 47.09±6.95, < 0.001). Cultural belief was negatively correlated to depression among the medical students (=-0.215, < 0.001), and those with a high-level cultural belief had lower levels of depression (6.09±3.88 7.42 ± 3.82 9.00 ± 4.90, < 0.001). The total and all the dimensions scores of CTCBS of the students without depressive symptoms were significantly higher than those in students with depressive symptoms. The medical students with lower cultural beliefs had a higher positive rate for depression screening (37.8% 18.8% 12.2%).Medical students have a high level of cultural beliefs. Strong culture beliefs are beneficial to relieve depression symptoms and reduce the incidence rate of depression. Chinese traditional culture education should be strengthened in the quality education of medical students.


Subject(s)
Asian Continental Ancestry Group , Depression , Female , Humans , Male , Students, Medical , Surveys and Questionnaires
18.
Article in Chinese | WPRIM | ID: wpr-828733

ABSTRACT

Children, as a special vulnerable group, are more susceptible to severe physical injury and psychological trauma in an earthquake. The Pediatric Disaster Branch of Chinese Pediatric Society of Chinese Medical Association and the Pediatric Branch of Chinese People's Liberation Army formulated the expert consensus on on-site medical rescue and transfer of children in an earthquake. The consensus introduces the treatment principles and precautions of on-site treatment and subsequent transfer for children in an earthquake, in order to better serve children in this emergency.


Subject(s)
Asian Continental Ancestry Group , Child , Consensus , Earthquakes , Humans
19.
Article in Chinese | WPRIM | ID: wpr-828685

ABSTRACT

The Chinese and English names of pertussis or whooping cough show the important clinical features of the disease in terms of its course and cough characteristics respectively. In the clinical description of typical pertussis, the meanings of the Chinese and English words are not completely consistent, such as spastic cough versus paroxysmal cough, spasmodic stage/phase versus paroxysmal stage/phase, and "back-hook" versus whoop, and some descriptions in English are not seen in Chinese. This article aims to provide more comprehensive information for the understanding of pertussis by comparing the descriptions of typical clinical manifestations of pertussis in Chinese and English literatures and to put forward suggestions for the diagnosis of pertussis syndrome based on typical clinical manifestations.


Subject(s)
Asian Continental Ancestry Group , Bordetella pertussis , Humans , Language , Whooping Cough
20.
Article in Chinese | WPRIM | ID: wpr-828502

ABSTRACT

A case of Gilbert syndrome (GS) with a heterozygous mutation in the gene is reported. The patient had no symptoms except for recurrent sclera icterus since childhood. Laboratory examinations revealed an elevated unconjugated bilirubin. Biliary obstruction, hemolysis and other diseases that might cause jaundice were excluded. *28 and c.211G>A heterozygous mutations in gene were found, which may be another type of mutation causing GS in Chinese population.


Subject(s)
Asian Continental Ancestry Group , Bilirubin , Gilbert Disease , Genetics , Glucuronosyltransferase , Genetics , Heterozygote , Humans , Mutation
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