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1.
J. Health Biol. Sci. (Online) ; 10(1): 1-9, 01/jan./2022. ilus, tab
Article in Portuguese | LILACS | ID: biblio-1411337

ABSTRACT

Objetivos: evidenciar as relações e a existência do agravamento do Transtorno do Espectro Autista devido à disbiose intestinal. Métodos: revisão integrativa realizada segundo a pergunta norteadora: Existe comprovação científica entre a relação do TEA e disbiose intestinal que favoreça a melhora na prática clínica e indicações de possíveis respostas? Buscou-se por artigos publicados entre janeiro de 2016 e janeiro de 2021, nas bases de dados: PubMed, SciELO, LILACS, GOOGLE ACADÊMICO. Foram utilizados os descritores (DeCS): "Transtorno do Espectro Autista"; "Microbiota gastrointestinal"; "Disbiose", associados pelo operador booleano "E". Foram incluidos artigos de revisões bibliográficas, completos, originais, limitados aos idiomas inglês e português brasileiro, publicados nos últimos cinco anos, e que, após leitura do resumo, estivessem dentro do escopo da revisão. Resultados: Foram identificados 52 manuscritos e, após aplicação dos critérios de inclusão e exclusão, foram considerados 11 artigos que evidenciam o agravamento do TEA por fatores intrínsecos à microbiota intestinal. Conclusão: existe importante influência causal do eixo bidirecional cérebro-intestino-microbiota na etiologia e exacerbaçao das manifestações clínicas do Transtorno do Espectro Autista devido à disbiose intestinal e aos fatores gastrointestinais de origem idiopática.


Objectives: to highlight the relationships and the existence of Autistic Spectrum Disorder aggravation due to intestinal dysbiosis. Methods: integrative review conducted according to the guiding question: Is there scientific evidence of the relationship between ASD and intestinal dysbiosis that favors improvement in clinical practice and indications of possible answers? We searched for articles published between January 2016 and January 2021 in databases: PubMed, SciELO, LILACS, and GOOGLE ACADEMIC. The following descriptors (DeCS) were used: "Autistic Spectrum Disorder"; "Gastrointestinal microbiota"; "Dysbiosis", associated with the Boolean operator "AND". We included literature review articles, complete, original, limited to English and Brazilian Portuguese languages, published in the last five years, and which, after reading the abstract, were within the scope of the review. Results: 52 manuscripts were identified, and after applying the inclusion and exclusion criteria, 11 articles were considered that show the worsening of ASD due to factors intrinsic to the intestinal microbiota. Conclusion: there is an important causal influence of the bidirectional brain-gut-microbiota axis in the etiology and exacerbation of clinical manifestations of Autism Spectrum Disorder due to intestinal dysbiosis and gastrointestinal factors of idiopathic origin.


Subject(s)
Autism Spectrum Disorder , Alkalies , Dysbiosis , Microbiota , Gastrointestinal Microbiome , LILACS , Literature
2.
Arq. ciências saúde UNIPAR ; 26(3): 631-642, set-dez. 2022.
Article in Portuguese | LILACS | ID: biblio-1399312

ABSTRACT

Transtorno do espectro autista (TEA) é um transtorno do neurodesenvolvimento que se manifesta na infância, apresentando alterações na morfologia, fisiologia, conectividade cerebral e ocasionando em distúrbios motores. Objetivo: avaliar o déficit de equilíbrio em crianças com transtorno do espectro autista em uma cidade localizada no interior do Rio Grande do Sul. Método: a amostra foi composta por 11 crianças com idade entre 3 e 14 anos, frequentadores de uma instituição de atendimento a autistas. Os participantes foram submetidos às seguintes avaliações: Bateria Psicomotora (BPM), Timed-up and Go Test e Tinetti. Resultados: observou-se predomínio do sexo masculino, redução estatisticamente significativa dos escores da escala de equilíbrio, (24,27 ±4,1; p=0,03) e escore total (13,45 ±2,5; p=0,022), sem diferença no escore da escala de marcha (10,82 ± 2,4 ; p=0,059), através da Escala de Equilíbrio e Mobilidade de Tinetti, e, na avaliação da BPM, 54,54% apresentaram perfil psicomotor normal. Nas correlações, encontrou-se relação direta entre o fator praxia global da BPM e escore total de Tinetti (r= 0,522; p=0,05). Houve ainda relação entre os fatores psicomotores com o equilíbrio na BPM, sendo moderada para tonicidade (r= 0,582; p=0,03) e fortes entre noção do corpo (r=0,811; p=0,001), estruturação espaço temporal (r= 0,894; p=0,000), praxias global (r= 0,963; p=0,000) e fina (r=0,894; p=0,000). Em relação a análise dos fatores da BPM, a maioria dos pacientes apresentava dificuldade na praxia global, sendo 45,5% da amostra dispráxica. Foi possível ainda estabelecer correlação moderada entre a Praxia Global da BPM e o TUG (r=0,548, p=0,04) e, embora não significativa,com a Tinetti (r=0,522, p=0,05),. Foi observada também uma correlação moderada entre a Tonicidade e a TUG (R=0,601,p=0,025).Conclusão: crianças com TEA apresentam alteração no equilíbrio, representando um baixo risco de quedas, e comprometimento da praxia global, assim como uma correlação entre déficit de equilíbrio e alterações na tonicidade, noção do corpo, estruturação espaço temporal e praxias global e fina desses indivíduos.


Autistic Spectrum Disorder (ASD) is a neurodevelopmental disorder that manifests in childhood, with alterations in morphology, physiology, brain connectivity and causing motor disorders. Objective: to assess the balance deficit in children with ASD in a city located in the interior of Rio Grande do Sul. Method: the sample consisted of 11 children aged between 3 and 14 years old, regulars at an autism care institution. Participants were submitted to the following evaluations: Psychomotor Battery, Timed-Up and Go Test, and Tinetti. Results: there was a predominance of males, a statistically significant reduction in the balance scale scores (24,27 ±4,1; p=0.03) and total score (13,45 ±2,5; p=0.022), with no difference in the gait scale score (10,82 ± 2,4; p=0.059), using the Tinetti Balance and Mobility Scale, and, in the assessment of the BPM, 54.54% had a normal psychomotor profile. In the correlations, a direct relationship was found between the global BPM praxis factor and the total Tinetti score (r= 0.522). There was also a relationship between psychomotor factors and BPM balance, being moderate for tonicity (r= 0.582), and strong between body notion (r=0.811), temporal space structuring (r= 0.894), global praxis (r= 0.963), and fine praxis (r=0.894). Regarding the analysis of BPM factors, most patients had difficulty in global praxis, with 45.5% of the dyspraxic sample. It was also possible to establish a moderate correlation between the Global Praxia of the BPM and the TUG (r=0.548, p=0.04) and, although not significant, with Tinetti (r=0.522, p=0.05). There was also a moderatecorrelation between tonicity and TUG (r=0.601, p=0.025). Conclusion: children with ASD present balance alterations, representing a low risk of falls, and impairment of global praxis, as well as correlation between balance deficits and alterations with tonicity, body notion, temporal space structure, and global and fine praxis of these individuals.


El trastorno del espectro autista (TEA) es un trastorno del neurodesarrollo que se manifiesta en la infancia, presentando cambios en la morfología, la fisiología, la conectividad cerebral y provocando trastornos motores. Objetivo: evaluar el déficit de equilibrio en niños con trastorno del espectro autista en una ciudad del interior de Rio Grande do Sul. Método: la muestra consistió en 11 niños de entre 3 y 14 años, que asistían a una institución para pacientes autistas. Los participantes fueron sometidos a las siguientes evaluaciones: Batería psicomotriz (BPM), Test de tiempo y marcha y Tinetti. Resultados: se observó un predominio de varones, reducción estadísticamente significativa de las puntuaciones de la escala de equilibrio, (24,27 ±4,1; p=0,03) y de la puntuación total (13,45±2,5; p=0,022), sin diferencia en la puntuación de la escala de marcha (10,82 ± 2,4 ; p=0,059), a través de la Escala de Equilibrio y Movilidad de Tinetti, y, en la evaluación del BPM, el 54,54% presentó perfil psicomotor normal. En las correlaciones, se encontró una relación directa entre el factor de praxis global del BPM y la puntuación total de Tinetti (r= 0,522; p=0,05). También hubo una relación entre los factores psicomotores y el equilibrio en el BPM, siendo moderada para la tonicidad (r= 0,582; p=0,03) y fuerte entre la noción corporal (r=0,811; p=0,001), la estructuración espacio-temporal (r= 0,894; p=0,000), las prácticas globales (r= 0,963; p=0,000) y las finas (r=0,894; p=0,000). En cuanto al análisis de los factores de la BPM, la mayoría de los pacientes tenían dificultades en la praxis global, siendo el 45,5% de la muestra disprática. También se pudo establecer una correlación moderada entre la Praxis Global del BPM y el TUG (r=0,548, p=0,04) y, aunque no significativa, con el Tinetti (r=0,522, p=0,05),. También se observó una correlación moderada entre la tonicidad y el TUG (R=0,601,p=0,025).Conclusión: los niños con TEA presentan alteración del equilibrio, representando un bajo riesgo de caídas, y alteración de la praxis global, así como una correlación entre el déficit de equilibrio y las alteraciones de la tonicidad, la noción corporal, la estructuración espacio-temporal y la praxis global y fina de estos individuos.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Child, Exceptional/statistics & numerical data , Postural Balance , Autism Spectrum Disorder , Accidental Falls/statistics & numerical data , Evaluation Studies as Topic , Motor Disorders
3.
Arq. ciências saúde UNIPAR ; 26(3): 458-469, set-dez. 2022.
Article in English | LILACS | ID: biblio-1399130

ABSTRACT

Objectives: This study aimed to make a bibliographic update on the already published data on bumetanide, addressing the main information on its use in Autism Spectrum Disorder (ASD). Methods: This was an integrative narrative review in which the following databases were used: Web of Science, MEDLINE, ScienceDirect, and Scielo. The descriptors used were: Autism Spectrum Disorder, Autistic Disorder and Bumetanide. It was considered only articles published in English and French. Original articles, randomized clinical trials, case reports, and review articles were included. Results: The results show that the use of bumetanide alters regions of the brain linked to the positive development of language, improvement of visual contact, improvement in social interactions, among others. Studies are also concerned about the safety and efficacy of bumetanide in ASD since several adverse effects have been reported. The most frequent were hypokalemia, polyuria, and loss of appetite. Conclusion: Bumetanide has proven as effective in improving some important symptoms in ASD, especially linked to language and social interaction, however, studies with larger groups of patients and with longer treatment and observation time are needed to confirm the efficacy and clarify the safety profile in use for people with ASD.


Objetivo: O objetivo deste trabalho foi fazer uma atualização bibliográfica sobre os dados já publicados da bumetanida, abordando as principais informações sobre seu uso no Transtorno do Espectro Autista (TEA). Metodologia: Foi realizada uma revisão do tipo narrativa integrativa, da qual foram utilizadas as bases de dados: Web of Science, MEDLINE, ScienceDirect e Scielo, com a utilização dos seguintes descritores: Autism Spectrum Disorder, Autistic Disorder e Bumetanide. Foram considerados apenas artigos publicados nas línguas inglesa e francesa. Foram incluídos artigos originais, ensaios clínicos randomizados e relatos de caso. Foram excluídos artigos de revisão. Resultados: Os resultados mostram que o uso da bumetanida altera regiões do cérebro ligadas ao desenvolvimento positivo da linguagem, melhora do contato visual, melhora nas interações sociais, entre outros. Os estudos também se preocupam em relacionar a segurança e a eficácia da bumetanida no TEA, do qual foram relatados diversos efeitos adversos, sendo os mais frequentes a hipocalemia, a poliúria e a perda de apetite. Conclusão: A bumetanida mostrou ser eficaz na melhoria de alguns importantes sintomas no TEA, especialmente ligados à linguagem e interação social, entretanto, estudos com grupos maiores de pacientes e com maior tempo de tratamento e observação são necessários para confirmar a eficácia e esclarecer o perfil de segurança no uso para pessoas com TEA.


: Este estudio tuvo como objetivo realizar una actualización bibliográfica sobre los datos ya publicados sobre la bumetanida, abordando la principal información sobre su uso en el Trastorno del Espectro Autista (TEA). Métodos: Se trata de una revisión narrativa integradora en la que se utilizaron las siguientes bases de datos: Web of Science, MEDLINE, ScienceDirect y Scielo. Los descriptores utilizados fueron: Trastorno del Espectro Autista, Trastorno Autista y Bumetanida. Se consideraron sólo los artículos publicados en inglés y francés. Se incluyeron artículos originales, ensayos clínicos aleatorios, informes de casos y artículos de revisión. Resultados: Los resultados muestran que el uso de la bumetanida altera regiones del cerebro relacionadas con el desarrollo positivo del lenguaje, la mejora del contacto visual, la mejora de las interacciones sociales, entre otros. Los estudios también se preocupan por la seguridad y eficacia de la bumetanida en el TEA, ya que se han reportado varios efectos adversos. Los más frecuentes fueron la hipocalemia, la poliuria y la pérdida de apetito. Conclusiones: La bumetanida ha demostrado ser eficaz en la mejora de algunos síntomas importantes en el TEA, especialmente vinculados al lenguaje y la interacción social, sin embargo, se necesitan estudios con grupos más grandes de pacientes y con mayor tiempo de tratamiento y observación para confirmar la eficacia y aclarar el perfil de seguridad en el uso para personas con TEA.


Subject(s)
Autistic Disorder/drug therapy , Bumetanide/adverse effects , Bumetanide/pharmacology , Autism Spectrum Disorder/drug therapy , Appetite Depressants/antagonists & inhibitors , Polyuria , Drug-Related Side Effects and Adverse Reactions , Social Interaction/drug effects , Language Development
4.
Subj. procesos cogn ; 26(1): 73-99, ago. 2022.
Article in Spanish | LILACS, BINACIS, UNISALUD | ID: biblio-1392525

ABSTRACT

Muchos niños con trastorno del espectro autista (TEA) presentan dificultad en la comprensión de narraciones orales. Investigaciones relacionadas reportan peores desempeños en inferencias emocionales respecto a otros tipos de inferencias. En este estudio participaron 15 niños con TEA entre 8 y 12 años, agrupados según nivel intelectual. Se evaluó la memoria de trabajo, la atención sostenida y el vocabulario; y medidas de comprensión como, la generación de inferencias y el recuerdo de información literal. Los resultados evidenciaron mejores desempeños en preguntas a inferencias emocionales y explicativas en los lectores con TEA sin déficit cognitivo en comparación a sus pares con déficit cognitivo. Además, no se encontraron diferencias significativas en desempeños a preguntas de información literal. Finalmente, el grupo con déficit cognitivo mostró mejor rendimiento en preguntas de inferencias explicativas respecto a otro tipo de inferencias, estos desempeños podrían vincularse con el tipo de material, narraciones orales acompañadas de ilustraciones AU


A lot of children with Autism Spectrum Disorder (ASD) present difficulty in oral narrative comprehension. Related research reports worst performance in emotional inferences than other inferences type. This study involved 15 children with ASD between 8 and 12 years, grouped according to the intellectual level. Working memory, vocabulary and sustained attention were assessed. Also, comprehension measures such as generating inferences and recalling literal information. The results evidenced better performance in emotional and explanatory inference questions in readers with ASD and without cognitive deficit than their peers with cognitive deficit. In addition, no significant differences were found in performance on literal information questions. Finally, the group with cognitive deficit showed better performance in questions of explanatory inferences compared to other types of inferences, these performances could be linked to the type of material, oral narrations accompanied by illustrations AU


Subject(s)
Humans , Male , Female , Child , Comprehension , Autism Spectrum Disorder/complications , Language Disorders , Hispanic or Latino , Social Skills
5.
Lima; Perú. Ministerio de Salud. Dirección General de Intervenciones Estratégicas en Salud Pública. Dirección de Salud Mental; 2 ed; Jul. 2022. 56 p. ilus.
Monography in Spanish | LILACS, LIPECS, MINSAPERU | ID: biblio-1380416

ABSTRACT

El documento se enmarca dentro del tercer lineamiento de la política sectorial en salud mental que determina las acciones para el cuidado integral de la salud mental de la población, con énfasis en grupos en condiciones de mayor vulnerabilidad. Asimismo, surge como complemento a las orientaciones para el cuidado integral de la salud mental de las personas con Trastorno del Espectro Autista (TEA), el cual enfatiza la necesidad de realizar una detección e intervención temprana en niñas y niños con riesgo de TEA para favorecer su desarrollo. Además, responde a la necesidad de fortalecer las competencias de los profesionales del primer nivel de atención, en la detección temprana del TEA, y contar con una herramienta de uso práctico que pueda orientar en la toma de decisiones y desarrollar habilidades para la detección y abordaje inicial de esta condición. Los objetivos del presente documento son facilitar la detección temprana del TEA en los profesionales del primer nivel de atención y proveer las pautas para la intervención inicial con las familias


Subject(s)
Primary Health Care , Autistic Disorder , Risk Groups , Mental Health , Comprehensive Health Care , Autism Spectrum Disorder
6.
Med. infant ; 29(2): 139-145, Junio 2022. ilus
Article in Spanish | LILACS, BINACIS, UNISALUD | ID: biblio-1382244

ABSTRACT

El Trastorno del Espectro Autista (TEA) es una condición que afecta el neurodesarrollo caracterizada por presentar alteraciones en la comunicación, conducta y en las interacciones sociales, y que afecta el funcionamiento del individuo a lo largo de su vida. Los tratamientos recomendados por la evidencia científica incluyen un enfoque interdisciplinario que combina intervenciones educativas, terapias psicológicas/conductuales, terapia del habla y el lenguaje, terapia ocupacional/física y tratamientos médicos. Para muchas familias, barreras económicas y geográficas limitan el acceso a los tratamientos específicos. Este y otros motivos llevan a incorporar tratamientos alternativos y/o complementarios. El Centro Nacional de Medicina Complementaria y Alternativa (NIH-EEUU) define los Tratamientos Alternativos Complementarios (TAC) como "un grupo de diversos sistemas médicos y de cuidados de la salud; prácticas y productos que generalmente no son considerados parte de la medicina convencional". La prevalencia del uso de TAC en personas con TEA está entre las más altas respecto a otras patologías y a otros trastornos del desarrollo, con porcentajes entre 52% y 95%. Su uso debe ser preguntado en las consultas de seguimiento, y debe discutirse sobre riesgos, beneficios y costos. La cantidad y el tipo de intervención que reciben niños, niñas, adolescentes (NNyA) y adultos con TEA varían enormemente en todo el mundo e incluso dentro de un mismo país y región. El pronóstico del TEA es mejorado cuando el diagnóstico es oportuno y temprano y el abordaje educativo terapéutico es iniciado y orientado a aspectos funcionales y centrados en la familia. (AU)


Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by alterations in communication, behavior, and social interactions that affect the individual's functioning throughout life. Evidence-based treatments include an interdisciplinary approach that combines educational interventions, psychological/behavioral therapies, speech and language therapy, occupational/physical therapy, and medical treatments. For many families, economic and geographic barriers limit access to specific treatments. This and other reasons have led to the incorporation of alternative and/or complementary treatments. The National Center for Complementary and Integrative Health (NCCIH - USA) defines complementary alternative medicine (CAM) as "a group of diverse medical and health care systems, practices and products that are not generally considered part of conventional medicine". The prevalence of the use of CAM in people with ASD is among the highest compared to other diseases and developmental disorders, with percentages ranging from 52% to 95%. Their use should be considered in follow-up visits, and risks, benefits, and costs should be discussed. The amount and type of intervention received by children, adolescents, and adults with ASD varies greatly around the world and even within the same country and region. The prognosis of ASD is improved with timely diagnosis and early, family-centered and functionally oriented educational and therapeutic approaches


Subject(s)
Humans , Complementary Therapies/adverse effects , Complementary Therapies/methods , Complementary Therapies/statistics & numerical data , Evidence-Based Medicine , Autism Spectrum Disorder/therapy
7.
Rev. otorrinolaringol. cir. cabeza cuello ; 82(2): 258-269, jun. 2022. ilus, tab
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1389848

ABSTRACT

Resumen La hiperacusia se define como la intolerancia a ciertos sonidos cotidianos que causa angustia y discapacidad significativas en las actividades sociales, ocupacionales, recreativas y otras actividades cotidianas. Los sonidos pueden percibirse como incómodamente fuertes, desagradables, atemorizantes o dolorosos. Se encuentra presente en aproximadamente un 3% población general, y aumenta significativamente en trastornos del espectro autista (TEA), alcanzando entre un 15% a 40%. Los mecanismos fisiopatológicos no son del todo claros, pero se ha propuesto, una alteración en el funcionamiento de mecanismos reflejos y de regulación, tanto a nivel de la vía auditiva periférica, como central, incluyendo estructuras no relacionadas directamente con la vía auditiva. El siguiente texto tiene como objetivo analizar la relación entre hiperacusia y TEA, enfatizando en la frecuencia en que se presentan como comorbilidades, en los posibles mecanismos fisiopatológicos, y en actualizaciones en el abordaje diagnóstico y terapéutico. Se realiza una revisión bibliográfica cualitativa en Pubmed con artículos entre los años 2008-2020 utilizando los términos: "hyperacusis autism", "sistema olivococlear", arrojando 39 artículos, de los cuales se seleccionaron en base a la temática de cada uno, evaluada por los autores. A pesar de una significativa relación entre hiperacusia y TEA, los mecanismos fisiopatológicos de ambas patologías siguen siendo un misterio. Existen estudios que sugieren pruebas de screening no invasivas que relacionan ambas patologías, pero debido a los sesgos de selección, todavía no son factibles de usar en forma universal. El abordaje terapéutico ha sido poco explorado, y no se dispone de fármacos que hayan demostrado su efectividad, por el contrario, algunos de ellos empeoran la sintomatología. Se recomienda al tratante, seguir un camino largo, en conjunto con el paciente, donde las terapias no farmacológicas como la terapia cognitivo conductual han mostrado tener buenos resultados.


Abstract Hyperacusis is defined as intolerance to certain sounds that causes significant distress and disability in social, occupational, recreational and other activities. Sounds can be perceived as uncomfortably loud, unpleasant, frightening, or painful. It is present in approximately 3% of the general population, and increases significantly in autism spectrum disorders (ASD), between 15% and 40%. The pathophysiological mechanisms are not entirely clear, but an alteration in the functioning of reflex and regulatory mechanisms has been proposed, both at the peripheral and central auditory pathways, including structures not directly related to the auditory pathway. The therapeutic approach has been little explored as there are no drugs that have demonstrated their effectiveness, on the contrary, some of them worsen the symptoms. The practitioner is recommended to follow a long path, in conjunction with the patient, where non-pharmacological therapies such as cognitive behavioral therapy have been shown to have good results. The following text shows a review of the literature with articles referring to the subject between the years 2008-2019.


Subject(s)
Humans , Hyperacusis/epidemiology , Autism Spectrum Disorder/complications , Hyperacusis/etiology , Auditory Pathways , Afferent Pathways , Efferent Pathways
8.
J. bras. psiquiatr ; 71(1): 32-39, jan.-mar. 2022. tab
Article in English | LILACS | ID: biblio-1365065

ABSTRACT

OBJECTIVE: The relationship between mental health and contextual factors has been increasingly investigated in the scientific literature to identify elements that may configure themselves as protective. The present study aimed to identify what resources (activities, family outings, toys, material elements, and learning) were offered in the daily lives of children with mental disorders, and from this, verify whether the offer of such resources in the family was associated with areas of greatest damage relative to mental health problems. METHODS: Thirty-three caregivers of/people responsible for children between 6 and 12 years of age with most frequent diagnoses in attention-deficit hyperactivity disorder and autism spectrum disorder seen at a general hospital participated. We used the Strengths and Difficulties Questionnaire (SDQ ­ parents version) and Family Environment Resources Inventory (RAF). RESULTS: From a descriptive and correlational analysis, it was revealed that the more the mental health problems were present in children, the lower the family resources offer. CONCLUSIONS: The environmental resources offer proved to be protective for child development. Such findings are relevant to aid in outlining strategies for promoting mental health among children.


OBJETIVO: As relações entre saúde mental e fatores contextuais têm sido cada vez mais investigadas na literatura científica no sentido de identificar elementos que possam se configurar como protetivos. Este estudo teve por objetivo identificar quais recursos (atividades, passeios com a família, brinquedos, elementos materiais e de aprendizagem) eram oferecidos no cotidiano das crianças que apresentam transtornos mentais e, a partir disso, verificar se há associações entre a oferta de tais recursos no ambiente familiar e as áreas de maior prejuízo em relação a problemas de saúde mental. MÉTODOS: Participaram 33 cuidadores/responsáveis de/por crianças entre 6 e 12 anos de idade com diagnósticos mais frequentes de transtorno do déficit de atenção e hiperatividade e transtorno do espectro autista acompanhadas em um hospital geral. Foram utilizados: Questionário de Capacidades e Dificuldades (SDQ ­ versão pais) e Inventário de Recursos do Ambiente Familiar (RAF). RESULTADOS: A partir de uma análise descritiva e correlacional, revelou-se que quanto mais problemas de saúde mental estão presentes nas crianças, menor é a oferta de recursos no ambiente familiar. CONCLUSÃO: A oferta de recursos ambientais mostrou-se protetiva para o desenvolvimento infantil. Tais achados são relevantes para auxiliar no delineamento de estratégias para a promoção de saúde mental destinada ao público infantil.


Subject(s)
Humans , Child , Attention Deficit Disorder with Hyperactivity/diagnosis , Caregivers/psychology , Family Relations/psychology , Autism Spectrum Disorder/diagnosis , Mental Disorders/psychology , Child Development , Cross-Sectional Studies , Surveys and Questionnaires/standards , Protective Factors
9.
Distúrb. comun ; 34(1): e53197, mar. 2022. ilus
Article in Portuguese | LILACS | ID: biblio-1396366

ABSTRACT

Introdução: A terapia indireta é uma abordagem de intervenção terapêutica na qual se realizam orientações familiares e um treinamento dos cuidadores para que o entendimento da mesma seja ampliado. Este tipo de intervenção é relevante porque são os familiares as pessoas mais próximas das crianças, e, por meio das orientações, aprimoram o elo e a interação para o amadurecimento da comunicação funcional da criança. Objetivo: Analisar achados acerca dos benefícios da orientação familiar nas dificuldades comunicativas de crianças com diagnóstico de Transtorno do Espectro do Autismo. Estratégia de pesquisa: Levantamento na literatura publicada nas línguas inglesa, portuguesa e espanhola. Foram incluídos artigos originais publicados na íntegra no período de janeiro de 1999 a novembro de 2019, com grau de recomendação A, B e C e níveis de evidência 1, 2, 3 4, segundo o Oxford Centre. Resultados: Foram encontrados 934 artigos, 55 excluídos por duplicata e 31 foram selecionados para leitura na íntegra. Destes, 15 foram considerados para análise do estudo. Discussão: A terapia indireta, por meio da orientação familiar, no processo de reabilitação de crianças no espectro aponta que o trabalho de promoção do desenvolvimento das habilidades comunicativas de crianças com TEA promove ganhos na comunicação. Também, mostram que uma intervenção indireta aumenta a capacidade de reflexão e autocrítica dos cuidadores. Conclusão: O processo terapêutico indireto de crianças com diagnóstico de TEA, fornece mudanças positivas no processo de desenvolvimento de linguagem dessas crianças e existe uma relação direta e positiva entre orientação familiar e dificuldade comunicativa dessas crianças.


Introduction: Indirect therapy is a therapeutic intervention approach in which family orientations and training of caregivers are carried out so that their understanding is broadened. This type of intervention is relevant because family members are the people closest to the children, and, through the guidelines, they improve the link and the interaction for the maturation of the child's functional communication. Objective: To analyze findings about the benefits of familiar orientations, in the communicative difficulties of children diagnosed with ASD. Research strategy: Survey of national and international literature, published in English, Portuguese and Spanish. Original articles published in full from January 1999 to November 2019 were included, with degree of recommendation A, B and C and levels of evidence 1, 2, 3 4, according to the Oxford Center. Results: 934 articles were found, 55 excluded by duplicate and 31 were selected for reading in full. Of these, 15 were considered for analysis of the study. Discussion: Indirect therapy, through family guidance, in the process of rehabilitation of children on the spectrum points out that the work of promoting the development of the communicative skills of children with ASD promotes gains in communication. They also show that an indirect intervention increases the caregivers' capacity for reflection and self-criticism. Conclusion: The indirect therapeutic process of children diagnosed with ASD provides positive changes in the language development process of these children and there is a direct and positive relationship between family orientation and communicative difficulties in these children.


Introducción: La terapia indirecta es un enfoque terapéutico en el que se realizan orientaciones familiares y la formación de los cuidadores para ampliar su comprensión. Este tipo de intervención es relevante porque los familiares son las personas más cercanas a los niños y, a través de las pautas, mejoran el vínculo y la interacción para la maduración de la comunicación funcional del niño. Objetivo: Analizar los hallazgos sobre los beneficios de la orientación familiar en las dificultades comunicativas de los niños diagnosticados con TEA. Estrategia de investigación: Encuesta de literatura nacional e internacional, publicada en inglés, portugués y español. Se incluyeron artículos originales publicados íntegramente desde enero de 1999 hasta noviembre de 2019, con grado de recomendación A, B y C y niveles de evidencia 1, 2, 3 4, según el Centro de Oxford. Resultados: Se encontraron 934 artículos, 55 excluidos por duplicado y 31 seleccionados para lectura completa. De estos, 15 fueron considerados para el análisis del estudio. Discusión: La terapia indirecta, a través de la orientación familiar, en el proceso de rehabilitación de los niños en el espectro señala que el trabajo de promover el desarrollo de las habilidades comunicativas de los niños con TEA promueve ganancias en la comunicación. Conclusión: El proceso terapéutico indirecto de los niños diagnosticados con TEA proporciona cambios positivos en el proceso de desarrollo del lenguaje de estos niños y existe una relación directa y positiva entre la orientación familiar y las dificultades comunicativas en estos niños.


Subject(s)
Humans , Male , Female , Communication Disorders/therapy , Autism Spectrum Disorder/therapy , Parent-Child Relations , Professional-Family Relations , Child Language , Language Therapy
10.
Distúrb. comun ; 34(1): e52065, mar. 2022. tab, ilus
Article in Portuguese | LILACS | ID: biblio-1396217

ABSTRACT

Introdução: O Transtorno do Espectro Autista é um transtorno neurodesenvolvimental caracterizado pelas dificuldades de comunicação por deficiência da linguagem e do uso da imaginação para lidar com jogos simbólicos, dificuldade de socialização e padrão de comportamento restritivo e repetitivo. Objetivo: Descrever as características da interação em relação à brincadeira funcional e simbólica de três crianças com suspeita de TEA. Método: Fizeram parte do estudo três pacientes do sexo masculino na faixa etária entre 3 anos a 4 anos e 6 meses, provenientes de demanda espontânea de serviço fonoaudiológico de um hospital pediátrico. Os procedimentos constituíram-se de entrevista inicial com os pais/responsáveis e a análise da interação com o avaliador através da brincadeira semiestruturada proposta pelo Protocolo de Avaliação Comportamental para Crianças com Suspeita de Transtorno do Espectro Autista - Revisado (PROTEA-R). Resultados: As 2 crianças com risco de TEA apresentaram prejuízo do uso da linguagem para comunicação e falta de efetividade em atenção compartilhada, enquanto a que não apresentou risco utiliza a linguagem para se comunicar e demonstra adequada função de atenção compartilhada. Observou-se que características da brincadeira funcional e simbólica e a atenção compartilhada, se presentes, são aspectos que atenuam o risco para TEA. Além disso, a ausência de ecolalia também é uma variável que auxilia o possível diagnóstico. Conclusão: A observação da brincadeira se mostrou efetiva na avaliação das funções comunicacionais e interacionais de crianças autistas, auxiliando no direcionamento e na otimização do processo terapêutico.


Introduction: Autism Spectrum Disorder is a neurodevelopmental disorder characterized by communication difficulties due to language deficiency and the use of imagination to deal with symbolic games, difficulty in socialization and pattern of restrictive and repetitive behavior. Objective: To describe the interaction characteristics in relation to functional and symbolic play of three children with suspected ASD. Method: Three male patients aged between 3 years and 4 years and 6 months, from spontaneous demand for a speech therapy service of a pediatric hospital, were part of the study. The procedures consisted of an initial interview with parents/guardians and the analysis of interaction with the evaluator through semi-structured play proposed by the Behavioral Assessment Protocol for Children with Suspected Autism Spectrum Disorder - Revised (PROTEA-R). Results: The 2 children at risk of ASD presented impaired use of language for communication and lack of effectiveness in shared attention, while the one who did not present risk uses language to communicate and demonstrate adequate shared attention function. It was observed that characteristics of functional and symbolic play and shared attention, if present, are aspects that attenuate the risk for ASD. In addition, the absence of ecolalia is also a variable that aids the possible diagnosis. Conclusion: The observation of play was effective in the evaluation of the communication allocated functions of autistic children, assisting in the direction and optimization of the therapeutic process.


Introducción: El Trastorno del Espectro Autista es un trastorno del neurodesarrollo caracterizado por dificultades de comunicación debido a la deficiencia del lenguaje y el uso de la imaginación para tratar los juegos simbólicos, la dificultad en la socialización y el patrón de comportamiento restrictivo y repetitivo. Objetivo: Describir las características de la interacción en relación con el juego funcional y simbólico de tres niños con sospecha de TEA. Método: Tres pacientes varones de entre 3 años y 4 años y 6 meses, por la demanda espontánea de un servicio de logoterapia de un hospital pediátrico, formaron parte del estudio. Los procedimientos consistieron en una entrevista inicial con los padres/tutores y el análisis de la interacción con el evaluador a través del juego semiestructurado propuesto por el Protocolo de Evaluación del Comportamiento para Niños con Sospecha de Trastorno del Espectro Autista - Revisado (PROTEA-R). Resultados: Los 2 niños en riesgo de TEA presentaban un uso deficiente del lenguaje para la comunicación y la falta de eficacia en la atención compartida, mientras que aquellos que no presentaban un lenguaje de uso de riesgo para comunicar y demostrar una función de atención compartida adecuada. Se observó que las características del juego funcional y simbólico y la atención compartida, si están presentes, son aspectos que atenúan el riesgo para el TEA. Además, la ausencia de ecolalia es también una variable que ayuda a un posible diagnóstico. Conclusión: La observación del juego fue eficaz en la evaluación de las funciones asignadas de comunicación de los niños autistas, ayudando en la dirección y optimización del proceso terapéutico.


Subject(s)
Humans , Male , Child, Preschool , Play and Playthings/psychology , Communication , Autism Spectrum Disorder , Child Language , Cross-Sectional Studies
12.
Psicol. Estud. (Online) ; 27: e58929, 2022.
Article in Spanish | LILACS, INDEXPSI | ID: biblio-1376060

ABSTRACT

RESUMEN En el presente artículo, escrito en el contexto de la pandemia 2020-2021 y en el marco del cumplimento del Aislamiento Social Preventivo y Obligatorio (ASPO), analizamos dos experiencias comunitarias vinculadas al cuidado de las infancias y adolescencias que se desarrollan en las provincias de Neuquén y Río Negro (Patagonia Argentina). Dicho análisis es resultado de una investigación cualitativa realizada desde la perspectiva de la Psicología Social Crítica y las Políticas Públicas en la que buscamos recuperar los saberes sociales que estas iniciativas comunitarias pueden aportar al diseño y reformulación de las políticas públicas de cuidado. Específicamente, las experiencias que aquí presentamos son: la Asociación Civil GAIA-Nueva Crianza, conformada por familias de niñes y adolescentes trans; y la Asociación Civil Lazos Azules, integrada por familias de niños y adolescentes con TEA (Trastorno del Espectro Autista). Si bien las dos asociaciones son muy diferentes entre sí, ambas coinciden en estar protagonizadas por familias que, a partir de haber escuchado y prestado atención a las necesidades de sus hijo/a/es, se organizaron colectivamente para visibilizar la realidad de sus niño/a/es y adolescentes generando distintas acciones. Dichas acciones tienden no sólo a hacer efectivos los derechos de las infancias y adolescencias, especialmente aquellos vinculados a la identidad, la educación y la salud, sino que están orientadas a incidir en las políticas públicas de cuidado a nivel local desde lo que Boaventura de Sousa Santos denomina la sociología de las emergencias y desde lo que Rita Segato designa como una politicidad en clave femenina anfibia.


RESUMO. Neste artigo, escrito no contexto da pandemia 2020-2021 e no quadro do cumprimento do Isolamento Social Preventivo e Obrigatório (ASPO), analisamos duas experiências comunitárias relacionadas com o cuidado de crianças e adolescentes que ocorrem nas províncias de Neuquén e Río Negro (Patagônia Argentina). Esta análise é resultado de uma pesquisa qualitativa realizada na perspectiva da Psicologia Social Crítica e das Políticas Públicas, na qual buscamos resgatar o conhecimento social de que essas iniciativas comunitárias podem contribuir para o desenho e reformulação das políticas públicas de atenção. Especificamente, as experiências que aqui apresentamos são: a Associação Civil GAIA-Nueva Crianza, formada por famílias de crianças e adolescentes trans; e a Associação Civil Lazos Azules, formada por famílias de crianças e adolescentes com TEA (Transtorno do Espectro do Autismo). Embora as duas associações sejam muito diferentes entre si, ambas coincidem no fato de serem lideradas por famílias que, depois de ouvir e atentar para as necessidades dos filhos, se organizam coletivamente para tornar visível a realidade dos filhos. a / es e adolescentes gerando diferentes ações. Essas ações tendem não só a efetivar os direitos da criança e do adolescente, especialmente aqueles vinculados à identidade, educação e saúde, mas visam influenciar as políticas públicas de atenção em nível local a partir do que Boaventura de Sousa Santos denomina a sociologia das emergências e do que Rita Segato designa como feminilidade anfíbia chave de politicidade.


ABSTRACT In this article, written in the context of the 2020-2021 pandemic and in compliance with the Preventive and Compulsory Social Isolation (ASPO), we analyze two community experiences related to the care of children and adolescents that take place in the provinces of Neuquén and Río Negro (Argentinian Patagonia). This analysis is the result of a qualitative study carried out from the perspective of Critical Social Psychology and Public Policy, in which we seek to recover the social knowledge that these community initiatives can contribute to the design and reformulation of public care policies. Specifically, the experiences we present here are the GAIA-Nueva Crianza Civil Association, made up of families of trans children and adolescents; and the Lazos Azules civil association, made up of families of children and adolescents with ASD (autism spectrum disorder). Although the two associations are very different from each other, they both coincide in being led by families who, after having listened and paid attention to the needs of their children, they organized collectively to make visible the reality of their children and adolescents by generating different actions. These actions tend not only to make effective the rights of children and adolescents, especially those linked to identity, education and health, but are also aimed at influencing public care policies at the local level, from what Boaventura de Sousa Santos calls the sociology of emergencies and from what Rita Segato designates amphibious feminine key politicity.


Subject(s)
Humans , Male , Female , Child , Adolescent , Psychology, Social/education , Public Policy , Child Welfare/psychology , Education , Social Isolation/psychology , Child Care/psychology , Autism Spectrum Disorder/ethnology , Gender Diversity , Gender Identity , Anthropology, Cultural/education
13.
Einstein (Säo Paulo) ; 20: eRC5795, 2022.
Article in English | LILACS | ID: biblio-1360403

ABSTRACT

ABSTRACT Hyperhidrosis is characterized by excessive sweating and it affects almost 5% of the population. The affected age group is wide, and it can affect from children to elderlies. There are two types of hyperhidrosis: generalized and focal. Treatment depends on the symptoms presented. In more severe cases, radiofrequency sympatholysis and bilateral thoracic sympathectomy are the options. However, recurrence is possible or the postoperative appearance of conditions called compensatory hyperhidrosis or reflex hyperhidrosis. We describe two cases of patients treated with Cannabidiol who had significant and unexpected improvement of hyperhidrosis. The first patient received Cannabidiol specific for public presentations at work, and the second patient had a diagnosis of autism spectrum disorder. The hyperhidrosis improved in both patients immediately after using Cannabidiol.


Subject(s)
Humans , Child , Cannabidiol/therapeutic use , Autism Spectrum Disorder , Hyperhidrosis/drug therapy , Sympathectomy , Treatment Outcome , Patient Satisfaction
14.
Psicol. USP ; 332022.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1367239

ABSTRACT

Este estudo de caso mediado pela internet objetivou avaliar possíveis relações entre contação de histórias associada a exercícios de yoga e autorregulação de crianças com transtorno do espectro autista. Para tanto, pais e cuidadores foram instruídos a utilizar vídeos de contação de histórias, vídeos com demonstração de rotinas de exercícios de yoga e formulários de avaliação, totalizando três encontros. Relações entre controle por contingências e governo por regras foram investigadas. Verificamos resultados positivos nos dois casos estudados, um deles mediado pelos pais da criança e outro pela acompanhante terapêutica. Em conclusão, o envolvimento de pessoas de referência no treino de autorregulação demonstrou gerar efeitos positivos no comportamento das crianças e nas relações interpessoais estabelecidas. Estudos futuros poderão se valer do delineamento testado e do material interventivo para alcançar um maior número de crianças com desenvolvimento atípico e típico


This internet-mediated case study aimed to evaluate possible relationships between storytelling associated with yoga exercises and self-regulation of children with Autism Spectrum Disorder. To this end, parents and caregivers were instructed to use storytelling videos, videos with demonstration of yoga exercise routines and evaluation forms in a total of three meetings. Relationships between contingency-shaped and rule-governed behavior were investigated. We found positive results in the two cases studied, one mediated by the child's parents and the other by the therapeutic companion. In conclusion, the involvement of relevant people in self-regulation training has been shown to generate positive effects on children's behavior and also on established interpersonal relationships. Future studies may use the tested design and intervention material to reach a greater number of children with atypical and typical development


Cette étude de cas médiatisée par Internet visait à évaluer les relations possibles entre la narration associée aux exercices de yoga et l'autorégulation d'enfants atteints de troubles du spectre autistique. À cette fin, les parents et les soignants ont été invités à utiliser des vidéos de narration, des vidéos avec démonstration de routines d'exercices de yoga et des formulaires d'évaluation dans un total de trois réunions. Les relations entre les comportements contingents et régis par des règles ont été étudiées. Nous avons trouvé des résultats positifs dans les deux cas étudiés, l'un médiatisé par les parents de l'enfant et l'autre par le compagnon thérapeutique. En conclusion, il a été démontré que l'implication des personnes concernées dans la formation à l'autorégulation a des effets positifs sur le comportement des enfants et sur les relations interpersonnelles établies. Les études futures peuvent utiliser la conception testée et le matériel d'intervention pour atteindre un plus grand nombre d'enfants au développement atypique et typique


Este estudio de caso mediado por Internet tuvo como objetivo evaluar las posibles relaciones entre la narración asociada con los ejercicios de yoga y la autorregulación de los niños con trastorno del espectro autista. Con este fin, se instruyó a los padres y cuidadores a utilizar videos narrativos, videos con demostración de rutinas de ejercicios de yoga y formularios de evaluación en un total de tres reuniones. Se investigaron las relaciones entre el comportamiento en forma de contingencia y el regido por reglas. Encontramos resultados positivos en los dos casos estudiados, uno mediado por los padres del niño y otro por el acompañante terapéutico. En conclusión, se ha demostrado que la participación de personas relevantes en la formación de autorregulación genera efectos positivos en el comportamiento de los niños y también en las relaciones interpersonales establecidas. Los estudios futuros pueden utilizar el diseño probado y el material de intervención para llegar a un mayor número de niños con un desarrollo típico y atípico


Subject(s)
Humans , Male , Female , Child , Yoga , Social Skills , Autism Spectrum Disorder/therapy , Emotional Regulation , Internet-Based Intervention , Literature , Family , Caregivers , Interpersonal Relations
15.
Audiol., Commun. res ; 27: e2447, 2022. graf
Article in Portuguese | LILACS | ID: biblio-1383890

ABSTRACT

RESUMO O objetivo deste estudo foi produzir análise multimodal exploratória sobre a atenção compartilhada. Utilizou-se a ferramenta ELAN (EUDICO Language Annotator), software com recursos para sincronização temporal e especiais para modalidades verbal e não verbal, que facilitam a visualização e anotação de contextos interacionais. Foram analisados e transcritos trechos de dez minutos de sessão de avaliação fonoaudiológica de uma criança em investigação para transtorno do espectro do autismo (TEA) e outra, com desenvolvimento típico, pareadas por faixa etária e gênero. Foram investigadas e quantificadas as ocorrências espontâneas de direcionamento do olhar das crianças para: os olhos do interlocutor; os brinquedos e/ou brincadeiras; os olhos do interlocutor - brinquedos (atenção compartilhada). As ocorrências de direcionamento do olhar diferiram entre as crianças de forma quantitativa e qualitativa. A criança com suspeita de TEA não produziu episódio de atenção compartilhada, nem direcionou seu olhar para o interlocutor. Foram 56 ocorrências de direcionamentos de olhar apenas para os brinquedos. A criança em desenvolvimento típico produziu 18 ocorrências de atenção compartilhada, sendo que, em todas as vezes que direcionou o olhar para os olhos do interlocutor, o fez para compartilhar o brinquedo ou brincadeira. Observou-se, ainda, 37 ocorrências de direcionamento do olhar para o brinquedo. A partir da análise exploratória produzida pela ferramenta ELAN, foi possível observar que houve diferença em número de ocorrência e trajetória do olhar entre as duas crianças e verificar que a atenção compartilhada esteve ausente na criança com risco para TEA.


ABSTRACT The aim of this study was to produce exploratory multimodal analysis on joint attention. We used the ELAN tool: software with resources for temporal and special synchronization for verbal and non-verbal modalities that facilitate the visualization and annotation of interactional contexts. Excerpts of ten minutes of speech and language pathology evaluation of the child with suspected ASD and of another child with typical development matched by age group and gender, were analyzed and transcribed. Spontaneous occurrences of the child's gaze were investigated: a) Towards the interlocutor's eyes. b) Towards toys or play. c) Towards the interlocutor's eyes and toys (Joint Attention). The occurrences of look direction differed between children in a quantitative and qualitative way. The child with suspected ASD did not produce an episode of joint attention, nor did he direct his gaze to the interlocutor. There were 56 occurrences of gazing towards the toys. The typical child produced 18 occurrences of joint attention, and whenever he directed his eyes to the interlocutor's eyes, he did so with the intention of sharing the toy or play. We also observed 37 occurrences of gazing towards the toy or play. From the exploratory analysis produced by ELAN tool, it was possible to observe that there were differences in the number of occurrences and look direction between the evaluated children and to verify that the joint attention was absent in the child with ASD risk.


Subject(s)
Humans , Child , Autism Spectrum Disorder/diagnosis , Eye-Tracking Technology/instrumentation , Combined Modality Therapy , Speech, Language and Hearing Sciences
16.
Article in Chinese | WPRIM | ID: wpr-936290

ABSTRACT

OBJECTIVE@#To investigate the mechanism of valproic acid (VPA) -induced impairment of the dendritic spines and synapses in the prefrontal cortex (PFC) for causing core symptoms of autism spectrum disorder (ASD) in mice.@*METHODS@#Female C57 mice were subjected to injections of saline or VPA on gestational days 10 and 12, and the male offspring mice in the two groups were used as the normal control group and ASD model group (n=10), respectively. Another 20 male mice with fetal exposure to VPA were randomized into two groups for stereotactic injection of DMSO or Wortmannin into the PFC (n=10). Open field test, juvenile play test and 3-chamber test were used to evaluate autistic behaviors of the mice. The density of dendrite spines in the PFC was observed with Golgi staining. Western blotting and immunofluorescence staining were used to detect the expressions of p-PI3K, PI3K, p-AKT, AKT, p-mTOR, mTOR and the synaptic proteins PSD95, p-Syn, and Syn in the PFC of the mice.@*RESULTS@#Compared with the normal control mice, the mice with fetal exposure to VPA exhibited obvious autism-like behaviors with significantly decreased density of total, mushroom and stubby dendritic spines (P < 0.05) and increased filopodia dendritic spines (P < 0.05) in the PFC. The VPA-exposed mice also showed significantly increased expressions of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR (P < 0.01) and lowered expressions of PSD95 and p-Syn/Syn in the PFC (P < 0.05 or 0.001). Wortmannin injection into the PFC obviously improved the ASD-like phenotype and dendritic spine development, down-regulated PI3K/Akt/mTOR signaling pathway and up-regulated the synaptic proteins in VPA-exposed mice.@*CONCLUSION@#In male mice with fetal exposure to VPA, excessive activation of PI3K/Akt/mTOR signaling pathway and decreased expressions of the synaptic proteins PSD95 and p-Syn cause dendritic spine damage and synaptic development disturbance in the PFC, which eventually leads to ASD-like phenotype.


Subject(s)
Animals , Autism Spectrum Disorder/chemically induced , Autistic Disorder/chemically induced , Dendritic Spines , Disease Models, Animal , Female , Male , Mice , Phosphatidylinositol 3-Kinases , Prefrontal Cortex , Prenatal Exposure Delayed Effects , Valproic Acid/adverse effects
17.
Article in Chinese | WPRIM | ID: wpr-928632

ABSTRACT

OBJECTIVES@#To study the effect of parent-child cooperative music therapy on the core symptoms of children with autism spectrum disorder (ASD) and their mothers.@*METHODS@#In this prospective study, 112 children with ASD and their mothers were divided into a music therapy group and an applied behavior analysis (ABA) group using a random number table (n=56 each). The children in the ABA group were treated with ABA, and those in the music therapy group were given parent-child cooperative music therapy in addition to the ABA treatment. The duration of intervention was 8 weeks for both groups. Childhood Autism Rating Scale (CARS), Autism Behavior Checklist (ABC), Parenting Stress Index-Short form (PSI-SF), Family APGAR Index, and Herth Hope Index (HHI) were used to evaluate the core symptoms of children with ASD and the parenting stress, family APGAR index, and hope level of mothers before and after intervention.@*RESULTS@#A total of 100 child-mother dyads completed the whole study, with 50 child-mother dyads in each group. After intervention, the children in the music therapy group had significantly lower total score of ABC scale and scores of sensation, social interaction, and somatic movement, as well as a significantly lower total score of CARS than those in the ABA group (P<0.05). After intervention, compared with the mothers in the ABA group, the mothers in the music therapy group had significantly higher total score of PSI-SF and score of parent-child dysfunctional interaction, significantly higher total score of HHI and scores of each dimension, and significantly higher total score of APGAR and scores of cooperation and intimacy (P<0.05).@*CONCLUSIONS@#Parent-child cooperative music therapy combined with ABA can alleviate the core symptoms of children with ASD, reduce the parenting stress of their mothers, and improve family APGAR index and hope level.


Subject(s)
Autism Spectrum Disorder/therapy , Child , Female , Humans , Mothers , Music Therapy , Parent-Child Relations , Prospective Studies
18.
Neuroscience Bulletin ; (6): 249-262, 2022.
Article in English | WPRIM | ID: wpr-929098

ABSTRACT

The radial migration of cortical pyramidal neurons (PNs) during corticogenesis is necessary for establishing a multilayered cerebral cortex. Neuronal migration defects are considered a critical etiology of neurodevelopmental disorders, including autism spectrum disorders (ASDs), schizophrenia, epilepsy, and intellectual disability (ID). TRIO is a high-risk candidate gene for ASDs and ID. However, its role in embryonic radial migration and the etiology of ASDs and ID are not fully understood. In this study, we found that the in vivo conditional knockout or in utero knockout of Trio in excitatory precursors in the neocortex caused aberrant polarity and halted the migration of late-born PNs. Further investigation of the underlying mechanism revealed that the interaction of the Trio N-terminal SH3 domain with Myosin X mediated the adherence of migrating neurons to radial glial fibers through regulating the membrane location of neuronal cadherin (N-cadherin). Also, independent or synergistic overexpression of RAC1 and RHOA showed different phenotypic recoveries of the abnormal neuronal migration by affecting the morphological transition and/or the glial fiber-dependent locomotion. Taken together, our findings clarify a novel mechanism of Trio in regulating N-cadherin cell surface expression via the interaction of Myosin X with its N-terminal SH3 domain. These results suggest the vital roles of the guanine nucleotide exchange factor 1 (GEF1) and GEF2 domains in regulating radial migration by activating their Rho GTPase effectors in both distinct and cooperative manners, which might be associated with the abnormal phenotypes in neurodevelopmental disorders.


Subject(s)
Autism Spectrum Disorder/metabolism , Cell Movement/genetics , Humans , Interneurons/metabolism , Neurodevelopmental Disorders/genetics , Neurons/metabolism , Rho Guanine Nucleotide Exchange Factors/genetics
19.
Article in English | WPRIM | ID: wpr-928586

ABSTRACT

OBJECTIVES@#To study the serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) in children with autism spectrum disorder (ASD) and their association with the core symptoms of ASD.@*METHODS@#A total of 150 ASD children aged 2-7 years (ASD group) and 165 healthy children matched for age and sex (control group) who were recruited at the outpatient service of Chongqing Health Center for Women and Children were enrolled as subjects. Autism Behavior Checklist (ABC) and Childhood Autism Rating Scale (CARS) were used to evaluate the core symptoms of the ASD children. Chemiluminescence was used to measure the serum levels of IGF-1 and IGFBP-3 in both groups.@*RESULTS@#The ASD group had a significantly lower serum level of IGF-1 than the control group (P<0.05). The children with severe ASD had significantly lower serum levels of IGF-1 and IGFBP-3 than those with mild-to-moderate ASD (P<0.001). For the children aged 2-3 years, the ASD group had a significantly lower serum level of IGF-1 than the control group (P<0.05). Boys had a significantly lower serum level of IGF-1 than girls in both ASD and control groups (P<0.05). The serum levels of IGF-1 and IGFBP-3 were negatively correlated with the total score of CARS (r=-0.32 and -0.40 respectively, P<0.001).@*CONCLUSIONS@#The reduction in serum IGF-1 level in early childhood may be associated with the development of ASD, and the serum levels of IGF-1 and IGFBP-3 are associated with the core symptoms of ASD children.


Subject(s)
Autism Spectrum Disorder , Autistic Disorder , Child , Child, Preschool , Female , Humans , Insulin-Like Growth Factor Binding Protein 3 , Insulin-Like Growth Factor I , Male
20.
Article in Chinese | WPRIM | ID: wpr-928435

ABSTRACT

OBJECTIVE@#To explore the genetic basis for a child manifesting with intellectual disability, language delay and autism spectrum disorder.@*METHODS@#Genomic DNA was extracted from peripheral blood samples of the child and his family members, and subjected to whole exome sequencing. Candidate variants were verified by Sanger sequencing and interpreted according to the guidelines of the American College of Medical Genetics and Genomics.@*RESULTS@#The child was found to harbor a heterozygous c.568C>T (p.Q190X) nonsense variant of the ADNP gene, which was not detected in either parent by Sanger sequencing.@*CONCLUSION@#The clinical and genetic testing both suggested that the child has Helsmoortel-van der Aa syndrome due to ADNP gene mutation, which is extremely rare in China.


Subject(s)
Abnormalities, Multiple/genetics , Autism Spectrum Disorder/genetics , Autistic Disorder/genetics , Child , Heterozygote , Homeodomain Proteins/genetics , Humans , Intellectual Disability/genetics , Mutation , Nerve Tissue Proteins/genetics , Rare Diseases
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