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Article in English | WPRIM | ID: wpr-17407


In this work, we used a preparation of diminazene, which belongs to the group of aromatic diamidines. This compound acts on the causative agents of blood protozoan diseases produced by both flagellated protozoa (Trypanosoma) and members of the class Piroplasmida (Babesia, Theileria, and Cytauxzoon) in various domestic and wild animals, and it is widely used in veterinary medicine. We examined the behavior of water-disperse diminazene (immobilized in Tween 80 micelles) at the cellular and organismal levels. We assessed the interaction of an aqueous and a water-disperse preparation with cells of the reticuloendothelial system. We compared the kinetic parameters of aqueous and water-disperse diminazene in sheep erythrocytes and plasma. The therapeutic properties of these two preparations were also compared. We found that the surface-active substances improved intracellular penetration of the active substance through interaction with the cell membrane. In sheep blood erythrocytes, micellar diminazene accumulated more than its aqueous analog. This form was also more effective therapeutically than the aqueous analog. Our findings demonstrate that use of micellar diminazene allows the injection dose to be reduced by 30%.

Animals , Babesiosis/drug therapy , Diminazene/metabolism , Dose-Response Relationship, Drug , Female , Macrophages, Peritoneal/cytology , Male , Micelles , Polysorbates , Rats , Sheep/blood , Sheep Diseases/drug therapy , Trypanocidal Agents/pharmacokinetics
Journal of the Egyptian Society of Parasitology. 2008; 38 (1): 265-272
in English | IMEMR | ID: emr-88266


Babesiosis is tick-borne malaria-like disease. Man is an opportuneistic host for Babesia species. This paper presented the second Egyptian human babesiosis. The signs and symptoms, CBC, liver functions and kidney functions tests and all other serologic tests did not give any definite diagnosis. Also, he was sero-negative for malaria infection. The patient was critically diagnosed by the demonstration of the typical ring forms of Babesia species in stained blood smears. He was successfully treated with Quinine and Clindamycin, and was discharged from the hospital after the clinical and parasitological improvement. The epidemiology of zoonotic babesiosis was discussed

Humans , Male , Humans , Review Literature as Topic , Signs and Symptoms , Serologic Tests , Antibodies , Zoonoses , Quinine , Clindamycin , Babesiosis/drug therapy
Iranian Journal of Veterinary Research. 2007; 62 (4): 155-157
in English | IMEMR | ID: emr-146202


Babesiosis is the only intraerythrocytic parasitic disease that affects horses. Signs include fever, depression, anorexia, weakness, ataxia, lacrimation, mucoid nasal discharge, icterus and hemoglobinuria. Death may occur within 48 hours or chronic cases may persist for months. In May 2001, a three year old cross-bred mare was referred to the veterinary teaching hospital of Kerman university, with anorexia and depression for five days and jaundice in conjunctiva. Hematological examination revealed a PCV of 40.In the blood smear, Babesiaequiwas observed and typified. Treatment was performed by Imizol [4mg/kg, im] for three days. The animal got better and vital signs were normal after completion of the treatment. The mucous membrane was completely normal and the appetite was normal as well

Animals , Babesiosis/drug therapy , Babesiosis/diagnosis , Imidocarb , Antiprotozoal Agents